Detection And Determination Of The Stages Of Coronary Artery Disease

Abstract

A method having clinically sufficient degree of diagnostic accuracy for detecting the presence of coronary artery disease in a human patient from the general population and for distinguishing between the stages of the disease in that patient is disclosed. The stages are, first, the non-acute stage, which is either asymptomatic coronary artery disease or stable angina, second, the acute stage known as unstable angina, and, third, the acute stage known as acute myocardial infarction. The diseased state (as opposed to the non-diseased state) is indicated by the clinically significant presence of a first marker in a sample from the patient. The presence of one of the two acute stages, unstable angina or acute myocardial infarction, is indicated by the clinically significant presence of a second marker in a sample from the patient. The presence of the more severe acute stage known as acute myocardial infarction is indicated by the clinically significant presence of a third marker in a sample from the patient. Preferably the first marker comprises OxLDL, the second marker comprises MDA-modified LDL, and the third marker is a troponin. Preferably the OxLDL and MDA-modified LDL are detected using monoclonal antibodies that can detect the presence of those markers in undiluted human plasma at concentrations as low as 0.02 milligrams/deciliter.


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Document History
  • Publication: Oct 20, 2009
  • Application: Jan 16, 2007
    US US 65409707 A
  • Priority: Jan 16, 2007
    US US 65409707 A
  • Priority: Jun 18, 2002
    US US 17479702 A
  • Priority: Jul 16, 2001
    US US 90656001 A
  • Priority: Sep 4, 1998
    US US 14815898 A

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