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Search Applicants and Owners separately:Univ* Connecti*. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 2880
Search Applicants and Owners separately:Univ* Connecti*. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 2880
A is a direct bond,\n
B is N(R5),\n\nR5 is hydrogen, OH, alkyl or substituted alkyl;\n
R2 comprises —(CH2)n—Z;\n\nn is an integer from 0 to about 7;\n
wherein Z comprises, H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8, C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)jOX3, O(CH2)jNX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X6, —CH═CHX8, —C≡CX8;\n
X1 and X2 each independently comprise H or alkyl, or\n
X1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from O, N or S, or\n
X1 and X2 together comprise part of an imide ring having about 5 to about 6 members,\n
X3 comprises H, alkyl, aryl, NO2, (CH2)mCN, hydroxyloweralkyl, or alkyl-NX1X2,\n
X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein\n
X7 comprises H, alkyl, NO2, NO, P(O)(OX8)2, PH(O)(OX8), S(O)kN(alkyl)2, S(O)kX8, S(O)kOX8, COOX8, CONX8, SO3H, COX8, wherein\n
X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or —CX9═CHX10 wherein\n
X9 and X10 each independently comprise H or alkyl\n
Wherein m is an integer from 0 to 7\n
j is an integer from 0 to about 6, or\n
k is an integer from 0 to about 2; or\n
R2 comprises —(CH2)n—Z;\n
n is an integer from 0 to about 7; and\n
Z comprises a carbocyclic ring having about 4 to about 7 ring members, a heterocyclic ring having about 4 to about 7 ring members, an aromatic ring having about 5 to about 7 ring members, a heteroaromatic ring having about 5 to about 7 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring, a heteropolycyclic ring; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the —(CH2)n— group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or\n
R2 comprises —(CH2)n—Z;\n
n is an integer from 0 to about 7; and\n
Z comprises a 5 member unsaturated ring having 0 to 4 independently selected heteroatoms as ring members, a substituted 5 member unsaturated ring having 0 to 4 independently selected heteroatoms as ring members, a 6 member aromatic ring having 0 to 5 independently selected heteroatoms as ring members or a substituted 6 member aromatic ring having 0 to 5 independently selected heteroatoms; and wherein the connecting point between the —(CH2)n— group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or\n
R2 comprises —(CH2)n—Z;\n
n is an integer from 0 to about 7; and\n
Z comprises 1-, 2- or 3-pyrrolidinyl, 1-, 2-, 3- or 4-piperidinyl, 2-, 3- or 4-morpholinyl, 2-, 3- or 4-thiomorpholinyl, 1-, 2- or 3-azetidinyl, 1- or 2-piperazinyl, 2- or 3-tetrahydrofuranyl; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the —(CH2)n— group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or\n
R2 comprises —(CH2)n—Z;\n
n is an integer from 0 to about 7; and\n
Z comprises\n\n
wherein X and Y each independently comprise, H, halogen, CF3, CF2H, N3, NCS, ON, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8, C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)jOX3, O(CH2)jNX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X6, —CH═CHX8, —C≡CX8;\n
X1 and X2 each independently comprise H or alkyl, or\n
X1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from O, N or S, or\n
X1 and X2 together comprise part of an imide ring having about 5 to about 6 members,\n
X3 comprises H, alkyl, aryl, NO2, (CH2)mCN, hydroxyloweralkyl, or alkyl-NX1X2,\n
X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein\n
X7 comprises H, alkyl, NO2, NO, P(O)(OX8)2, PH(O)(OX8), S(O)kN(alkyl)2, S(O)kX8, S(O)kOX8, COOX8, CONX8, SO3H, COX8, wherein\n
X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or —CX9═CHX10 wherein\n
X9 and X10 each independently comprise H or alkyl\n
Wherein m is an integer from 0 to 7\n
j is an integer from 0 to about 6, or\n
k is an integer from 0 to about 2\n
W comprises H or alkyl; or\n
R2 comprises —(CH2)n—Z;\n
n is an integer from 0 to about 7; and\n
Z comprises a carbocyclic ring having 6 ring atoms fused to a heterocyclic ring having from 5 to 7 ring atoms, a carbocyclic ring having 6 ring atoms fused to a heteroaromatic ring having from 5 to 7 ring atoms, a heterocyclic ring having 6 ring atoms fused to a heterocyclic ring having from 5 to 7 ring atoms, an heterocyclic ring having 6 ring atoms fused to a heteroaromatic ring having from 5 to 7 ring atoms, an aromatic ring having 6 ring atoms fused to a heterocyclic ring having from 5 to 7 ring atoms, an aromatic ring having 6 ring atoms fused to a heteroaromatic ring having from 5 to 7 ring atoms, a heteroaromatic ring having 6 ring atoms fused to a heterocyclic ring having from 5 to 7 ring atoms or a heteroaromatic ring having 6 ring atoms fused to a heteroaromatic ring having from 5 to 7 ring atoms; or\n
R2 comprises —(CH2)n—Z;\n
n comprises an integer from 0 to about 7; and\n
Z comprises an unsaturated ring having 5 ring atoms and 0 to 2 independently selected heteroatoms as ring members fused to an unsaturated ring having 5 ring atoms and 0 to 4 independently selected heteroatoms as ring members, an unsaturated ring having 5 ring atoms and 0 to 2 independently selected heteroatoms as ring members fused to an unsaturated ring having 6 or 7 ring atoms and 0 to 3 independently selected heteroatoms as ring members or an unsaturated ring having 6 ring atoms and 0 to 4 independently selected heteroatoms as ring members fused to an unsaturated ring having 6 or 7 ring atoms and 0 to 4 independently selected heteroatoms as ring members; or\n
R2 comprises —(CH2)m-Q1-(CH2)n—Z;\n
Q1 comprises NH, O, S, —CH═CH—, —C≡C—, —CO, SO2 or OSO2;\n
m is an integer from 1 to about 7;\n
n is an integer from 0 to about 7; and\n
wherein Z comprises, H, halogen, CF3, CF2H, N3, NCS, ON, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8, C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)jOX3, O(CH2)jNX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X6, —CH═CHX8, —C≡CX8;\n
X1 and X2 each independently comprise H or alkyl, or\n
X1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from O, N or S, or\n
X1 and X2 together comprise part of an imide ring having about 5 to about 6 members,\n
X3 comprises H, alkyl, aryl, NO2, (CH2)mCN, hydroxyloweralkyl, or alkyl-NX1X2,\n
X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein\n
X7 comprises H, alkyl, NO2, NO, P(O)(OX8)2, PH(O)(OX8), S(O)kN(alkyl)2, S(O)kX8, S(O)kOX8, COOX8, CONX8, SO3H, COX8, wherein\n
X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or —CX9═CHX10 wherein\n
X9 and X10 each independently comprise H or alkyl\n
Wherein m is an integer from 0 to 7\n
j is an integer from 0 to about 6, or\n
k is an integer from 0 to about 2; or\n
R2 comprises -Q2-(CH2)n—Z;\n
Q2 is optionally present and if present comprises —CH2—NH, —CH2—O, —CH2—S, —CH2—SO2 or —CH2—OSO2;\n
n is an integer from 0 to about 7;\n
wherein Z comprises, H, halogen, CF3, CF2H, N3, NCS, ON, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8, C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)jOX3, O(CH2)jNX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X6, —CH═CHX8, —C≡CX8;\n
X1 and X2 each independently comprise H or alkyl, or\n
X1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from O, N or S, or\n
X1 and X2 together comprise part of an imide ring having about 5 to about 6 members,\n
X3 comprises H, alkyl, aryl, NO2, (CH2)mCN, hydroxyloweralkyl, or alkyl-NX1X2,\n
X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein\n
X7 comprises H, alkyl, NO2, NO, P(O)(OX8)2, PH(O)(OX8), S(O)kN(alkyl)2, S(O)kX8, S(O)kOX8, COOX8, CONX8, SO3H, COX8, wherein\n
X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or —CX9═CHX10 wherein\n
X9 and X10 each independently comprise H or alkyl\n
Wherein m is an integer from 0 to 7\n
j is an integer from 0 to about 6,\n
k is an integer from 0 to about 2; or\n
R2 comprises —(CH2)m-Q1-(CH2)n—Z;\n
Q1 comprises NH, O, S, CH═CH, C≡C, CO, SO2 or OSO2;\n
m is an integer from 1 to about 7;\n
n is an integer from 0 to about 7;\n
Z comprises a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring; or\n
R2 comprises —(CH2)m-Q1-(CH2)n—Z;\n
Q1 comprises NH, O, S, CH═CH, C≡C, CO, SO2 or OSO2;\n
m is an integer from 1 to about 7;\n
n is an integer from 0 to about 7;\n
Z comprises a carbocyclic ring having about 4 to about 7 ring members, a heterocyclic ring having about 4 to about 7 ring members, an aromatic ring having about 5 to about 7 ring members, a heteroaromatic ring having about 5 to about 7 ring members; a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring, a heteropolycyclic ring or any above group substituted on at least one available ring atom by an alkyl group or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the —(CH2)n— group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or\n
R2 comprises —(CH2)m-Q1-(CH2)n—Z;\n
Q1 comprises NH, O, S, CH═CH, C≡C, CO, SO2 or OSO2;\n
m is an integer from 1 to about 7;\n
n is an integer from 0 to about 7; and\n
Z comprises a 5 member unsaturated ring having 0 to 4 independently selected heteroatoms as ring members, a substituted 5 member unsaturated ring having 0 to 4 independently selected heteroatoms as ring members, a 6 member aromatic ring having 0 to 5 independently selected heteroatoms as ring members or a substituted 6 member aromatic ring having 0 to 5 independently selected heteroatoms; and wherein the connecting point between the —(CH2)n— group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or\n
R2 comprises —(CH2)m-Q1-(CH2)n—Z;\n
Q1 comprises NH, O, S, CH═CH, C≡C, CO, SO2 or OSO2;\n
m is an integer from 1 to about 7;\n
n is an integer from 0 to about 7;\n
Z comprises 1-, 2- or 3-pyrrolidinyl, 1-, 2-, 3- or 4-piperidinyl, 2-, 3- or 4-morpholinyl, 2-, 3- or 4-thiomorpholinyl, 1-, 2- or 3-azetidinyl, 1- or 2-piperazinyl, 2- or 3-tetrahydrofuranyl; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the —(CH2)n— group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or\n
R2 comprises —(CH2)m-Q1-(CH2)n—Z;\n
Q1 comprises NH, O, S, CH═CH, C≡C, CO, SO2 or OSO2;\n
m is an integer from 1 to about 7;\n
n is an integer from 0 to about 7; and\n
Z comprises\n\n
wherein X and Y each independently comprise\n
H, halogen, CF3, CF2H, N3, NCS, ON, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8, C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)jOX3, O(CH2)jNX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X6, —CH═CHX8, —C≡CX8;\n
X1 and X2 each independently comprise H or alkyl, or\n
X1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from O, N or S, or\n
X1 and X2 together comprise part of an imide ring having about 5 to about 6 members,\n
X3 comprises H, alkyl, aryl, NO2, (CH2)mCN, hydroxyloweralkyl, or alkyl-NX1X2,\n
X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein\n
X7 comprises H, alkyl, NO2, NO, P(O)(OX8)2, PH(O)(OX8), S(O)kN(alkyl)2, S(O)kX8, S(O)kOX8, COOX8, CONX8, SO3H, COX8, wherein\n
X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or —CX9═CHX10 wherein\n
X9 and X10 each independently comprise H or alkyl\n
Wherein m is an integer from 0 to 7\n
j is an integer from 0 to about 6,\n
k is an integer from 0 to about 2\n
W comprises H or alkyl; or\n
R2 comprises —(CH2)m-Q1-(CH2)n—Z;\n
Q1 comprises NH, O, S, CH═CH, C≡C, CO, SO2 or OSO2;\n
m is an integer from 1 to about 7;\n
n is an integer from 0 to about 7; and\n
Z comprises an unsaturated ring having 5 ring atoms and 0 to 2 independently selected heteroatoms as ring members fused to an unsaturated ring having 5 ring atoms and 0 to 4 independently selected heteroatoms as ring members, an unsaturated ring having 5 ring atoms and 0 to 2 independently selected heteroatoms as ring members fused to an unsaturated ring having 6 or 7 ring atoms and 0 to 4 independently selected heteroatoms as ring members or an unsaturated ring having 6 ring atoms and 0 to 4 independently selected heteroatoms as ring members fused to an unsaturated ring having 6 or 7 ring atoms and 0 to 4 independently selected heteroatoms as ring members; or\n
R2 comprises —(CH2)m-Q1-(CH2)n—Z;\n
Q1 comprises NH, O, S, CH═CH, C≡C, CO, SO2 or OSO2;\n
m is an integer from 1 to about 7;\n
n is an integer from 0 to about 7; and\n
Z comprises\n\n
R2 comprises -T-(CH2)n—Z;\n
n comprises an integer from 0 to about 7;\n
T comprises a carbocyclic ring having 3 to about 8 ring members, an unsaturated ring having 3 to about 8 carbon atoms as ring members, an aromatic ring having 5 to about 8 carbon atoms as ring members, a heterocyclic ring having 3 to about 8 ring members, a heteroaromatic ring having 5 to about 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring; and\n
Z comprises, H, halogen, CF3, CF2H, N3, NCS, ON, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8, C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)jOX3, O(CH2)jNX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X6, —CH═CHX8, —C≡CX8;\n
X1 and X2 each independently comprise H or alkyl, or\n
X1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from O, N or S, or\n
X1 and X2 together comprise part of an imide ring having about 5 to about 6 members,\n
X3 comprises H, alkyl, aryl, NO2, (CH2)mCN, hydroxyloweralkyl, or alkyl-NX1X2,\n
X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein\n
X7 comprises H, alkyl, NO2, NO, P(O)(OX8)2, PH(O)(OX8), S(O)kN(alkyl)2, S(O)kX8, S(O)kOX8, COOX8, CONX8, SO3H, COX8, wherein\n
X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or —CX9═CHX10 wherein\n
X9 and X10 each independently comprise H or alkyl\n
Wherein m is an integer from 0 to 7\n\nj is an integer from 0 to about 6,\nk is an integer from 0 to about 2; or\n
R2 comprises -T-(CH2)n—Z;\n
n comprises an integer from 0 to about 7;\n
T comprises a carbocyclic ring having 3 to about 8 ring members, an unsaturated ring having 3 to about 8 carbon atoms as ring members, an aromatic ring having 5 to about 8 carbon atoms as ring members, a heterocyclic ring having 3 to about 8 ring members, a heteroaromatic ring having 5 to about 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring; and\n
Z comprises a carbocyclic ring having about 4 to about 7 ring members, a heterocyclic ring having about 4 to about 7 ring members, an aromatic ring having about 5 to about 7 ring members, a heteroaromatic ring having about 5 to about 7 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring, a heteropolycyclic ring; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the —(CH2)n— group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or\n
R2 comprises -T-(CH2)n—Z;\n
n comprises an integer from 0 to about 7;\n
T comprises a carbocyclic ring having 3 to about 8 ring members, an unsaturated ring having 3 to about 8 carbon atoms as ring members, an aromatic ring having 5 to about 8 carbon atoms as ring members, a heterocyclic ring having 3 to about 8 ring members, a heteroaromatic ring having 5 to about 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring; and\n
Z comprises 1-, 2- or 3-pyrrolidinyl, 1-, 2-, 3- or 4-piperidinyl, 2-, 3- or 4-morpholinyl, 2-, 3- or 4-thiomorpholinyl, 1-, 2- or 3-azetidinyl, 1- or 2-piperazinyl, 2- or 3-tetrahydrofuranyl; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the —(CH2)n— group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or\n
R2 comprises -T-(CH2)n—Z;\n
n comprises an integer from 0 to about 7;\n
T comprises a carbocyclic ring having 3 to about 8 ring members, an unsaturated ring having 3 to about 8 carbon atoms as ring members, an aromatic ring having 5 to about 8 carbon atoms as ring members, a heterocyclic ring having 3 to about 8 ring members, a heteroaromatic ring having 5 to about 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring; and\n
Z comprises\n\n
wherein X and Y each independently comprise\n
H, halogen, CF3, CF2H, N3, NCS, ON, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8, C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)jOX3, O(CH2)jNX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X6, —CH═CHX8, —C≡CX8;\n
X1 and X2 each independently comprise H or alkyl, or\n
X1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from O, N or S, or\n
X1 and X2 together comprise part of an imide ring having about 5 to about 6 members,\n
X3 comprises H, alkyl, aryl, NO2, (CH2)mCN, hydroxyloweralkyl, or alkyl-NX1X2,\n
X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein\n
X7 comprises H, alkyl, NO2, NO, P(O)(OX8)2, PH(O)(OX8), S(O)kN(alkyl)2, S(O)kX8, S(O)kOX8, COOX8, CONX8, SO3H, COX8, wherein\n
X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or —CX9═CHX10 wherein\n
X9 and X10 each independently comprise H or alkyl\n
Wherein m is an integer from 0 to 7\n
j is an integer from 0 to about 6,\n
k is an integer from 0 to about 2\n
W comprises H or alkyl; or\n
R2 comprises -T-(CH2)n—Z;\n
n comprises an integer from 0 to about 7;\n
T comprises a carbocyclic ring having 3 to about 8 ring members, an unsaturated ring having 3 to about 8 carbon atoms as ring members, an aromatic ring having 5 to about 8 carbon atoms as ring members, a heterocyclic ring having 3 to about 8 ring members, a heteroaromatic ring having 5 to about 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring; and\n
Z comprises an unsaturated ring having 5 ring atoms and 0 to 2 independently selected heteroatoms as ring members fused to an unsaturated ring having 5 ring atoms and 0 to 4 independently selected heteroatoms as ring members, an unsaturated ring having 5 ring atoms and 0 to 2 independently selected heteroatoms as ring members fused to an unsaturated ring having 6 or 7 ring atoms and 0 to 4 independently selected heteroatoms as ring members or an unsaturated ring having 6 ring atoms and 0 to 3 independently selected heteroatoms as ring members fused to an unsaturated ring having 6 or 7 ring atoms and 0 to 4 independently selected heteroatoms as ring members; or\n
R2 comprises -T-(CH2)m-Q1-(CH2)n—Z;\n\nm and n independently comprises an integer from 0 to about 7;\nT comprises a carbocyclic ring having 3 to about 8 ring members, an unsaturated ring having 3 to about 8 carbon atoms as ring members, an aromatic ring having 5 to about 8 carbon atoms as ring members, a heterocyclic ring having 3 to about 8 ring members, a heteroaromatic ring having 5 to about 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;\nQ1 comprises NH, O, S, CH═CH, C≡C, CO, SO2 or OSO2; and\nZ comprises, H, halogen, CF3, CF2H, N3, NCS, ON, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8, C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)jOX3, O(CH2)jNX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X6, —CH═CHX8, —C≡CX8;\n
X1 and X2 each independently comprise H or alkyl, or\n
X1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from O, N or S, or\n
X1 and X2 together comprise part of an imide ring having about 5 to about 6 members,\n
X3 comprises H, alkyl, aryl, NO2, (CH2)mCN, hydroxyloweralkyl, or alkyl-NX1X2,\n
X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein\n
X7 comprises H, alkyl, NO2, NO, P(O)(OX8)2, PH(O)(OX8), S(O)kN(alkyl)2, S(O)kX8, S(O)kOX8, COOX8, CONX8, SO3H, COX8, wherein\n
X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or —CX9═CHX10 wherein\n
X9 and X10 each independently comprise H or alkyl\n
Wherein m is an integer from 0 to 7\n\nj is an integer from 0 to about 6,\nk is an integer from 0 to about 2; or\n
R2 comprises -T-(CH2)m-Q1-(CH2)n—Z;\n
m and n independently comprises an integer from 0 to about 7;\n
T comprises a carbocyclic ring having 3 to about 8 ring members, an unsaturated ring having 3 to about 8 carbon atoms as ring members, an aromatic ring having 5 to about 8 carbon atoms as ring members, a heterocyclic ring having 3 to about 8 ring members, a heteroaromatic ring having 5 to about 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;\n
Q1 comprises NH, O, S, CH═CH, C≡C, CO, SO2 or OSO2; and\n
Z comprises a carbocyclic ring having about 4 to about 7 ring members, a heterocyclic ring having about 4 to about 7 ring members, an aromatic ring having about 5 to about 7 ring members, a heteroaromatic ring having about 5 to about 7 ring members, a bicyclic ring, a heterobicyclic ring, a polycyclic ring, a heteropolycyclic ring; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the —(CH2)n— group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or\n
R2 comprises -T-(CH2)m-Q1-(CH2)n—Z;\n
m and n independently comprises an integer from 0 to about 7;\n
T comprises a carbocyclic ring having 3 to about 8 ring members, an unsaturated ring having 3 to about 8 carbon atoms as ring members, an aromatic ring having 5 to about 8 carbon atoms as ring members, a heterocyclic ring having 3 to about 8 ring members, a heteroaromatic ring having 5 to about 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;\n
Q1 comprises NH, O, S, CH═CH, C≡C, CO, SO2 or OSO2; and\n
Z comprises 1-, 2- or 3-pyrrolidinyl, 1-, 2-, 3- or 4-piperidinyl, 2-, 3- or 4-morpholinyl, 2-, 3- or 4-thiomorpholinyl, 1-, 2- or 3-azetidinyl, 1- or 2-piperazinyl, 2- or 3-tetrahydrofuranyl; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the —(CH2)n— group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or\n
R2 comprises -T-(CH2)m-Q1-(CH2)n—Z;\n
m and n independently comprises an integer from 0 to about 7;\n
T comprises a carbocyclic ring having 3 to about 8 ring members, an unsaturated ring having 3 to about 8 carbon atoms as ring members, an aromatic ring having 5 to about 8 carbon atoms as ring members, a heterocyclic ring having 3 to about 8 ring members, a heteroaromatic ring having 5 to about 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;\n
Q1 comprises N, O, S, CH═CH, C≡C, CO, SO2 or OSO2; and\n
Z comprises\n\n
wherein X and Y each independently comprise\n
H, halogen, CF3, CF2H, N3, NCS, ON, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8, C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)jOX3, O(CH2)jNX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X6, —CH═CHX8, —C≡CX8;\n
X1 and X2 each independently comprise H or alkyl, or\n
X1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from O, N or S, or\n
X1 and X2 together comprise part of an imide ring having about 5 to about 6 members,\n
X3 comprises H, alkyl, aryl, NO2, (CH2)mCN, hydroxyloweralkyl, or alkyl-NX1X2,\n
X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein\n
X7 comprises H, alkyl, NO2, NO, P(O)(OX8)2, PH(O)(OX8), S(O)kN(alkyl)2, S(O)kX8, S(O)kOX8, COOX8, CONX8, SO3H, COX8, wherein\n
X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or —CX9═CHX10 wherein\n
X9 and X10 each independently comprise H or alkyl\n
Wherein m is an integer from 0 to 7\n\nj is an integer from 0 to about 6,\nk is an integer from 0 to about 2\n
W comprises H or alkyl; or\n
R2 comprises -T-(CH2)m-Q1-(CH2)n—Z;\n
m and n independently comprises an integer from 0 to about 7;\n
T comprises a carbocyclic ring having 3 to about 8 ring members, an unsaturated ring having 3 to about 8 carbon atoms as ring members, an aromatic ring having 5 to about 8 carbon atoms as ring members, a heterocyclic ring having 3 to about 8 ring members, a heteroaromatic ring having 5 to about 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;\n
Q1 comprises NH, O, S, CH═CH, C≡C, CO, SO2 or OSO2; and\n
Z comprises an unsaturated ring having 5 ring atoms and 0 to 2 independently selected heteroatoms as ring members fused to an unsaturated ring having 5 ring atoms and 0 to 2 independently selected heteroatoms as ring members, an unsaturated ring having 5 ring atoms and 0 to 2 independently selected heteroatoms as ring members fused to an unsaturated ring having 6 or 7 ring atoms and 0 to 4 independently selected heteroatoms as ring members or an unsaturated ring having 6 ring atoms and 0 to 3 independently selected heteroatoms as ring members fused to an unsaturated ring having 6 or 7 ring atoms and 0 to 4 independently selected heteroatoms as ring members, or\n
R2 comprises -T-(CH2)m-Q1-(CH2)n—Z;\n
T comprises a carbocyclic ring having 3 to about 8 ring members, an unsaturated ring having 3 to about 8 carbon atoms as ring members, an aromatic ring having 5 to about 8 carbon atoms as ring members, a heterocyclic ring having 3 to about 8 ring members, a heteroaromatic ring having 5 to about 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;\n
m and n independently comprises an integer from 0 to about 7;\n
Q1 comprises NH, O, S, CH═CH, C≡C, CO, SO2 or OSO2; and\n
Z comprises:\n\n
\n\nE comprises a C1 to about C4, linear or branched alkyl group, a phenyl group, a substituted phenyl group, a benzyl group or a substituted benzyl group; or\n
R2 comprises -T-(CH2)m-Q1-(CH2)n—Z;\n\n\nT comprises a carbocyclic ring having 3 to about 8 ring members, an unsaturated ring having 3 to about 8 carbon atoms as ring members, an aromatic ring having 5 to about 8 carbon atoms as ring members, a heterocyclic ring having 3 to about 8 ring members, a heteroaromatic ring having 5 to about 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;\nm and n independently comprises an integer from 0 to about 7;\nQ1 comprises NH, O, S, CH═CH, C≡C, CO, SO2 or OSO2;\nZ comprises\n
\n\n\n\nk is an integer from 1 to about 5,\nA1 and A2 each independently comprise a C1 to about C4 alkyl group, a phenyl group or a substituted phenyl group;\n
R3 comprises\n\n
\n\nwherein G comprises CH, C(CH3), C(CN) or N,\nL, K and J each independently comprise (CH2)n, (CH3)2, C═O, O, —CHOH, C(CH3)OM1, C(CH2)n(X)Y, NM1, SO2 SO or S, and at least one of L, K or J is SO2,\nn is an integer from 0 to about 7;\nM1 is H, alkyl, C(O)M2 where\nM2 is H, alkyl, NM3M4, OM5 and M3, M4 and M5 are independently H, OH or alkyl\n
and X and Y each independently comprise, H, halogen, CF3, CF2H, N3, NCS, ON, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8, C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)jOX3, O(CH2)jNX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X6, —CH═CHX8, —C≡CX8;\n
X1 and X2 each independently comprise H or alkyl, or\n
X1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from O, N or S, or\n
X1 and X2 together comprise part of an imide ring having about 5 to about 6 members,\n
X3 comprises H, alkyl, NO2, (CH2)mCN, hydroxyloweralkyl, or alkyl-NX1X2,\n
X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein\n
X7 comprises H, alkyl, NO2, NO, P(O)(OX8)2, PH(O)(OX8), S(O)kN(alkyl)2, S(O)kX8, S(O)kOX8, COOX8, CONX8, SO3H, COX8, wherein\n
X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or —CX9═CHX10 wherein\n
X9 and X10 each independently comprise H or alkyl\n
Wherein m is an integer from 0 to 7\n
j is an integer from 0 to about 6, or\n\nk is an integer from 0 to about 2\nor\n
R1 comprises -T-(CH2)m-Q-(CH2)n—Z,\n
m and n independently comprises an integer from 0 to about 7;\n
T comprises a carbocyclic ring having 3 to about 8 ring members, an unsaturated ring having 3 to about 8 carbon atoms as ring members, an aromatic ring having 5 to about 8 carbon atoms as ring members, a heterocyclic ring having 3 to about 8 ring members, a heteroaromatic ring having 5 to about 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;\n
Q comprises CH═CH, C≡C;\n
Z comprises\n
H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8, C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)jOX3, O(CH2)jNX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X6, —CH═CHX8, —C≡CX8;\n
X1 and X2 each independently comprise H or alkyl, or\n
X1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from O, N or S, or\n
X1 and X2 together comprise part of an imide ring having about 5 to about 6 members,\n
X3 comprises H, alkyl, NO2, (CH2)mCN, hydroxyloweralkyl, or alkyl-NX1X2,\n
X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein\n
X7 comprises H, alkyl, NO2, NO, P(O)(OX8)2, PH(O)(OX8), S(O)kN(alkyl)2, S(O)kX8, S(O)kOX8, COOX8, CONX8, SO3H, COX8, wherein\n
X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or —CX9═CHX10 wherein\n
X9 and X10 each independently comprise H or alkyl\n
Wherein m is an integer from 0 to 7\n
j is an integer from 0 to about 6, or\n
k is an integer from 0 to about 2; or\n
R1 comprises -T-(CH2)m-Q-(CH2)n—Z;\n
m and n independently comprises an integer from 0 to about 7;\n
T comprises a carbocyclic ring having 3 to about 8 ring members, an unsaturated ring having 3 to about 8 carbon atoms as ring members, an aromatic ring having 5 to about 8 carbon atoms as ring members, a heterocyclic ring having 3 to about 8 ring members, a heteroaromatic ring having 5 to about 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;\n
Q comprises CH═CH, C≡C; and\n
Z comprises a carbocyclic ring having about 4 to about 7 ring members, a heterocyclic ring having about 4 to about 7 ring members, an aromatic ring having about 5 to about 7 ring members, a heteroaromatic ring having about 5 to about 7 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring, a heteropolycyclic ring; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the —(CH2)n— group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or\n
R1 comprises -T-(CH2)m-Q-(CH2)n—Z;\n
m and n independently comprises an integer from 0 to about 7;\n
T comprises a carbocyclic ring having 3 to about 8 ring members, an unsaturated ring having 3 to about 8 carbon atoms as ring members, an aromatic ring having 5 to about 8 carbon atoms as ring members, a heterocyclic ring having 3 to about 8 ring members, a heteroaromatic ring having 5 to about 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;\n
Q comprises CH═CH, C≡C; and\n
Z comprises 1-, 2- or 3-pyrrolidinyl, 1-, 2-, 3- or 4-piperidinyl, 2-, 3- or 4-morpholinyl, 2-, 3- or 4-thiomorpholinyl, 1-, 2- or 3-azetidinyl, 1- or 2-piperazinyl, 2- or 3-tetrahydrofuranyl; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the —(CH2)n— group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or\n
R1 comprises -T-(CH2)m-Q-(CH2)n—Z;\n
m and n independently comprises an integer from 0 to about 7;\n
T comprises a carbocyclic ring having 3 to about 8 ring members, an unsaturated ring having 3 to about 8 carbon atoms as ring members, an aromatic ring having 5 to about 8 carbon atoms as ring members, a heterocyclic ring having 3 to about 8 ring members, a heteroaromatic ring having 5 to about 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;\n
Q comprises CH═CH, C≡C; and\n
Z comprises\n\n
wherein X and Y each independently comprise\n
H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8, C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)jOX3, O(CH2)jNX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X6, —CH═CHX8, —C≡CX8;\n
X1 and X2 each independently comprise H or alkyl, or\n
X1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from O, N or S, or\n
X1 and X2 together comprise part of an imide ring having about 5 to about 6 members,\n
X3 comprises H, alkyl, NO2, (CH2)mCN, hydroxyloweralkyl, or alkyl-NX1X2,\n
X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein\n
X7 comprises H, alkyl, NO2, NO, P(O)(OX8)2, PH(O)(OX8), S(O)kN(alkyl)2, S(O)kX8, S(O)kOX8, COOX8, CONX8, SO3H, COX8, wherein\n
X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or —CX9═CHX10 wherein\n
X9 and X10 each independently comprise H or alkyl\n
Wherein m is an integer from 0 to 7\n
j is an integer from 0 to about 6,\n
k is an integer from 0 to about 2,\n
W comprises H or alkyl; or\n
R1 comprises -T-(CH2)m-Q-(CH2)n—Z;\n
m and n independently comprises an integer from 0 to about 7;\n
T comprises a carbocyclic ring having 3 to about 8 ring members, an unsaturated ring having 3 to about 8 carbon atoms as ring members, an aromatic ring having 5 to about 8 carbon atoms as ring members, a heterocyclic ring having 3 to about 8 ring members, a heteroaromatic ring having 5 to about 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;\n
Q comprises CH═CH, C≡C; and\n
Z comprises an unsaturated ring having 5 ring atoms and 0 to 2 independently selected heteroatoms as ring members fused to an unsaturated ring having 5 ring atoms and 0 to 4 independently selected heteroatoms as ring members, an unsaturated ring having 5 ring atoms and 0 to 2 independently selected heteroatoms as ring members fused to an unsaturated ring having 6 or 7 ring atoms and 0 to 4 independently selected heteroatoms as ring members or an unsaturated ring having 6 ring atoms and 0 to 3 independently selected heteroatoms as ring members fused to an unsaturated ring having 6 or 7 ring atoms and 0 to 4 independently selected heteroatoms as ring members; or\n
R1 comprises -T-(CH2)m-Q-(CH2)n—Z;\n
T comprises a carbocyclic ring having 3 to about 8 ring members, an unsaturated ring having 3 to about 8 carbon atoms as ring members, an aromatic ring having 5 to about 8 carbon atoms as ring members, a heterocyclic ring having 3 to about 8 ring members, a heteroaromatic ring having 5 to about 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;\n
m and n independently comprises an integer from 0 to about 7;\n
Q comprises CH═CH, C≡C;\n
Z comprises\n\n
\n\nE comprises a C1 to about C4, linear or branched alkyl group, a phenyl group, a substituted phenyl group, a benzyl group or a substituted benzyl group; or\n
R1 comprises -T-(CH2)m-Q-(CH2)n—Z;\n
T comprises a carbocyclic ring having 3 to about 8 ring members, an unsaturated ring having 3 to about 8 carbon atoms as ring members, an aromatic ring having 5 to about 8 carbon atoms as ring members, a heterocyclic ring having 3 to about 8 ring members, a heteroaromatic ring having 5 to about 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;\n
m and n independently comprises an integer from 0 to about 7;\n
Q comprises CH═CH, C≡C; and\n
Z comprises\n\n
\n\nR1 comprises —(CH2)n—Z;\nk is an integer from 1 to about 5, and\nA1 and A2 each independently comprise a C1 to about C4 alkyl group, a phenyl group or a substituted phenyl group; or\n
n is an integer from 0 to about 7;\n
wherein Z comprises, H, halogen, CF3, CF2H, N3, NCS, ON, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8, C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)jOX3, O(CH2)jNX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X6, —CH═CHX8, —C≡CX8;\n
X1 and X2 each independently comprise H or alkyl, or\n
X1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from O, N or S, or\n
X1 and X2 together comprise part of an imide ring having about 5 to about 6 members,\n
X3 comprises H, alkyl, aryl, NO2, (CH2)mCN, hydroxyloweralkyl, or alkyl-NX1X2,\n
X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein\n
X7 comprises H, alkyl, NO2, NO, P(O)(OX8)2, PH(O)(OX8), S(O)kN(alkyl)2, S(O)kX8, S(O)kOX8, COOX8, CONX8, SO3H, COX8, wherein\n
X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or —CX9═CHX10 wherein\n
X9 and X10 each independently comprise H or alkyl\n
Wherein m is an integer from 0 to 7\n
j is an integer from 0 to about 6, or\n
k is an integer from 0 to about 2; or\n
R1 comprises —(CH2)n—Z;\n
n is an integer from 0 to about 7; and\n
Z comprises a carbocyclic ring having about 4 to about 7 ring members, a heterocyclic ring having about 4 to about 7 ring members, an aromatic ring having about 5 to about 7 ring members, a heteroaromatic ring having about 5 to about 7 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring, a heteropolycyclic ring; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the —(CH2)n— group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or\n
R1 comprises —(CH2)n—Z;\n
n is an integer from 0 to about 7; and\n
Z comprises a 5 member unsaturated ring having 0 to 4 independently selected heteroatoms as ring members, a substituted 5 member unsaturated ring having 0 to 4 independently selected heteroatoms as ring members, a 6 member aromatic ring having 0 to 5 independently selected heteroatoms as ring members or a substituted 6 member aromatic ring having 0 to 5 independently selected heteroatoms; and wherein the connecting point between the —(CH2)n— group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or\n
R1 comprises —(CH2)n—Z;\n
n is an integer from 0 to about 7; and\n
Z comprises 1-, 2- or 3-pyrrolidinyl, 1-, 2-, 3- or 4-piperidinyl, 2-, 3- or 4-morpholinyl, 2-, 3- or 4-thiomorpholinyl, 1-, 2- or 3-azetidinyl, 1- or 2-piperazinyl, 2- or 3-tetrahydrofuranyl; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the —(CH2)n— group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or\n
R1 comprises —(CH2)n—Z;\n
n is an integer from 0 to about 7; and\n
Z comprises\n\n
wherein X and Y each independently comprise, H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8, C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)jOX3, O(CH2)jNX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X6, —CH═CHX8, —C≡CX8;\n
X1 and X2 each independently comprise H or alkyl, or\n
X1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from O, N or S, or\n
X1 and X2 together comprise part of an imide ring having about 5 to about 6 members,\n
X3 comprises H, alkyl, aryl, NO2, (CH2)mCN, hydroxyloweralkyl, or alkyl-NX1X2,\n
X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein\n
X7 comprises H, alkyl, NO2, NO, P(O)(OX8)2, PH(O)(OX8), S(O)kN(alkyl)2, S(O)kX8, S(O)kOX8, COOX8, CONX8, SO3H, COX8, wherein\n
X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or —CX9═CHX10 wherein\n
X9 and X10 each independently comprise H or alkyl\n
Wherein m is an integer from 0 to 7\n
j is an integer from 0 to about 6, or\n
k is an integer from 0 to about 2\n
W comprises H or alkyl; or\n
R1 comprises —(CH2)n—Z;\n
n is an integer from 0 to about 7; and\n
Z comprises a carbocyclic ring having 6 ring atoms fused to a heterocyclic ring having from 5 to 7 ring atoms, a carbocyclic ring having 6 ring atoms fused to a heteroaromatic ring having from 5 to 7 ring atoms, a heterocyclic ring having 6 ring atoms fused to a heterocyclic ring having from 5 to 7 ring atoms, an heterocyclic ring having 6 ring atoms fused to a heteroaromatic ring having from 5 to 7 ring atoms, an aromatic ring having 6 ring atoms fused to a heterocyclic ring having from 5 to 7 ring atoms, an aromatic ring having 6 ring atoms fused to a heteroaromatic ring having from 5 to 7 ring atoms, a heteroaromatic ring having 6 ring atoms fused to a heterocyclic ring having from 5 to 7 ring atoms or a heteroaromatic ring having 6 ring atoms fused to a heteroaromatic ring having from 5 to 7 ring atoms; or\n
R1 comprises —(CH2)n—Z;\n
n comprises an integer from 0 to about 7; and\n
Z comprises an unsaturated ring having 5 ring atoms and 0 to 2 independently selected heteroatoms as ring members fused to an unsaturated ring having 5 ring atoms and 0 to 4 independently selected heteroatoms as ring members, an unsaturated ring having 5 ring atoms and 0 to 2 independently selected heteroatoms as ring members fused to an unsaturated ring having 6 or 7 ring atoms and 0 to 3 independently selected heteroatoms as ring members or an unsaturated ring having 6 ring atoms and 0 to 4 independently selected heteroatoms as ring members fused to an unsaturated ring having 6 or 7 ring atoms and 0 to 4 independently selected heteroatoms as ring members; or\n
R1 comprises —(CH2)m-Q1-(CH2)n—Z;\n
Q1 comprises NH, O, S, —CH═CH—, —C≡C—, —CO, SO2 or OSO2;\n
m is an integer from 1 to about 7;\n
n is an integer from 0 to about 7; and\n
wherein Z comprises, H, halogen, CF3, CF2H, N3, NCS, ON, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8, C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)jOX3, O(CH2)jNX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X6, —CH═CHX8, —C≡CX8;\n
X1 and X2 each independently comprise H or alkyl, or\n
X1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from O, N or S, or\n
X1 and X2 together comprise part of an imide ring having about 5 to about 6 members,\n
X3 comprises H, alkyl, aryl, NO2, (CH2)mCN, hydroxyloweralkyl, or alkyl-NX1X2,\n
X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein\n
X7 comprises H, alkyl, NO2, NO, P(O)(OX8)2, PH(O)(OX8), S(O)kN(alkyl)2, S(O)kX8, S(O)kOX8, COOX8, CONX8, SO3H, COX8, wherein\n
X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or —CX9═CHX10 wherein\n
X9 and X10 each independently comprise H or alkyl\n
Wherein m is an integer from 0 to 7\n
j is an integer from 0 to about 6, or\n
k is an integer from 0 to about 2; or\n
R1 comprises -Q2-(CH2)n—Z;\n
Q2 is optionally present and if present comprises —CH2—NH, —CH2—O, —CH2—S, —CH2—SO2 or —CH2—OSO2;\n
n is an integer from 0 to about 7;\n
wherein Z comprises, H, halogen, CF3, CF2H, N3, NCS, ON, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8, C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)jOX3, O(CH2)jNX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X6, —CH═CHX8, —C≡CX8;\n
X1 and X2 each independently comprise H or alkyl, or\n
X1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from O, N or S, or\n
X1 and X2 together comprise part of an imide ring having about 5 to about 6 members,\n
X3 comprises H, alkyl, aryl, NO2, (CH2)mCN, hydroxyloweralkyl, or alkyl-NX1X2,\n
X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein\n
X7 comprises H, alkyl, NO2, NO, P(O)(OX8)2, PH(O)(OX8), S(O)kN(alkyl)2, S(O)kX8, S(O)kOX8, COOX8, CONX8, SO3H, COX8, wherein\n
X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or —CX9═CHX10 wherein\n
X9 and X10 each independently comprise H or alkyl\n
Wherein m is an integer from 0 to 7\n
j is an integer from 0 to about 6,\n
k is an integer from 0 to about 2; or\n
R1 comprises —(CH2)m-Q1-(CH2)n—Z;\n
Q1 comprises NH, O, S, CH═CH, C≡C, CO, SO2 or OSO2;\n
m is an integer from 1 to about 7;\n
n is an integer from 0 to about 7;\n
Z comprises a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring; or\n
R1 comprises —(CH2)m-Q1-(CH2)n—Z;\n
Q1 comprises NH, O, S, CH═CH, C≡C, CO, SO2 or OSO2;\n
m is an integer from 1 to about 7;\n
n is an integer from 0 to about 7;\n
Z comprises a carbocyclic ring having about 4 to about 7 ring members, a heterocyclic ring having about 4 to about 7 ring members, an aromatic ring having about 5 to about 7 ring members, a heteroaromatic ring having about 5 to about 7 ring members; a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring, a heteropolycyclic ring or any above group substituted on at least one available ring atom by an alkyl group or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the —(CH2)n— group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or\n
R1 comprises —(CH2)m-Q1-(CH2)n—Z;\n
Q1 comprises NH, O, S, CH═CH, C≡C, CO, SO2 or OSO2;\n
m is an integer from 1 to about 7;\n
n is an integer from 0 to about 7; and\n
Z comprises a 5 member unsaturated ring having 0 to 4 independently selected heteroatoms as ring members, a substituted 5 member unsaturated ring having 0 to 4 independently selected heteroatoms as ring members, a 6 member aromatic ring having 0 to 5 independently selected heteroatoms as ring members or a substituted 6 member aromatic ring having 0 to 5 independently selected heteroatoms; and wherein the connecting point between the —(CH2)n— group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or\n
R1 comprises —(CH2)m-Q1-(CH2)n—Z;\n
Q1 comprises NH, O, S, CH═CH, C≡C, CO, SO2 or OSO2;\n
m is an integer from 1 to about 7;\n
n is an integer from 0 to about 7;\n
Z comprises 1-, 2- or 3-pyrrolidinyl, 1-, 2-, 3- or 4-piperidinyl, 2-, 3- or 4-morpholinyl, 2-, 3- or 4-thiomorpholinyl, 1-, 2- or 3-azetidinyl, 1- or 2-piperazinyl, 2- or 3-tetrahydrofuranyl; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the —(CH2)n— group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or\n
R1 comprises —(CH2)m-Q1-(CH2)n—Z;\n
Q1 comprises NH, O, S, CH═CH, C≡C, CO, SO2 or OSO2;\n
m is an integer from 1 to about 7;\n
n is an integer from 0 to about 7; and\n
Z comprises\n\n
wherein X and Y each independently comprise\n
H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8, C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)jOX3, O(CH2)jNX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X6, —CH═CHX8, —C≡CX8;\n
X1 and X2 each independently comprise H or alkyl, or\n
X1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from O, N or S, or\n
X1 and X2 together comprise part of an imide ring having about 5 to about 6 members,\n
X3 comprises H, alkyl, aryl, NO2, (CH2)mCN, hydroxyloweralkyl, or alkyl-NX1X2,\n
X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein\n
X7 comprises H, alkyl, NO2, NO, P(O)(OX8)2, PH(O)(OX8), S(O)kN(alkyl)2, S(O)kX8, S(O)kOX8, COOX8, CONX8, SO3H, COX8, wherein\n
X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or —CX9═CHX10 wherein\n
X9 and X10 each independently comprise H or alkyl\n
Wherein m is an integer from 0 to 7\n
j is an integer from 0 to about 6,\n
k is an integer from 0 to about 2\n
W comprises H or alkyl; or\n
R1 comprises —(CH2)m-Q1-(CH2)n—Z;\n
Q1 comprises NH, O, S, CH═CH, C≡C, CO, SO2 or OSO2;\n
m is an integer from 1 to about 7;\n
n is an integer from 0 to about 7; and\n
Z comprises an unsaturated ring having 5 ring atoms and 0 to 2 independently selected heteroatoms as ring members fused to an unsaturated ring having 5 ring atoms and 0 to 4 independently selected heteroatoms as ring members, an unsaturated ring having 5 ring atoms and 0 to 2 independently selected heteroatoms as ring members fused to an unsaturated ring having 6 or 7 ring atoms and 0 to 4 independently selected heteroatoms as ring members or an unsaturated ring having 6 ring atoms and 0 to 4 independently selected heteroatoms as ring members fused to an unsaturated ring having 6 or 7 ring atoms and 0 to 4 independently selected heteroatoms as ring members; or\n
R1 comprises —(CH2)m-Q1-(CH2)n—Z;\n
Q1 comprises NH, O, S, CH═CH, C≡C, CO, SO2 or OSO2;\n
m is an integer from 1 to about 7;\n
n is an integer from 0 to about 7; and\n
Z comprises\n\n
R1 comprises -T-(CH2)n—Z;\n
n comprises an integer from 0 to about 7;\n
T comprises a carbocyclic ring having 3 to about 8 ring members, an unsaturated ring having 3 to about 8 carbon atoms as ring members, an aromatic ring having 5 to about 8 carbon atoms as ring members, a heterocyclic ring having 3 to about 8 ring members, a heteroaromatic ring having 5 to about 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring; and\n
Z comprises, H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8, C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)jOX3, O(CH2)jNX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X6, —CH═CHX8, —C≡CX8;\n
X1 and X2 each independently comprise H or alkyl, or\n
X1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from O, N or S, or\n
X1 and X2 together comprise part of an imide ring having about 5 to about 6 members,\n
X3 comprises H, alkyl, aryl, NO2, (CH2)mCN, hydroxyloweralkyl, or alkyl-NX1X2,\n
X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein\n
X7 comprises H, alkyl, NO2, NO, P(O)(OX8)2, PH(O)(OX8), S(O)kN(alkyl)2, S(O)kX8, S(O)kOX8, COOX8, CONX8, SO3H, COX8, wherein\n
X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or —CX9═CHX10 wherein\n
X9 and X10 each independently comprise H or alkyl\n
Wherein m is an integer from 0 to 7\n\nj is an integer from 0 to about 6,\nk is an integer from 0 to about 2; or\n
R1 comprises -T-(CH2)n—Z;\n
n comprises an integer from 0 to about 7;\n
T comprises a carbocyclic ring having 3 to about 8 ring members, an unsaturated ring having 3 to about 8 carbon atoms as ring members, an aromatic ring having 5 to about 8 carbon atoms as ring members, a heterocyclic ring having 3 to about 8 ring members, a heteroaromatic ring having 5 to about 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring; and\n
Z comprises a carbocyclic ring having about 4 to about 7 ring members, a heterocyclic ring having about 4 to about 7 ring members, an aromatic ring having about 5 to about 7 ring members, a heteroaromatic ring having about 5 to about 7 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring, a heteropolycyclic ring; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the —(CH2)n— group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or\n
R1 comprises -T-(CH2)n—Z;\n
n comprises an integer from 0 to about 7;\n
T comprises a carbocyclic ring having 3 to about 8 ring members, an unsaturated ring having 3 to about 8 carbon atoms as ring members, an aromatic ring having 5 to about 8 carbon atoms as ring members, a heterocyclic ring having 3 to about 8 ring members, a heteroaromatic ring having 5 to about 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring; and\n
Z comprises 1-, 2- or 3-pyrrolidinyl, 1-, 2-, 3- or 4-piperidinyl, 2-, 3- or 4-morpholinyl, 2-, 3- or 4-thiomorpholinyl, 1-, 2- or 3-azetidinyl, 1- or 2-piperazinyl, 2- or 3-tetrahydrofuranyl; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the —(CH2)n— group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or\n
R1 comprises -T-(CH2)n—Z;\n
n comprises an integer from 0 to about 7;\n
T comprises a carbocyclic ring having 3 to about 8 ring members, an unsaturated ring having 3 to about 8 carbon atoms as ring members, an aromatic ring having 5 to about 8 carbon atoms as ring members, a heterocyclic ring having 3 to about 8 ring members, a heteroaromatic ring having 5 to about 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring; and\n
Z comprises\n\n
wherein X and Y each independently comprise\n
H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8, C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)jOX3, O(CH2)jNX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X6, —CH═CHX8, —C≡CX8;\n
X1 and X2 each independently comprise H or alkyl, or\n
X1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from O, N or S, or\n
X1 and X2 together comprise part of an imide ring having about 5 to about 6 members,\n
X3 comprises H, alkyl, aryl, NO2, (CH2)mCN, hydroxyloweralkyl, or alkyl-NX1X2,\n
X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein\n
X7 comprises H, alkyl, NO2, NO, P(O)(OX8)2, PH(O)(OX8), S(O)kN(alkyl)2, S(O)kX8, S(O)kOX8, COOX8, CONX8, SO3H, COX8, wherein\n
X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or —CX9═CHX10 wherein\n
X9 and X10 each independently comprise H or alkyl\n
Wherein m is an integer from 0 to 7\n
j is an integer from 0 to about 6,\n
k is an integer from 0 to about 2\n
W comprises H or alkyl; or\n
R1 comprises -T-(CH2)n—Z;\n
n comprises an integer from 0 to about 7;\n
T comprises a carbocyclic ring having 3 to about 8 ring members, an unsaturated ring having 3 to about 8 carbon atoms as ring members, an aromatic ring having 5 to about 8 carbon atoms as ring members, a heterocyclic ring having 3 to about 8 ring members, a heteroaromatic ring having 5 to about 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring; and\n
Z comprises an unsaturated ring having 5 ring atoms and 0 to 2 independently selected heteroatoms as ring members fused to an unsaturated ring having 5 ring atoms and 0 to 4 independently selected heteroatoms as ring members, an unsaturated ring having 5 ring atoms and 0 to 2 independently selected heteroatoms as ring members fused to an unsaturated ring having 6 or 7 ring atoms and 0 to 4 independently selected heteroatoms as ring members or an unsaturated ring having 6 ring atoms and 0 to 3 independently selected heteroatoms as ring members fused to an unsaturated ring having 6 or 7 ring atoms and 0 to 4 independently selected heteroatoms as ring members; or\n
R1 comprises -T-Q-(CH2)n—Z,\n
each n independently comprises an integer from 0 to about 7;\n
T comprises a carbocyclic ring having 3 to about 8 ring members, an unsaturated ring having 3 to about 8 carbon atoms as ring members, an aromatic ring having 5 to about 8 carbon atoms as ring members, a heterocyclic ring having 3 to about 8 ring members, a heteroaromatic ring having 5 to about 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;\n
Q comprises CH═CH, C≡C;\n
Z comprises H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8, C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)jOX3, O(CH2)jNX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X6, —CH═CHX8, —C≡CX8;\n
X1 and X2 each independently comprise H or alkyl, or\n
X1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from O, N or S, or\n
X1 and X2 together comprise part of an imide ring having about 5 to about 6 members,\n
X3 comprises H, alkyl, NO2, (CH2)mCN, hydroxyloweralkyl, or alkyl-NX1X2,\n
X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein\n
X7 comprises H, alkyl, NO2, NO, P(O)(OX8)2, PH(O)(OX8), S(O)kN(alkyl)2, S(O)kX8, S(O)kOX8, COOX8, CONX8, SO3H, COX8, wherein\n
X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or —CX9═CHX10 wherein\n
X9 and X10 each independently comprise H or alkyl\n
Wherein m is an integer from 0 to 7\n
j is an integer from 0 to about 6, or\n
k is an integer from 0 to about 2; or\n
R1 comprises -T-Q-(CH2)n—Z;\n
each n independently comprises an integer from 0 to about 7;\n
T comprises a carbocyclic ring having 3 to about 8 ring members, an unsaturated ring having 3 to about 8 carbon atoms as ring members, an aromatic ring having 5 to about 8 carbon atoms as ring members, a heterocyclic ring having 3 to about 8 ring members, a heteroaromatic ring having 5 to about 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;\n
Q comprises CH═CH, C≡C; and\n
Z comprises a carbocyclic ring having about 4 to about 7 ring members, a heterocyclic ring having about 4 to about 7 ring members, an aromatic ring having about 5 to about 7 ring members, a heteroaromatic ring having about 5 to about 7 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring, a heteropolycyclic ring; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the —(CH2)n— group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or\n
R1 comprises -T-Q-(CH2)n—Z;\n
each n independently comprises an integer from 0 to about 7;\n
T comprises a carbocyclic ring having 3 to about 8 ring members, an unsaturated ring having 3 to about 8 carbon atoms as ring members, an aromatic ring having 5 to about 8 carbon atoms as ring members, a heterocyclic ring having 3 to about 8 ring members, a heteroaromatic ring having 5 to about 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;\n
Q comprises CH═CH, C≡C; and\n
Z comprises 1-, 2- or 3-pyrrolidinyl, 1-, 2-, 3- or 4-piperidinyl, 2-, 3- or 4-morpholinyl, 2-, 3- or 4-thiomorpholinyl, 1-, 2- or 3-azetidinyl, 1- or 2-piperazinyl, 2- or 3-tetrahydrofuranyl; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the —(CH2)n— group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or\n
R1 comprises -T-Q-(CH2)n—Z;\n
each n independently comprises an integer from 0 to about 7;\n
T comprises a carbocyclic ring having 3 to about 8 ring members, an unsaturated ring having 3 to about 8 carbon atoms as ring members, an aromatic ring having 5 to about 8 carbon atoms as ring members, a heterocyclic ring having 3 to about 8 ring members, a heteroaromatic ring having 5 to about 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;\n
Q comprises CH═CH, C≡C; and\n
Z comprises\n\n
wherein X and Y each independently comprise\n
H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8, C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)jOX3, O(CH2)jNX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X6, —CH═CHX8, —C≡CX8;\n
X1 and X2 each independently comprise H or alkyl, or\n
X1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from O, N or S, or\n
X1 and X2 together comprise part of an imide ring having about 5 to about 6 members,\n
X3 comprises H, alkyl, NO2, (CH2)mCN, hydroxyloweralkyl, or alkyl-NX1X2,\n
X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein\n
X7 comprises H, alkyl, NO2, NO, P(O)(OX8)2, PH(O)(OX8), S(O)kN(alkyl)2, S(O)kX8, S(O)kOX8, COOX8, CONX8, SO3H, COX8, wherein\n
X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or —CX9═CHX10 wherein\n
X9 and X10 each independently comprise H or alkyl\n
Wherein m is an integer from 0 to 7\n
j is an integer from 0 to about 6,\n
k is an integer from 0 to about 2,\n
W comprises H or alkyl; or\n
R1 comprises -T-Q-(CH2)n—Z;\n
each n independently comprises an integer from 0 to about 7;\n
T comprises a carbocyclic ring having 3 to about 8 ring members, an unsaturated ring having 3 to about 8 carbon atoms as ring members, an aromatic ring having 5 to about 8 carbon atoms as ring members, a heterocyclic ring having 3 to about 8 ring members, a heteroaromatic ring having 5 to about 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;\n
Q comprises CH═CH, C≡C; and\n
Z comprises an unsaturated ring having 5 ring atoms and 0 to 2 independently selected heteroatoms as ring members fused to an unsaturated ring having 5 ring atoms and 0 to 4 independently selected heteroatoms as ring members, an unsaturated ring having 5 ring atoms and 0 to 2 independently selected heteroatoms as ring members fused to an unsaturated ring having 6 or 7 ring atoms and 0 to 4 independently selected heteroatoms as ring members or an unsaturated ring having 6 ring atoms and 0 to 3 independently selected heteroatoms as ring members fused to an unsaturated ring having 6 or 7 ring atoms and 0 to 4 independently selected heteroatoms as ring members; or\n
R1 comprises -T-Q-(CH2)n—Z;\n
T comprises a carbocyclic ring having 3 to about 8 ring members, an unsaturated ring having 3 to about 8 carbon atoms as ring members, an aromatic ring having 5 to about 8 carbon atoms as ring members, a heterocyclic ring having 3 to about 8 ring members, a heteroaromatic ring having 5 to about 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;\n
each n independently comprises an integer from 0 to about 7;\n
Q comprises CH═CH, C≡C;\n
Z comprises\n\n
\n\nE comprises a C1 to about C4, linear or branched alkyl group, a phenyl group, a substituted phenyl group, a benzyl group or a substituted benzyl group; or\n
R1 comprises -T-Q-(CH2)n—Z;\n
T comprises a carbocyclic ring having 3 to about 8 ring members, an unsaturated ring having 3 to about 8 carbon atoms as ring members, an aromatic ring having 5 to about 8 carbon atoms as ring members, a heterocyclic ring having 3 to about 8 ring members, a heteroaromatic ring having 5 to about 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;\n
each n independently comprises an integer from 0 to about 7;\n
Q comprises CH═CH, C≡C; and\n
Z comprises\n\n
\n\nk is an integer from 1 to about 5, and\nA1 and A2 each independently comprise a C1 to about C4 alkyl group, a phenyl group or a substituted phenyl group; and\n
R4 comprises H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OH, ONO2, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8, C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)jOX3, O(CH2)jNX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X6, —CH═CHX8, —C≡CX8;\n
X1 and X2 each independently comprise H or alkyl, or\n
X1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from O, N or S, or\n
X1 and X2 together comprise part of an imide ring having about 5 to about 6 members,\n
X3 comprises H, alkyl, NO2, (CH2)mCN, hydroxyloweralkyl, or alkyl-NX1X2,\n
X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein\n
X7 comprises H, alkyl, NO2, NO, P(O)(OX8)2, PH(O)(OX8), S(O)kN(alkyl)2, S(O)kX8, S(O)kOX8, COOX8, CONX8, SO3H, COX8, wherein\n
X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or —CX9═CHX10 wherein\n
X9 and X10 each independently comprise H or alkyl\n
Wherein m is an integer from 0 to 7\n
j is an integer from 0 to about 6, or\n
k is an integer from 0 to about 2; or\n
R4 comprises a carbocyclic ring having about 4 to about 7 ring members, a heterocyclic ring having about 4 to about 7 ring members, an aromatic ring having about 5 to about 7 ring members, a heteroaromatic ring having about 5 to about 7 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring; or\n
R4 comprises\n\n
R4 comprises —(CH2)d—Z;\n
d is an integer from 1 to about 6;\n
Z comprises H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8, C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)jOX3, O(CH2)jNX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X6, —CH═CHX8, —C≡CX8;\n
X1 and X2 each independently comprise H or alkyl, or\n
X1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from O, N or S, or\n
X1 and X2 together comprise part of an imide ring having about 5 to about 6 members,\n
X3 comprises H, alkyl, NO2, (CH2)mCN, hydroxyloweralkyl, or alkyl-NX1X2,\n
X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein\n
X7 comprises H, alkyl, NO2, NO, P(O)(OX8)2, PH(O)(OX8), S(O)kN(alkyl)2, S(O)kX8, S(O)kOX8, COOX8, CONX8, SO3H, COX8, wherein\n
X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or —CX9═CHX10 wherein\n
X9 and X10 each independently comprise H or alkyl\n
Wherein m is an integer from 0 to 7\n
j is an integer from 0 to about 6,\n
k is an integer from 0 to about 2; or\n
R4 comprises —(CH2)d—Z;\n
d is an integer from 1 to about 6; and\n
Z comprises a carbocyclic ring having about 4 to about 7 ring members, a heterocyclic ring having about 4 to about 7 ring members, an aromatic ring having about 5 to about 7 ring members, a heteroaromatic ring having about 5 to about 7 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring, a heteropolycyclic ring; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the —(CH2)d— group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or\n
R4 comprises —(CH2)d—Z;\n
d is an integer from 1 to about 6; and\n
Z comprises 1-, 2- or 3-pyrrolidinyl, 1-, 2-, 3- or 4-piperidinyl, 2-, 3- or 4-morpholinyl, 2-, 3- or 4-thiomorpholinyl, 1-, 2- or 3-azetidinyl, 1- or 2-piperazinyl, 2- or 3-tetrahydrofuranyl; or any above group substituted on at least one ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the —(CH2)d— group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or\n
R4 comprises —(CH2)m-Q1-(CH2)n—Z;\n
Q1 comprises NH, O, S, CH═CH, C≡C, CO, SO2 or OSO2;\n
m is an integer from 1 to about 7;\n
n is an integer from 0 to about 7; and\n
Z comprises\n
H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8, C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)jOX3, O(CH2)jNX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X6, —CH═CHX8, —C≡CX8;\n
X1 and X2 each independently comprise H or alkyl, or\n
X1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from O, N or S, or\n
X1 and X2 together comprise part of an imide ring having about 5 to about 6 members,\n
X3 comprises H, alkyl, NO2, (CH2)mCN, hydroxyloweralkyl, or alkyl-NX1X2,\n
X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein\n
X7 comprises H, alkyl, NO2, NO, P(O)(OX8)2, PH(O)(OX8), S(O)kN(alkyl)2, S(O)kX8, S(O)kOX8, COOX8, CONX8, SO3H, COX8, wherein\n
X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or —CX9═CHX10 wherein\n
X9 and X10 each independently comprise H or alkyl\n
Wherein m is an integer from 0 to 7\n
j is an integer from 0 to about 6, or\n
k is an integer from 0 to about 2; or\n
R4 comprises —(CH2)m-Q1-(CH2)n—Z;\n
Q1 comprises NH, O, S, CH═CH, C≡C, CO, SO2 or OSO2;\n
m is an integer from 1 to about 7;\n
n is an integer from 0 to about 7; and\n
Z comprises a carbocyclic ring having about 4 to about 7 ring members, a heterocyclic ring having about 4 to about 7 ring members, an aromatic ring having about 5 to about 7 ring members, a heteroaromatic ring having about 5 to about 7 ring members; a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring, a heteropolycyclic ring; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the —(CH2)n— group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or\n
R4 comprises —(CH2)m-Q1-(CH2)n—Z;\n
Q1 comprises NH, O, S, CH═CH, C≡C, CO, SO2 or OSO2;\n
m is an integer from 1 to about 7;\n
n is an integer from 0 to about 7; and\n
Z comprises 1-, 2- or 3-pyrrolidinyl, 1-, 2-, 3- or 4-piperidinyl, 2-, 3- or 4-morpholinyl, 2-, 3- or 4-thiomorpholinyl, 1-, 2- or 3-azetidinyl, 1- or 2-piperazinyl, 2- or 3-tetrahydrofuranyl; or any above group substituted on at least one available ring atom by an alkyl; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the —(CH2)n— group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or\n
R4 comprises —(CH2)m-Q1-(CH2)n—Z;\n
Q1 comprises NH, O, S, CH═CH, C≡C, CO, SO2 or OSO2;\n
m is an integer from 1 to about 7;\n
n is an integer from 0 to about 7; and\n
Z comprises\n\n
wherein X and Y each independently comprise\n
H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8, C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)jOX3, O(CH2)jNX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X6, —CH═CHX8, —C≡CX8;\n
X1 and X2 each independently comprise H or alkyl, or\n
X1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from O, N or S, or\n
X1 and X2 together comprise part of an imide ring having about 5 to about 6 members,\n
X3 comprises H, alkyl, NO2, (CH2)mCN, hydroxyloweralkyl, or alkyl-NX1X2,\n
X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein\n
X7 comprises H, alkyl, NO2, NO, P(O)(OX8)2, PH(O)(OX8), S(O)kN(alkyl)2, S(O)kX8, S(O)kOX8, COOX8, CONX8, SO3H, COX8, wherein\n
X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or —CX9═CHX10 wherein\n
X9 and X10 each independently comprise H or alkyl\n
Wherein m is an integer from 0 to 7\n
j is an integer from 0 to about 6,\n
k is an integer from 0 to about 2,\n
W comprises H or alkyl."],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["A pharmaceutical composition containing a therapeutically effective amount of at least one compound of claim 1."],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["A method of modulating the function of cannabinoid receptors in an individual or animal comprising administering to the individual or animal a therapeutically effective amount of at least one compound of claim 1."],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 3 comprising selectively stimulating a CB1 cannabinoid receptor in said individual or animal."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["A method of treating or reducing the severity of a condition selected from the group consisting of obesity; metabolic disorders consisting of insulin related deficiencies and lipid profiles, hepatic diseases, cardiometabolic diseases, diabetes and appetite disorders; cancer chemotherapy; benign prostatic hypertrophy; schizophrenia; Parkinson's disease; marijuana abuse; and alcohol, opioid, nicotine or cocaine addiction in an individual or animal having that condition comprising administering to the individual or animal a therapeutically effective amount of at least one compound of claim 1."],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["A compound of claim 1 wherein at least one atom in the compound is an unnatural isotope."],"number":6,"annotation":false,"claim":true,"title":false},{"lines":["A compound of claim 1, and physiologically accepted salts thereof, selected from one of the following structures:"],"number":7,"annotation":false,"claim":true,"title":false},{"lines":["A compound of claim 1, and physiologically accepted salts thereof, consisting of the following structure:"],"number":8,"annotation":false,"claim":true,"title":false},{"lines":["A compound of claim 1, wherein\n
R2 comprises —(CH2)n—Z;\n
n is an integer from 0 to about 7; and\nZ comprises a carbocyclic ring having about 4 to about 7 ring members, a heterocyclic ring having about 4 to about 7 ring members, an aromatic ring having about 5 to about 7 ring members, a heteroaromatic ring having about 5 to about 7 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring, a heteropolycyclic ring; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the —(CH2)n— group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or\n
R2 comprises —(CH2)n—Z;\n
n is an integer from 0 to about 7; and\n
Z comprises\n\n
wherein X and Y each independently comprise, H, halogen, CF3, CF2H, N3, NCS, ON, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8, C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)jOX3, O(CH2)jNX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X6, —CH═CHX8, —C≡CX8;\n
X1 and X2 each independently comprise H or alkyl, or\n
X1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from O, N or S, or\n
X1 and X2 together comprise part of an imide ring having about 5 to about 6 members,\n
X3 comprises H, alkyl, aryl, NO2, (CH2)mCN, hydroxyloweralkyl, or alkyl-NX1X2,\n
X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein\n
X7 comprises H, alkyl, NO2, NO, P(O)(OX8)2, PH(O)(OX8), S(O)kN(alkyl)2, S(O)kX8, S(O)kOX8, COOX8, CONX8, SO3H, COX8, wherein\n
X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or —CX9═CHX10 wherein\n
X9 and X10 each independently comprise H or alkyl\n
Wherein m is an integer from 0 to 7\n
j is an integer from 0 to about 6, or\n
k is an integer from 0 to about 2\n
W comprises H or alkyl; or\n
R2 comprises —(CH2)n—Z;\n
n is an integer from 0 to about 7; and\n
Z comprises a carbocyclic ring having 6 ring atoms fused to a heterocyclic ring having from 5 to 7 ring atoms, a carbocyclic ring having 6 ring atoms fused to a heteroaromatic ring having from 5 to 7 ring atoms, a heterocyclic ring having 6 ring atoms fused to a heterocyclic ring having from 5 to 7 ring atoms, an heterocyclic ring having 6 ring atoms fused to a heteroaromatic ring having from 5 to 7 ring atoms, an aromatic ring having 6 ring atoms fused to a heterocyclic ring having from 5 to 7 ring atoms, an aromatic ring having 6 ring atoms fused to a heteroaromatic ring having from 5 to 7 ring atoms, a heteroaromatic ring having 6 ring atoms fused to a heterocyclic ring having from 5 to 7 ring atoms or a heteroaromatic ring having 6 ring atoms fused to a heteroaromatic ring having from 5 to 7 ring atoms;\n
R1 comprises -T-Q-(CH2)n—Z;\n
n is an integer from 0 to about 7;\n
T comprises a carbocyclic ring having 3 to about 8 ring members, an unsaturated ring having 3 to about 8 carbon atoms as ring members, an aromatic ring having 5 to about 8 carbon atoms as ring members, a heterocyclic ring having 3 to about 8 ring members, a heteroaromatic ring having 5 to about 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;\n
Q comprises C≡C."],"number":9,"annotation":false,"claim":true,"title":false},{"lines":["A compound of claim 1, wherein\n
R2 comprises —(CH2)n—Z;\n
n is 0; and\n
Z comprises an aromatic ring having about 5 to about 7 ring members, a heteroaromatic ring having about 5 to about 7 ring members; or\n
R2 comprises —(CH2)n—Z;\n
n is an integer from 0 to about 7; and\n
Z comprises\n\n
wherein X and Y each independently comprise, H, halogen, CF3, CF2H, N3, NCS, ON, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8, C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)jOX3, O(CH2)jNX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X6, —CH═CHX8, —C≡CX8;\n
X1 and X2 each independently comprise H or alkyl, or\n
X1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from O, N or S, or\n
X1 and X2 together comprise part of an imide ring having about 5 to about 6 members,\n
X3 comprises H, alkyl, aryl, NO2, (CH2)mCN, hydroxyloweralkyl, or alkyl-NX1X2,\n
X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein\n
X7 comprises H, alkyl, NO2, NO, P(O)(OX8)2, PH(O)(OX8), S(O)kN(alkyl)2, S(O)kX8, S(O)kOX8, COOX8, CONX8, SO3H, COX8, wherein\n
X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or —CX9═CHX10 wherein\n
X9 and X10 each independently comprise H or alkyl\n
Wherein m is an integer from 0 to 7\n
j is an integer from 0 to about 6, or\n
k is an integer from 0 to about 2\n
W comprises H or alkyl; or\n
R1 comprises -T-Q-(CH2)n—Z;\n
n is an integer from 0 to about 7;\n
T comprises an aromatic ring having 5 to about 8 carbon atoms as ring members, a heteroaromatic ring having 5 to about 8 ring members;\n
Q comprises C≡C."],"number":10,"annotation":false,"claim":true,"title":false},{"lines":["A compound of claim 1, wherein\n
R2 comprises —(CH2)n—Z;\n
n is an integer from 0 to about 7; and\n
Z comprises a carbocyclic ring having about 4 to about 7 ring members, a heterocyclic ring having about 4 to about 7 ring members, an aromatic ring having about 5 to about 7 ring members, a heteroaromatic ring having about 5 to about 7 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring, a heteropolycyclic ring; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the —(CH2)n— group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or\n
R2 comprises —(CH2)n—Z;\n
n is an integer from 0 to about 7; and\n
Z comprises\n\n
wherein X and Y each independently comprise, H, halogen, CF3, CF2H, N3, NCS, ON, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8, C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)jOX3, O(CH2)jNX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X6, —CH═CHX8, —C≡CX8;\n
X1 and X2 each independently comprise H or alkyl, or\n
X1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from O, N or S, or\n
X1 and X2 together comprise part of an imide ring having about 5 to about 6 members,\n
X3 comprises H, alkyl, aryl, NO2, (CH2)mCN, hydroxyloweralkyl, or alkyl-NX1X2,\n
X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein\n
X7 comprises H, alkyl, NO2, NO, P(O)(OX8)2, PH(O)(OX8), S(O)kN(alkyl)2, S(O)kX8, S(O)kOX8, COOX8, CONX8, SO3H, COX8, wherein\n
X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or —CX9═CHX10 wherein\n
X9 and X10 each independently comprise H or alkyl\n
Wherein m is an integer from 0 to 7\n
j is an integer from 0 to about 6, or\n
k is an integer from 0 to about 2\n
W comprises H or alkyl; or\n
R2 comprises —(CH2)n—Z;\n
n is an integer from 0 to about 7; and\n
Z comprises a carbocyclic ring having 6 ring atoms fused to a heterocyclic ring having from 5 to 7 ring atoms, a carbocyclic ring having 6 ring atoms fused to a heteroaromatic ring having from 5 to 7 ring atoms, a heterocyclic ring having 6 ring atoms fused to a heterocyclic ring having from 5 to 7 ring atoms, an heterocyclic ring having 6 ring atoms fused to a heteroaromatic ring having from 5 to 7 ring atoms, an aromatic ring having 6 ring atoms fused to a heterocyclic ring having from 5 to 7 ring atoms, an aromatic ring having 6 ring atoms fused to a heteroaromatic ring having from 5 to 7 ring atoms, a heteroaromatic ring having 6 ring atoms fused to a heterocyclic ring having from 5 to 7 ring atoms or a heteroaromatic ring having 6 ring atoms fused to a heteroaromatic ring having from 5 to 7 ring atoms;\n
R1 comprises -T-Q-(CH2)n—Z,\n
n is an integer from 0 to about 7;\n
T comprises an aromatic ring having 5 to about 8 carbon atoms as ring members or a heteroaromatic ring having 5 to about 8 ring members;\n
Q comprises C≡C; and\n
Z comprises CN, alkyl-CN, or ONO2."],"number":11,"annotation":false,"claim":true,"title":false},{"lines":["A compound of claim 1 wherein\n
R2 comprises —(CH2)n—Z;\n
n is an integer from 0 to about 7;\n
Z is OX3; and\n
X3 is NO2."],"number":12,"annotation":false,"claim":true,"title":false},{"lines":["A compound of claim 1 wherein\n
R1 comprises -T-Q-(CH2)n—Z;\n
n is an integer from 0 to about 7;\n
T comprises a carbocyclic ring having 3 to about 8 ring members, an unsaturated ring having 3 to about 8 carbon atoms as ring members, an aromatic ring having 5 to about 8 carbon atoms as ring members, a heterocyclic ring having 3 to about 8 ring members, a heteroaromatic ring having 5 to about 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;\n
Z is OX3; and\n
X3 is NO2."],"number":13,"annotation":false,"claim":true,"title":false},{"lines":["A compound of claim 1 wherein\n
R4 comprises —(CH2)d—Z, or —(CH2)m-Q1-(CH2)n—Z."],"number":14,"annotation":false,"claim":true,"title":false},{"lines":["A compound of claim 1, wherein\n
R1 comprises\n
-T-(CH2)m-Q1-(CH2)n—Z;\n
—(CH2)n—Z;\n
—(CH2)m-Q1-(CH2)n—Z;\n
-T-(CH2)n—Z; or\n
-T-Q-(CH2)n—Z; and\n
R2 comprises\n
—(CH2)n—Z;\n
—(CH2)m-Q1-(CH2)n—Z;\n
-T-(CH2)n—Z; or\n
-T-(CH2)m-Q1-(CH2)n—Z."],"number":15,"annotation":false,"claim":true,"title":false},{"lines":["A compound of claim 1, wherein\n
R3 is\n\nand\n
R2 is selected from"],"number":16,"annotation":false,"claim":true,"title":false},{"lines":["A compound of claim 1, and physiologically accepted salts thereof, comprising a structure selected from the group consisting of:\n
5-(4-[4-cyanobut-1-ynyl]phenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(1,1-dioxothiomorpholino)-1H-pyrazole-3-carboxamide\n
1-(2-chloro-4-fluorophenyl)-5-(4-(4-cyanobut-1-yn-1-yl)phenyl)-N-(1,1-dioxidothiomorpholino)-4-ethyl-1H-pyrazole-3-carboxamide;\n
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-N-(1,1-dioxidothiomorpholino)-4-methyl-1H-pyrazole-3-carboxamide;\n
5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-N-(1,1-dioxidothiomorpholino)-4-methyl-1H-pyrazole-3-carboxamide;\n
1-(2,4-dichlorophenyl)-N-(1,1-dioxidothiomorpholino)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxamide;\n
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-N-(1,1-dioxidothiomorpholino)-4-ethyl-1H-pyrazole-3-carboxamide;\n
5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-N-(1,1-dioxidothiomorpholino)-4-ethyl-1H-pyrazole-3-carboxamide;\n
1-(2,4-dichlorophenyl)-N-(1,1-dioxidothiomorpholino)-4-ethyl-5-(4-iodophenyl)-1H-pyrazole-3-carboxamide;\n
1-(2-chloro-4-fluorophenyl)-5-(4-chlorophenyl)-N-(1,1-dioxidothiomorpholino)-4-ethyl-1H-pyrazole-3-carboxamide;\n
5-(4-bromophenyl)-1-(2-chloro-4-fluorophenyl)-N-(1,1-dioxidothiomorpholino)-4-ethyl-1H-pyrazole-3-carboxamide;\n
1-(2-chloro-4-fluorophenyl)-N-(1,1-dioxidothiomorpholino)-4-ethyl-5-(4-iodophenyl)-1H-pyrazole-3-carboxamide; and\n
4-(4-(1-(2,4-dichlorophenyl)-3-((1,1-dioxidothiomorpholino)carbamoyl)-4-methyl-1H-pyrazol-5-yl)phenyl)but-3-yn-1-yl nitrate."],"number":17,"annotation":false,"claim":true,"title":false},{"lines":["A compound of claim 1, wherein\n
R3 comprises\n\n
\n"],"number":18,"annotation":false,"claim":true,"title":false},{"lines":["A compound of claim 1, wherein\nwherein G comprises CH or N,\nL, K and J each independently comprise (CH2)n, and at least one of L, K or J is SO2,\nn is an integer from 0 to about 7.\n
R3 is\n\nand\n
R4 is alkyl or CN."],"number":19,"annotation":false,"claim":true,"title":false},{"lines":["A compound of claim 1, wherein\n
R3 is\n\nand\n
Q is C≡C."],"number":20,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}