Optical Sampling Interface System For In-vivo Measurement Of Tissue


An optical sampling interface system is disclosed that minimizes and compensates for errors that result from sampling variations and measurement site state fluctuations. Embodiments of the invention use a guide that does at least one of, induce the formation of a tissue meniscus, minimize interference due to surface irregularities, control variation in the volume of tissue sampled, use a two-part guide system, use a guide that controls rotation of a sample probe and allows z-axis movement of the probe, use a separate base module and sample module in conjunction with a guide, and use a guide that controls rotation. Optional components include an occlusive element and a coupling fluid.

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Document History
  • Publication: Oct 20, 2009
  • Application: Dec 8, 2004
    US US 800104 A
  • Priority: Dec 8, 2004
    US US 800104 A
  • Priority: Sep 18, 2003
    US US 47285603 A
  • Priority: Mar 7, 2003
    US US 0307065 W
  • Priority: Jun 12, 2002
    US US 17092102 A
  • Priority: Mar 8, 2002
    US US 36288502 P
  • Priority: May 2, 2000
    US US 56378200 A

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