{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"US_7560096_B2","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"102-500-819-275-088","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11671,"type":"PATENT","title":"University of Virginia - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":4846,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8334,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
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delivering a quantity of predetermined gene treatment preparation or pharmaceutical drug in vivo into a mammalian subject having a target site and a treatment condition, wherein said treatment condition is one of a cardiac condition and a pulmonary condition;\n
injecting a predetermined quantity of gaseous phase hyperpolarized 129Xe in vivo into a mammalian subject such that the hyperpolarized gas is delivered to the target site in gaseous or dissolved form;\n
generating a NMR image or spectroscopic signal of the target site associated with the injected hyperpolarized 129Xe gas; and\n
evaluating the NMR image or spectroscopic signal to evaluate the efficacy of the gene treatment or drug on the treatment condition."],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 1, further comprising the step of acquiring at least two sets of data, the data representing two temporally spaced apart points in time, to evaluate if the treatment condition is influenced by the drug or gene therapy introduced in said delivering step."],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 1, further comprising the step of evaluating whether the drug is properly delivered to the target site."],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 1, wherein said at least two data sets correspond with a hyperpolarized 129Xe gas NMR signal data acquisition obtained both before said delivering step and after said delivering step."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 2, further comprising at least one of adjusting the quantity or formulation of the drug and confirming the proper delivery to the target site."],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 1, wherein the treatment condition is one of cardiac function and pulmonary function, and wherein the target site is selected so as to administer polarized 129Xe gas to a region representative of that condition."],"number":6,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}