Compositions And Methods Of Synthesis Of Pyridinolypiperidine 5-ht1f Agonists


The present invention provides a novel polymorph of the hemisuccinate salt of 2,4,6-trifluoro-N-[6-(1-methyl-piperidine-4-carbonyl)-pyridin-2-yl]-benzamide (Form A) characterized by a unique X-ray diffraction pattern and Differential Scanning Calorimetry profile, as well as a unique crystalline structure. This polymorph is useful in pharmaceutical compositions, for example, for the treatment and prevention of migraine. The invention also provides a process for the synthesis of pyridinoylpiperidine compounds of Formula I in high yield and high purity. In particular, the provides a process for the preparation of 2,4,6-trifluoro-N-[6-(1-methyl-piperidine-4-carbonyl)-pyridin-2-yl]-benzamide, its hemisuccinate salt and polymorph (Form A).

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Document History
  • Publication: Apr 15, 2014
  • Application: Mar 31, 2011
    US US 201113637566 A
  • Priority: Mar 31, 2011
    US US 201113637566 A
  • Priority: Mar 31, 2011
    US US 2011/0030740 W
  • Priority: Apr 2, 2010
    US US 32051710 P

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