{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"US_7868158_B2","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"146-267-243-982-983","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11615,"type":"PATENT","title":"Baylor College of Medicine - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":4595,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8290,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately: baylor coll* medi*
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 4296
Search Applicants and Owners separately: baylor coll* medi*
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 4296
(i) an inhibitor of the expression of any one or more of a suppressor of cytokine signaling (SOCS) selected from the group consisting of: SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS6, SOCS7 and a cytokine-inducible SH2-domain-containing protein (CIS); and\n
(ii) a cytokine or a Toll-like receptor (TLR) agonist, wherein the TLR agonist is selected from the group consisting of: Poly I:C, lipopolysaccharide (LPS), and a CpG oligonucleotide,\n
wherein said inhibitor is a small interfering RNA (siRNA)."],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 1, wherein said siRNA is selected from the group consisting of a double stranded oligonucleotide, a single stranded oligonucleotide, and a polynucleotide."],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 1, wherein said siRNA is chemically synthesized."],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 1, further comprising a physiologically acceptable carrier."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 4, wherein said physiologically acceptable carrier is a liposome."],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 1, wherein said inhibitor is encoded by an isolated polynucleotide cloned into an expression vector."],"number":6,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 6, wherein said expression vector is selected from the group consisting of a plasmid DNA, a viral vector, a bacterial vector and a mammalian vector."],"number":7,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 6, wherein said expression vector further comprises an integration signal sequence which facilitates integration of said isolated polynucleotide into the genome of a host cell."],"number":8,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 1 further comprising an antigen having at least one epitope, wherein said epitope is capable of eliciting an immune response in a mammal."],"number":9,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 9, wherein said antigen is expressed by an expression vector."],"number":10,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 9, wherein said antigen is an isolated polypeptide."],"number":11,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 9, wherein said at least one epitope induces a CD4+ T-cell response in a mammal."],"number":12,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 9, wherein said at least one epitope induces a CD8+ T-cell response in a mammal."],"number":13,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 9, wherein said at least one epitope induces a B cell response in a mammal."],"number":14,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 9, wherein said antigen is associated with a disease."],"number":15,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 15, wherein said disease is selected from the group consisting of an infectious disease, a cancer and an autoimmune disease."],"number":16,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 15, wherein said antigen is associated with an infectious disease."],"number":17,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 17, wherein said infectious disease is caused by a pathogenic microorganism selected from the group consisting of a virus, a bacterium, a fungus and a protozoan."],"number":18,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 9, wherein said antigen is encoded by a viral gene."],"number":19,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 19, wherein said viral gene is derived from a virus selected from the group consisting of a hepatitis B virus, a hepatitis C virus, a human immunodeficiency virus, a papillomavirus, and a herpesvirus."],"number":20,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 19, wherein said antigen is encoded by a viral gene selected from the group consisting of a hepatitis B virus e antigen gene, a hepatitis B virus surface antigen gene, and a hepatitis B virus core antigen gene."],"number":21,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 19, wherein said antigen is encoded by a viral gene selected from the group consisting of a human immunodeficiency virus Env gp160 gene, Gag gene, Pol gene, Rev gene, Tat gene, Vif gene, and Nef gene."],"number":22,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 19, wherein said antigen is encoded by a viral gene selected from the group consisting of a papillomavirus E7 gene and a papillomavirus E6."],"number":23,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 20, wherein said antigen is encoded by a viral gene derived from a herpesvirus selected from the group consisting of a herpes simplex virus type 1, a herpes simplex virus type 2, an Epstein-Barr virus, a cytomegalovirus, a human herpes virus 6, a human herpes virus 7 and a human herpes virus 8."],"number":24,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 16, wherein said cancer is selected from the group consisting of a breast cancer, a cervical cancer, a melanoma, a renal cancer and a prostate cancer."],"number":25,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 9, wherein said antigen is a tumor-associated antigen is selected from the group consisting of an overexpressed tumor-associated antigen, a testis-tumor antigen, a mutated tumor-associated antigen, a differentiation tumor-associated antigen tyrosinase, MART, tip, MAGE-1, MAGE-2, MAGE-3, gp100, HER-2, Ras and PSA."],"number":26,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 26, wherein said tumor-associated antigen is selected from the group consisting of BCR-ABL, CASP, CDK, Ras, p53, HER-2/neu, CEA, MUC, TW1, PAP, survivin, telomerase, EGFR, PSMA, PSA, PSCA, tyrosinase, MART, TRP, gp100, MART, MAGE, BAGE, GAGE, LAGE/NY-ESO, RAGE, SSX-2, CD19, and CD20."],"number":27,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 15, wherein said disease is selected from the group consisting of rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, psoriasis and Crohn's disease."],"number":28,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 1, wherein said cytokine or TLR agonist is expressed by an expression vector."],"number":29,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 1, wherein said cytokine is an isolated polypeptide."],"number":30,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 1, wherein said cytokine is selected from group consisting of IL-12, TNFα, IFNα, IFNβ, IFNγ, IL-7, IL-2, IL-6, IL-15, IL-21, and IL-23."],"number":31,"annotation":false,"claim":true,"title":false},{"lines":["A composition for enhancing immunopotency of a cell, said composition comprising a pharmaceutically acceptable carrier and a vector comprising a first polynucleotide encoding a siRNA inhibitor wherein said inhibitor inhibits the expression of any one or more of a suppressor of cytokine signaling (SOCS) selected from the group consisting of SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS6, SOCS7 and a cytokine-inducible SH2-domain-containing protein (CIS) in said cell, and a second polynucleotide encoding an antigen having at least one epitope, wherein said at least one epitope induces an immune response in a mammal."],"number":32,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 32, wherein said vector is selected from the group consisting of a plasmid DNA, a viral vector, a bacterial vector and a mammalian vector."],"number":33,"annotation":false,"claim":true,"title":false},{"lines":["A composition for enhancing immunopotency of a cell, said composition comprising a pharmaceutically acceptable carrier and a vector comprising a first polynucleotide encoding a siRNA inhibitor, wherein said inhibitor inhibits the expression of any one or more of a suppressor of cytokine signaling (SOCS) selected from the group consisting of SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS6, SOCS7 and a cytokine-inducible SH2-domain-containing protein (CIS) in said cell, and a second polynucleotide encoding a cytokine or TLR agonist, wherein the TLR agonist is selected from the group consisting of: Poly I:C, lipopolysaccharide (LPS), and a CpG oligonucleotide."],"number":34,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 34, wherein said second polynucleotide encoding a cytokine is selected from group consisting of IL-12, TNFα, IFNα, IFNβ, IFNγ, IL-7, IL-2, IL-6, IL-15, IL-21, and IL-23."],"number":35,"annotation":false,"claim":true,"title":false},{"lines":["An isolated cell comprising one or more of a suppressor of cytokine signaling (SOCS) selected from the group consisting of SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS6, SOCS7 and a cytokine-inducible SH2-domain-containing protein (CIS) and a cytokine or a Toll-like receptor (TLR) agonist, wherein the TLR agonist is selected from the group consisting of: Poly I:C, lipopolysaccharide (LPS), and a CpG oligonucleotide."],"number":36,"annotation":false,"claim":true,"title":false},{"lines":["The cell of claim 36, wherein the cell is an immune cell selected from the group consisting of an APC, a dendritic cell, a monocyte/macrophage, a T cell and a B cell."],"number":37,"annotation":false,"claim":true,"title":false},{"lines":["The cell of claim 37, wherein the T cell is a cytotoxic T cell, a helper T cell, and a regulatory T cell."],"number":38,"annotation":false,"claim":true,"title":false},{"lines":["The cell of claim 36 further comprising an antigen having at least one epitope, wherein said epitope is capable of eliciting an immune response in a mammal."],"number":39,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}