Metallodrugs Having Improved Pharmacological Properties, And Methods Of Manufacture And Use Thereof

Abstract

It is an object of the present invention to provide improved pharmacological properties to molecules which bind to a target with low affinity (hereinafter referred to as a “ligand moiety”) through linkage of such molecules to a metal binding moiety, thereby generating a combination molecule commonly referred to as a “metallodrug” or “metallotherapeutic.” The metal binding domain of metallodrugs typically catalyzes oxido-reductase chemistry or acts as a Lewis-Acid catalyst, resulting in modification of proteins and nucleic acids that are in close proximity due to binding of the ligand moiety to its target.


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Document History
  • Publication: Oct 14, 2014
  • Application: May 12, 2012
    US US 201213470299 A
  • Priority: May 12, 2012
    US US 201213470299 A
  • Priority: May 12, 2011
    US US 201161485528 P

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