{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"US_7666583_B2","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"091-150-677-002-548","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":8819,"type":"PATENT","title":"Yale University","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":8278,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8206,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search applicants and owners = \"Yale univ\", \"Univ Yale\", \"Yale University\", \"University Yale\", \"Univ Yal*\", \"Yal* Univ*\", \"Yale Entrepreneurial Institute\".
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Total patents: 7360
Search applicants and owners = \"Yale univ\", \"Univ Yale\", \"Yale University\", \"University Yale\", \"Univ Yal*\", \"Yal* Univ*\", \"Yale Entrepreneurial Institute\".
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Total patents: 7360
(a) measuring the expression levels of four or more biomarkers in a sample from a subject, wherein four of the biomarkers are prolactin, osteopontin (OPN), leptin, and insulin-like growth factor II (IGF-II);\n
(b) comparing the expression level of prolactin, OPN, leptin, and IGF-II to a predetermined standard for prolactin, OPN, leptin, and IGF-II, respectively, wherein a significant difference in the expression level of two or more of the prolactin, OPN, leptin, and IGF-II biomarkers in the sample as compared to a predetermined standard for each of the prolactin, OPN, leptin, and IGF-II biomarkers diagnoses or aids in the diagnosis of ovarian cancer, and wherein a significant difference in the expression level for prolactin or OPN is an increase in the expression level of prolactin or OPN compared to the predetermined standards for prolactin and OPN, respectively; and a significant difference in the expression level for leptin or IGF-II is a decrease in the level of expression of leptin or IGF-II compared to the predetermined standards for leptin and IGF-II, respectively."],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the predetermined standard corresponds to: (a) the expression levels of the biomarker in healthy subjects, or (b) the expression levels of the biomarker in non-cancerous tissue from the same subject."],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein each biomarker is assigned a score of 0 or 1, wherein a biomarker is assigned a score of 0 if the expression of the biomarker is not significantly different from the expression of the biomarker in a predetermined standard and wherein a biomarker is assigned a score of 1 if the expression of the biomarker is significantly different from the expression of the biomarker in a predetermined standard; wherein the subject is assigned an overall score which corresponds to the sum of the assigned scores from four or more different markers; and wherein a given threshold (t) is used to diagnose or aid in the diagnosis of cancer."],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, further comprising measuring expression of cancer antigen 125 (CA 125 ) as a biomarker for ovarian cancer."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 4, wherein a biomarker for ovarian cancer in addition to prolactin, OPN, leptin, and IGF-II is selected from the group: MIF, E-selectin, EGF, IL-17, MPIF,1, and IL-2sRa."],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein a biomarker for ovarian cancer in addition to prolactin, OPN, leptin, and IGF-II is selected from the group: 6Ckine, angiotensin converting enzyme (ACE), brain-derived neurotrophic factor (BDNF), E-Selectin, epidermal growth factor (EGF), eotaxin-2 (Eot-2), epidermal growth factor receptor 1 (ErbB 1), follistatin, hemofiltrate CC chemokine 4 (HCC4), herpes virus entry mediator (HVEM), insulin-like growth factor binding protein 2 (IGFBP-1), interleukin-17 (IL-17), interleukin 1 soluble receptor II (IL-1sRII), interleukin 2 soluble receptor alpha (IL-2 sRα), macrophage colony stimulating factor receptor (M-CSF R), macrophage migration inhibitory factor (MIF), macrophage inflammatory protein 1 alpha (MIP-1α), macrophage inflammatory protein 3 beta (MIP3β), matrix Metalloproteinase-8 (MMP-8), matrix metalloproteinase 7 (MMP-7), myeloid progenitor inhibitory factor 1 (MPIF- 1), pulmonary and activation-regulated chemokine (PARC), platelet-derived growth factor receptor beta (PDGF Rβ), protein C, tumor necrosis factor receptor 1 (TNF-RI), tumor necrosis factor alpha (TNF-α), soluble Vascular Adhesion Protein-1(sVAP-1), vascular endothelial growth factor receptor 2 (VEGF R2), VEGF receptor 3 (VEGF R3), human stratum corneum chymotryptic enzyme (HSCCE), kallikrein 4, kallikrein 5, kallikrein 6 (protease M), kallikrein 8, kallikrein 9, kallikrein 10, cancer antigen 125 (CA 125), CA15-3, CA19-9, OVX1, lysophosphatidic acid (LPA), carcinoembryonic antigen (CEA), macrophage colony-stimulating factor (M-CSF), prostasin, CA54-61, CA72, HMFG2, interleukin-6 (IL-6), interleukin-10 (IL-10), LSA, NB70K, PLAP, TAG72, TPA, UGTF, WAP four-disulfide core domain 2 (HE4), matrix metalloprotease 2, tetranectin, inhibin, mesothelyn, MUC1, vascular endothelial growth factor (VEGF) NOTCH3, E2F transcription factor 3 (E2F3), GTPase activating protein (RACGAP1), hemotological and neurological expressed 1 (HN1), apolipoprotein A1, laminin, claudin 3 (CLDN3), claudin 4, tumor-associated calcium signal transducer 1 (TROP-1/Ep-CAM), tumor-associated calcium signal transducer 2 (TROP-2), ladinin 1, S100A2, SERPIN2 (PAI-2), CD24, lipocalin 2, matriptase (TADG-15), stratifin, transforming growth factor-beta receptor III (TGF-β-RIII), platelet-derived growth factor receptor alpha, SEMACAP3, ras homology gene family member I (ARHI), thrombospondin 2, disabled-2/differentially expressed in ovarian carcinoma 2 (Dab2/DOC2), and haptoglobin-alpha subunit."],"number":6,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein a biomarker for ovarian cancer in addition to prolactin, OPN, leptin and IGF-II is selected from the group: MIF, E-selectin, EGF, IL-17, MPIF,1, and IL-2sRa."],"number":7,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the sample is a body fluid, cell or tissue sample."],"number":8,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 8, wherein the body fluid sample is blood or serum."],"number":9,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, further comprising detecting an additional biomarker for ovarian cancer."],"number":10,"annotation":false,"claim":true,"title":false},{"lines":["A method of monitoring the progression of ovarian cancer in a subject comprising\n
(a) measuring the expression levels of four or more biomarkers in a first sample from the subject and a subsequent sample from the subject, wherein four of the biomarkers are prolactin, osteopontin (OPN), leptin, and insulin-like growth factor II (IGF-II);\n
(b) comparing the expression of the prolactin, OPN, Leptin, and IGF-II biomarkers in the first sample to the expression of the prolactin, OPN, leptin, and IGF-II biomarkers in the subsequent sample wherein a significant difference in the expression level of two or more of the prolactin, OPN, leptin, and IGF-II biomarkers in a sample as compared to a predetermined standard for each of the prolactin, OPN, leptin, and IGF-II biomarkers, and a significant difference for prolactin or OPN is an increase in the level of prolactin or OPN compared to the predetermined standards for prolactin and OPN, respectively; and a significant difference for leptin or IGF-II is a decrease in the level of leptin or IGF-II compared to the predetermined standards for leptin and IGF-II, respectively, and wherein an increase in the number of significantly different expression levels of the prolactin, OPN, letin, and IGF-II biomarkers in the first sample compared to the subsequent sample indicates progression of ovarian cancer in the subject and a decrease in the number of significantly different expression levels of the prolactin, OPN, leptin, and IGF-II biomarkers in the first sample compared to the subsequent sample indicates regression of ovarian cancer in the subject."],"number":11,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 11, further comprising comparing the expression of cancer antigen 125 (CA 125) in the first sample and the subsequent sample."],"number":12,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 12, wherein a biomarker for ovarian cancer in addition to prolactin, OPN, leptin, and IGF-II is selected from the group: MIF, E-selectin, EGF, IL-17, MPIF,1, and IL-2sRa."],"number":13,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 11, wherein a biomarker for ovarian cancer in addition to prolactin, OPN, leptin, and IGF-II is selected from the group: MIF, E-selectin, EGF, IL-17, MPIF.1, and IL-2sRa."],"number":14,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 11, wherein a biomarker for ovarian cancer in addition to prolactin, OPN, leptin, and IGF-II is selected from the group: 6Ckine, angiotensin converting enzyme (ACE), brain-derived neurotrophic factor (BDNF), E-Selectin, epidermal growth factor (EGF), eotaxin-2 (Eot-2), epidermal growth factor receptor 1 (ErbB1), follistatin, hemofiltrate CC chemokine 4 (HCC4), herpes virus entry mediator (HVEM), insulin-like growth factor binding protein 2 (IGFBP-1), interleukin-17 (IL-17), interleukin 1 soluble receptor II (IL-1 sRII), interleukin 2 soluble receptor alpha (IL-2 sRα), macrophage colony stimulating factor receptor (M-CSF R), macrophage migration inhibitory factor (MIF), macrophage inflammatory protein 1 alpha (MIP-1α), macrophage inflammatory protein 3 beta (MIP3β), matrix Metalloproteinase-8 (MMP-8), matrix metalloproteinase 7 (MMP-7), myeloid progenitor inhibitory factor 1 (MPIF-1), pulmonary and activation-regulated chemokine (PARC), platelet-derived growth factor receptor beta (PDGF Rβ), protein C, tumor necrosis factor receptor I (TNF-RI), tumor necrosis factor alpha (TNF-α), soluble Vascular Adhesion Protein-1 (sVAP-1), vascular endothelial growth factor receptor 2 (VEGF R2), VEGF receptor 3 (VEGF R3), human stratum comeum chymotryptic enzyme (HSCCE), kallikrein 4, kallikrein 5, kallikrein 6 (protease M), kallikrein 8, kallikrein 9 kallikrein 10, cancer antigen 125 (CA 125), CA15-3, CA19-9, OVX1, lysophosphatidic acid (LPA), carcinoembryonic antigen (CEA), macrophage colony-stimulating factor (M-CSF), prostasin, CA54-61, CA72, HMFG2, interleukin-6 (IL-6), interleukin-10(IL-10), LSA, NB70K, PLAP, TAG72, TPA, UGTF, WAP four-disulfide core domain 2 (HE4), matrix metalloprotease 2, tetranectin, inhibin, mesothelyn, MUC1, vascular endothelial growth factor (VEGF) NOTCH-3, E2F transcription factor 3 (E2F3), GTPase activating protein (RACGAP 1), hemotological and neurological expressed 1 (HN1), apolipoprotein A1, laminin, claudin 3 (CLDN3), claudin 4, tumor-associated calcium signal transducer 1 (TROP-1/Ep-CAM), tumor-associated calcium signal transducer 2 (TROP-2), ladinin 1, S100A2, SERPIN2 (PAI-2), CD24, lipocalin 2, matriptase (TADG-15), stratifin, transforming growth factor-beta receptor III (TGF-β-RIII), platelet-derived growth factor receptor alpha, SEMACAP3, ras homology gene family member I (ARHI), thrombospondin 2, disabled-2/differentially expressed in ovarian carcinoma 2 (Dab2/DOC2), and haptoglobin-alpha subunit."],"number":15,"annotation":false,"claim":true,"title":false},{"lines":["A method for diagnosing or aiding in the diagnosis of ovarian cancer in a subject comprising;\n
(a) measuring the expression levels of four or more biomarkers in a sample from a subject, wherein the four biomarkers are prolactin, osteopontin (OPN), leptin, and insulin-like growth factor II (LOP-II);\n
(b) comparing the expression level of prolactin to a prolactin split point, wherein if the prolactin expression level for the subject is below the prolactin split point, a score corresponding to healthy is assigned and if the prolactin expression level is at or above the prolactin split point, a score corresponding to cancer is assigned;\n
(c) comparing the expression level of OPN to an OPN split point, wherein if the OPN expression level for the subject is below the OPN split point, a score corresponding to healthy is assigned and if the OPN expression level is at or above the OPN split point a score corresponding to cancer is assigned;\n
(d) comparing the expression level of leptin to a leptin split point, wherein if the leptin expression level is below the leptin split point a score corresponding to cancer is assigned and if the leptin expression level is at or above the leptin split point a score corresponding to healthy is assigned;\n
(e) comparing the expression level of IGF-II to an IGF-II split point, wherein if the IGF-II expression level is below the IGF-II split point, a score corresponding to cancer is assigned and if the IGF-II expression level is at or above the IGF-II split point, a score corresponding to healthy is assigned;\n
(f) calculating the total number of scores corresponding to cancer for the prolactin, OPN, leptin, and IGF-II biomarkers whose expression levels in the sample were determined and comparing the total number of scores corresponding to cancer with a predetermined score (t), wherein a total number of scores corresponding to cancer greater than (t) diagnoses or aids in the diagnosis of ovarian cancer in the subject; and\n
(g) determining the diagnosis or aiding in determining the diagnosis of ovarian cancer in the subject based on the calculation of the total number of scores corresponding to cancer for the prolactin, OPN, Leptin, and IGF-II biomarkers."],"number":16,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 16, wherein a score corresponding to cancer is 1 and a score corresponding to normal is 0 and wherein a sum of scores for a subject that is two or greater indicates ovarian cancer and a sum of scores for the subject that is less than two indicates healthy."],"number":17,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 16, further comprising measuring the expression of cancer antigen 125 (CA 125)."],"number":18,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 18, wherein the method further comprises comparing the expression level of CA125 to a predetermined CA125 standard, wherein if the CA125 expression level is above the predetermined CA125 standard, a score corresponding to cancer is assigned and if the CA125 expression level is at or below the predetermined CA125 standard, a score corresponding to healthy is assigned."],"number":19,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 18, wherein a biomarker for ovarian cancer in addition to prolactin, OPN, leptin, and IGF-II is selected from the group: MIF, E-selectin, EGF, IL-17, MPIF.1, and IL-2sRa."],"number":20,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 16, wherein a biomarker for ovarian cancer in addition to prolactin, OPN, Leptin, and IGF-II is selected from the group: 6Ckine, angiotensin converting enzyme (ACE), brain-derived neurotrophic factor (BDNF), E-Selectin, epidermal growth factor (EGF), eotaxin-2 (Eot-2), epidermal growth factor receptor 1 (ErbB1), fotlistatin, hemofiltrate CC chemokine 4 (HCC4), herpes virus entry mediator (HVEM), insulin-like growth factor binding protein 2 (IGFBP- 1), interleukin- 17 (IL- 17), interleukin 1 soluble receptor II (IL- 1 sRII), interleukin 2 soluble receptor alpha (IL-2 sRα), macrophage colony stimulating factor receptor (M-CSF R), macrophage migration inhibitory factor (MIF), macrophage inflammatory protein 1 alpha (MIP-1α), macrophage inflammatory protein 3 beta (MIP3β), matrix Metalloproteinase-8 (MMP-8), matrix metalloproteinase 7 (MMP-7), myeloid progenitor inhibitory factor 1 (MPIF-1), pulmonary and activation-regulated chemokine (PARC), platelet-derived growth factor receptor beta (PDGF Rβ), protein C, tumor necrosis factor receptor I (TNF-RI), tumor necrosis factor alpha (TNF-α), soluble Vascular Adhesion Protein-1 (sVAP-1), vascular endothelial growth factor receptor 2 (VEGF R2), VEGE receptor 3 (VEGE R3), human stratum corneum chymotryptic enzyme (HSCCE), kallikrein 4, kallikrein 5, kallikrein 6 (protease M), kallikrein 8, kallikrein 9, kallikrein 10, cancer antigen 125 (CA 125), CA15-3, CA19-9, OVX1, lysophosphatidic acid (LPA), carcinoembryonic antigen (CEA), macrophage colony-stimulating factor (M-CSF), prostasin, CA54-61, CA72, HMFG2, interleukin-6 (IL-6), interleukin-10 (IL-10), LSA, NB70K, PLAP, TAG72, TPA, UGTF, WAP four-disulfide core domain 2 (HE4), matrix metalloprotease 2, tetranectin, inhibin, mesothelyn, MUC1, vascular endothelial growth factor (VEGF), NOTCH3, E2F transcription factor 3 (E2F3), GTPase activating protein (RACGAP1), hemotological and neurological expressed 1 (HN1), apolipoprotein A1, laminin, claudin 3 (CLDN3), claudin 4, tumor-associated calcium signal transducer 1 (TROP-1/Ep-CAM), tumor-associated calcium signal transducer 2 (TROP-2), ladinin 1, S100A2, SERPIN2(PAI-2), CD24, lipocalin 2, matriptase (TADG-15), stratifrn, transforming growth factor-beta receptor III (TGF-β-RIII), platelet-derived growth factor receptor alpha, SEMACAP3, ras homology gene family member I (ARHI), thrombospondin 2, disabled-2/differentially expressed in ovarian carcinoma 2 (Dab2/DOC2), and haptoglobin-alpha subunit."],"number":21,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 16, wherein the sample is a body fluid, cell, or tissue sample."],"number":22,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 22, wherein the body fluid sample is blood or serum."],"number":23,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 16, wherein the prolactin, OPN, leptin, and IGF-II predetermined standards are prolactin, OPN, leptin, and IGF-II split points, respectively, and wherein each split point divides the expression level for its respective biomarker in the sample into two intervals: a first interval for healthy and a second interval for ovarian cancer."],"number":24,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 16, wherein a biomarker for ovarian cancer in addition to prolactin, OPN, leptin, and IGF-II is selected from the group: MIF, E-selectin, EGF, IL-17, MPIF.1, and IL-2sRa."],"number":25,"annotation":false,"claim":true,"title":false},{"lines":["A method of monitoring the progression of ovarian cancer in a subject comprising:\n
(a) measuring the expression levels of four or more biomarkers in a first sample from the subject and a subsequent sample from the subject, wherein four of the four or more biomarkers are prolactin, osteopontin (OPN), leptin, and insulin-like growth factor II (IGF-II);\n
(b) comparing the expression level of prolactin in each sample to a prolactin split point, wherein if the prolactin expression level for a sample is below the prolactin split point, a score corresponding to healthy is assigned to that sample and if the prolactin expression level for a sample is at or above the prolactin split point, a score corresponding to cancer is assigned to that sample;\n
(c) comparing the expression level of OPN in a sample to an OPN split point, wherein if the OPN expression level for either sample is below the OPN split point, a score corresponding to healthy is assigned to that sample and if the OPN expression level for a sample is at or above the OPN split point, a score corresponding to cancer is assigned to that sample;\n
(d) comparing the expression level of leptin in a sample to a leptin split point, wherein if the leptin expression level for a sample is below the leptin split point, a score corresponding to cancer is assigned to that sample and if the leptin expression level for a sample is at or above the leptin split point, a score corresponding to healthy is assigned to that sample;\n
(e) comparing the expression level of IGF-II in each sample to an IGF-II split point, wherein if the IGF-II expression level for a sample is below the IGF-II split point, a score corresponding to cancer is assigned to that sample and if the IGF-II expression level for a sample is at or above the IGF-II split point, a score corresponding to healthy is assigned to that sample;\n
(f) calculating the total number of scores for each sample corresponding to cancer for the prolactin, OPN, leptin, and IGF-II biomarkers whose expression levels in the samples were determined; and\n
(g) comparing each sample's total number scores corresponding to cancer, wherein a difference in the total number of scores between the first and subsequent samples monitors the progression of the ovarian cancer in the subject."],"number":26,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 26, wherein the four or more biomarkers comprise prolactin, OPN, leptin, IGF-II and cancer antigen 125 (CA 125)."],"number":27,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 27, wherein a biomarker for ovarian cancer in addition to prolactin, OPN, leptin, and IGF-II is selected from the group: MIF, E-selectin, EGF, IL-17, MPIF.1, and IL-2sRa."],"number":28,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 26, wherein a biomarker for ovarian cancer in addition to prolactin, OPN, Leptin, and IGF-II is selected from the group: MIF, E-selectin, EGF, IL-17, MPIF, 1 and IL-2sRa."],"number":29,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 26, wherein a score corresponding to cancer is 1 and a score corresponding to normal is 0 and wherein a sum of scores for the first sample or subsequent sample that is two or greater indicates ovarian cancer for that sample."],"number":30,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 26, wherein the prolactin, OPN, leptin, and IGF-II predetermined standards are prolactin, OPN, leptin, and IGF-II split points, respectively, and wherein each split point divides the expression level for its respective biomarker in the sample into two intervals: a first interval for healthy and a second interval for ovarian cancer."],"number":31,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 26, wherein a biomarker for ovarian cancer in addition to prolactin, OPN, leptin, and IGF-II is selected from the group: 6Ckine, angiotensin converting enzyme (ACE), brain-derived neurotrophic factor (BDNF), E-Selectin, epidermal growth factor (EGF), eotaxin-2 (Eot-2), epidermal growth factor receptor 1 (ErbB1), follistatin, hemofiltrate CC chemokine 4 (HCC4), herpes virus entry mediator (HVEM), insulin-like growth factor binding protein 2 (IGFBP-1), interleukin-17 (IL-17), interleukin 1 soluble receptor II (IL-1 sRII), interleukin 2 soluble receptor alpha (IL-2 sRα), macrophage colony stimulating factor receptor (M-CSF R), macrophage migration inhibitory factor (MIF), macrophage inflammatory protein 1 alpha (MIP-1α), macrophage inflammatory protein 3 beta (MIP3β), matrix Metalloproteinase-8 (MMP-8), matrix metalloproteinase 7 (MMP-7), myeloid progenitor inhibitory factor 1 (MPIF-1), pulmonary and activation-regulated chemokine (PARC), platelet-derived growth factor receptor beta (PDGF Rβ), protein C, tumor necrosis factor receptor I (TNF-RI), tumor necrosis factor alpha (TNF-α), soluble Vascular Adhesion Protein-1 (sVAP-1), vascular endothelial growth factor receptor 2 (VEGF R2), VEGF receptor 3 (VEGF R3), human stratum corneum chymotryptic enzyme (HSCCE), kallikrein 4, kallikreiri 5, kallikrein 6 (protease M), kallikrein 8, kallikrein 9, kallikrein 10, cancer antigen 125 (CA 125), CA15-3, CA19-9, OVX1, lysophosphatidic acid (LPA), carcinoembryonic antigen (CEA), macrophage colony-stimulating factor (M-CSF), prostasin, CA54-61, CA72, HMFG2, interleukin-6 (IL-6), interleukin-10 (IL-10), LSA, NB70K, PLAP, TAG72, TPA, UGTF, WAP four-disulfide core domain 2 (HE4), matrix metalloprotease 2, tetranectin, inhibin, mesothelyn, MUC1, vascular endothelial growth factor (VEGF) NOTCH3, E2F transcription factor 3 (E2F3), GTPase activating protein (RACGAP1), hemotological and neurological expressed 1 (HN1), apolipoprotein A1, laminin, claudin 3 (CLDN3), claudin 4, tumor-associated calcium signal transducer 1 (TROP-1/Ep-CAM), tumor-associated calcium signal transducer 2 (TROP-2), ladinin 1, S100A2, SERPIN2(PAI-2), CD24, lipocalin 2, matriptase (TADG-15), stratifin, transforming growth factor-beta receptor III (TGF-β-RIII), platelet-derived growth factor receptor alpha, SEMACAP3, ras homology gene family member I (ARHI), thrombospondin 2, disabled-2/differentially expressed in ovarian carcinoma 2 (Dab2/DOC2), and haptoglobin-alpha subunit."],"number":32,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}