The invention relates to the rational mutagenesis of polypeptides of α/β T-cell receptors that mediate an oncogen-specific T-cell response, nucleic acids encoding these and their use in the therapy, diagnosis and/or prevention of cancerous diseases. The invention further relates to a T-cell response-mediating MDM2-protein-specific α/β T-cell receptor, which has been rationally mutated by means of the method according to the present invention, and the uses thereof.

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Document History
  • Publication: Jan 18, 2011
  • Application: Oct 14, 2005
    US US 52907205 A
  • Priority: Sep 24, 2003
    EP EP 0310633 W
  • Priority: Sep 24, 2002
    DE DE 10244457 A

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