Compositions That Bind Antiterminator Rna And Assay For Screening For Such Compositions


Compounds that are selective binding agents specific for RNA secondary and tertiary structures and a fluorescence assay for detecting the binding of small molecules to T-box antiterminator model mRNAs. The compounds include novel tri-substituted oxazolidinones and amino alcohols. The assay provides fluorescently labeled model mRNAs that include conserved sequence information typical of antiterminator bulge regions found in the mRNA of T-box gene regulatory systems.

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Document History
  • Publication: Jun 23, 2009
  • Application: Oct 24, 2005
    US US 25747105 A
  • Priority: Oct 24, 2005
    US US 25747105 A
  • Priority: Aug 23, 2002
    US US 22661402 A
  • Priority: Aug 24, 2001
    US US 31489801 P

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