Card Proteins Involved In Cell Death Regulation

Abstract

The present invention provides NB-ARC and CARD-containing proteins (NACs), nucleic acid molecules encoding NACs and antibodies specific for at least one NAC. The invention further provides chimeric NAC proteins. The invention also provides screening assays for identifying an agent that can effectively alter the association of a NAC with a NAC-associated protein. The invention further provides methods of modulating apoptosis in a cell by introducing into the cell a nucleic acid molecule encoding a NAC or an antisense nucleotide sequence. The invention also provides a method of using a reagent that can specifically bind to a NAC to diagnose a pathology that is characterized by an increased or decreased level of apoptosis in a cell.


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Document History
  • Publication: Aug 9, 2011
  • Application: Oct 17, 2007
    US US 87413907 A
  • Priority: Oct 17, 2007
    US US 87413907 A
  • Priority: Apr 20, 2004
    US US 82892004 A
  • Priority: Sep 1, 1999
    US US 38822199 A

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