Heteropyrrole Analogs Acting On Cannabinoid Receptors


Disclosed are biologically active hetero pyrrole analogs such as imidazoles, thiazoles, oxazoles and pyrazoles capable of interacting with the CB1 and/or CB2 cannabinoid receptors. Aspects disclose hetero pyrrole analogs acting as CB1 and/or CB 1 receptor antagonists, having selectivity for the CB 1 or CB2 receptor, acting as neutral antagonists, acting preferentially on CB 1 receptors located in the peripheral nervous system, and/or acting as nitric oxide donors. Pharmaceutical preparations employing the disclosed analogs and methods of administering therapeutically effective amounts of the disclosed analogs to provide a physiological effect are also disclosed.

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Document History
  • Publication: Oct 7, 2014
  • Application: Feb 19, 2009
    US US 200913202499 A
  • Priority: Feb 19, 2009
    US US 200913202499 A
  • Priority: Feb 19, 2009
    US US 2009/0001054 W
  • Priority: Jan 10, 2006
    US US 2006/0000720 W
  • Priority: Jan 10, 2005
    US US 64254405 P

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