{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"US_8404636_B2","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"011-911-305-921-414"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11687,"type":"PATENT","title":"George Mason University - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":589,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8343,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately:george mason uni*; george uni*
Select more for logical variants.
Add to collection.
Select all patents in the collection and expand by simple families.
Add to collection. Total patents: 527
Search Applicants and Owners separately:george mason uni*; george uni*
Select more for logical variants.
Add to collection.
Select all patents in the collection and expand by simple families.
Add to collection. Total patents: 527
wherein the CAMP:\n
a. comprises the amino acid sequence RGRRSSRRKK (SEQ ID NO: 3);\n
b. is connected to the antimicrobial agent directly or through a linker segment, the antimicrobial agent being connected to the CAMP or the linker segment through a stable or cleavable bond; and\n
c. carries and facilitates the delivery of the conjugated antimicrobial agent to a microbe."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The cationic antimicrobial peptide conjugate according to claim 1, wherein the CAMP comprises an amide group located on the C-terminus."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The cationic antimicrobial peptide conjugate according to claim 1, wherein the linker segment affixes the antimicrobial agent to the CAMP through acylation of the amino group of the N-terminus of the CAMP."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The cationic antimicrobial peptide conjugate according to claim 1, wherein the antimicrobial agent is levofloxacin."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The cationic antimicrobial peptide conjugate according to claim 1, wherein the antimicrobial agent is chloramphenicol."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The cationic antimicrobial peptide conjugate according to claim 1, wherein the antimicrobial agent is a diazeniumdiolate."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["A method of producing a cationic antimicrobial peptide conjugate (CAMP) comprising:\n
a. identifying a suitable carrier CAMP comprising the amino acid sequence RGRRSSRRKK (SEQ ID NO: 3);\n
b. identifying a suitable antimicrobial agent; and\n
c. creating a conjugate by conjugating the CAMP of step a with the antimicrobial agent of step b, wherein the CAMP:\n"],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 7, wherein the CAMP comprises an amide group located on the C-terminus."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 7, wherein the linker segment affixes the antimicrobial agent to the CAMP through acylation of the amino group of the N-terminus of the CAMP."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 7, wherein the antimicrobial agent is levofloxacin."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 7, wherein the antimicrobial agent is chloramphenicol."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 7, wherein the antimicrobial agent is a diazeniumdiolate."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["The cationic antimicrobial peptide conjugate according to claim 1, wherein the linker connects the antimicrobial agent to the CAMP via an amide bond between a carboxyl group of the linker and a side chain of a lysine residue of the CAMP."],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["The cationic antimicrobial peptide conjugate according to claim 1, wherein the antimicrobial agent or the linker is attached to the CAMP via an amide bond formed with a primary amino group of at least one of the N-terminus of the CAMP and a lysine side chain of the CAMP."],"number":14,"annotation":false,"title":false,"claim":true},{"lines":["The cationic antimicrobial peptide conjugate according to claim 1, wherein the CAMP carries and facilitates the delivery of more than one of the conjugated antimicrobial agent to the microbe."],"number":15,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 7, comprising conjugating the antimicrobial agent to the CAMP via an amide bond between a carboxyl group of the linker and a side chain of a lysine residue of the CAMP."],"number":16,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 7, comprising conjugating the antimicrobial agent or the linker to the CAMP through an amide bond formed between a carboxyl group of the antimicrobial agent or the linker and a primary amino group of at least one of the N-terminus of the CAMP and a lysine side chain of the CAMP."],"number":17,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 7, wherein the CAMP carries and facilitates the delivery of more than one of the conjugated antimicrobial agent to the microbe."],"number":18,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}i. comprises the amino acid sequence RGRRSSRRKK (SEQ ID NO: 3);\nii. is connected to the antimicrobial agent directly or through a linker segment, the antimicrobial agent being connected to the CAMP or the linker segment through a stable or cleavable bond; and\niii. carries and facilitates the delivery of the conjugated antimicrobial agent to a microbe.\n