Composition And Method For The Treatment Of Hyperkalemia

Abstract

The internalization sequence at the C-terminal end of the ROMK protein has been identified and sequenced. It has been discovered determined that endocytosis is triggered by binding of the ROMK internalization sequence to ARH protein, which is co-localized and expressed with ROMK. New methods of treating or preventing hyperkalemia have been discovered that include administering to a patient who is at risk of developing hyperkalemia or who has hyperkalemia, a therapeutically effective amount of an agent that blocks the interaction of the ROMK internalization sequence with ARH protein, thereby preventing or reducing ARH-induced endocytosis of ROMK.


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Document History
  • Publication: Oct 16, 2012
  • Application: Oct 9, 2009
    US US 57685109 A
  • Priority: Oct 9, 2009
    US US 57685109 A
  • Priority: Oct 9, 2008
    US US 10424708 P

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