Human Anti-mesothelin Monoclonal Antibodies


Disclosed herein are isolated human monoclonal antibodies that specifically bind human mesothelin with a binding affinity of about 25 nM or less. Nucleic acids encoding these antibodies, expression vectors including these nucleic acid molecules, and isolated host cells that express the nucleic acid molecules are also disclosed. The antibodies can be used to detect human mesothelin in a sample. Methods of diagnosing cancer, or confirming a diagnosis of cancer, are disclosed herein that utilize these antibodies. Methods of treating a subject with cancer are also disclosed.

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Document History
  • Publication: Jan 22, 2013
  • Application: Mar 25, 2009
    US US 93406009 A
  • Priority: Mar 25, 2009
    US US 93406009 A
  • Priority: Mar 25, 2009
    US US 2009/0038228 W
  • Priority: Mar 27, 2008
    US US 4000508 P

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