Metallodrugs Having Improved Pharmacological Properties, And Methods Of Manufacture And Use Thereof


It is an object of the present invention to provide improved pharmacological properties to molecules which bind to a target with low affinity (hereinafter referred to as a “ligand moiety”) through linkage of such molecules to a metal binding moiety, thereby generating a combination molecule commonly referred to as a “metallodrug” or “metallotherapeutic.” The metal binding domain of metallodrugs typically catalyzes oxido-reductase chemistry or acts as a Lewis-Acid catalyst, resulting in modification of proteins and nucleic acids that are in close proximity due to binding of the ligand moiety to its target.

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Document History
  • Publication: Oct 14, 2014
  • Application: May 12, 2012
    US US 201213470299 A
  • Priority: May 12, 2012
    US US 201213470299 A
  • Priority: May 12, 2011
    US US 201161485528 P

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