Use Of Monomycolyl Glycerol (mmg) As An Adjuvant

Abstract

Here we identify MMG and its alpha- and ketomycolic acid derivatives as highly bioactive lipids derived from M. bovis BCG (Copenhagen) capable of stimulating and activating human DC's at exceedingly low doses. In addition to their direct role as immunostimulators of human DC's we demonstrate their use in the development of a new generation of adjuvants suitable for human administration. We furthermore identify a number of highly active synthetic MMG analogues with great potential in cancer treatment, and for vaccine adjuvants against both infectious disease and disorders like Alzheimers disease.


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Document History
  • Publication: Oct 22, 2013
  • Application: Jun 26, 2008
    US US 66610208 A
  • Priority: Jun 26, 2008
    DK DK 2008000239 W
  • Priority: Jun 29, 2007
    DK DK PA200700965 A

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