Fas Ligand Derived Polypeptides


This invention provides a polypeptide useful in the field of medicines, a DNA which encodes the novel polypeptide, a recombinant DNA molecule which contains the DNA, a transformant transformed with the DNA or the recombinant DNA molecule, a process for the purification of the polypeptide, a process for the production of the polypeptide, an antibody which recognizes the polypeptide, an oligonucleotide complementary to the DNA and a screening method. Particularly this invention provides a polypeptide, which is Fas ligand or a fragment thereof. This polypeptide can be used as an effective ingredient of a medicament for regulating the apoptosis in a living body. This polypeptide is obtained by identifying a DNA fragment, which encodes the polypeptide, transforming a desired host with a recombinant DNA molecule, which contains the DNA fragment, and purifying the polypeptide produced by the resulting transformant. This polypeptide has a cytoplasmic domain, a transmembrane domain and extracellular domain and takes part in apoptosis.

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Document History
  • Publication: Nov 24, 2009
  • Application: Jun 7, 2004
    US US 86193404 A
  • Priority: Jun 7, 2004
    US US 86193404 A
  • Priority: Jul 16, 1996
    US US 68370396 A
  • Priority: Nov 10, 1994
    US US 33921494 A
  • Priority: Oct 18, 1994
    JP 27837894 A
  • Priority: Sep 7, 1994
    JP 23936394 A
  • Priority: Jul 8, 1994
    JP 18095594 A
  • Priority: Mar 18, 1994
    JP 7434494 A
  • Priority: Dec 13, 1993
    JP 34252693 A
  • Priority: Nov 10, 1993
    JP 30597593 A

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