{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"US_8026049_B2","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"038-412-569-040-585"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":8892,"type":"PATENT","title":"University of Wisconsin Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":15082,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8214,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners = \"Wisconsin University\" , \"University of Wisconsin\", \"Wisconsin Univ\", \" Univ Wisconsin\" , \"Wisco* Alum* Res* Found*\".
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Search Applicants and Owners = \"Wisconsin University\" , \"University of Wisconsin\", \"Wisconsin Univ\", \" Univ Wisconsin\" , \"Wisco* Alum* Res* Found*\".
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a) obtaining a biological sample comprising a plurality of biomarkers from the subject, wherein the biomarker levels are related to the disease state, and the disease state is sepsis;\n
b) detecting the plurality of biomarkers;\n
c) determining a profile of the detected biomarkers; and\n
d) comparing the profile of the detected biomarkers to a standard biomarker profile, wherein the profile of the detected biomarkers comprise Ala, Tyr and His each having increased levels of at least 50% compared to the standard biomarker profile, thereby providing information useful for diagnosing sepsis."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the biological sample comprises blood or blood plasma."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the standard biomarker level is from an internal reference."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein a sample metabolome portrait is determined from the biomarker profile and the information useful for diagnosing the disease state is obtained by fitting the sample metabolome portrait to a standard metabolome phase portrait."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 further comprising:\n
a) repeating the steps of claim 1 on a second biological sample, wherein the second biological sample is obtained from the subject at a different time; and\n
b) comparing the biomarker profiles of the two biological samples to provide information useful for diagnosing the disease state."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 wherein the biomarkers are detected by NMR, mass spectroscopy, ELISA, fluorescence labeling techniques, flow cytometry, chromatography, capillary electrophoresis or chemical sensor."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the disease state is associated with a viral infection or a bacterial infection."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the subject is a mammal and said mammal is selected from the group consisting of avian, bovine, swine, horse, sheep and human."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the plurality of biomarkers form a clique capable of providing information useful for diagnosing the disease state."],"number":9,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}