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The present invention provides a novel mechanistic pathway and methods related to this pathway for the identification of compounds for the treatment of diseases involving cell proliferation, invasion and/or metastasis such as cancer. In particular, the instant invention relates to the phosphatase activity of Eya and the Eya-Six complex as a target for identifying novel therapeutic agents for the treatment of proliferative, invasive and/or metastatic disorders, and compositions identified using the methods disclosed herein.

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Document History
  • Publication: Jul 16, 2013
  • Application: Dec 8, 2009
    US US 200913133593 A
  • Priority: Dec 8, 2009
    US US 200913133593 A
  • Priority: Dec 8, 2009
    US US 2009/0067220 W
  • Priority: Dec 8, 2008
    US US 12056408 P

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