Batches Of Recombinant Adenovirus With Altered Terminal Ends

Abstract

Described is a composition comprising a plurality of recombinant adenovirus particles, being a recombinant human adenovirus of serotype 5, 26, 34, 35, 48, 49 or 50, or a recombinant simian adenovirus, characterized in that the genomes of essentially all adenovirus particles in the composition comprise as the 5′ terminal nucleotides the nucleotide sequence: CTATCTAT (nucleotides 1-8 of SEQ ID NO:7). Also described are methods to produce such compositions.


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Document History
  • Publication: Jan 13, 2015
  • Application: Mar 11, 2013
    US US 201313794318 A
  • Priority: Mar 11, 2013
    US US 201313794318 A
  • Priority: Mar 12, 2012
    US US 201261609678 P

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