Inhibitors Of Pghs-2transactivator Activity

Abstract

Prostaglandin-endoperoxide H synthase (PGHS-2) converts arachidonic acid to prostaglandin H2. PGHS-2 is an inducible gene product undetectable in most normal human tissues, but abundant in cancer cells. The present invention exploits a previously undisclosed transcriptional function of PGHS-2 distinct from its well-established enzymatic role to identify potential therapeutic agents useful in treating cancer. The method comprises a DNA binding assay in which PGHS-2 protein binding to the C/EBP, CRE and NF-κB regions of the PGHS-2 promoter in the presence and absence of test compounds is evaluated to identify inhibitors of PGHS-2 transactivation activity.


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Document History
  • Publication: Apr 19, 2011
  • Application: May 23, 2006
    US US 92091006 A
  • Priority: May 23, 2006
    US US 92091006 A
  • Priority: May 23, 2006
    US US 2006/0019965 W
  • Priority: May 23, 2005
    US US 68362605 P

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