Botryllamides And Method Of Inhibiting Pgp In A Mammal Afflicted With Cancer


Disclosed are methods of enhancing the chemotherapeutic treatment of tumor cells, reducing resistance of a cancer cell to a chemotherapeutic agent, a method of inhibiting ABCG2, Pgp, or MRP1 in a mammal afflicted with cancer, and a method of increasing the bioavailability of an ABCG2 substrate drug in a mammal. The methods comprise administering effective amounts of certain compounds to the mammal, for example, a compound of the formula (I): Formula (I), wherein R1, R2, R3, X1, X2, X3, a, and b are as described herein. Uses of these compounds in the preparation of a medicament are also disclosed. Also disclosed are compounds of formula (II), pharmaceutical compositions comprising such compounds and uses thereof.

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Document History
  • Publication: Jun 25, 2013
  • Application: Dec 29, 2008
    US US 81114408 A
  • Priority: Dec 29, 2008
    US US 81114408 A
  • Priority: Dec 29, 2008
    US US 2008/0088446 W
  • Priority: Jan 3, 2008
    US US 1875808 P

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