{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"US_8226930_B2","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"101-191-728-269-704"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11656,"type":"PATENT","title":"University of Goettingen - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":761,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8322,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
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comprising the step of administering a pharmaceutical composition comprising\n
(i) a human MeCP2 protein or biologically active fragment of said human MeCP2 protein, or a derivative of said protein or fragment, and\n
(ii) a protein transduction domain, wherein the MeCP2 protein is fused to the protein transduction domain,\n
to a subject suffering from Rett syndrome,\n
wherein said fragment comprises at least 150 contiguous amino acids of the MeCP2 protein; and wherein said derivative of said protein or fragment has at least 60% sequence identity with the amino acid sequence of the MeCP2 protein or fragment thereof; and wherein said fragment or said derivative has at least 60% of the biological activity of the naturally occurring MeCP2 protein in a transcription assay which measures the ability of a protein to bind methylated cytosines."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the MeCP2 protein or biologically active fragment or derivative thereof is selected from the group consisting of human MeCP2 isoform e1 as encoded by SEQ ID NO: 1 or human MeCP2 isoform e2 as encoded by SEQ ID NO: 2, or a biologically active fragment of any one of said isoforms, and a derivative of said isoforms or said fragments."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein said protein transduction domain has at least 60% sequence identity to the amino acid sequence of the TAT protein transduction domain (SEQ ID NO:54), said domain having TAT transduction activity."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 3, wherein said protein transduction domain has at least 70% sequence identity to the amino acid sequence of the TAT protein transduction domain (SEQ ID NO: 54)."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein said pharmaceutical composition is administered at least every other day or once a day."],"number":5,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}