{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"US_8486939_B2","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"055-320-326-220-336"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11805,"type":"PATENT","title":"The University of Auckland Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":2641,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8435,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
each R1 is independently hydrogen, C1-6 alkyl, —S—C1-6 alkyl, —S(O)—C1-6 alkyl, or —SO2—C1-6 alkyl;\n
each R2 and R3 is independently (a) hydrogen, cyano, halo, or nitro; (b) C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C6-14 aryl, C7-15 aralkyl, heteroaryl, or heterocyclyl; or (c) —C(O)R1a, —C(O)OR1b, —C(O)NR1bR1c, —C(NRa)NR1bR1c, —OR1a, —OC(O)R1a, —OC(O)OR1a, —OC(O)NR1bR1c, —OC(═NR1a)NR1bR1c, —OS(O)R1a, —OS(O)2R1a, —OS(O)NR1bR1c, —OS(O)2NR1bR1c, —NR1bR1c, —NR1aC(O)R1d, —NR1aC(O)OR1d, —NR1aC(O)NR1bR1c, —NR1aC(═NR1d)NR1bR1c, —NR1aS(O)R1d, —NR1aS(O)2R1d, —NR1aS(O)NR1bR1c, —NR1aS(O)2NR1bR1c, —SR1a, —S(O)R1a, —S(O)2R1a, —S(O)NR1bR1c, or —S(O)2NR1bR1c;\n
each R4 and R5 is independently hydrogen or C1-6 alkyl; or R4 and R5 are linked together to form a bond, C1-6 alkylene, C1-6 heteroalkylene, C2-6 alkenylene, or C2-6 heteroalkenylene;\n
each R6 is independently C6-14 aryl, C7-15 aralkyl, heteroaryl, or heteroaryl-C1-6 alkyl;\n
each U is independently —C(O)—, —C(O)O—, —C(O)NR1a—, —O—, —OC(O)O—, —OC(O)NR1a—, —NR1a—, —NR1aC(O)NR1d—, —NR1aS(O)—, —NR1aS(O)2—, —NR1aS(O)NR1d—, —NR1aS(O)2NR1d—, —S—, —S(O)—, or —S(O)2—;\n
each X, Y, and Z is N;\n
each A, B, D, and E is independently a bond, C, O, N, S, NR9, CR9, or CR9R10, where each R9 and R10 is independently hydrogen, halo, C1-6 alkyl, C2-6 alkenyl, or C2-6 alkynyl; wherein the bonds between A, B, D, and E may be saturated or unsaturated; with the proviso that no more than one of A, B, D, and E are a bond; and\n
each R1a, R1b, R1c, and R1d is independently (i) hydrogen; or (ii) C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C6-14 aryl, C7-15 aralkyl, heteroaryl, or heterocyclyl;\n
wherein each alkyl, alkylene, heteroalkylene, alkenyl, alkenylene, heteroalkenylene, alkynyl, cycloalkyl, aryl, aralkyl, heteroaryl, and heterocyclyl R1, R2, R3, R4, R5, R6, R9, R10, R1a, R1b, R1c, or R1d is optionally substituted with one or more groups, each independently selected from (a) cyano, halo, and nitro; (b) C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C6-14 aryl, C7-15 aralkyl, heteroaryl, and heterocyclyl, each of which is further optionally substituted with one or more substituents Q; and (c) —C(O)Ra, —C(O)ORa, —C(O)NRbRc, —C(NRa)NRbRc, —ORa, —OC(O)Ra, —OC(O)ORa, —OC(O)NRbRc, —OC(═NRa)NRbRc, —OS(O)Ra, —OS(O)2Ra, —OS(O)NRbRc, —OS(O)2NRbRc, —NRbRc, —NRaC(O)Rd, —NRaC(O)ORd, —NRaC(O)NRbRc, —NRaC(═NRd)NRbRc, —NRaS(O)Rd, —NRaS(O)NRbRc, —SRa, —S(O)Ra, and —S(O)NRbRc, wherein each Ra, Rb, Rc, and Rd is independently (i) hydrogen; (ii) C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C6-14 aryl, C7-15 aralkyl, heteroaryl, or heterocyclyl, each optionally substituted with one or more substituents Q; or (iii) Rb and Rc together with the N atom to which they are attached form heterocyclyl, optionally substituted with one or more substituents Q;\n
wherein each Q is independently selected from the group consisting of (a) cyano, halo, and nitro; (b) C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C6-14 aryl, C7-15 aralkyl, heteroaryl, and heterocyclyl; and (c) —C(O)Re, —C(O)ORe, —C(O)NRfRg, —C(NRe)NRfRg, —ORe, —OC(O)Re, —OC(O)ORe, —OC(O)NRfRg, —OC(═NRe)NRfRg, —OS(O)Re, —OS(O)2Re, —OS(O)NRfRg, —OS(O)2NRfRg, —NRfRg, —NReC(O)Rh, —NReC(O)ORh, —NReC(O)NRfRg, —NReC(═NRh)NRfRg, —NReS(O)Rh, —NReS(O)NRfRg, —SRe, —S(O)Re, and —S(O)NRfRg, wherein each Re, Rf, Rg, and Rh is independently (i) hydrogen; (ii) C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C6-14 aryl, C7-15 aralkyl, heteroaryl, or heterocyclyl; or (iii) Rf and Rg together with the N atom to which they are attached form heterocyclyl."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1 having the structure of Formula II, Ia, or Ib:\nor an enantiomer, a mixture of enantiomers, or a mixture of two or more diastereomers thereof; or a pharmaceutically acceptable salt or prodrug thereof."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1 having the structure of Formula VIII:\nor an enantiomer, a mixture of enantiomers, or a mixture of two or more diastereomers thereof; or a pharmaceutically acceptable salt or prodrug thereof."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1 having the structure of Formula IX\nor an enantiomer, a mixture of enantiomers, or a mixture of two or more diastereomers thereof; or a pharmaceutically acceptable salt prodrug thereof."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1, wherein A is N."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1, wherein B is N."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1, wherein B is CH or CH2."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1, wherein D is N."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1, wherein D is CH or CH2."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1, wherein R6 is C6-14 aryl, optionally substituted with one or more substituents Q."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 10, wherein R6 is phenyl, optionally substituted with one or more substituents, each independently selected from the group consisting of halo, cyano, nitro, amino, hydroxyl, and methoxy."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 10, wherein R6 is phenyl, aminophenyl, nitrophenyl, or methoxyphenyl."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1, wherein R6 is C7-15 aralkyl, optionally substituted with one or more substituents Q."],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 13, wherein R6 is —(CRARB)m—C6-14 aryl, and each RA and RB is independently (a) hydrogen, cyano, halo, or nitro; (b) C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C6-14 aryl, C7-15 aralkyl, heteroaryl, or heterocyclyl; and m is an integer of 1, 2, or 3; and where each alkyl, alkenyl, alkynyl, cycloalkyl, aryl, aralkyl, heteroaryl, and heterocyclyl is optionally substituted with one or more substituents Q."],"number":14,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 13, wherein R6 is benzyl, optionally substituted with one or more substituents Q."],"number":15,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 13, wherein R6 is benzyl or phenyl-ethyl, each optionally substituted with one or more substituents Q."],"number":16,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1, wherein R6 is heteroaryl, optionally substituted with one or more substituents Q."],"number":17,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 17, wherein R6 is pyrazolyl, imidazolyl, thiazolyl, 1,2,3-triazolyl, tetrazolyl, pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl, or quinolinyl, each optionally substituted with one or more substituents Q."],"number":18,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 17, wherein each substituent is independently -L-(CRCRD)n—RE, where RC and RD are each independently (a) hydrogen, cyano, halo, or nitro; (b) C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C6-14 aryl, C7-15 aralkyl, heteroaryl, or heterocyclyl; each optionally substituted with one or more substituents Q; RE is hydrogen, —NRFRG, or heterocyclyl; L is a bond, —O—, or —N(RH)—; RF, RG, and RH are each independently hydrogen or C1-6 alkyl; and n is an integer of 0, 1, 2, or 3; and where each alkyl and heterocyclyl is independently, optionally substituted with one or more substituents Q."],"number":19,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 19, wherein L is a bond, —O—, —NH—, or —N(CH3)—."],"number":20,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 19, wherein RC and RD are hydrogen."],"number":21,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 19, wherein RE is hydrogen, methylamino, dimethylamino, pyrrolidinyl, piperidinyl, or morpholinyl, wherein the pyrrolidinyl, piperidinyl, and morpholinyl are independently, optionally substituted with methyl."],"number":22,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 17, wherein each substituent is independently selected from the group consisting of amino, fluoro, chloro, methyl, (dimethylamino)methyl, (dimethylamino)ethyl, (dimethylamino)propyl, morpholinylmethyl, (morpholinyl)ethyl, (morpholinyl)propyl, methoxy, (dimethylamino)ethoxy, (dimethylamino)propoxy, (morpholinyl)ethoxy, (morpholinyl)propoxy, (methyl-piperidinyl)oxy, (methyl-pyrrolidinyl)-oxy, methylamino, dimethylamino, (dimethylamino)ethylamino, (dimethylaminoethyl)-(methyl)amino, (dimethylamino)propylamino, ((dimethylamino)propyl)(methyl)amino, (morpholinyl)ethylamino, ((morpholinyl)ethyl)(methyl)amino, (morpholinyl)propylamino, ((morpholinyl)propyl)(methyl)amino, methyl-piperidinylamino, (methyl-piperidinyl)-(methyl)amino, methyl-piperazinyl, and (dimethylamino)-piperidinyl."],"number":23,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 18, wherein R6 is pyridinyl."],"number":24,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 24, wherein R6 is 3-pyridinyl."],"number":25,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1 having the structure of Formula III:\nor an enantiomer, a mixture of enantiomers, or a mixture of two or more diastereomers thereof; or a pharmaceutically acceptable salt or prodrug thereof;wherein:\n
U is —C(O)—, —C(O)O—, —C(O)NR1a—, —O—, —OC(O)O—, —OC(O)NR1a—, —NR1a—, —NR1aC(O)NR1d—, —NR1aS(O)—, —NR1aS(O)2—, —NR1aS(O)NR1d—, —NR1aS(O)2NR1d—, —S—, —S(O)—, or —S(O)2—; and\n
R8 is (a) hydrogen, cyano, halo, or nitro; (b) C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C6-14 aryl, C7-15 aralkyl, heteroaryl, or heterocyclyl; each optionally substituted with one or more substituents Q; or (c) —C(O)R1a, —C(O)OR1b, —C(O)NR1bR1c, —C(NRa)NR1bR1c, —OR1a, —OC(O)R1a, —OC(O)OR1a, —OC(O)NR1bR1c, —OC(═NR1a)NR1bR1c, —OS(O)R1a, —OS(O)2R1a, —OS(O)NR1bR1c, —OS(O)2NR1bR1c, —NR1bR1c, —NR1aC(O)R1d, —NR1aC(O)OR1d, —NR1aC(O)NR1bR1c, —NR1aC(═NR1d)NR1bR1c, —NR1aS(O)R1d, —NR1aS(O)2R1d, —NR1aS(O)NR1bR1c, —NR1aS(O)2NR1bR1c, —SR1a, —S(O)R1a, —S(O)2R1a—S(O)NR1bR1c, or —S(O)2NR1bR1c."],"number":26,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1 having the structure of Formula IV:\nor an enantiomer, a mixture of enantiomers, or a mixture of two or more diastereomers thereof; or a pharmaceutically acceptable salt or prodrug thereof;wherein:\n
R8 is (a) hydrogen, cyano, halo, or nitro; (b) C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C6-14 aryl, C7-15 aralkyl, heteroaryl, or heterocyclyl; each optionally substituted with one or more substituents Q; or (c) —C(O)R1a, —C(O)OR1b, —C(O)NR1bR1c, —C(NRa)NR1bR1c, —OR1a, —OC(O)R1a, —OC(O)OR1a, —OC(O)NR1bR1c, —OC(═NR1a)NR1bR1c, —OS(O)R1a, —OS(O)2R1a, —OS(O)NR1bR1c, —OS(O)2NR1bR1c, —NR1bR1c, —NR1aC(O)R1d, —NR1aC(O)OR1d, —NR1aC(O)NR1bR1c, —NR1aC(═NR1d)NR1bR1c, —NR1aS(O)R1d, —NR1aS(O)2R1d, —NR1aS(O)NR1bR1c, —NR1aS(O)2NR1bR1c, —SR1a, —S(O)R1a, —S(O)2R1a, —S(O)NR1bR1c, or —S(O)2NR1bR1c;\n
each RA and RB is independently (a) hydrogen, cyano, halo, or nitro; (b) C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C6-14 aryl, C7-15 aralkyl, heteroaryl, or heterocyclyl; each optionally substituted with one or more substituents Q; and\n
m is an integer of 1, 2, or 3."],"number":27,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 26, wherein R8 is hydrogen, hydroxyl, or methoxy."],"number":28,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1 having the structure of Formula V:\nor an enantiomer, a mixture of enantiomers, or a mixture of two or more diastereomers thereof; or a pharmaceutically acceptable salt or prodrug thereof;wherein:\n
A2, A3, and A4 are each independently C, N, or CR8; with the proviso that no more than one of A2, A3, and A4 is N;\n
each RA and RB are each independently (a) hydrogen, cyano, halo, or nitro; (b) C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C6-14 aryl, C7-15 aralkyl, heteroaryl, or heterocyclyl; each optionally substituted with one or more substituents Q;\n
each R8 is independently (a) hydrogen, cyano, halo, or nitro; (b) C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C6-14 aryl, C7-15 aralkyl, heteroaryl, or heterocyclyl; each optionally substituted with one or more substituents Q; or (c) —C(O)R1a, —C(O)OR1b, —C(O)NR1bR1c, —C(NRa)NR1bR1c, —OR1a, —OC(O)R1a, —OC(O)OR1a, —OC(O)NR1bR1c, —OC(═NR1a)NR1bR1c, —OS(O)R1a, —OS(O)2R1a, —OS(O)NR1bR1c, —OS(O)2NR1bR1c, —NR1bR1c, —NR1aC(O)R1d, —NR1aC(O)OR1d, —NR1aC(O)NR1bR1c, —NR1aC(═NR1d)NR1bR1c, —NR1aS(O)R1d, —NR1aS(O)2R1d, —NR1aS(O)NR1bR1c, —NR1aS(O)2NR1bR1c, —SR1a, —S(O)R1a, —S(O)2R1a, —S(O)NR1bR1c, or —S(O)2NR1bR1c; and\n
p is an integer of 0, 1, 2, or 3."],"number":29,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 29, wherein A2, A3, and A4 are independently CR8."],"number":30,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 29, wherein A2 is N, and A3 and A4 are independently CR8."],"number":31,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 29, wherein A2 and A4 are independently CR8, and A3 is N."],"number":32,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 29, wherein A2 and A3 are independently CR8, and A4 is N."],"number":33,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 29 having the structure of Formula VI:\nor an enantiomer, a mixture of enantiomers, or a mixture of two or more diastereomers thereof; or a pharmaceutically acceptable salt or prodrug thereof."],"number":34,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1 having the structure of Formula VII:\nor an enantiomer, a mixture of enantiomers, or a mixture of two or more diastereomers thereof; or a pharmaceutically acceptable salt or prodrug thereof;wherein:\n
E2, E3, and E4 are each independently C, N, O, S, CR8, or NR8;\n
each RA and RB is independently (a) hydrogen, cyano, halo, or nitro; (b) C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C6-14 aryl, C7-15 aralkyl, heteroaryl, or heterocyclyl; each optionally substituted with one or more substituents Q;\n
each R8 is independently (a) hydrogen, cyano, halo, or nitro; (b) C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C6-14 aryl, C7-15 aralkyl, heteroaryl, or heterocyclyl; each optionally substituted with one or more substituents Q; or (c) —C(O)R1a, —C(O)OR1b, —C(O)NR1bR1c, —C(NRa)NR1bR1c, —OR1a, —OC(O)R1a, —OC(O)OR1a, —OC(O)NR1bR1c, —OC(═NR1a)NR1bR1c, —OS(O)R1a, —OS(O)2R1a, —OS(O)NR1bR1c, —OS(O)2NR1bR1c, —NR1bR1c, —NR1aC(O)R1d, —NR1aC(O)OR1d, —NR1aC(O)NR1bR1c, —NR1aC(═NR1d)NR1bR1c, —NR1aS(O)R1d, —NR1aS(O)2R1d, —NR1aS(O)NR1bR1c, —NR1aS(O)2NR1bR1c, —SR1a, —S(O)R1a, —S(O)2R1a, —S(O)NR1bR1c, or —S(O)2NR1bR1c; and\n
p is an integer of 0, 1, 2, or 3."],"number":35,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 35, wherein E2, E3, and E4 are CR8."],"number":36,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 35, wherein E2 and E4 are CR8, and E3 is NR8, O, or S."],"number":37,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 35, wherein E2 and E3 are N, and E4 is CR8."],"number":38,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 35, wherein E2, E3, and E4 are N."],"number":39,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 29, wherein R8 is hydrogen."],"number":40,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 29, wherein R8 is -L-(CRCRD)n—RE, where RC and RD are each independently (a) hydrogen, cyano, halo, or nitro; (b) C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C6-14 aryl, C7-15 aralkyl, heteroaryl, or heterocyclyl; RE is hydrogen, —NRFRG, or heterocyclyl; L is a bond, —O—, or —N(RH)—; RF, RG, and RH are each independently hydrogen or C1-6 alkyl; and n is an integer of 0, 1, 2, or 3."],"number":41,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 41, wherein L is a bond, —O—, —NH—, or —N(CH3)—."],"number":42,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 41, wherein RC and RD are hydrogen."],"number":43,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 41, wherein RE is hydrogen, methylamino, dimethylamino, pyrrolidinyl, piperidinyl, or morpholinyl, wherein the pyrrolidinyl, piperidinyl, and morpholinyl are independently, optionally substituted with methyl."],"number":44,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 41, wherein R8 is independently selected from the group consisting of amino, fluoro, chloro, methyl, (dimethylamino)methyl, (dimethylamino)ethyl, (dimethylamino)propyl, morpholinylmethyl, (morpholinyl)ethyl, (morpholinyl)propyl, methoxy, (dimethylamino)ethoxy, (dimethylamino)propoxy, (morpholinyl)ethoxy, (morpholinyl)propoxy, (methyl-piperidinyl)oxy, (methyl-pyrrolidinyl)oxy, methylamino, dimethylamino, (dimethylamino)ethylamino, (dimethylaminoethyl)(methyl)amino, (dimethylamino)propylamino, ((dimethylamino)propyl)(methyl)amino, (morpholinyl)ethylamino, ((morpholinyl)ethyl)(methyl)amino, (morpholinyl)propylamino, ((morpholinyl)propyl)(methyl)amino, methyl-piperidinylamino, (methyl-piperidinyl)(methyl)amino, methyl-piperazinyl, and (dimethylamino)-piperidinyl."],"number":45,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 27, wherein RA and RB are hydrogen."],"number":46,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1, wherein R1 is C1-6 alkyl, —S—C1-6 alkyl or —SO2—C1-6 alkyl, where each alkyl is independently, optionally substituted with one to three halo."],"number":47,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 47, wherein R1 is methyl, fluoromethyl, difluoromethyl, trifluoromethyl, methanesulfanyl, or methanesulfonyl."],"number":48,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 47, wherein R1 is difluoromethyl."],"number":49,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 47, wherein R1 is methanesulfanyl."],"number":50,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 47, wherein R1 is methanesulfonyl."],"number":51,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1, wherein R2 is hydrogen, C1-6 alkyl, or —O—C1-6 alkyl, where each alkyl is optionally substituted with one or more substituents Q."],"number":52,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 52, wherein R2 is hydrogen."],"number":53,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 52, wherein R2 is methoxy."],"number":54,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1, wherein R3 is hydrogen, amino, or C1-6 alkyl, optionally substituted with one or more substituents Q."],"number":55,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 55, wherein R3 is hydrogen."],"number":56,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 55, wherein R3 is amino."],"number":57,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1, wherein R4 is hydrogen or C1-6 alkyl, optionally substituted with one or more substituents Q."],"number":58,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 58, wherein R4 is hydrogen."],"number":59,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1, wherein R5 is hydrogen or C1-6 alkyl, optionally substituted with one or more substituents Q."],"number":60,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 60, wherein R5 is hydrogen."],"number":61,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1, wherein R4 and R5 are linked together to form a bond or C1-6 alkylene."],"number":62,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 62, wherein R4 and R5 are linked together to form a bond, methylene, or ethylene."],"number":63,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1, wherein U is —O—, —NR1a—, —S—, —S(O)—, or —S(O)2—, where R1a is C1-6 alkyl, optionally substituted with one or more substituents Q."],"number":64,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 64, wherein U is —O—, —NH—, —NCH3—, —S—, —S(O)—, or —S(O)2—."],"number":65,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 64, wherein U is —NH—."],"number":66,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1 selected from the group consisting of:\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-(3-pyridinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-(3-pyridinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-N-methyl-6-(4-morpholinyl)-N-(3-pyridinyl)-1,3,5-triazin-2-amine;\n
4-[2-(methylsulfanyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-(3-pyridinyl)-1,3,5-triazin-2-amine;\n
4-[2-(methylsulfonyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-(3-pyridinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-phenyl-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-N-methyl-6-(4-morpholinyl)-N-phenyl-1,3,5-triazin-2-amine;\n
N-benzyl-4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
N-benzyl-4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-N-methyl-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
2-(difluoromethyl)-1-[4-(4-morpholinyl)-6-phenoxy-1,3,5-triazin-2-yl]-1H-benzimidazole;\n
2-(difluoromethyl)-1-[4-(4-morpholinyl)-6-(phenylsulfanyl)-1,3,5-triazin-2-yl]-1H-benzimidazole;\n
2-(difluoromethyl)-1-[4-(4-morpholinyl)-6-(phenylsulfonyl)-1,3,5-triazin-2-yl]-1H-benzimidazole;\n
N-(2-chloro-5-pyrimidinyl)-4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-N-methyl-6-(4-morpholinyl)-N-(5-pyrimidinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-N-methyl-6-(4-morpholinyl)-N-(5-pyrimidinyl)-1,3,5-triazin-2-amine;\nand enantiomers, mixtures of enantiomers, or mixtures of two or more diastereomers thereof; and pharmaceutically acceptable salts and prodrugs thereof."],"number":67,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1 selected from the group consisting of:\n
N-[4-[6-amino-2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-N-(3-pyridinyl)amine;\n
N5-[4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-2,5-pyridinediamine;\n
N5-[4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-N2-[3-(dimethylamino)propyl]-2,5-pyridinediamine;\n
N5-[4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-N2-[3-(dimethylamino)propyl]-N2-methyl-2,5-pyridinediamine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-N-(6-methoxy-3-pyridinyl)-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-N-{6-[3-(dimethylamino)propoxy]-3-pyridinyl}-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-(5-pyrimidinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-(3-pyridazinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-N-(1-methyl-1H-imidazol-5-yl)-6-(4-morpholinyl)-1,3,5-triazin-2-amine; and\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-N-(1-methyl-1H-pyrazol-5-yl)-6-(4-morpholinyl)-1,3,5-triazin-2-amine; and enantiomers, mixtures of enantiomers, or mixtures of two or more diastereomers thereof; and pharmaceutically acceptable salts and prodrugs thereof."],"number":68,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1 selected from the group consisting of:\n
4-[4-methoxy-2-(methylsulfonyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-(3-pyridinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-(2-pyridinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-(2-pyridinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-(4-pyridinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-(4-pyridinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-(4-pyrimidinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-(4-pyrimidinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-(5-pyrimidinyl)-1,3,5-triazin-2-amine;\n
2-(difluoromethyl)-1-[4-(4-morpholinyl)-6-(3-pyridinyloxy)-1,3,5-triazin-2-yl]-1H-benzimidazole;\n
2-(difluoromethyl)-4-methoxy-1-[4-(4-morpholinyl)-6-(3-pyridinyloxy)-1,3,5-triazin-2-yl]-1H-benzimidazole;\n
2-(difluoromethyl)-1-[4-(4-morpholinyl)-6-(5-pyrimidinyloxy)-1,3,5-triazin-2-yl]-1H-benzimidazole;\n
2-(difluoromethyl)-4-methoxy-1-[4-(4-morpholinyl)-6-(5-pyrimidinyloxy)-1,3,5-triazin-2-yl]-1H-benzimidazole;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-N-(1-methyl-1H-pyrazol-4-yl)-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-N-(1-methyl-1H-pyrazol-4-yl)-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-(2-pyridinylmethyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-(2-pyridinylmethyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-(3-pyridinylmethyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-(3-pyridinylmethyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-(4-pyridinylmethyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-(4-pyridinylmethyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-N-methyl-6-(4-morpholinyl)-N-(2-pyridinylmethyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-N-methyl-6-(4-morpholinyl)-N-(2-pyridinylmethyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-N-methyl-6-(4-morpholinyl)-N-(3-pyridinylmethyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-N-methyl-6-(4-morpholinyl)-N-(3-pyridinylmethyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-N-methyl-6-(4-morpholinyl)-N-(4-pyridinylmethyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-N-methyl-6-(4-morpholinyl)-N-(4-pyridinylmethyl)-1,3,5-triazin-2-amine;\n
2-(difluoromethyl)-1-[4-(4-morpholinyl)-6-(2-pyridinylmethoxy)-1,3,5-triazin-2-yl]-1H-benzimidazole;\n
2-(difluoromethyl)-4-methoxy-1-[4-(4-morpholinyl)-6-(2-pyridinylmethoxy)-1,3,5-triazin-2-yl]-1H-benzimidazole;\n
2-(difluoromethyl)-1-[4-(4-morpholinyl)-6-(3-pyridinylmethoxy)-1,3,5-triazin-2-yl]-1H-benzimidazole;\n
2-(difluoromethyl)-4-methoxy-1-[4-(4-morpholinyl)-6-(3-pyridinylmethoxy)-1,3,5-triazin-2-yl]-1H-benzimidazole;\n
2-(difluoromethyl)-1-[4-(4-morpholinyl)-6-(4-pyridinylmethoxy)-1,3,5-triazin-2-yl]-1H-benzimidazole;\n
2-(difluoromethyl)-4-methoxy-1-[4-(4-morpholinyl)-6-(4-pyridinylmethoxy)-1,3,5-triazin-2-yl]-1H-benzimidazole;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-[2-(2-pyridinyl)ethyl]-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-[2-(2-pyridinyl)ethyl]-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-[2-(3-pyridinyl)ethyl]-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-[2-(3-pyridinyl)ethyl]-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-[2-(4-pyridinyl)ethyl]-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-[2-(4-pyridinyl)ethyl]-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-N-[2-(1H-imidazol-4-yl)ethyl]-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-N-[2-(1H-imidazol-4-yl)ethyl]-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
N-[4-[6-amino-2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-N-(3-pyridinyl)amine;\n
N-[4-[2-(difluoromethyl)-6-(methylamino)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-N-(3-pyridinyl)amine;\n
N-[4-[2-(difluoromethyl)-4-methoxy-6-(methylamino)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-N-(3-pyridinyl)amine;\n
N-[4-[2-(difluoromethyl)-6-(dimethylamino)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-N-(3-pyridinyl)amine;\n
N-[4-[2-(difluoromethyl)-6-(dimethylamino)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-N-(3-pyridinyl)amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-N-(6-methoxy-3-pyridinyl)-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-N-(2-methoxy-4-pyridinyl)-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-N-(2-methoxy-4-pyridinyl)-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-N-(2-methoxy-5-pyrimidinyl)-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-N-(2-methoxy-5-pyrimidinyl)-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-N-{6-[2-(dimethylamino)ethoxy]-3-pyridinyl}-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-N-{6-[2-(dimethylamino)ethoxy]-3-pyridinyl}-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-{6-[2-(4-morpholinyl)ethoxy]-3-pyridinyl}-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-{6-[2-(4-morpholinyl)ethoxy]-3-pyridinyl}-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-N-{6-[3-(dimethylamino)propoxy]-3-pyridinyl}-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-{6-[3-(4-morpholinyl)propoxy]-3-pyridinyl}-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-{6-[3-(4-morpholinyl)propoxy]-3-pyridinyl}-1,3,5-triazin-2-amine;\n
N5-[4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-2,5-pyridinediamine;\n
N5-[4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-N2-methyl-2,5-pyridinediamine;\n
N5-[4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-N2-methyl-2,5-pyridinediamine;\n
N5-[4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-N2,N2-dimethyl-2,5-pyridinediamine;\n
N5-[4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-N2,N2-dimethyl-2,5-pyridinediamine;\n
N5-[4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-N2-[2-(dimethylamino)ethyl]-2,5-pyridinediamine;\n
N5-[4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-N2-[2-(dimethylamino)ethyl]-2,5-pyridinediamine;\n
N5-[4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-N2-[2-(4-morpholinyl)ethyl]-2,5-pyridinediamine;\n
N5-[4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-N2-[2-(4-morpholinyl)ethyl]-2,5-pyridinediamine;\n
N5-[4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-N2-[2-(dimethylamino)ethyl]-N2-methyl-2,5-pyridinediamine;\n
N5-[4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-N2-[2-(dimethylamino)ethyl]-N2-methyl-2,5-pyridinediamine;\n
N5-[4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-N2-methyl-N2-[2-(4-morpholinyl)ethyl]-2,5-pyridinediamine;\n
N5-[4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-N2-methyl-N2-[2-(4-morpholinyl)ethyl]-2,5-pyridinediamine;\n
N5-[4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-N2-[3-(dimethylamino)propyl]-2,5-pyridinediamine;\n
N5-[4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-N2-[3-(dimethylamino)propyl]-N2-methyl-2,5-pyridinediamine;\n
N5-[4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-N2-[3-(4-morpholinyl)propyl]-2,5-pyridinediamine;\n
N5-[4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-N2-[3-(4-morpholinyl)propyl]-2,5-pyridinediamine;\n
N5-[4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-N2-methyl-N2-[3-(4-morpholinyl)propyl]-2,5-pyridinediamine;\n
N5-[4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-N2-methyl-N2-[3-(4-morpholinyl)propyl]-2,5-pyridinediamine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-N-{6-[2-(dimethylamino)ethyl]-3-pyridinyl}-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-N-{6-[2-(dimethylamino)ethyl]-3-pyridinyl}-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-{6-[2-(4-morpholinyl)ethyl]-3-pyridinyl}-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-{6-[2-(4-morpholinyl)ethyl]-3-pyridinyl}-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-N-{2-[2-(dimethylamino)ethyl]-5-pyrimidinyl}-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-N-{2-[2-(dimethylamino)ethyl]-5-pyrimidinyl}-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-{2-[2-(4-morpholinyl)ethyl]-5-pyrimidinyl}-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-{2-[2-(4-morpholinyl)ethyl]-5-pyrimidinyl}-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-N-{5-[2-(dimethylamino)ethoxy]-3-pyridinyl}-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-N-{5-[2-(dimethylamino)ethoxy]-3-pyridinyl}-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-{5-[2-(4-morpholinyl)ethoxy]-3-pyridinyl}-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-{5-[2-(4-morpholinyl)ethoxy]-3-pyridinyl}-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-N-{5-[3-(dimethylamino)propoxy]-3-pyridinyl}-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-N-{5-[3-(dimethylamino)propoxy]-3-pyridinyl}-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-{5-[3-(4-morpholinyl)propoxy]-3-pyridinyl}-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-{5-[3-(4-morpholinyl)propoxy]-3-pyridinyl}-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-N-{2-[2-(dimethylamino)ethoxy]-4-pyridinyl}-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-N-{2-[2-(dimethylamino)ethoxy]-4-pyridinyl}-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-{2-[2-(4-morpholinyl)ethoxy]-4-pyridinyl}-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-{2-[2-(4-morpholinyl)ethoxy]-4-pyridinyl}-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-N-{2-[3-(dimethylamino)propoxy]-4-pyridinyl}-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-N-{2-[3-(dimethylamino)propoxy]-4-pyridinyl}-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-{2-[3-(4-morpholinyl)propoxy]-4-pyridinyl}-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-{2-[3-(4-morpholinyl)propoxy]-4-pyridinyl}-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-N-{2-[2-(dimethylamino)ethoxy]-5-pyrimidinyl}-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-N-{2-[2-(dimethylamino)ethoxy]-5-pyrimidinyl}-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-N-{2-[3-(dimethylamino)propoxy]-5-pyrimidinyl}-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-N-{2-[3-(dimethylamino)propoxy]-5-pyrimidinyl}-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-{2-[2-(4-morpholinyl)ethoxy]-5-pyrimidinyl}-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-{2-[2-(4-morpholinyl)ethoxy]-5-pyrimidinyl}-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-{2-[3-(4-morpholinyl)propoxy]-5-pyrimidinyl}-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-{2-[3-(4-morpholinyl)propoxy]-5-pyrimidinyl}-1,3,5-triazin-2-amine;\n
N5-[4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-N2-[2-(dimethylamino)ethyl]-2,5-pyrimidinediamine;\n
N5-[4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-N2-[2-(dimethylamino)ethyl]-2,5-pyrimidinediamine;\n
N5-[4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-N2-[2-(dimethylamino)ethyl]-N2-methyl-2,5-pyrimidinediamine;\n
N5-[4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-N2-[2-(dimethylamino)ethyl]-N2-methyl-2,5-pyrimidinediamine;\n
N5-[4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-N2-[3-(dimethylamino)propyl]-2,5-pyrimidinediamine;\n
N5-[4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-N2-[3-(dimethylamino)propyl]-2,5-pyrimidinediamine;\n
N5-[4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-N2-[3-(dimethylamino)propyl]-N2-methyl-2,5-pyrimidinediamine;\n
N5-[4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-N2-[3-(dimethylamino)propyl]-N2-methyl-2,5-pyrimidinediamine;\n
N5-[4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-N2-[2-(4-morpholinyl)ethyl]-2,5-pyrimidinediamine;\n
N5-[4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-N2-[2-(4-morpholinyl)ethyl]-2,5-pyrimidinediamine;\n
N5-[4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-N2-methyl-N2-[2-(4-morpholinyl)ethyl]-2,5-pyrimidinediamine;\n
N5-[4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-N2-methyl-N2-[2-(4-morpholinyl)ethyl]-2,5-pyrimidinediamine;\n
N5-[4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-N2-[3-(4-morpholinyl)propyl]-2,5-pyrimidinediamine;\n
N5-[4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-N2-[3-(4-morpholinyl)propyl]-2,5-pyrimidinediamine;\n
N5-[4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-N2-methyl-N2-[3-(4-morpholinyl)propyl]-2,5-pyrimidinediamine;\n
N5-[4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-N2-methyl-N2-[3-(4-morpholinyl)propyl]-2,5-pyrimidinediamine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-N-[6-(4-methyl-1-piperazinyl)-3-pyridinyl]-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-N-[6-(4-methyl-1-piperazinyl)-3-pyridinyl]-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-N-[2-(4-methyl-1-piperazinyl)-5-pyrimidinyl]-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-N-[2-(4-methyl-1-piperazinyl)-5-pyrimidinyl]-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-N-{6-[4-(dimethylamino)-1-piperidinyl]-3-pyridinyl}-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-N-{6-[4-(dimethylamino)-1-piperidinyl]-3-pyridinyl}-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-N-{2-[4-(dimethylamino)-1-piperidinyl]-5-pyrimidinyl}-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-N-{2-[4-(dimethylamino)-1-piperidinyl]-5-pyrimidinyl}-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
N5-[4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-N2-(1-methyl-4-piperidinyl)-2,5-pyridinediamine;\n
N5-[4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-N2-(1-methyl-4-piperidinyl)-2,5-pyridinediamine;\n
N5-[4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-N2-methyl-N2-(1-methyl-4-piperidinyl)-2,5-pyridinediamine;\n
N5-[4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-N2-methyl-N2-(1-methyl-4-piperidinyl)-2,5-pyridinediamine;\n
N5-[4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-N2-(1-methyl-4-piperidinyl)-2,5-pyrimidinediamine;\n
N5-[4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-N2-(1-methyl-4-piperidinyl)-2,5-pyrimidinediamine;\n
N5-[4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-N2-methyl-N2-(1-methyl-4-piperidinyl)-2,5-pyrimidinediamine;\n
N5-[4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-N2-methyl-N2-(1-methyl-4-piperidinyl)-2,5-pyrimidinediamine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-N-{6-[(1-methyl-4-piperidinyl)oxy]-3-pyridinyl}-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-N-{6-[(1-methyl-4-piperidinyl)oxy]-3-pyridinyl}-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-N-{2-[(1-methyl-4-piperidinyl)oxy]-5-pyrimidinyl}-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-N-{2-[(1-methyl-4-piperidinyl)oxy]-5-pyrimidinyl}-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-N-{6-[(1-methyl-3-pyrrolidinyl)oxy]-3-pyridinyl}-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-N-{6-[(1-methyl-3-pyrrolidinyl)oxy]-3-pyridinyl}-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-N-{2-[(1-methyl-3-pyrrolidinyl)oxy]-5-pyrimidinyl}-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-N-{2-[(1-methyl-3-pyrrolidinyl)oxy]-5-pyrimidinyl}-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-N-{1-[2-(dimethylamino)ethyl]-1H-pyrazol-4-yl}-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-N-{1-[2-(dimethylamino)ethyl]-1H-pyrazol-4-yl}-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-{1-[2-(4-morpholinyl)ethyl]-1H-pyrazol-4-yl}-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-{1-[2-(4-morpholinyl)ethyl]-1H-pyrazol-4-yl}-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-N-{1-[3-(dimethylamino)propyl]-1H-pyrazol-4-yl}-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-N-{1-[3-(dimethylamino)propyl]-1H-pyrazol-4-yl}-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-{1-[3-(4-morpholinyl)propyl]-1H-pyrazol-4-yl}-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-{1-[3-(4-morpholinyl)propyl]-1H-pyrazol-4-yl}-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-(1,3-thiazol-5-yl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-(1,3-thiazol-5-yl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-N-{2-[(dimethylamino)methyl]-1,3-thiazol-5-yl}-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-N-{2[(dimethylamino)methyl]-1,3-thiazol-5-yl}-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-[2-(4-morpholinylmethyl)-1,3-thiazol-5-yl]-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-[2-(4-morpholinylmethyl)-1,3-thiazol-5-yl]-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-N-(1-methyl-1H-imidazol-5-yl)-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-N-(1-methyl-1H-1,2,3-triazol-5-yl)-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-N-(1-methyl-1H-1,2,3-triazol-5-yl)-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-N-(2-methyl-2H-1,2,3-triazol-4-yl)-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-N-(2-methyl-2H-1,2,3-triazol-4-yl)-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-N-(1-methyl-1H-1,2,3-triazol-4-yl)-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-N-(1-methyl-1H-1,2,3-triazol-4-yl)-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-N-(2-methyl-2H-tetrazol-5-yl)-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-N-(2-methyl-2H-tetrazol-5-yl)-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-N-(1-methyl-1H-tetrazol-5-yl)-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-N-(1-methyl-1H-tetrazol-5-yl)-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
N5-[4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-2,5-pyrimidinediamine;\n
N5-[4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-2,5-pyrimidinediamine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-(2-pyrazinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl) -N-(2-pyrazinyl)-1,3,5-triazin-2-amine;\n
N2-[4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-2-pyrazinediamine;\n
N2-[4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-2-pyrazinediamine;\n
N2-[4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-2,6-pyrazinediamine;\n
N2-[4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl) -1,3,5-triazin-2-yl]-2,6-pyrazinediamine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-N-(6-methoxy-2-pyrazinyl)-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-N-(6-methoxy-2-pyrazinyl)-6-(4-morpholinyl)-1,3,5-triazin-2-amine; and\n
N-[4-[6-amino-2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-N-(3-pyridinyl)amine;\nand enantiomers, mixtures of enantiomers, or mixtures of two or more diastereomers thereof; and pharmaceutically acceptable salts and prodrugs thereof."],"number":69,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1 selected from the group consisting of:\n
N-[4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-3-quinolinamine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-(2-pyrimidinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-(4-pyrimidinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-(5-pyrimidinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-N-(4-methoxy-3-pyridinyl)-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-N-(6-fluoro-3-pyridinyl)-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
N-(6-chloro-3-pyridinyl)-4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\n
4-(2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl)-N-(6-methoxypyrimidin-4-yl)-6-morpholino-1,3,5-triazin-2-amine;\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-N-(3-pyridazinyl)-1,3,5-triazin-2-amine; and\n
4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-N-(6-methoxy-3-pyridazinyl)-6-(4-morpholinyl)-1,3,5-triazin-2-amine;\nand enantiomers, mixtures of enantiomers, or mixtures of two or more diastereomers thereof; and pharmaceutically acceptable salts and prodrugs thereof."],"number":70,"annotation":false,"title":false,"claim":true},{"lines":["A pharmaceutical composition comprising the compound of claim 1, or an enantiomer, a mixture of enantiomers, or a mixture of two or more diastereomers thereof; or a pharmaceutically acceptable salt or prodrug thereof; and one or more pharmaceutically acceptable carriers."],"number":71,"annotation":false,"title":false,"claim":true},{"lines":["The pharmaceutical composition of claim 71, further comprising a second therapeutic agent."],"number":72,"annotation":false,"title":false,"claim":true},{"lines":["The pharmaceutical composition of claim 71, wherein the composition is formulated for single dose administration."],"number":73,"annotation":false,"title":false,"claim":true},{"lines":["The pharmaceutical composition of claim 71, wherein the composition is formulated as oral, parenteral, or intravenous dosage form."],"number":74,"annotation":false,"title":false,"claim":true},{"lines":["The pharmaceutical composition of claim 74, wherein the oral dosage form is a tablet or capsule."],"number":75,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 14, wherein m is 2."],"number":76,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 76, wherein each RA is independently hydrogen or C1-6 alkyl optionally substituted with one or more substituents Q."],"number":77,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 76, wherein each RA is independently hydrogen or methyl."],"number":78,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 76, wherein each RB is independently hydrogen or C1-6 alkyl optionally substituted with one or more substituents Q."],"number":79,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 76, wherein each RB is independently hydrogen or methyl."],"number":80,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 76, wherein each RA and RB is independently hydrogen or methyl."],"number":81,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 27, wherein m is 2."],"number":82,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 82, wherein each RA is independently hydrogen or C1-6 alkyl optionally substituted with one or more substituents Q."],"number":83,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 82, wherein each RA is independently hydrogen or methyl."],"number":84,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 82, wherein each RB is independently hydrogen or C1-6 alkyl optionally substituted with one or more substituents Q."],"number":85,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 82, wherein each RB is independently hydrogen or methyl."],"number":86,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 82, wherein each RA and RB is independently hydrogen or methyl."],"number":87,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}