{"search_session":{},"preferences":{"l":"fr","queryLanguage":"fr"},"patentId":"US_8673872_B2","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"106-847-644-627-421","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":6810,"type":"PATENT","title":"University of Western Australia","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":1173,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8195,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
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Owner = University of Western Australia
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Applicant=Univ Western Australia.
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Search Applicants and Owners(us) = ' Univ* Weste* Aus*', ' Weste* Aus* Univ*' ,
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Total patents = 1040
Search applicants and owners= \"Univ Pennsylvania\", \"Pennsylvania Univ\", \"Univ Penns*\", \"Penn* Univ\", \"University of Pennsylvania\", \"Pennsylvania University\".
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Owner = University of Western Australia
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Applicant=Univ Western Australia.
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Search applicants and owners= \"Univ Pennsylvania\", \"Pennsylvania Univ\", \"Univ Penns*\", \"Penn* Univ\", \"University of Pennsylvania\", \"Pennsylvania University\".
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a) selecting an miRNA capable of interacting with the sequence UCUUCC in the 3′-untranslated region (UTR) of the mRNA of said EGFR or of a downstream effector molecule selected from the group consisting of Raf-1, CALM3, CAMK2D, PAK1, and ADCY9; and\n
b) contacting said cell with said miRNA under conditions whereby expression of EGFR in said cell is reduced."],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the 3′-UTR comprises a sequence which is encoded by a sequence having at least about 90% identity with at least one sequence selected from the group consisting of the sequences set forth in SEQ ID NOs:1-11."],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the 3′-UTR is encoded by a sequence contained within the sequence set forth in SEQ ID NO:1."],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein said contacting comprises contacting said cell with an agent comprising a nucleic acid molecule encoding an miRNA precursor, wherein said precursor is processed in said cell to form said miRNA."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the said miRNA is miR-7."],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 5, wherein the miR-7 is the sequence set forth in SEQ ID NO: 48."],"number":6,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the miRNA comprises the sequence set fourth in SEQ ID NO: 52."],"number":7,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the miRNA comprises a nucleic acid molecule having at least about 90% identity with the sequence set forth in SEQ ID NO: 48."],"number":8,"annotation":false,"claim":true,"title":false},{"lines":["A method of inhibiting the growth or differentiation of a cell expressing EGFR or a downstream effector molecule, comprising:\n
a) selecting an miRNA capable of interacting with the sequence UCUUCC in the 3′-untranslated region (UTR) of the mRNA of said EGFR or of a downstream effector molecule selected from the group consisting of Raf-1, CALM3, CAMK2D, PAK1, and ADCY9; and\n
b) contacting said cell with said miRNA under conditions whereby growth or differentiation of said cell is inhibited."],"number":9,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 9, wherein-said cell is a cancer cell."],"number":10,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 10, wherein said cancer cell is selected from the group consisting of a brain cancer cell, a lung cancer cell, a breast cancer cell, a prostate cancer cell, and a colon cancer cell."],"number":11,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 10, wherein said cancer cell is from a cancer cell line."],"number":12,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 9, wherein the miRNA comprises the sequence set forth in SEQ ID NO: 52."],"number":13,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 9, wherein the miRNA is miR-7."],"number":14,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 9, wherein the miR-7 is the sequence set forth in SEQ ID NO: 48."],"number":15,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 9, wherein the miRNA comprises a nucleic acid molecule having at least about 90% identity with the sequence set forth in SEQ ID NO: 48."],"number":16,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}