Optical Molecular Sensors For Cytochrome P450 Activity


The invention provides a compound, useful as an optical probe or sensor of the activity of at least one cytochrome P450 enzyme, and methods of using the compound to screen candidate drugs, and candidate drugs identified by these methods. The optical probe of the invention is a compound having the generic structure Y-L-Q, wherein Q is a chemical moiety that gives rise to optical properties in its hydroxy or hyrdoxylate, phenol or phenoxide form that are different from the optical properties that arise from its ether form.

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Document History
  • Publication: Apr 10, 2012
  • Application: Jul 7, 2009
    US US 49904709 A
  • Priority: Jul 7, 2009
    US US 49904709 A
  • Priority: Dec 10, 2007
    US US 95377007 A
  • Priority: Sep 12, 2006
    US US 53113606 A
  • Priority: Dec 20, 2002
    US US 32702202 A
  • Priority: Dec 10, 1999
    US US 45892799 A
  • Priority: Apr 28, 1999
    US US 30152599 A
  • Priority: Dec 14, 1998
    US US 11225298 P

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