{"search_session":{},"preferences":{"l":"ru","queryLanguage":"ru"},"patentId":"US_7776588_B2","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"179-932-837-938-562","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":8904,"type":"PATENT","title":"Univ Washington Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":15386,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8219,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search applicants and owners= \"Univ Washington', \"Washington Univ\", \"University of Washington\", \" Washington University\", \"Univ Washington NOT state\", \" Univ Washington NOT state NOT George\".
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Total patent: 10892
Search Applicants and Owners separately : \"wash* univ* st* lou*\"; \"univ* wash* lou*\"; \"Washington University St Louis\"; \"Wash* U* St Lo*\", \" Wash* U* in St Lo*\";
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Search Applicants and Owners separately:Washington State Univ*. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1231
Search applicants and owners= \"Univ Washington', \"Washington Univ\", \"University of Washington\", \" Washington University\", \"Univ Washington NOT state\", \" Univ Washington NOT state NOT George\".
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Total patent: 10892
Search Applicants and Owners separately : \"wash* univ* st* lou*\"; \"univ* wash* lou*\"; \"Washington University St Louis\"; \"Wash* U* St Lo*\", \" Wash* U* in St Lo*\";
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 9644
Search Applicants and Owners separately:Washington State Univ*. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1231
contacting a first canine cell with the compound, wherein the first canine cell has a truncation mutation in a mdr1 gene at residues 294-297 of SEQ ID NO: 1, which mutation results in the canine cell having a truncated P-gp protein, to produce a contacted canine cell; and\n
comparing a characteristic of the contacted canine cell with\n
a) the same characteristic of the first canine cell prior to contact with the compound,\n
b) the same characteristic of a similar canine cell not contacted with the compound, or\n
c) the same characteristic of a second canine cell contacted with the compound, wherein the second canine cell does not have a truncation mutation in its mdr1 gene;\n
wherein a difference in the characteristic indicates the compound has a biological effect in the canine cell having the truncated P-gp protein."],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein contacting the canine cells with the compound occurs in vivo."],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the canine cell is a gastrointestinal tissue cell, a renal tissue cell, a brain capillary endothelial cell, a liver tissue cell, a placental cell, bronchiolar epithelial cell, or an adrenal cortical cell."],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the characteristic of the cell being compared is genetic, physiological, chemical, or morphological."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the biological effect results from a defect in efflux of the compound from the contacted canine cell."],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the first canine cell is a neoplastic canine cell."],"number":6,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the compound is a neurokinin receptor antagonist, anti-emetic agent, beta-adrenergic receptor antagonist, antiinfective agent, antiepileptic agent, antineoplastic agent, analgesic agent, anti-psychotic agent, anti-parasitic agent or anti-depressive agent."],"number":7,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the compound is an antiviral agent."],"number":8,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the canine cell is a dog cell."],"number":9,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 9, wherein the dog cell is a Collie cell."],"number":10,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the first canine cell is contacted in vitro."],"number":11,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 2, wherein contacting the first canine cell in vivo comprises administering the compound to a dog."],"number":12,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}