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Search Applicants and Owners separately:Univ* Connecti*. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 2880
Search Applicants and Owners separately:Univ* Connecti*. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 2880
A is a direct bond;\n
B is N(R5),\n\nR5 is selected from hydrogen, alkyl and substituted alkyl;\n
R1 and R2 are each independently —(CH2)n—Z,\n\n\nn is 0, and\nZ is selected from a carbocyclic ring having about 4 to about 7 ring members, a heterocyclic ring having about 4 to about 7 ring members, an aromatic ring having about 5 to about 7 ring members, a heteroaromatic ring having about 5 to about 7 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring, a heteropolycyclic ring; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the —(CH2)n— group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or\nZ is selected from a 5 member unsaturated ring having 0 to 4 independently selected heteroatoms as ring members, a substituted 5 member unsaturated ring having 0 to 4 independently selected heteroatoms as ring members, a 6 member aromatic ring having 0 to 5 independently selected heteroatoms as ring members or a substituted 6 member aromatic ring having 0 to 5 independently selected heteroatoms; and wherein the connecting point between the —(CH2)n— group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or\nZ is selected from 1-, 2- or 3-pyrrolidinyl, 1-, 2-, 3- or 4-piperidinyl, 2-, 3- or 4-morpholinyl, 2-, 3- or 4-thiomorpholinyl, 1-, 2- or 3-azetidinyl, 1- or 2-piperazinyl, 2- or 3-tetrahydrofuranyl; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the —(CH2)n— group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or\nZ is selected from\n
\n\n\n\nwherein X and Y are each independently selected from H, halogen, N3, NCS, CN, NO2, NX1X2, OX3, OAc, O-acyl, O-aroyl, O(CH2)jOX3, O(CH2)jNX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, alkyl, alcohol, alkoxy, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl, alkylsulfonyl and methylene dioxy when Z comprises a structure having two adjacent carbon atoms,\n\nX1 and X2 are each independently selected from H and alkyl, or\nX1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from O, N or S, or\nX1 and X2 together comprise part of an imide ring having about 5 to about 6 members,\nX3 is selected from H, alkyl, hydroxyloweralkyl and alkyl-NX1X2; or\nZ is selected from a carbocyclic ring having 6 ring atoms fused to a heterocyclic ring having from 5 to 7 ring atoms, a carbocyclic ring having 6 ring atoms fused to a heteroaromatic ring having from 5 to 7 ring atoms, a heterocyclic ring having 6 ring atoms fused to a heterocyclic ring having from 5 to 7 ring atoms, an heterocyclic ring having 6 ring atoms fused to a heteroaromatic ring having from 5 to 7 ring atoms, an aromatic ring having 6 ring atoms fused to a heterocyclic ring having from 5 to 7 ring atoms, an aromatic ring having 6 ring atoms fused to a heteroaromatic ring having from 5 to 7 ring atoms, a heteroaromatic ring having 6 ring atoms fused to a heterocyclic ring having from 5 to 7 ring atoms or a heteroaromatic ring having 6 ring atoms fused to a heteroaromatic ring having from 5 to 7 ring atoms; or\nZ is selected from an unsaturated ring having 5 ring atoms and 0 to 2 independently selected heteroatoms as ring members fused to an unsaturated ring having 5 ring atoms and 0 to 4 independently selected heteroatoms as ring members, an unsaturated ring having 5 ring atoms and 0 to 2 independently selected heteroatoms as ring members fused to an unsaturated ring having 6 or 7 ring atoms and 0 to 3 independently selected heteroatoms as ring members or an unsaturated ring having 6 ring atoms and 0 to 4 independently selected heteroatoms as ring members fused to an unsaturated ring having 6 or 7 ring atoms and 0 to 4 independently selected heteroatoms as ring members; or\n
R1 and R2 are each independently -T-(CH2)n—Z,\n\n\nn is 0,\nT is selected from a carbocyclic ring having 3 to about 8 ring members, an unsaturated ring having 3 to about 8 carbon atoms as ring members, an aromatic ring having 5 to about 8 carbon atoms as ring members, a heterocyclic ring having 3 to about 8 ring members, a heteroaromatic ring having 5 to about 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring and a heteropolycyclic ring, and\nZ is selected from H, halogen, N3, NCS, CN, NO2, NX1X2, OX3, OAc, O-acyl, O-aroyl, O(CH2)jOH, O(CH2)jOX3, O(CH2)jNX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, alkoxy, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl and alkylsulfonyl,\n\nX1 and X2 each independently is selected from H and alkyl, or\nX1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from O, N or S, or\nX1 and X2 together comprise part of an imide ring having about 5 to about 6 members,\nX3 is selected from H, alkyl, hydroxyloweralkyl and or alkyl-NX1 X2,\nj is an integer from 0 to about 6; or\nZ is selected from a carbocyclic ring having about 4 to about 7 ring members, a heterocyclic ring having about 4 to about 7 ring members, an aromatic ring having about 5 to about 7 ring members, a heteroaromatic ring having about 5 to about 7 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring, a heteropolycyclic ring; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the —(CH2)n— group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or\nZ is selected from 1-, 2- or 3-pyrrolidinyl, 1-, 2-, 3- or 4-piperidinyl, 2-, 3- or 4-morpholinyl, 2-, 3- or 4-thiomorpholinyl, 1-, 2- or 3-azetidinyl, 1- or 2-piperazinyl, 2- or 3-tetrahydrofuranyl; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the —(CH2)n— group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or\nZ is selected from\n
\n\nwherein X and Y are each independently selected from H, halogen, N3, NCS, CN, NO2, NX1X2, OX3, OAc, O-acyl, O-aroyl, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, alkyl, alcohol, alkoxy, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl, alkylsulfonyl and methylene dioxy when Z comprises a structure having two adjacent carbon atoms,\n\nX1 and X2 are each independently is selected from H or alkyl, or\nX1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from O, N or S, or\nX1 and X2 together comprise part of an imide ring having about 5 to about 6 members,\nX3 is selected from H, alkyl, hydroxyloweralkyl and alkyl-NX1X2; or\nZ is selected from an unsaturated ring having 5 ring atoms and 0 to 2 independently selected heteroatoms as ring members fused to an unsaturated ring having 5 ring atoms and 0 to 4 independently selected heteroatoms as ring members, an unsaturated ring having 5 ring atoms and 0 to 2 independently selected heteroatoms as ring members fused to an unsaturated ring having 6 or 7 ring atoms and 0 to 4 independently selected heteroatoms as ring members and an unsaturated ring having 6 ring atoms and 0 to 3 independently selected heteroatoms as ring members fused to an unsaturated ring having 6 or 7 ring atoms and 0 to 4 independently selected heteroatoms as ring members; or\n
R1 and R2 are each independently -T-(CH2)n-Q1-(CH2)m—Z,\n\n\nn is 0,\nm is an integer from 0 to about 7,\nT is selected from a carbocyclic ring having 3 to about 8 ring members, an unsaturated ring having 3 to about 8 carbon atoms as ring members, an aromatic ring having 5 to about 8 carbon atoms as ring members, a heterocyclic ring having 3 to about 8 ring members, a heteroaromatic ring having 5 to about 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring and a heteropolycyclic ring,\nQ1 is selected from NH, O, S, CH═CH, CO, SO2 and OSO2, and\nZ is selected from H, halogen, N3, NCS, CN, NO2, NX1X2, OX3, OAc, O-acyl, O-aroyl, O(CH2)jOX3, O(CH2)jNX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, alkyl, alcohol, alkoxy, alkylmercapto, alkylamino or di-alkylamino, alkylsulfinyl and alkylsulfonyl,\n\nX1 and X2 each independently selected from H and alkyl, or\nX1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from O, N or S, or\nX1 and X2 together comprise part of an imide ring having about 5 to about 6 members,\nX3 is selected from H, alkyl, hydroxyloweralkyl and alkyl-NX1 X2,\nj is an integer from 0 to about 6; or\nZ is selected from a carbocyclic ring having about 4 to about 7 ring members, a heterocyclic ring having about 4 to about 7 ring members, an aromatic ring having about 5 to about 7 ring members, a heteroaromatic ring having about 5 to about 7 ring members, a bicyclic ring, a heterobicyclic ring, a polycyclic ring, a heteropolycyclic ring; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the (CHO, —(CH2)m— group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or\nZ is selected from 1-, 2- or 3-pyrrolidinyl, 1-, 2-, 3- or 4-piperidinyl, 2-, 3- or 4-morpholinyl, 2-, 3- or 4-thiomorpholinyl, 1-, 2- or 3-azetidinyl, 1- or 2-piperazinyl, 2- or 3-tetrahydrofuranyl; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the —(CHz)m— group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or\nZ is selected from\n
\n\n\n\n\nwherein X and Y are each independently is selected from H, halogen, N3, NCS, CN, NO2, NX1X2, OX3, OAc, O-acyl, O-aroyl, O(CH2)jOX3O(CH2)jNX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, alkyl, alcohol, alkoxy, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl, alkylsulfonyl and methylene dioxy when Z comprises a structure having two adjacent carbon atoms,\n\nX1 and X2 are each independently is selected from H and alkyl, or\nX1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from O, N or S, or\nX1 and X2 together comprise part of an imide ring having about 5 to about 6 members,\nX3 is selected from H, alkyl, hydroxyloweralkyl and alkyl-NX1X2; or\nZ is selected from an unsaturated ring having 5 ring atoms and 0 to 2 independently selected heteroatoms as ring members fused to an unsaturated ring having 5 ring atoms and 0 to 2 independently selected heteroatoms as ring members, an unsaturated ring having 5 ring atoms and 0 to 2 independently selected heteroatoms as ring members fused to an unsaturated ring having 6 or 7 ring atoms and 0 to 4 independently selected heteroatoms as ring members or an unsaturated ring having 6 ring atoms and 0 to 3 independently selected heteroatoms as ring members fused to an unsaturated ring having 6 or 7 ring atoms and 0 to 4 independently selected heteroatoms as ring members; or\nZ is selected from\n
\n\n\n\n\nwherein E is selected from a C1 to about C4 linear or branched alkyl group, a phenyl group, a substituted phenyl group, a benzyl group and a substituted benzyl group; or\nZ is selected from\n
\n\n\n\nwherein k is an integer from 1 to about 5, A1 and A2 are each independently selected from a C1 to about C4 alkyl group, a phenyl group and a substituted phenyl group;\n
R3 is selected from a carbocyclic ring having about 4 to about 7 members, a heterocyclic ring having about 4 to about 7 members, an aromatic ring having about 5 to about 7 ring members, a heteroaromatic ring having about 5 to about 7 members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring and a heteropolycyclic ring; or\n
R3 is\n\n
\n\nwherein G is selected from CH and N, and L and J each independently selected from (CH2)n, O, NH and S, n is an integer from 0 to about 7; or\n
R3 is\n\n
\n\nwherein G, L and J are each independently selected from CH and N; or\n
R3 is selected from\n\n
\n\nwherein X and Y are independently selected from H, halogen, N3, NCS, phenyl, CN, NO2, NX1X2, OX3, OAc, O-acyl, O-aroyl, O(CH2)jOX3, O(CH2)jNX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, alkyl, alcohol, alkoxy, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl and alkylsulfonyl,\n\nX1 and X2 are each independently selected from H and alkyl, or\nX1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from O, N or S, or\nX1 and X2 together comprise part of an imide ring having about 5 to about 6 members),\nX3 is selected from H, alkyl, hydroxyloweralkyl and alkyl-NX1 X2,\nj is an integer from 0 to about 6; or\n
R3 is selected from a carbocyclic ring having 4 to 6 ring atoms fused to a heterocyclic ring having from 5 to 7 ring atoms, a carbocyclic ring having 4 to 6 ring atoms fused to a heteroaromatic ring having from 5 to 7 ring atoms, a heterocyclic ring having 6 ring atoms fused to a heterocyclic ring having from 5 to 7 ring atoms, a heterocyclic ring having 6 ring atoms fused to a heteroaromatic ring having from 5 to 7 ring atoms, an aromatic ring having 6 ring atoms fused to a heterocyclic ring having from 5 to 7 ring atoms, an aromatic ring having 6 ring atoms fused to a heteroaromatic ring having from 5 to 7 ring atoms, a heteroaromatic ring having 6 ring atoms fused to a heterocyclic ring having from 5 to 7 ring atoms, and a heteroaromatic ring having 6 ring atoms fused to a heteroaromatic ring having from 5 to 7 ring atoms;\n
R4 is selected from H, halogen, N3, NCS, phenyl, CN, NO2, NX1X2, OX3, OAc, O-acyl, O-aroyl, O(CH2)jOX3, O(CH2)jNX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, alkyl, alcohol, alkoxy, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl and alkylsulfonyl,\n\nX1 and X2 are each independently selected from H and alkyl, or\nX1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from O, N or S, or\nX1 and X2 together comprise part of an imide ring having about 5 to about 6 members),\nX3 is selected from H, alkyl, hydroxyloweralkyl and alkyl-NX1X2,\nj is an integer from 0 to about 6; or\n
R4 is selected from a carbocyclic ring having about 4 to about 7 ring members, a heterocyclic ring having about 4 to about 7 ring members, an aromatic ring having about 5 to about 7 ring members, a heteroaromatic ring having about 5 to about 7 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring and a heteropolycyclic ring; or\n
R4 is selected from\n\n
or\n
R4 is —(CH2)d—Z,\n\nd is an integer from 1 to about 6, and\nZ is selected from H, halogen, N3, NCS, phenyl, CN, NO2, NX1X2, OX3, OAc, O-acyl, O-aroyl, O(CH2)jOH, O(CH2)jOX3, O(CH2)jNX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, alkyl, alkoxy, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl and alkylsulfonyl,\n\nX1 and X2 are each independently selected from H and alkyl, or\nX1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from O, N or S, or\nX1 and X2 together comprise part of an imide ring having about 5 to about 6 members),\nX3 is selected from H, alkyl, hydroxyloweralkyl and alkyl-NX1 X2,\nj is an integer from 0 to about 6; or\nZ is selected from a carbocyclic ring having about 4 to about 7 ring members, a heterocyclic ring having about 4 to about 7 ring members, an aromatic ring having about 5 to about 7 ring members, a heteroaromatic ring having about 5 to about 7 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring, a heteropolycyclic ring; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the —(CH2)d— group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or\nZ is selected from 1-, 2- or 3-pyrrolidinyl, 1-, 2-, 3- or 4-piperidinyl, 2-, 3- or 4-morpholinyl, 2-, 3- or 4-thiomorpholinyl, 1-, 2- or 3-azetidinyl, 1- or 2-piperazinyl, 2- or 3-tetrahydrofuranyl; or any above group substituted on at least one ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the —(CH2)d— group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or\n
R4 is —(CH2)p-Q1-(CH2)q—Z,\n\n\nQ1 is selected from NH, O, S, CH═CH, CO, SO2 and OSO2,\np is an integer from 1 to about 7,\ng is an integer from 0 to about 7, and\nZ is selected from H, halogen, N3, NCS, phenyl, CN, NO2, NX1X2, OX3, OAc, O-acyl, O-aroyl, NH-acyl, NH-aroyl, O(CH2)jOX3, O(CH2)jNX1X2, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, alkyl, alkoxy, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl and alkylsulfonyl,\n\nX1 and X2 are each independently selected from H or alkyl, or\nX1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from O, N or S, or\nX1 and X2 together comprise part of an imide ring having about 5 to about 6 members,\nX3 is selected from H, alkyl, hydroxyloweralkyl and alkyl-NX1 X2,\nj is an integer from 0 to about 6; or\nZ is selected from a carbocyclic ring having about 4 to about 7 ring members, a heterocyclic ring having about 4 to about 7 ring members, an aromatic ring having about 5 to about 7 ring members, a heteroaromatic ring having about 5 to about 7 ring members; a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring, a heteropolycyclic ring; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the —(CH2)q— group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or\nZ is selected from 1-, 2- or 3-pyrrolidinyl, 1-, 2-, 3- or 4-piperidinyl, 2-, 3- or 4-morpholinyl, 2-, 3- or 4-thiomorpholinyl, 1-, 2- or 3-azetidinyl, 1- or 2-piperazinyl, 2- or 3-tetrahydrofuranyl; or any above group substituted on at least one available ring atom by an alkyl; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the —(CH2)q— group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or\nZ is selected from\n
\n\n\n\nwherein X and Y are each independently selected from H, halogen, N3, NCS, CN, NO2, NX1X2, OX3, OAc, O-acyl, O-aroyl, O(CH2)jOX3, O(CH2)jNX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, alkyl, alcohol, alkoxy, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl, alkylsulfonyl and methylene dioxy when Z comprises a structure having two adjacent carbon atoms,\n\nX1 and X2 are each independently selected from H and alkyl, or\nX1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from O, N or S, or\nX1 and X2 together comprise part of an imide ring having about 5 to about 6 members,\nX3 is selected from H, alkyl, hydroxyloweralkyl and alkyl-NX1X2,\nJ is an integer from 0 to about 6;\n
with the proviso that when either of R1 and R2 is phenyl [optionally substituted with one more members selected from halogen, (C1-C6) alkyl, (C1-C6) alkoxy, trifluoromethyl, cyano, nitro, (C1-C6) alkyl sulfonyl, (C1-C6) alkyl sulfonyl amino, (C1-C6) alkyl carbonyl-amino, (C1-C6) alkyl amino-carbonyl-amino and phenyl], (C2-C6) alkyl, cyclohexyl [optionally substituted with (C1-C6) alkyl, (C1-C6) alkoxy, trifluoromethyl, cyano or one or more fluorine atoms], 1-naphthyl or 2-naphthyl [optionally substituted with one or more members selected from halogen, (C1-C6) alkyl, (C1-C6) alkoxy, trifluoromethyl and cyano], benzyl [optionally substituted on the phenyl ring with one or more members selected from halogen, (C1-C6) alkyl, (C1-C6) alkoxy, trifluoromethyl and cyano], a 5- to 10-membered saturated or unsaturated heterocyclic radical [optionally substituted with one or more members selected from fluorine, (C1-C6) alkyl, (C1-C6) alkoxy, trifluoromethyl and cyano] and a 5- to 10-membered aromatic monocyclic or bicyclic heterocyclic radical [optionally substituted with one more members selected form halogen, (C1-C6) alkyl, (C1-C6) alkoxy, trifloromethyl, cyano, nitro and phenyl]; then R4 can not be H, (C1-C6) alkyl, benzyl, chloro, or bromo;\n
and the proviso that when either R1 or\n
R2 is phenyl, thienyl, 2-pyridinyl, 3-pyridinyl, 4-pyridinyl, pyrimidinyl, pyrazinyl, pyridazinyl, triazinyl or any above group substituted with 1, 2, 3 or 4 substituents which can be the same or different, selected from C1-3 alkyl, C1-3 alkoxy, hydroxy, halogen, trifluoromethyl, trifluoromethylthio, trifluoromethoxy, nitro, amino, mono- or dialkyl(C1-2)-amino, mono- or dialkyl(C1-2)-amido, (C1-3)-alkoxycarbonyl, carboxyl, cyano, carbornyl, acetyl and naphthyl; then R4 can not be H, halogen, CN, carbornyl, formyl, acetyl, trifluoroacetyl, fluoroacetyl, propionyl, sulfamoyl, methanesulfonyl, methylsulfanyl, branched or unbranched C1-4 alkyl group, which C1-4 alkyl group may be substituted with 1 to 3 fluoro atoms or with a single bromo, chloro, iodo, cyano or hydroxy group."],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["A pharmaceutical preparation comprising a therapeutically effective amount of at least one of the compounds of claim 1 wherein the compound is in isolated and substantially purified form and at least one member selected from an excipient, a vehicle, an adjuvant, a flavoring, a colorant, or a preservative."],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1 wherein at least one of R1 or R2 is -T-(CH2)n—Z."],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1 wherein at least one of R1 or R2 is -T-(CH2)n-Q1-(CH2)m—Z."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1 wherein R3 is selected from a heterocyclic ring having about 4 to about 7 members, a heteroaromatic ring having about 5 to about 7 members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring and a heteropolycyclic ring."],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1 wherein R4 is selected from a carbocyclic ring having about 4 to about 7 ring members, a heterocyclic ring having about 4 to about 7 ring members, an aromatic ring having about 5 to about 7 ring members, a heteroaromatic ring having about 5 to about 7 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring and a heteropolycyclic ring."],"number":6,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, wherein\n
R1 is -T-(CH2)n-Q1-(CH2)m—Z;\n"],"number":7,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, wherein\nT is selected from an aromatic ring or a heteroaromatic ring; and\nQ1 is C≡C.\n
R1 is -T-(CH2)n-Q1-(CH2)m—Z;\n\n\nT is selected from an aromatic ring;\nQ1 is C≡C; and\nR2 is selected from\n
\n"],"number":8,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 8, wherein\n\n\nwherein X and Y are each independently selected from H, halogen, N3, NCS, CN, NO2, NX1X2, OX3, OAc, O-acyl, O-aroyl, O(CH2)jOX3, O(CH2)jNX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, alkyl, alcohol, alkoxy, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl, alkylsulfonyl and methylene dioxy when Z comprises a structure having two adjacent carbon atoms,\n\nX1 and X2 are each independently selected from H and alkyl, or\nX1 and X2 together comprise part of a heterocyclic ring having 4 to 7 ring members and optionally one additional heteroatom selected from O, N or S, or\nX1 and X2 together comprise part of an imide ring having 5 to 6 members,\nX3 is selected from H, alkyl, hydroxyloweralkyl and alkyl-NX1X2.\n
R4 is selected from H, halogen, N3, NCS, phenyl, CN, NO2, NX1X2, OX3, OAc, O-acyl, O-aroyl, O(CH2)jOX3, O(CH2)jNX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, alkyl, alcohol, alkoxy, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl and alkylsulfonyl,\n\nX1 and X2 are each independently selected from H and alkyl, or\nX1 and X2 together comprise part of a heterocyclic ring having 4 to 7 ring members and optionally one additional heteroatom selected from O, N or S, or\nX1 and X2 together comprise part of an imide ring having 5 to 6 members),\nX3 is selected from H, alkyl, hydroxyloweralkyl and alkyl-NX1X2,\nj is an integer from 0 to 6; or\n
R4 is —(CH2)d—Z,\n\nd is an integer from 1 to 6, and\nZ is selected from H, CN, OX3, O(CH2)jOX3, O(CH2)jNX1X2, NH—C(halogen)3, alkyl, alkoxy, alkylmercapto, alkylsulfinyl and alkylsulfonyl,\n\nX1 and X2 are each independently selected from H and alkyl, or\nX1 and X2 together comprise part of a heterocyclic ring having 4 to 7 ring members and optionally one additional heteroatom selected from O, N or S, or\nX1 and X2 together comprise part of an imide ring having 5 to 6 members),\nX3 is selected from H, alkyl, hydroxyloweralkyl and alkyl-NX1X2,\n
j is an integer from 0 to 6."],"number":9,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, wherein\n
R1 is -T-(CH2)n-Q1-(CH2)m—Z;\n\n\nT is selected from a heteroaromatic ring;\nQ1 is C≡C; and\nR2 is selected from\n
\n"],"number":10,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 10, wherein\n\n\nwherein X and Y are each independently selected from H, halogen, N3, NCS, CN, NO2, NX1X2, OX3, OAc, O-acyl, O-aroyl, O(CH2)jOX3, O(CH2)jNX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, alkyl, alcohol, alkoxy, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl, alkylsulfonyl and methylene dioxy when Z comprises a structure having two adjacent carbon atoms,\n\nX1 and X2 are each independently selected from H and alkyl, or\nX1 and X2 together comprise part of a heterocyclic ring having 4 to 7 ring members and optionally one additional heteroatom selected from O, N or S, or\nX1 and X2 together comprise part of an imide ring having 5 to 6 members,\nX3 is selected from H, alkyl, hydroxyloweralkyl and alkyl-NX1X2.\n
R4 is selected from H, halogen, N3, NCS, phenyl, ON, NO2, NX1X2, OX3, OAc, O-acyl, O-aroyl, O(CH2)jOX3, O(CH2)jNX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, alkyl, alcohol, alkoxy, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl and alkylsulfonyl,\n\nX1 and X2 are each independently selected from H and alkyl, or\nX1 and X2 together comprise part of a heterocyclic ring having 4 to 7 ring members and optionally one additional heteroatom selected from O, N or S, or\nX1 and X2 together comprise part of an imide ring having 5 to 6 members),\nX3 is selected from H, alkyl, hydroxyloweralkyl and alkyl-NX1X2,\nj is an integer from 0 to 6; or\n
R4 is —(CH2)d—Z,\n\nd is an integer from 1 to 6, and\nZ is selected from H, CN, OX3, O(CH2)jOX3, O(CH2)jNX1X2, NH—C(halogen)3, alkyl, alkoxy, alkylmercapto, alkylsulfinyl and alkylsulfonyl,\n\nX1 and X2 are each independently selected from H and alkyl, or\nX1 and X2 together comprise part of a heterocyclic ring having 4 to 7 ring members and optionally one additional heteroatom selected from O, N or S, or\nX1 and X2 together comprise part of an imide ring having 5 to 6 members),\nX3 is selected from H, alkyl, hydroxyloweralkyl and alkyl-NX1 X2,\n
j is an integer from 0 to 6."],"number":11,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 8, wherein\n
R3 is selected from a carbocyclic ring having 4 to 7 members, a heterocyclic ring having 4 to 7 members, an aromatic ring having 5 to 7 ring members, a heteroaromatic ring having 5 to 7 members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring and a heteropolycyclic ring."],"number":12,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 10, wherein\n
R3 is selected from a carbocyclic ring having 4 to 7 members, a heterocyclic ring having 4 to 7 members, an aromatic ring having 5 to 7 ring members, a heteroaromatic ring having 5 to 7 members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring and a heteropolycyclic ring."],"number":13,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, wherein\n
R1 is -T-(CH2)n-Q1-(CH2)m—Z,\n"],"number":14,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, wherein\nT is phenyl; and\nQ1 is C≡C.\n
R1 is -T-(CH2)n-Q1-(CH2)m—Z,\n"],"number":15,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, wherein\nT is thienyl; and\nQ1 is C≡C.\n
R1 is -T-(CH2)n—Z,\n"],"number":16,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1 and physiologically accepted salts thereof, selected from one of the following structures:"],"number":17,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, wherein\nT is phenyl; and\nZ is heteroaromatic.\n
R1 and R2 are each independently -T-(CH2)n—Z,\n"],"number":18,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 18, wherein R4 is selected from the group consisting of —CH3, —CH2CH3, CN, —S-alkyl, —SO2-alkyl and —O-alkyl."],"number":19,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 7 wherein R4 is selected from the group consisting of —CH3, —CH2CH3, CN, —S-alkyl, —SO2-alkyl and —O-alkyl."],"number":20,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}T is selected from the group consisting of an aromatic ring and a heteroaromatic ring; and\nZ is a heteroaromatic ring.\n