Human Immunodeficiency Virus Type 1 (hiv-1)-neutralizing Human Single-chain Antibodies With Improved Breadth And Potency


The present invention provides an antibody to human immunodeficiency virus (HIV) envelope glycoprotein that can recognize one or more strains of HIV, wherein the epitope of HIV recognized by the antibody is inducible, and wherein the antibody binding to the epitope is enhanced by the presence of CD4 and the HIV co-receptor, and related fusion proteins, conjugates, nucleic acids, vectors, host cells, compositions and methods of use to inhibit an infection of a human at risk of becoming infected with HIV, to reduce the severity of an infection of a human infected with HIV, and to treat an infection of a human with HIV.

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Document History
  • Publication: Feb 7, 2012
  • Application: Jul 24, 2009
    US US 50891309 A
  • Priority: Jul 24, 2009
    US US 50891309 A
  • Priority: Dec 15, 2004
    US US 51296604 A
  • Priority: May 6, 2003
    US US 0314095 W
  • Priority: May 6, 2002
    US US 37840602 P

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