Peptides And Calcium Regulation In Mammalian Cells


Calcium channels in a variety of tissues may contain different subunits, including several different γ (gamma) subunits. We report studies regarding structural features of certain gamma subunits, for example the N-terminal first transmembrane domain (TM1) of the subunit γ6. We disclose that certain structural motifs, for example a GxxxG-like structural motif as described herein, can mediate subunit function for calcium channels. A particular peptide motif that has been identified as significant for the ability to mediate a decrease in calcium current is GxxxA. Compositions and methods are disclosed which are useful in modifying calcium regulation in mammalian cells. In various embodiments, calcium current is modified.

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Document History
  • Publication: Sep 20, 2011
  • Application: Sep 29, 2006
    US US 53732306 A
  • Priority: Sep 29, 2006
    US US 53732306 A
  • Priority: Sep 30, 2005
    US US 72270705 P

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