{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"US_7524873_B2","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"147-700-757-926-365","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[],"notes":[],"inventorships":[],"privateCollections":[],"publicCollections":[],"privateNotes":[],"landscapeCollections":[],"landscapeNotes":[]},"document":{"record_lens_id":"147-700-757-926-365","lens_id":["147-700-757-926-365","071-630-525-569-630"],"doc_key":"US_7524873_B2_20090428","created":"2016-01-15T07:21:20.728","docdb_id":57186173,"lens_internal":{"earliest_lens_id_created_time":"2016-01-15T07:21:20.728","last_modified":"2024-03-26T10:16:56.672","legacy_pub_key":"US_7524873_B2","has_doc_lang":true,"has_biblio_lang":true,"has_all_title_lang":true,"has_all_abstract_lang":true,"has_all_claims_lang":true,"has_description_lang":true},"jurisdiction":"US","doc_number":"7524873","kind":"B2","date_published":"2009-04-28","year_published":2009,"ids":["US_7524873_B2","147-700-757-926-365","071-630-525-569-630","US_7524873_B2_20090428","US","7524873","B2","US7524873B2","US7524873","7524873B2"],"lang":"en","publication_type":"GRANTED_PATENT","application_reference":{"jurisdiction":"US","doc_number":"70033607","kind":"A","date":"2007-01-30"},"priority_claim":[{"jurisdiction":"US","doc_number":"70033607","kind":"A","date":"2007-01-30"},{"jurisdiction":"US","doc_number":"6108405","kind":"A","date":"2005-02-18"},{"jurisdiction":"US","doc_number":"44494603","kind":"A","date":"2003-05-22"},{"jurisdiction":"US","doc_number":"44106503","kind":"P","date":"2003-01-17"},{"jurisdiction":"US","doc_number":"38305002","kind":"P","date":"2002-05-23"}],"priority_claim.source":"DOCDB","earliest_priority_claim_date":"2002-05-23","title":{"en":[{"text":"Calcium receptor modulating agents","lang":"en","source":"DOCDB","data_format":"DOCDBA"}]},"title_lang":["en"],"has_title":true,"applicant":[{"name":"AMGEN INC","residence":"US","sequence":1,"app_type":"applicant"}],"applicant_count":1,"has_applicant":true,"inventor":[{"name":"KELLY MICHAEL G","residence":"US","sequence":1},{"name":"XU SHIMIN","residence":"US","sequence":2},{"name":"XI NING","residence":"US","sequence":3},{"name":"MILLER PHILIP","residence":"GB","sequence":4},{"name":"KINCAID JOHN F","residence":"US","sequence":5},{"name":"GHIRON CHIARA","residence":"IT","sequence":6},{"name":"COULTER THOMAS S","residence":"GB","sequence":7}],"inventor_count":7,"has_inventor":true,"agent":[{"name":"Olga Mekhovich","sequence":1}],"agent_count":1,"has_agent":true,"owner":[],"owner_count":0,"owner_all":[],"owner_all_count":0,"has_owner":false,"primary_examiner":{"name":"Taofiq A Solola","department":"1625"},"has_examiner":true,"class_ipcr":[{"symbol":"A61K31/4439","version_indicator":"2006-01-01","class_symbol_position":"F","class_value":"I","action_date":"2009-04-28","class_status":"B","class_data_source":"H","generating_office":"US","sequence":1},{"symbol":"A61K31/137","version_indicator":"2006-01-01","class_symbol_position":"L","class_value":"I","action_date":"2006-03-10","class_status":"R","class_data_source":"M","generating_office":"JP","sequence":2},{"symbol":"A61K31/145","version_indicator":"2006-01-01","class_symbol_position":"L","class_value":"I","action_date":"2006-03-10","class_status":"R","class_data_source":"M","generating_office":"JP","sequence":3},{"symbol":"A61K31/167","version_indicator":"2006-01-01","class_symbol_position":"L","class_value":"I","action_date":"2006-03-10","class_status":"R","class_data_source":"M","generating_office":"JP","sequence":4},{"symbol":"A61K31/275","version_indicator":"2006-01-01","class_symbol_position":"L","class_value":"I","action_date":"2006-03-10","class_status":"R","class_data_source":"M","generating_office":"JP","sequence":5},{"symbol":"A61K31/341","version_indicator":"2006-01-01","class_symbol_position":"L","class_value":"I","action_date":"2006-03-10","class_status":"R","class_data_source":"M","generating_office":"JP","sequence":6},{"symbol":"A61K31/357","version_indicator":"2006-01-01","class_symbol_position":"L","class_value":"I","action_date":"2006-03-10","class_status":"R","class_data_source":"M","generating_office":"JP","sequence":7},{"symbol":"A61K31/36","version_indicator":"2006-01-01","class_symbol_position":"L","class_value":"I","action_date":"2006-03-10","class_status":"R","class_data_source":"M","generating_office":"JP","sequence":8},{"symbol":"A61K31/381","version_indicator":"2006-01-01","class_symbol_position":"L","class_value":"I","action_date":"2006-03-10","class_status":"R","class_data_source":"M","generating_office":"JP","sequence":9},{"symbol":"A61K31/4045","version_indicator":"2006-01-01","class_symbol_position":"L","class_value":"I","action_date":"2006-03-10","class_status":"R","class_data_source":"M","generating_office":"JP","sequence":10},{"symbol":"A61K31/417","version_indicator":"2006-01-01","class_symbol_position":"L","class_value":"I","action_date":"2006-03-10","class_status":"R","class_data_source":"M","generating_office":"JP","sequence":11},{"symbol":"A61K31/4184","version_indicator":"2006-01-01","class_symbol_position":"L","class_value":"I","action_date":"2006-03-10","class_status":"R","class_data_source":"M","generating_office":"JP","sequence":12},{"symbol":"A61K31/42","version_indicator":"2006-01-01","class_symbol_position":"L","class_value":"I","action_date":"2006-03-10","class_status":"R","class_data_source":"M","generating_office":"JP","sequence":13},{"symbol":"A61K31/423","version_indicator":"2006-01-01","class_symbol_position":"L","class_value":"I","action_date":"2006-03-10","class_status":"R","class_data_source":"M","generating_office":"JP","sequence":14},{"symbol":"A61K31/426","version_indicator":"2006-01-01","class_symbol_position":"L","class_value":"I","action_date":"2006-03-10","class_status":"R","class_data_source":"M","generating_office":"JP","sequence":15},{"symbol":"A61K31/4418","version_indicator":"2006-01-01","class_symbol_position":"L","class_value":"I","action_date":"2006-03-10","class_status":"R","class_data_source":"M","generating_office":"JP","sequence":16},{"symbol":"A61K31/443","version_indicator":"2006-01-01","class_symbol_position":"L","class_value":"I","action_date":"2006-03-10","class_status":"R","class_data_source":"M","generating_office":"JP","sequence":17},{"symbol":"A61K31/4465","version_indicator":"2006-01-01","class_symbol_position":"L","class_value":"I","action_date":"2006-03-10","class_status":"R","class_data_source":"M","generating_office":"JP","sequence":18},{"symbol":"A61K31/47","version_indicator":"2006-01-01","class_symbol_position":"L","class_value":"I","action_date":"2006-03-10","class_status":"R","class_data_source":"M","generating_office":"JP","sequence":19},{"symbol":"A61K31/4965","version_indicator":"2006-01-01","class_symbol_position":"L","class_value":"I","action_date":"2006-03-10","class_status":"R","class_data_source":"M","generating_office":"JP","sequence":20},{"symbol":"A61K31/50","version_indicator":"2006-01-01","class_symbol_position":"L","class_value":"I","action_date":"2006-03-10","class_status":"R","class_data_source":"M","generating_office":"JP","sequence":21},{"symbol":"A61K31/505","version_indicator":"2006-01-01","class_symbol_position":"L","class_value":"I","action_date":"2006-03-10","class_status":"R","class_data_source":"M","generating_office":"JP","sequence":22},{"symbol":"A61K31/52","version_indicator":"2006-01-01","class_symbol_position":"L","class_value":"I","action_date":"2006-03-10","class_status":"R","class_data_source":"M","generating_office":"JP","sequence":23},{"symbol":"A61K31/5377","version_indicator":"2006-01-01","class_symbol_position":"L","class_value":"I","action_date":"2006-03-10","class_status":"R","class_data_source":"M","generating_office":"JP","sequence":24},{"symbol":"A61P3/14","version_indicator":"2006-01-01","class_value":"I","action_date":"2006-05-21","class_status":"R","class_data_source":"M","generating_office":"WO","sequence":25},{"symbol":"A61P5/18","version_indicator":"2006-01-01","class_value":"I","action_date":"2006-05-21","class_status":"R","class_data_source":"M","generating_office":"WO","sequence":26},{"symbol":"A61P5/20","version_indicator":"2006-01-01","class_symbol_position":"L","class_value":"I","action_date":"2006-03-10","class_status":"R","class_data_source":"M","generating_office":"JP","sequence":27},{"symbol":"A61P19/10","version_indicator":"2006-01-01","class_value":"I","action_date":"2006-05-21","class_status":"R","class_data_source":"M","generating_office":"WO","sequence":28},{"symbol":"C07B53/00","version_indicator":"2006-01-01","class_symbol_position":"L","class_value":"I","action_date":"2006-03-10","class_status":"R","class_data_source":"M","generating_office":"JP","sequence":29},{"symbol":"C07C209/28","version_indicator":"2006-01-01","class_symbol_position":"L","class_value":"I","action_date":"2006-03-10","class_status":"R","class_data_source":"M","generating_office":"JP","sequence":30},{"symbol":"C07C211/27","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":31},{"symbol":"C07C211/29","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":32},{"symbol":"C07C211/30","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":33},{"symbol":"C07C211/55","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":34},{"symbol":"C07C215/46","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":35},{"symbol":"C07C217/54","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":36},{"symbol":"C07C217/58","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":37},{"symbol":"C07C229/38","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":38},{"symbol":"C07C233/43","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":39},{"symbol":"C07C235/20","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":40},{"symbol":"C07C237/30","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":41},{"symbol":"C07C255/58","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":42},{"symbol":"C07C255/59","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":43},{"symbol":"C07C275/40","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":44},{"symbol":"C07C311/08","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":45},{"symbol":"C07C317/32","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":46},{"symbol":"C07D207/26","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":47},{"symbol":"C07D207/32","version_indicator":"2006-01-01","class_value":"A","action_date":"2008-05-31","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":48},{"symbol":"C07D207/325","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":49},{"symbol":"C07D209/08","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":50},{"symbol":"C07D209/10","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":51},{"symbol":"C07D209/44","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":52},{"symbol":"C07D211/22","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":53},{"symbol":"C07D211/26","version_indicator":"2006-01-01","class_symbol_position":"L","class_value":"I","action_date":"2006-03-10","class_status":"R","class_data_source":"M","generating_office":"JP","sequence":54},{"symbol":"C07D211/70","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":55},{"symbol":"C07D213/26","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":56},{"symbol":"C07D213/30","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":57},{"symbol":"C07D213/38","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":58},{"symbol":"C07D213/61","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":59},{"symbol":"C07D213/62","version_indicator":"2006-01-01","class_symbol_position":"L","class_value":"I","action_date":"2006-03-10","class_status":"R","class_data_source":"M","generating_office":"JP","sequence":60},{"symbol":"C07D213/64","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":61},{"symbol":"C07D213/65","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":62},{"symbol":"C07D213/68","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":63},{"symbol":"C07D213/73","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":64},{"symbol":"C07D213/74","version_indicator":"2006-01-01","class_symbol_position":"L","class_value":"I","action_date":"2006-03-10","class_status":"R","class_data_source":"M","generating_office":"JP","sequence":65},{"symbol":"C07D213/75","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":66},{"symbol":"C07D213/82","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":67},{"symbol":"C07D215/12","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":68},{"symbol":"C07D231/56","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":69},{"symbol":"C07D233/22","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":70},{"symbol":"C07D235/06","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":71},{"symbol":"C07D235/08","version_indicator":"2006-01-01","class_symbol_position":"L","class_value":"I","action_date":"2006-03-10","class_status":"R","class_data_source":"M","generating_office":"JP","sequence":72},{"symbol":"C07D235/10","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":73},{"symbol":"C07D235/12","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":74},{"symbol":"C07D235/14","version_indicator":"2006-01-01","class_symbol_position":"L","class_value":"I","action_date":"2006-03-10","class_status":"R","class_data_source":"M","generating_office":"JP","sequence":75},{"symbol":"C07D237/14","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":76},{"symbol":"C07D239/26","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":77},{"symbol":"C07D239/34","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":78},{"symbol":"C07D239/42","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":79},{"symbol":"C07D239/47","version_indicator":"2006-01-01","class_symbol_position":"L","class_value":"I","action_date":"2006-03-10","class_status":"R","class_data_source":"M","generating_office":"JP","sequence":80},{"symbol":"C07D241/12","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":81},{"symbol":"C07D241/42","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":82},{"symbol":"C07D249/18","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":83},{"symbol":"C07D261/08","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":84},{"symbol":"C07D263/32","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":85},{"symbol":"C07D263/56","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":86},{"symbol":"C07D271/06","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":87},{"symbol":"C07D271/10","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":88},{"symbol":"C07D271/12","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":89},{"symbol":"C07D277/24","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":90},{"symbol":"C07D277/28","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":91},{"symbol":"C07D277/40","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":92},{"symbol":"C07D277/42","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":93},{"symbol":"C07D277/66","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":94},{"symbol":"C07D277/78","version_indicator":"2006-01-01","class_symbol_position":"L","class_value":"I","action_date":"2006-03-10","class_status":"R","class_data_source":"M","generating_office":"JP","sequence":95},{"symbol":"C07D285/00","version_indicator":"2006-01-01","class_value":"A","action_date":"2008-05-31","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":96},{"symbol":"C07D285/01","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":97},{"symbol":"C07D295/096","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":98},{"symbol":"C07D295/135","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":99},{"symbol":"C07D295/185","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":100},{"symbol":"C07D295/26","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":101},{"symbol":"C07D307/42","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":102},{"symbol":"C07D307/52","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":103},{"symbol":"C07D307/68","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":104},{"symbol":"C07D317/46","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":105},{"symbol":"C07D317/54","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":106},{"symbol":"C07D317/58","version_indicator":"2006-01-01","class_symbol_position":"L","class_value":"I","action_date":"2006-03-10","class_status":"R","class_data_source":"M","generating_office":"JP","sequence":107},{"symbol":"C07D319/18","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":108},{"symbol":"C07D321/10","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":109},{"symbol":"C07D333/16","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":110},{"symbol":"C07D333/20","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":111},{"symbol":"C07D333/56","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":112},{"symbol":"C07D401/12","version_indicator":"2006-01-01","class_symbol_position":"L","class_value":"I","action_date":"2009-04-28","class_status":"B","class_data_source":"H","generating_office":"US","sequence":113},{"symbol":"C07D405/12","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":114},{"symbol":"C07D471/04","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":115},{"symbol":"C07D473/00","version_indicator":"2006-01-01","class_symbol_position":"L","class_value":"I","action_date":"2006-03-10","class_status":"R","class_data_source":"M","generating_office":"JP","sequence":116},{"symbol":"C07D487/04","version_indicator":"2006-01-01","class_value":"I","action_date":"2005-10-08","class_status":"R","class_data_source":"M","generating_office":"EP","sequence":117}],"class_ipcr.first_symbol":"A61K31/4439","class_ipcr.later_symbol":["A61K31/137","A61K31/145","A61K31/167","A61K31/275","A61K31/341","A61K31/357","A61K31/36","A61K31/381","A61K31/4045","A61K31/417","A61K31/4184","A61K31/42","A61K31/423","A61K31/426","A61K31/4418","A61K31/443","A61K31/4465","A61K31/47","A61K31/4965","A61K31/50","A61K31/505","A61K31/52","A61K31/5377","A61P3/14","A61P5/18","A61P5/20","A61P19/10","C07B53/00","C07C209/28","C07C211/27","C07C211/29","C07C211/30","C07C211/55","C07C215/46","C07C217/54","C07C217/58","C07C229/38","C07C233/43","C07C235/20","C07C237/30","C07C255/58","C07C255/59","C07C275/40","C07C311/08","C07C317/32","C07D207/26","C07D207/32","C07D207/325","C07D209/08","C07D209/10","C07D209/44","C07D211/22","C07D211/26","C07D211/70","C07D213/26","C07D213/30","C07D213/38","C07D213/61","C07D213/62","C07D213/64","C07D213/65","C07D213/68","C07D213/73","C07D213/74","C07D213/75","C07D213/82","C07D215/12","C07D231/56","C07D233/22","C07D235/06","C07D235/08","C07D235/10","C07D235/12","C07D235/14","C07D237/14","C07D239/26","C07D239/34","C07D239/42","C07D239/47","C07D241/12","C07D241/42","C07D249/18","C07D261/08","C07D263/32","C07D263/56","C07D271/06","C07D271/10","C07D271/12","C07D277/24","C07D277/28","C07D277/40","C07D277/42","C07D277/66","C07D277/78","C07D285/00","C07D285/01","C07D295/096","C07D295/135","C07D295/185","C07D295/26","C07D307/42","C07D307/52","C07D307/68","C07D317/46","C07D317/54","C07D317/58","C07D319/18","C07D321/10","C07D333/16","C07D333/20","C07D333/56","C07D401/12","C07D405/12","C07D471/04","C07D473/00","C07D487/04"],"class_ipcr.inv_symbol":["A61K31/4439","A61K31/137","A61K31/145","A61K31/167","A61K31/275","A61K31/341","A61K31/357","A61K31/36","A61K31/381","A61K31/4045","A61K31/417","A61K31/4184","A61K31/42","A61K31/423","A61K31/426","A61K31/4418","A61K31/443","A61K31/4465","A61K31/47","A61K31/4965","A61K31/50","A61K31/505","A61K31/52","A61K31/5377","A61P3/14","A61P5/18","A61P5/20","A61P19/10","C07B53/00","C07C209/28","C07C211/27","C07C211/29","C07C211/30","C07C211/55","C07C215/46","C07C217/54","C07C217/58","C07C229/38","C07C233/43","C07C235/20","C07C237/30","C07C255/58","C07C255/59","C07C275/40","C07C311/08","C07C317/32","C07D207/26","C07D207/325","C07D209/08","C07D209/10","C07D209/44","C07D211/22","C07D211/26","C07D211/70","C07D213/26","C07D213/30","C07D213/38","C07D213/61","C07D213/62","C07D213/64","C07D213/65","C07D213/68","C07D213/73","C07D213/74","C07D213/75","C07D213/82","C07D215/12","C07D231/56","C07D233/22","C07D235/06","C07D235/08","C07D235/10","C07D235/12","C07D235/14","C07D237/14","C07D239/26","C07D239/34","C07D239/42","C07D239/47","C07D241/12","C07D241/42","C07D249/18","C07D261/08","C07D263/32","C07D263/56","C07D271/06","C07D271/10","C07D271/12","C07D277/24","C07D277/28","C07D277/40","C07D277/42","C07D277/66","C07D277/78","C07D285/01","C07D295/096","C07D295/135","C07D295/185","C07D295/26","C07D307/42","C07D307/52","C07D307/68","C07D317/46","C07D317/54","C07D317/58","C07D319/18","C07D321/10","C07D333/16","C07D333/20","C07D333/56","C07D401/12","C07D405/12","C07D471/04","C07D473/00","C07D487/04"],"class_ipcr.add_symbol":["C07D207/32","C07D285/00"],"class_ipcr.source":"DOCDB","class_cpc":[{"symbol":"A61P3/14","version_indicator":"2018-01-01","class_symbol_position":"L","class_value":"I","action_date":"2020-03-27","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":1},{"symbol":"A61P5/18","version_indicator":"2018-01-01","class_symbol_position":"L","class_value":"I","action_date":"2020-03-31","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":2},{"symbol":"A61P5/20","version_indicator":"2018-01-01","class_symbol_position":"L","class_value":"I","action_date":"2020-03-31","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":3},{"symbol":"A61P19/08","version_indicator":"2018-01-01","class_symbol_position":"L","class_value":"I","action_date":"2020-03-20","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":4},{"symbol":"A61P19/10","version_indicator":"2018-01-01","class_symbol_position":"L","class_value":"I","action_date":"2020-03-20","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":5},{"symbol":"A61P43/00","version_indicator":"2018-01-01","class_symbol_position":"L","class_value":"I","action_date":"2020-03-31","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":6},{"symbol":"C07C233/36","version_indicator":"2013-01-01","class_symbol_position":"F","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":7},{"symbol":"C07C233/36","version_indicator":"2013-01-01","class_symbol_position":"F","class_value":"I","action_date":"2019-08-22","class_status":"B","class_data_source":"H","generating_office":"US","sequence":8},{"symbol":"C07C211/27","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":9},{"symbol":"C07C211/27","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":10},{"symbol":"C07C211/29","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":11},{"symbol":"C07C211/29","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":12},{"symbol":"C07C211/30","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":13},{"symbol":"C07C211/30","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":14},{"symbol":"C07C211/55","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":15},{"symbol":"C07C211/55","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":16},{"symbol":"C07C215/46","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":17},{"symbol":"C07C215/46","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":18},{"symbol":"C07C217/54","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":19},{"symbol":"C07C217/54","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":20},{"symbol":"C07C217/58","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":21},{"symbol":"C07C217/58","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":22},{"symbol":"C07C229/38","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":23},{"symbol":"C07C229/38","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":24},{"symbol":"C07C233/43","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":25},{"symbol":"C07C233/43","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":26},{"symbol":"C07C233/46","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":27},{"symbol":"C07C233/46","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":28},{"symbol":"C07C235/20","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":29},{"symbol":"C07C235/20","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":30},{"symbol":"C07C237/30","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":31},{"symbol":"C07C237/30","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":32},{"symbol":"C07C255/58","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":33},{"symbol":"C07C255/58","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":34},{"symbol":"C07C255/59","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":35},{"symbol":"C07C255/59","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":36},{"symbol":"C07C275/40","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":37},{"symbol":"C07C275/40","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":38},{"symbol":"C07C311/08","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":39},{"symbol":"C07C311/08","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":40},{"symbol":"C07C317/32","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":41},{"symbol":"C07C317/32","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":42},{"symbol":"C07C2601/02","version_indicator":"2017-05-01","class_symbol_position":"L","class_value":"A","action_date":"2017-05-02","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":43},{"symbol":"C07C2601/02","version_indicator":"2017-05-01","class_symbol_position":"L","class_value":"A","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":44},{"symbol":"C07D207/26","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":45},{"symbol":"C07D207/26","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":46},{"symbol":"C07D207/27","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":47},{"symbol":"C07D207/27","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":48},{"symbol":"C07D207/325","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":49},{"symbol":"C07D207/325","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":50},{"symbol":"C07D209/08","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":51},{"symbol":"C07D209/08","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":52},{"symbol":"C07D209/10","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":53},{"symbol":"C07D209/10","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":54},{"symbol":"C07D209/44","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":55},{"symbol":"C07D209/44","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":56},{"symbol":"C07D211/22","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":57},{"symbol":"C07D211/22","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":58},{"symbol":"C07D211/70","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":59},{"symbol":"C07D211/70","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":60},{"symbol":"C07D213/26","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":61},{"symbol":"C07D213/26","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":62},{"symbol":"C07D213/30","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":63},{"symbol":"C07D213/30","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":64},{"symbol":"C07D213/38","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":65},{"symbol":"C07D213/38","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":66},{"symbol":"C07D213/61","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":67},{"symbol":"C07D213/61","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":68},{"symbol":"C07D213/64","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":69},{"symbol":"C07D213/64","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":70},{"symbol":"C07D213/65","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":71},{"symbol":"C07D213/65","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":72},{"symbol":"C07D213/68","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":73},{"symbol":"C07D213/68","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":74},{"symbol":"C07D213/73","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":75},{"symbol":"C07D213/73","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":76},{"symbol":"C07D213/75","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":77},{"symbol":"C07D213/75","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":78},{"symbol":"C07D213/82","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":79},{"symbol":"C07D213/82","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":80},{"symbol":"C07D215/12","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":81},{"symbol":"C07D215/12","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":82},{"symbol":"C07D215/14","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":83},{"symbol":"C07D215/14","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":84},{"symbol":"C07D231/56","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":85},{"symbol":"C07D231/56","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":86},{"symbol":"C07D233/22","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":87},{"symbol":"C07D233/22","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":88},{"symbol":"C07D235/06","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":89},{"symbol":"C07D235/06","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":90},{"symbol":"C07D235/10","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":91},{"symbol":"C07D235/10","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":92},{"symbol":"C07D235/12","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":93},{"symbol":"C07D235/12","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":94},{"symbol":"C07D237/08","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":95},{"symbol":"C07D237/08","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":96},{"symbol":"C07D237/14","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":97},{"symbol":"C07D237/14","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":98},{"symbol":"C07D239/26","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":99},{"symbol":"C07D239/26","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":100},{"symbol":"C07D239/34","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":101},{"symbol":"C07D239/34","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":102},{"symbol":"C07D239/42","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":103},{"symbol":"C07D239/42","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":104},{"symbol":"C07D241/12","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":105},{"symbol":"C07D241/12","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":106},{"symbol":"C07D241/42","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":107},{"symbol":"C07D241/42","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":108},{"symbol":"C07D249/18","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":109},{"symbol":"C07D249/18","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":110},{"symbol":"C07D261/08","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":111},{"symbol":"C07D261/08","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":112},{"symbol":"C07D263/32","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":113},{"symbol":"C07D263/32","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":114},{"symbol":"C07D263/56","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":115},{"symbol":"C07D263/56","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":116},{"symbol":"C07D271/06","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":117},{"symbol":"C07D271/06","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":118},{"symbol":"C07D271/08","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":119},{"symbol":"C07D271/08","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":120},{"symbol":"C07D271/10","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":121},{"symbol":"C07D271/10","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":122},{"symbol":"C07D271/12","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":123},{"symbol":"C07D271/12","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":124},{"symbol":"C07D277/24","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":125},{"symbol":"C07D277/24","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":126},{"symbol":"C07D277/28","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":127},{"symbol":"C07D277/28","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":128},{"symbol":"C07D277/40","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":129},{"symbol":"C07D277/40","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":130},{"symbol":"C07D277/42","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":131},{"symbol":"C07D277/42","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":132},{"symbol":"C07D277/66","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":133},{"symbol":"C07D277/66","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":134},{"symbol":"C07D285/01","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":135},{"symbol":"C07D285/01","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":136},{"symbol":"C07D295/096","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":137},{"symbol":"C07D295/096","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":138},{"symbol":"C07D295/135","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":139},{"symbol":"C07D295/135","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":140},{"symbol":"C07D295/185","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":141},{"symbol":"C07D295/185","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":142},{"symbol":"C07D295/26","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":143},{"symbol":"C07D295/26","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":144},{"symbol":"C07D307/42","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":145},{"symbol":"C07D307/42","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":146},{"symbol":"C07D307/52","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":147},{"symbol":"C07D307/52","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":148},{"symbol":"C07D307/68","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":149},{"symbol":"C07D307/68","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":150},{"symbol":"C07D317/46","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":151},{"symbol":"C07D317/46","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":152},{"symbol":"C07D317/54","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":153},{"symbol":"C07D317/54","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":154},{"symbol":"C07D319/18","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":155},{"symbol":"C07D319/18","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":156},{"symbol":"C07D321/10","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":157},{"symbol":"C07D321/10","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":158},{"symbol":"C07D333/16","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":159},{"symbol":"C07D333/16","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":160},{"symbol":"C07D333/20","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":161},{"symbol":"C07D333/20","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":162},{"symbol":"C07D333/56","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":163},{"symbol":"C07D333/56","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":164},{"symbol":"C07D401/12","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":165},{"symbol":"C07D401/12","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":166},{"symbol":"C07D405/12","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":167},{"symbol":"C07D405/12","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":168},{"symbol":"C07D471/04","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":169},{"symbol":"C07D471/04","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":170},{"symbol":"C07D487/04","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2013-01-01","class_status":"B","class_data_source":"H","generating_office":"EP","sequence":171},{"symbol":"C07D487/04","version_indicator":"2013-01-01","class_symbol_position":"L","class_value":"I","action_date":"2019-10-11","class_status":"B","class_data_source":"H","generating_office":"US","sequence":172}],"class_cpc_cset":[],"class_cpc.first_symbol":"C07C233/36","class_cpc.later_symbol":["A61P3/14","A61P5/18","A61P5/20","A61P19/08","A61P19/10","A61P43/00","C07C211/27","C07C211/27","C07C211/29","C07C211/29","C07C211/30","C07C211/30","C07C211/55","C07C211/55","C07C215/46","C07C215/46","C07C217/54","C07C217/54","C07C217/58","C07C217/58","C07C229/38","C07C229/38","C07C233/43","C07C233/43","C07C233/46","C07C233/46","C07C235/20","C07C235/20","C07C237/30","C07C237/30","C07C255/58","C07C255/58","C07C255/59","C07C255/59","C07C275/40","C07C275/40","C07C311/08","C07C311/08","C07C317/32","C07C317/32","C07C2601/02","C07C2601/02","C07D207/26","C07D207/26","C07D207/27","C07D207/27","C07D207/325","C07D207/325","C07D209/08","C07D209/08","C07D209/10","C07D209/10","C07D209/44","C07D209/44","C07D211/22","C07D211/22","C07D211/70","C07D211/70","C07D213/26","C07D213/26","C07D213/30","C07D213/30","C07D213/38","C07D213/38","C07D213/61","C07D213/61","C07D213/64","C07D213/64","C07D213/65","C07D213/65","C07D213/68","C07D213/68","C07D213/73","C07D213/73","C07D213/75","C07D213/75","C07D213/82","C07D213/82","C07D215/12","C07D215/12","C07D215/14","C07D215/14","C07D231/56","C07D231/56","C07D233/22","C07D233/22","C07D235/06","C07D235/06","C07D235/10","C07D235/10","C07D235/12","C07D235/12","C07D237/08","C07D237/08","C07D237/14","C07D237/14","C07D239/26","C07D239/26","C07D239/34","C07D239/34","C07D239/42","C07D239/42","C07D241/12","C07D241/12","C07D241/42","C07D241/42","C07D249/18","C07D249/18","C07D261/08","C07D261/08","C07D263/32","C07D263/32","C07D263/56","C07D263/56","C07D271/06","C07D271/06","C07D271/08","C07D271/08","C07D271/10","C07D271/10","C07D271/12","C07D271/12","C07D277/24","C07D277/24","C07D277/28","C07D277/28","C07D277/40","C07D277/40","C07D277/42","C07D277/42","C07D277/66","C07D277/66","C07D285/01","C07D285/01","C07D295/096","C07D295/096","C07D295/135","C07D295/135","C07D295/185","C07D295/185","C07D295/26","C07D295/26","C07D307/42","C07D307/42","C07D307/52","C07D307/52","C07D307/68","C07D307/68","C07D317/46","C07D317/46","C07D317/54","C07D317/54","C07D319/18","C07D319/18","C07D321/10","C07D321/10","C07D333/16","C07D333/16","C07D333/20","C07D333/20","C07D333/56","C07D333/56","C07D401/12","C07D401/12","C07D405/12","C07D405/12","C07D471/04","C07D471/04","C07D487/04","C07D487/04"],"class_cpc.inv_symbol":["A61P3/14","A61P5/18","A61P5/20","A61P19/08","A61P19/10","A61P43/00","C07C233/36","C07C233/36","C07C211/27","C07C211/27","C07C211/29","C07C211/29","C07C211/30","C07C211/30","C07C211/55","C07C211/55","C07C215/46","C07C215/46","C07C217/54","C07C217/54","C07C217/58","C07C217/58","C07C229/38","C07C229/38","C07C233/43","C07C233/43","C07C233/46","C07C233/46","C07C235/20","C07C235/20","C07C237/30","C07C237/30","C07C255/58","C07C255/58","C07C255/59","C07C255/59","C07C275/40","C07C275/40","C07C311/08","C07C311/08","C07C317/32","C07C317/32","C07D207/26","C07D207/26","C07D207/27","C07D207/27","C07D207/325","C07D207/325","C07D209/08","C07D209/08","C07D209/10","C07D209/10","C07D209/44","C07D209/44","C07D211/22","C07D211/22","C07D211/70","C07D211/70","C07D213/26","C07D213/26","C07D213/30","C07D213/30","C07D213/38","C07D213/38","C07D213/61","C07D213/61","C07D213/64","C07D213/64","C07D213/65","C07D213/65","C07D213/68","C07D213/68","C07D213/73","C07D213/73","C07D213/75","C07D213/75","C07D213/82","C07D213/82","C07D215/12","C07D215/12","C07D215/14","C07D215/14","C07D231/56","C07D231/56","C07D233/22","C07D233/22","C07D235/06","C07D235/06","C07D235/10","C07D235/10","C07D235/12","C07D235/12","C07D237/08","C07D237/08","C07D237/14","C07D237/14","C07D239/26","C07D239/26","C07D239/34","C07D239/34","C07D239/42","C07D239/42","C07D241/12","C07D241/12","C07D241/42","C07D241/42","C07D249/18","C07D249/18","C07D261/08","C07D261/08","C07D263/32","C07D263/32","C07D263/56","C07D263/56","C07D271/06","C07D271/06","C07D271/08","C07D271/08","C07D271/10","C07D271/10","C07D271/12","C07D271/12","C07D277/24","C07D277/24","C07D277/28","C07D277/28","C07D277/40","C07D277/40","C07D277/42","C07D277/42","C07D277/66","C07D277/66","C07D285/01","C07D285/01","C07D295/096","C07D295/096","C07D295/135","C07D295/135","C07D295/185","C07D295/185","C07D295/26","C07D295/26","C07D307/42","C07D307/42","C07D307/52","C07D307/52","C07D307/68","C07D307/68","C07D317/46","C07D317/46","C07D317/54","C07D317/54","C07D319/18","C07D319/18","C07D321/10","C07D321/10","C07D333/16","C07D333/16","C07D333/20","C07D333/20","C07D333/56","C07D333/56","C07D401/12","C07D401/12","C07D405/12","C07D405/12","C07D471/04","C07D471/04","C07D487/04","C07D487/04"],"class_cpc.add_symbol":["C07C2601/02","C07C2601/02"],"class_cpc.source":"DOCDB","class_national":[{"symbol":"514/340","symbol_position":"F"},{"symbol":"546/276.4","symbol_position":"L"}],"class_national.first_symbol":"514/340","class_national.later_symbol":["546/276.4"],"class_national.source":"DOCDB","reference_cited":[{"patent":{"num":1,"document_id":{"jurisdiction":"US","doc_number":"6908935","kind":"B2","date":"2005-06-21","name":"KELLY MICHAEL G [US], et al"},"lens_id":"138-929-416-772-424","category":[],"us_category":[],"cited_phase":"SEA","rel_claims":[],"sequence":1}}],"reference_cited.source":"DOCDB","reference_cited.patent_count":1,"cites_patent":true,"reference_cited.npl_count":0,"reference_cited.npl_resolved_count":0,"cites_npl":false,"cites_resolved_npl":false,"cited_by":{"patent_count":2,"patent":[{"lens_id":"062-518-754-565-143","document_id":{"jurisdiction":"US","doc_number":"8791147","kind":"B2"}},{"lens_id":"005-757-724-814-904","document_id":{"jurisdiction":"US","doc_number":"20110230517","kind":"A1"}}]},"cited_by_patent":true,"family":{"simple":{"size":18,"id":187965568,"member":[{"lens_id":"142-790-046-647-108","document_id":{"jurisdiction":"CA","doc_number":"2486399","kind":"A1","date":"2003-12-04"}},{"lens_id":"153-212-732-039-166","document_id":{"jurisdiction":"JP","doc_number":"4486882","kind":"B2","date":"2010-06-23"}},{"lens_id":"147-873-446-419-791","document_id":{"jurisdiction":"JP","doc_number":"2005527625","kind":"A","date":"2005-09-15"}},{"lens_id":"071-070-015-015-993","document_id":{"jurisdiction":"AU","doc_number":"2003233671","kind":"B2","date":"2007-08-16"}},{"lens_id":"089-683-112-224-813","document_id":{"jurisdiction":"US","doc_number":"20040082625","kind":"A1","date":"2004-04-29"}},{"lens_id":"130-110-458-478-569","document_id":{"jurisdiction":"EP","doc_number":"1509497","kind":"A1","date":"2005-03-02"}},{"lens_id":"131-180-229-312-901","document_id":{"jurisdiction":"AU","doc_number":"2003233671","kind":"B8","date":"2003-12-12"}},{"lens_id":"057-165-689-363-550","document_id":{"jurisdiction":"WO","doc_number":"2003099776","kind":"A1","date":"2003-12-04"}},{"lens_id":"162-056-516-970-604","document_id":{"jurisdiction":"US","doc_number":"7196102","kind":"B2","date":"2007-03-27"}},{"lens_id":"117-675-201-803-984","document_id":{"jurisdiction":"US","doc_number":"20070142381","kind":"A1","date":"2007-06-21"}},{"lens_id":"064-131-595-344-47X","document_id":{"jurisdiction":"PL","doc_number":"376438","kind":"A1","date":"2005-12-27"}},{"lens_id":"016-178-184-011-571","document_id":{"jurisdiction":"MX","doc_number":"PA04011471","kind":"A","date":"2005-02-14"}},{"lens_id":"043-143-772-160-409","document_id":{"jurisdiction":"JP","doc_number":"2010150268","kind":"A","date":"2010-07-08"}},{"lens_id":"147-700-757-926-365","document_id":{"jurisdiction":"US","doc_number":"7524873","kind":"B2","date":"2009-04-28"}},{"lens_id":"036-203-295-385-274","document_id":{"jurisdiction":"CA","doc_number":"2486399","kind":"C","date":"2010-07-20"}},{"lens_id":"138-929-416-772-424","document_id":{"jurisdiction":"US","doc_number":"6908935","kind":"B2","date":"2005-06-21"}},{"lens_id":"199-986-000-809-856","document_id":{"jurisdiction":"AU","doc_number":"2003233671","kind":"A1","date":"2003-12-12"}},{"lens_id":"108-641-804-453-272","document_id":{"jurisdiction":"US","doc_number":"20050143426","kind":"A1","date":"2005-06-30"}}]},"extended":{"size":20,"id":187911362,"member":[{"lens_id":"153-212-732-039-166","document_id":{"jurisdiction":"JP","doc_number":"4486882","kind":"B2","date":"2010-06-23"}},{"lens_id":"142-790-046-647-108","document_id":{"jurisdiction":"CA","doc_number":"2486399","kind":"A1","date":"2003-12-04"}},{"lens_id":"147-873-446-419-791","document_id":{"jurisdiction":"JP","doc_number":"2005527625","kind":"A","date":"2005-09-15"}},{"lens_id":"071-070-015-015-993","document_id":{"jurisdiction":"AU","doc_number":"2003233671","kind":"B2","date":"2007-08-16"}},{"lens_id":"130-110-458-478-569","document_id":{"jurisdiction":"EP","doc_number":"1509497","kind":"A1","date":"2005-03-02"}},{"lens_id":"089-683-112-224-813","document_id":{"jurisdiction":"US","doc_number":"20040082625","kind":"A1","date":"2004-04-29"}},{"lens_id":"131-180-229-312-901","document_id":{"jurisdiction":"AU","doc_number":"2003233671","kind":"B8","date":"2003-12-12"}},{"lens_id":"057-165-689-363-550","document_id":{"jurisdiction":"WO","doc_number":"2003099776","kind":"A1","date":"2003-12-04"}},{"lens_id":"162-056-516-970-604","document_id":{"jurisdiction":"US","doc_number":"7196102","kind":"B2","date":"2007-03-27"}},{"lens_id":"117-675-201-803-984","document_id":{"jurisdiction":"US","doc_number":"20070142381","kind":"A1","date":"2007-06-21"}},{"lens_id":"064-131-595-344-47X","document_id":{"jurisdiction":"PL","doc_number":"376438","kind":"A1","date":"2005-12-27"}},{"lens_id":"016-178-184-011-571","document_id":{"jurisdiction":"MX","doc_number":"PA04011471","kind":"A","date":"2005-02-14"}},{"lens_id":"035-046-248-696-480","document_id":{"jurisdiction":"AR","doc_number":"040640","kind":"A1","date":"2005-04-13"}},{"lens_id":"043-143-772-160-409","document_id":{"jurisdiction":"JP","doc_number":"2010150268","kind":"A","date":"2010-07-08"}},{"lens_id":"147-700-757-926-365","document_id":{"jurisdiction":"US","doc_number":"7524873","kind":"B2","date":"2009-04-28"}},{"lens_id":"036-203-295-385-274","document_id":{"jurisdiction":"CA","doc_number":"2486399","kind":"C","date":"2010-07-20"}},{"lens_id":"138-929-416-772-424","document_id":{"jurisdiction":"US","doc_number":"6908935","kind":"B2","date":"2005-06-21"}},{"lens_id":"044-902-643-495-06X","document_id":{"jurisdiction":"TW","doc_number":"200404765","kind":"A","date":"2004-04-01"}},{"lens_id":"199-986-000-809-856","document_id":{"jurisdiction":"AU","doc_number":"2003233671","kind":"A1","date":"2003-12-12"}},{"lens_id":"108-641-804-453-272","document_id":{"jurisdiction":"US","doc_number":"20050143426","kind":"A1","date":"2005-06-30"}}]}},"has_sequence":false,"legal_status":{"ipr_type":"patent for invention","granted":true,"earliest_filing_date":"2003-05-22","grant_date":"2009-04-28","anticipated_term_date":"2023-06-27","discontinuation_date":"2017-05-29","has_disclaimer":true,"patent_status":"EXPIRED","publication_count":2,"has_spc":false,"has_grant_event":false,"has_entry_into_national_phase":false},"abstract":{"en":[{"text":"The compounds of the invention are represented by the following general structure or a pharmaceutically acceptable salt thereof, and compositions containing them, wherein the variables are defined herein, and their use to reduce or inhibit PTH secretion, including methods for reducing or inhibiting PTH secretion and methods for treatment or prophylaxis of diseases associated with bone disorders, such as osteoporosis, or associated with excessive secretion of PTH, such as hyperparathyroidism. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.","lang":"en","source":"USPTO_FULLTEXT","data_format":"ORIGINAL"}]},"abstract_lang":["en"],"has_abstract":true,"claim":{"en":[{"text":"1. A compound selected from the group consisting of: (1R)-N-((6-(methyloxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-N-((6-(methyloxy)-4′-((trifluoromethyl)oxy)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine; (1R)-1-(3-(methyloxy)phenyl)-N-((6-(methyloxy)-4′-((trifluoromethyl)oxy)-1,1′-biphenyl-3-yl)methyl)ethanamine; (1R)-N-((3-(1,3-benzoxazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine; (1R)-N-((3′,6-bis(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine; (1R)-N-((4-(methyloxy)-3-(1-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-N-((3-(1-methyl-1H-indazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-N-((3-(2-methyl-1,3-benzoxazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-N-((3-(1-methyl-1H-indazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine; N-1,N-1-dimethyl-N-2-(4-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-N-2-phenyl-1,2-ethanediamine; (1R)-N-((6-chloro-3′-fluoro-3-biphenylyl)methyl)-1-(3-chlorophenyl)ethanamine; (1R)-N-((4-(methyloxy)-3-(2-methyl-1,3-thiazol-4-yl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-1-(3-(methyloxy)phenyl)-N-((6-(methyloxy)-3′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)ethanamine; (1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(6-((2,2,2-trifluoroethyl)oxy)-3-pyridinyl)phenyl)methyl)ethanamine; (1R)-N-((4-(methyloxy)-3-(3-thienyl)phenyl)methyl)-1-phenylethanamine; (1R)-N-((6-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine; (1R)-N-((4-(methyloxy)-3-(1-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)methyl)-1-phenylethanamine; (1R)-N-((6-chloro-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(2-pyrazinyl)phenyl)methyl)ethanamine; (1R)-N-((4-chloro-3-(3-pyridinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-N-((4-(methyloxy)-3-(2-pyrazinyl)phenyl)methyl)-1-phenylethanamine; (1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(1,3-thiazol-2-yl)phenyl)methyl)ethanamine; (1R)-N-((6-fluoro-4′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine; (1R)-N-((3-(1-(cyclopropylmethyl)-1H-indol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine; (1R)-N-((3-(1-methyl-1H-benzimidazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine; N-1,N-1-dimethyl-N-2-(4-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)phenyl)-N-2-phenyl-1,2-ethanediamine; (1R)-N-((6-fluoro-4′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine; (1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(3-thienyl)phenyl)methyl)ethanamine; (1R)-N-((3-(1,3-benzodioxol-5-yl)phenyl)methyl)-1-phenylethanamine; (1R)-N-((4-(methyloxy)-3-(5-(methyloxy)-2-pyridinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-N-((3-(3-furanyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-N-((3-(1-methyl-1H-indol-6-yl)-4-(methyloxy)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine; (1R)-N-((2′,6-bis(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine; (1R)-N-((4-(methyloxy)-3-(1,3-thiazol-2-yl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-N-((4-(methyloxy)-3-(5-(methyloxy)-2-pyridinyl)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine; (1R)-N-((3-imidazo[1,2-a]pyridin-6-yl-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine; ethyl 4-(2-(methyloxy)-5-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-1-piperidinecarboxylate; (1R)-N-((4-(methyloxy)-3-(6-(methyloxy)-3-pyridinyl)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine; (1R)-N-((6-(methyloxy)-4′-(methylsulfonyl)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine; (1R)-N-((4′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-N-((4-(methyloxy)-3-(4-piperidinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(6-quinoxalinyl)phenyl)methyl)ethanamine; 2-(5-(2-(methyloxy)-5-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-1H-indol-1-yl)acetamide; 2′-(methyloxy)-5′-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)-1,1′-biphenyl-3-carboxamide; (1R)-N-((4-((difluoromethyl)oxy)-3-(3-pyridinyl)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine; 2′-(methyloxy)-5′-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)-1,1′-biphenyl-3-carbonitrile; (1R)-N-((3-(6-(methyloxy)-3-pyridazinyl)phenyl)methyl)-1-phenylethanamine; (1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl)phenyl)methyl)ethanamine; (1R)-N-((4-(methyloxy)-3-(3-thienyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-N-((4-((difluoromethyl)oxy)-3-(3-pyridinyl)phenyl)methyl)-1-phenylethanamine; (1R)-N-((3-(2-methyl-2H-indazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine; (1R)-N-((3-(1-methyl-1H-benzimidazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine; 5-(2-(methyloxy)-5-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-3-pyridinecarboxamide; (1R)-N-((4-(methyloxy)-3-(1,3-thiazol-2-yl)phenyl)methyl)-1-phenylethanamine; (1R)-N-((4-(methyloxy)-3-(1-pyrrolidinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-N-((4-(methyloxy)-3-(6-methyl-3-pyridinyl)phenyl)methyl)-1-(4-methylphenyl)ethanamine; (1R)-N-((4-(3,5-dimethyl-4-isoxazolyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-N-((4-(methyloxy)-3-(2-methyl-1,3-thiazol-4-yl)phenyl)methyl)-1-phenylethanamine; (1R)-N-((4′,6-bis(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-N-((4-(methyloxy)-3-(6-(methyloxy)-3-pyridazinyl)phenyl)methyl)-1-phenylethanamine; 2′-(methyloxy)-5′-((((1R)-1-phenylethyl)amino)methyl)-1,1′-biphenyl-4-carboxamide; (1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(5-pyrimidinyl)phenyl)methyl)ethanamine; (1R)-N-((4-(methyloxy)-3-(4-(methyloxy)-2-pyridinyl)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine; (1R)-N-((3-(4-morpholinylsulfonyl)phenyl)methyl)-1-phenylethanamine; (1R)-N-((4-chloro-3-(3-pyridinyl)phenyl)methyl)-1-phenylethanamine; 5-(3-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-3-pyridinecarboxamide; (1R)-N-((3-(1-methyl-1H-benzimidazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine; 2′-(methyloxy)-5′-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)-1,1′-biphenyl-4-carboxamide; 1-methyl-5-(2-(methyloxy)-5-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-2(1H)-pyridinone; (1R)-N-((3-(1-benzothien-3-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-N-((6-(methyloxy)-4′-(methylsulfonyl)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-N-((3-(1-methyl-1H-imidazol-4-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine; (1R)-N-((3-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine; (1R)-N-((3-(1,3-benzodioxol-5-yl)phenyl)methyl)-1-(4-(methyloxy)phenyl)ethanamine; (1R)-N-((3-(1-acetyl-4-piperidinyl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-N-((6-(methyloxy)-4′-(methylsulfonyl)-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine; 2-(5-(2-(methyloxy)-5-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)phenyl)-1H-indol-1-yl)acetamide; N-(5-(3-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-2-pyridinyl)acetamide; 5-(2-(methyloxy)-5-((((1R)-1-(4-methylphenyl)ethyl)amino)methyl)phenyl)-3-pyridinecarboxamide; (1R)-N-((4-(methyloxy)-3-(5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl)phenyl)methyl)-1-phenylethanamine; (1R)-N-((3-(6-methyl-3-pyridinyl)phenyl)methyl)-1-phenylethanamine; (1R)-N-((4′,6-bis(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-phenyl-1-propanamine; 2′-(methyloxy)-5′-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)-1,1′-biphenyl-3-carboxylic acid; (1R)-N-((4′,6-bis(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine; N-((3-(6-((3-(diethylamino)propyl)oxy)-3-pyridinyl)-4-(methyloxy)phenyl)methyl)-N-((1R)-1-(1-naphthalenyl)ethyl)amine; (1R)-N-((4′,6-difluoro-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine; (1R)-1-(1-naphthalenyl)-N-((3-(2-pyridinyl)phenyl)methyl)ethanamine; (1R)-N-((4′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine; (1R)-N-((4-(methyloxy)-3-(1-methyl-4-piperidinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-N-((4′-fluoro-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine; 2′-(methyloxy)-5′-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)-1,1′-biphenyl-4-carboxamide; 1-methyl-5-(2-(methyloxy)-5-((((1R)-1-phenylethyl)amino)methyl)phenyl)-2(1H)-pyridinone; (1R)-N-((4-(methyloxy)-3-(2-((2,2,2-trifluoroethyl)oxy)-5-pyrimidinyl)phenyl)methyl)-1-phenylethanamine; (1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(2-(1-piperidinyl)-1,3-thiazol-4-yl)phenyl)methyl)ethanamine; (1R)-N-((3-imidazo[1,2-a]pyridin-6-yl-4-(methyloxy)phenyl)methyl)-1-phenylethanamine; (1R)-N-((6-fluoro-4′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(4-methylphenyl)ethanamine; (1R)-N-((3-(1H-indol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine; (1R)-N-((4-(methyloxy)-3-(6-methyl-3-pyridinyl)phenyl)methyl)-1-(2-naphthalenyl)ethanamine; (1R)-N-((2′-methyl-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine; (1R)-1-(1-naphthalenyl)-N-((6-((2,2,2-trifluoroethyl)oxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)ethanamine; (1R)-N-((4-(methyloxy)-3-(2-((2,2,2-trifluoroethyl)oxy)-5-pyrimidinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-N-((3-(6-methyl-3-pyridinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-1-(3-(methyloxy)phenyl)-N-((3-(6-(methyloxy)-3-pyridazinyl)phenyl)methyl)ethanamine; 2′-(methyloxy)-5′-((((1R)-1-phenylethyl)amino)methyl)-1,1′-biphenyl-3-carboxamide; (1R)-N-((4′-fluoro-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine; (1R)-N-((4-(methyloxy)-3-(6-((2-(1-pyrrolidinyl)ethyl)oxy)-3-pyridinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-N-((3′,4′-dimethyl-1,1′-biphenyl-3-yl)methyl)-1-(4-methylphenyl)ethanamine; (1R)-N-((4-(methyloxy)-3-(5-(methyloxy)-2-pyridinyl)phenyl)methyl)-1-phenylethanamine; ethyl 4-(2-(methyloxy)-5-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)phenyl)-1-piperidinecarboxylate; (1R)-N-((4-(methyloxy)-3-(6-(methyloxy)-3-pyridazinyl)phenyl)methyl)-1-(4-methylphenyl)ethanamine; (1R)-N-((4-(methyloxy)-3-(2-(1-piperidinyl)-1,3-thiazol-4-yl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-N-((4-methyl-3-(3-pyridinyl)phenyl)methyl)-1-phenylethanamine; (1R)-N-((4-(methyloxy)-3-(1-((methyloxy)acetyl)-4-piperidinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-N-((3′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine; (1R)-N-((3-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl)methyl)-1-phenylethanamine; (1R)-N-((3′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine; (1R)-N-((3-(1,3-benzothiazol-2-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-N-((2′-fluoro-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine; (1R)-N-((3-(2-methyl-1,3-benzoxazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine; N-((3-(6-((3-(diethylamino)propyl)oxy)-3-pyridinyl)-4-(methyloxy)phenyl)methyl)-N-((1R)-1-(3-(methyloxy)phenyl)ethyl)amine; ethyl 4-(2-(methyloxy)-5-((((1R)-1-phenylethyl)amino)methyl)phenyl)-1-piperidinecarboxylate; (1R)-N-((4′-fluoro-6-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(4-methylphenyl)ethanamine; N-(3′-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)-1,1′-biphenyl-3-yl)acetamide; 1-methyl-5-(2-(methyloxy)-5-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)phenyl)-2(1H)-pyridinone; 2′-(methyloxy)-5′-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)-1,1′-biphenyl-3-carboxylic acid; (1R)-N-((4-(methyloxy)-3-(3-thienyl)phenyl)methyl)-1-(2-naphthalenyl)ethanamine; (1R)-N-((4-(methyloxy)-3-(5-pyrimidinyl)phenyl)methyl)-1-phenylethanamine; (1R)-1-phenyl-N-((6-((2,2,2-trifluoroethyl)oxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)ethanamine; (1R)-N-((4-(methyloxy)-3-(1-methyl-4-piperidinyl)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine; N-ethyl-N′-(4′-(methyloxy)-5-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)-1,1′-biphenyl-2-yl)urea; 5-(2-(methyloxy)-5-((((1R)-1-phenylethyl)amino)methyl)phenyl)-1-(2,2,2-trifluoroethyl)-2(1H)-pyridinone; (1R)-N-((6-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(4-(methyloxy)phenyl)ethanamine; 5-(3-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)phenyl)-3-pyridinecarboxamide; 4′-(methyloxy)-5-((((1R)-1-phenylethyl)amino)methyl)-1,1′-biphenyl-2-ol; (1R)-N-((4-(methyloxy)-3-(2-(1-piperidinyl)-1,3-thiazol-4-yl)phenyl)methyl)-1-phenylethanamine; 4-oxo-4-((5-(3-((((1R)-1-phenylethyl)amino)methyl)phenyl)-2-pyridinyl)amino)butanoic acid; 5-(2-(methyloxy)-5-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)phenyl)-1-(2,2,2-trifluoroethyl)-2(1H)-pyridinone; (1R)-N-((4-(methyloxy)-3-(3-thienyl)phenyl)methyl)-1-(4-methylphenyl)ethanamine; N-ethyl-N′-(4′-(methyloxy)-5-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)-1,1′-biphenyl-2-yl)urea; 2′-(methyloxy)-5′-((((1R)-1-(4-methylphenyl)ethyl)amino)methyl)-1,1′-biphenyl-3-carbonitrile; (1R)-N-((4-(methyloxy)-3-(6-((2-(1-pyrrolidinyl)ethyl)oxy)-3-pyridinyl)phenyl)methyl)-1-phenylethanamine; 1-(2-(methyloxy)ethyl)-5-(2-(methyloxy)-5-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)phenyl)-2(1H)-pyridinone; 5-(2-(methyloxy)-5-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)phenyl)-2-furancarboxylic acid; 2-(5-(2-(methyloxy)-5-((((1R)-1-phenylethyl)amino)methyl)phenyl)-1H-indol-1-yl)acetamide; N-(4′-(methyloxy)-5-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)-1,1′-biphenyl-2-yl)methanesulfonamide; 1-(2-(methyloxy)ethyl)-5-(2-(methyloxy)-5-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-2(1H)-pyridinone; (1R)-N-((3-(2-methyl-1,3-oxazol-4-yl)-4-(methyloxy)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine; (1R)-N-((4-(methyloxy)-3-(1-methyl-4-piperidinyl)phenyl)methyl)-1-phenylethanamine; (1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(6-((2-(1-pyrrolidinyl)ethyl)oxy)-3-pyridinyl)phenyl)methyl)ethanamine; N-((3-(6-((3-(diethylamino)propyl)oxy)-3-pyridinyl)-4-(methyloxy)phenyl)methyl)-N-((1R)-1-phenylethyl)amine; (1R)-N-((4-(methyloxy)-3-(4-piperidinyl)phenyl)methyl)-1-phenylethanamine; (1R)-N-((4-(methyloxy)-3-(1-((methyloxy)acetyl)-4-piperidinyl)phenyl)methyl)-1-phenylethanamine; N,N-dimethyl-2-((5-((((1R)-1-phenylethyl)amino)methyl)-4′-(trifluoromethyl)-1,1′-biphenyl-2-yl)oxy)acetamide; N,N-dimethyl-2-((5-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)-4′-(trifluoromethyl)-1,1′-biphenyl-2-yl)oxy)acetamide; N,N-dimethyl-2-((5-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)-4′-(trifluoromethyl)-1,1′-biphenyl-2-yl)oxy)acetamide; 1-(2-(methyloxy)ethyl)-5-(2-(methyloxy)-5-((((1R)-1-phenylethyl)amino)methyl)phenyl)-2(1H)-pyridinone; 5-(2-(methyloxy)-5-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-1-(2,2,2-trifluoroethyl)-2(1H)-pyridinone; 1-(2-(methyloxy)-5-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-2-pyrrolidinone; 1-(2-(methyloxy)-5-((((1R)-1-phenylethyl)amino)methyl)phenyl)-2-pyrrolidinone; (1R)-1-(4-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(1,3-thiazol-2-yl)phenyl)methyl)ethanamine; (1R)-N-((2′-methyl-1,1′-biphenyl-3-yl)methyl)-1-(4-methylphenyl)ethanamine; (1R)-N-((4′-fluoro-1,1′-biphenyl-3-yl)methyl)-1-(4-methylphenyl)ethanamine; (1R)-N-((4-(methyloxy)-3-(2-pyrimidinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-N-((3-(6-(methyloxy)-3-pyridazinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-N-((2′-fluoro-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine; (1R)-1-(1-naphthalenyl)-N-((3-(1,3-thiazol-2-yl)phenyl)methyl)ethanamine; N-(5-(3-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)phenyl)-2-pyridinyl)acetamide; (1R)-1-(4-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(3-thienyl)phenyl)methyl)ethanamine; (1R)-N-((4-(methyloxy)-3-(2-pyrazinyl)phenyl)methyl)-1-(4-methylphenyl)ethanamine; (1R)-N-((4-(methyloxy)-3-(1,3-thiazol-2-yl)phenyl)methyl)-1-(2-naphthalenyl)ethanamine; (1R)-N-((4′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(2-naphthalenyl)ethanamine; (1R)-1-(3-(methyloxy)phenyl)-N-((3-(2-pyrazinyl)phenyl)methyl)ethanamine; (1R)-1-(3-(methyloxy)phenyl)-N-((3-(6-methyl-3-pyridinyl)phenyl)methyl)ethanamine; (1R)-N-((3′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(4-methylphenyl)ethanamine; (1R)-N-((3-(3-furanyl)phenyl)methyl)-1-phenylethanamine; (1R)-N-((4-(methyloxy)-3-(2-pyrazinyl)phenyl)methyl)-1-(2-naphthalenyl)ethanamine; N-(4′-(methyloxy)-5-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)-1,1′-biphenyl-2-yl)methanesulfonamide; (1R)-1-(3-(methyloxy)phenyl)-N-((3-(2-pyridinyl)phenyl)methyl)ethanamine; 5-(2-(methyloxy)-5-((((1R)-1-phenylethyl)amino)methyl)phenyl)-3-pyridinecarboxamide; (1R)-N-((3-(3-furanyl)phenyl)methyl)-1-(4-(methyloxy)phenyl)ethanamine; N-(3′-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)-1,1′-biphenyl-3-yl)acetamide; (1R)-N-((4′-fluoro-6-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(4-(methyloxy)phenyl)ethanamine; (1R)-1-(3-(methyloxy)phenyl)-N-((3-(1,3-thiazol-2-yl)phenyl)methyl)ethanamine; 5-(2-(methyloxy)-5-((((1R)-1-(4-methylphenyl)ethyl)amino)methyl)phenyl)-2-pyrimidinamine; (1R)-N-((4-(methyloxy)-3-(1,3-thiazol-2-yl)phenyl)methyl)-1-(4-methylphenyl)ethanamine; (1R)-1-(4-methylphenyl)-N-((3-(6-methyl-3-pyridinyl)phenyl)methyl)ethanamine; (1R)-1-(4-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(2-pyrazinyl)phenyl)methyl)ethanamine; (1R)-N-((4-(methyloxy)-3-(6-(methyloxy)-3-pyridazinyl)phenyl)methyl)-1-(4-(methyloxy)phenyl)ethanamine; (1R)-1-phenyl-N-((3-(1,3-thiazol-2-yl)phenyl)methyl)ethanamine; (1R)-N-((3-(1,3-benzodioxol-5-yl)phenyl)methyl)-1-(4-methylphenyl)ethanamine; (1R)-1-phenyl-N-((3-(2-pyridinyl)phenyl)methyl)ethanamine; 4-((5-(3-((((1R)-1-(4-(methyloxy)phenyl)ethyl)amino)methyl)phenyl)-2-pyridinyl)amino)-4-oxobutanoic acid; (1R)-N-((3-(1H-indol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(2-naphthalenyl)ethanamine; (1R)-N-((4-(methyloxy)-3-(6-(methyloxy)-3-pyridazinyl)phenyl)methyl)-1-(2-naphthalenyl)ethanamine; (1R)-N-((3-(3-furanyl)phenyl)methyl)-1-(4-methylphenyl)ethanamine; 5-(2-(methyloxy)-5-((((1R)-1-(4-methylphenyl)ethyl)amino)methyl)phenyl)-3-pyridinecarboxamide; (1R)-1-(3-(methyloxy)phenyl)-N-((3-(5-pyrimidinyl)phenyl)methyl)ethanamine; (1R)-N-((3′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(4-(methyloxy)phenyl)ethanamine; (1R)-N-((4-(methyloxy)-3-(5-pyrimidinyl)phenyl)methyl)-1-(4-methylphenyl)ethanamine; (1R)-N-((4-(methyloxy)-3-(3-pyridinyl)phenyl)methyl)-1-(4-methylphenyl)ethanamine; (1R)-1-(4-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(3-pyridinyl)phenyl)methyl)ethanamine; 5-(2-(methyloxy)-5-((((1R)-1-(2-naphthalenyl)ethyl)amino)methyl)phenyl)-3-pyridinecarboxamide; (1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(2-pyrimidinyl)phenyl)methyl)ethanamine; (1R)-1-phenyl-N-((3-(2-pyrazinyl)phenyl)methyl)ethanamine; (1R)-N-((4′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(4-(methyloxy)phenyl)ethanamine; (1R)-1-(4-methylphenyl)-N-((3-(9-methyl-9H-purin-6-yl)phenyl)methyl)ethanamine; (1R)-1-phenyl-N-((4-(1-pyrrolidinyl)phenyl)methyl)ethanamine; (1R)-N-((3-(6-methyl-3-pyridinyl)phenyl)methyl)-1-(2-naphthalenyl)ethanamine; (1R)-N-((4-(methyloxy)-3-(2-pyrimidinyl)phenyl)methyl)-1-phenylethanamine; (1R)-1-(4-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(5-pyrimidinyl)phenyl)methyl)ethanamine; and (1R)-1-(4-(methyloxy)phenyl)-N-((3-(6-(methyloxy)-3-pyridazinyl)phenyl)methyl)ethanamine; or a pharmaceutically acceptable salt thereof.","lang":"en","source":"USPTO_FULLTEXT","data_format":"ORIGINAL"},{"text":"2. The compound or pharmaceutically acceptable salt there of as set forth in claim 1 wherein the compound is selected from the group consisting of: (1R)-N-((6-(methyloxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-N-((6-(methyloxy)-4′-((trifluoromethyl)oxy)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine; (1R)-1-(3-(methyloxy)phenyl)-N-((6-(methyloxy)-4′-((tri fluoromethyl)oxy)-1,1′-biphenyl-3-yl)methyl)ethanamine; (1R)-N-((3-(1,3-benzoxazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine; (1R)-N-((3′,6-bis(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine; (1R)-N-((4-(methyloxy)-3-(1-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-N-((3-(1-methyl-1H-indazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-N-((3-(2-methyl-1,3-benzoxazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-N-((3-(1-methyl-1H-indazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine; N-1,N-1-dimethyl-N-2-(4-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-N-2-phenyl-1,2-ethanediamine; (1R)-N-((4-(methyloxy)-3-(2-methyl-1,3-thiazol-4-yl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-N-((6-chloro-3′-fluoro-3-biphenylyl)methyl)-1-(3-chlorophenyl)ethanamine; (1R)-1-(3-(methyloxy)phenyl)-N-((6-(methyloxy)-3′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)ethanamine; (1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(6-((2,2,2-trifluoroethyl)oxy)-3-pyridinyl)phenyl)methyl)ethanamine; (1R)-N-((4-(methyloxy)-3-(3-thienyl)phenyl)methyl)-1-phenylethanamine; (1R)-N-((6-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine; (1R)-N-((4-(methyloxy)-3-(1-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)methyl)-1-phenylethanamine; (1R)-N-((6-chloro-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(2-pyrazinyl)phenyl)methyl)ethanamine; (1R)-N-((4-chloro-3-(3-pyridinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-N-((4-(methyloxy)-3-(2-pyrazinyl)phenyl)methyl)-1-phenylethanamine; (1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(1,3-thiazol-2-yl)phenyl)methyl)ethanamine; (1R)-N-((6-fluoro-4′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine; (1R)-N-((3-(1-(cyclopropylmethyl)-1H-indol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine; (1R)-N-((3-(1-methyl-1H-benzimidazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine; N-1,N-1-dimethyl-N-2-(4-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)phenyl)-N-2-phenyl-1,2-ethanediamine; (1R)-N-((6-fluoro-4′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine; (1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(3-thienyl)phenyl)methyl)ethanamine; (1R)-N-((3-(1,3-benzodioxol-5-yl)phenyl)methyl)-1-phenylethanamine; (1R)-N-((4-(methyloxy)-3-(5-(methyloxy)-2-pyridinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-N-((3-(3-furanyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-N-((3-(1-methyl-1H-indol-6-yl)-4-(methyloxy)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine; (1R)-N-((2′,6-bis(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine; (1R)-N-((4-(methyloxy)-3-(1,3-thiazol-2-yl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-N-((4-(methyloxy)-3-(5-(methyloxy)-2-pyridinyl)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine; (1R)-N-((3-imidazo[1,2-a]pyridin-6-yl-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine; ethyl 4-(2-(methyloxy)-5-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-1-piperidinecarboxylate; (1R)-N-((4-(methyloxy)-3-(6-(methyloxy)-3-pyridinyl)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine; (1R)-N-((6-(methyloxy)-4′-(methylsulfonyl)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine; (1R)-N-((4′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-N-((4-(methyloxy)-3-(4-piperidinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(6-quinoxalinyl)phenyl)methyl)ethanamine; 2-(5-(2-(methyloxy)-5-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-1H-indol-1-yl)acetamide; 2′-(methyloxy)-5′-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)-1,1′-biphenyl-3-carboxamide; (1R)-N-((4-((difluoromethyl)oxy)-3-(3-pyridinyl)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine; 2′-(methyloxy)-5′-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)-1,1′-biphenyl-3-carbonitrile; (1R)-N-((3-(6-(methyloxy)-3-pyridazinyl)phenyl)methyl)-1-phenylethanamine; (1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl)phenyl)methyl)ethanamine; (1R)-N-((4-(methyloxy)-3-(3-thienyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-N-((4-((difluoromethyl)oxy)-3-(3-pyridinyl)phenyl)methyl)-1-phenylethanamine; (1R)-N-((3-(2-methyl-2H-indazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine; (1R)-N-((3-(1-methyl-1H-benzimidazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine; 5-(2-(methyloxy)-5-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-3-pyridinecarboxamide; (1R)-N-((4-(methyloxy)-3-(1,3-thiazol-2-yl)phenyl)methyl)-1-phenylethanamine; (1R)-N-((4-(methyloxy)-3-(1-pyrrolidinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-N-((4-(methyloxy)-3-(6-methyl-3-pyridinyl)phenyl)methyl)-1-(4-methylphenyl)ethanamine; (1R)-N-((4-(3,5-dimethyl-4-isoxazolyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-N-((4-(methyloxy)-3-(2-methyl-1,3-thiazol-4-yl)phenyl)methyl)-1-phenylethanamine; (1R)-N-((4′,6-bis(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-N-((4-(methyloxy)-3-(6-(methyloxy)-3-pyridazinyl)phenyl)methyl)-1-phenylethanamine; 2′-(methyloxy)-5′-((((1R)-1-phenylethyl)amino)methyl)-1,1′-biphenyl-4-carboxamide; (1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(5-pyrimidinyl)phenyl)methyl)ethanamine; (1R)-N-((4-(methyloxy)-3-(4-(methyloxy)-2-pyridinyl)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine; (1R)-N-((3-(4-morpholinylsulfonyl)phenyl)methyl)-1-phenylethanamine; (1R)-N-((4-chloro-3-(3-pyridinyl)phenyl)methyl)-1-phenylethanamine; 5-(3-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-3-pyridinecarboxamide; (1R)-N-((3-(1-methyl-1H-benzimidazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine; 2′-(methyloxy)-5′-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)-1,1′-biphenyl-4-carboxamide; 1-methyl-5-(2-(methyloxy)-5-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-2(1H)-pyridinone; (1R)-N-((3-(1-benzothien-3-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-N-((6-(methyloxy)-4′-(methylsulfonyl)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-N-((3-(1-methyl)-1H-imidazol-4-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine; (1R)-N-((3-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine; (1R)-N-((3-(1,3-benzodioxol-5-yl)phenyl)methyl)-1-(4-(methyloxy)phenyl)ethanamine; (1R)-N-((3-(1-acetyl-4-piperidinyl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-N-((6-(methyloxy)-4′-(methylsulfonyl)-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine; 2-(5-(2-(methyloxy)-5-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)phenyl)-1H-indol-1-yl)acetamide; N-(5-(3-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-2-pyridinyl)acetamide; 5-(2-(methyloxy)-5-((((1R)-1-(4-methylphenyl)ethyl)amino)methyl)phenyl)-3-pyridinecarboxamide; (1R)-N-((4-(methyloxy)-3-(5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl)phenyl)methyl)-1-phenylethanamine; (1R)-N-((3-(6-methyl-3-pyridinyl)phenyl)methyl)-1-phenylethanamine; (1R)-N-((4′,6-bis(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-phenyl-1-propanamine; 2′-(methyloxy)-5′-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)-1,1′-biphenyl-3-carboxylic acid; (1R)-N-((4′,6-bis(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine; N-((3-(6-((3-(diethylamino)propyl)oxy)-3-pyridinyl)-4-(methyloxy)phenyl)methyl)-N-((1R)-1-(1-naphthalenyl)ethyl)amine; (1R)-N-((4′,6-difluoro-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine; (1R)-1-(1-naphthalenyl)-N-((3-(2-pyridinyl)phenyl)methyl)ethanamine; (1R)-N-((4′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine; and (1R)-N-((4-(methyloxy)-3-(1-methyl-4-piperidinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine.","lang":"en","source":"USPTO_FULLTEXT","data_format":"ORIGINAL"},{"text":"3. The compound of pharmaceutically acceptable salt thereof as set forth in claim 1 , wherein the compound is selected from the group consisting of: (1R)-N-((6-(methyloxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-N-((6-(methyloxy)-4′-((trifluoromethyl)oxy)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine; (1R)-1-(3-(methyloxy)phenyl)-N-((6-(methyloxy)-4′-((trifluoromethyl)oxy)-1,1′-biphenyl-3-yl)methyl)ethanamine; (1R)-N-((3-(1,3-benzoxazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine; (1R)-N-((3′,6-bis(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine; (1R)-N-((4-(methyloxy)-3-(1-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-N-((3-(1-methyl-1H-indazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-N-((3-(2-methyl-1,3-benzoxazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-N-((3-(1-methyl-1H-indazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine; N-1,N-1-dimethyl-N-2-(4-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-N-2-phenyl-1,2-ethanediamine; (1R)-N-((4-(methyloxy)-3-(2-methyl-1,3-thiazol-4-yl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-1-(3-(methyloxy)phenyl)-N-((6-(methyloxy)-3′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)ethanamine; (1R)-N-((6-chloro-3′-fluoro-3-biphenylyl)methyl)-1-(3-chlorophenyl)ethanamine; (1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(6-((2,2,2-trifluoroethyl)oxy)-3-pyridinyl)phenyl)methyl)ethanamine; (1R)-N-((4-(methyloxy)-3-(3-thienyl)phenyl)methyl)-1-phenylethanamine; (1R)-N-((6-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine; (1R)-N-((4-(methyloxy)-3-(1-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)methyl)-1-phenylethanamine; (1R)-N-((6-chloro-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(2-pyrazinyl)phenyl)methyl)ethanamine; (1R)-N-((4-chloro-3-(3-pyridinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-N-((4-(methyloxy)-3-(2-pyrazinyl)phenyl)methyl)-1-phenylethanamine; (1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(1,3-thiazol-2-yl)phenyl)methyl)ethanamine; (1R)-N-((6-fluoro-4′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine; (1R)-N-((3-(1-(cyclopropylmethyl)-1H-indol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine; (1R)-N-((3-(1-methyl-1H-benzimidazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine; N-1,N-1-dimethyl-N-2-(4-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)phenyl)-N-2-phenyl-1,2-ethanediamine; (1R)-N-((6-fluoro-4′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine; (1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(3-thienyl)phenyl)methyl)ethanamine; (1R)-N-((3-(1,3-benzodioxol-5-yl)phenyl)methyl)-1-phenylethanamine; (1R)-N-((4-(methyloxy)-3-(5-(methyloxy)-2-pyridinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine; and (1R)-N-((3-(3-furanyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine.","lang":"en","source":"USPTO_FULLTEXT","data_format":"ORIGINAL"},{"text":"4. A pharmaceutical composition comprising a compound as set forth in claim 1 or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable diluent or carrier.","lang":"en","source":"USPTO_FULLTEXT","data_format":"ORIGINAL"},{"text":"5. A pharmaceutical composition comprising a compound as set forth in claim 2 or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable diluent or carrier.","lang":"en","source":"USPTO_FULLTEXT","data_format":"ORIGINAL"},{"text":"6. A pharmaceutical composition comprising a compound as set forth in claim 3 or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable diluent or carrier.","lang":"en","source":"USPTO_FULLTEXT","data_format":"ORIGINAL"}]},"claim_lang":["en"],"has_claim":true,"description":{"en":{"text":"CROSS-REFERENCES TO RELATED APPLICATIONS This application is a continuation of U.S. Ser. No. 11/061,084, filed Feb. 18, 2005, which is a divisional of U.S. Ser. No. 10/444,946 filed on May 22, 2003, which claims the benefit of U.S. Ser. No. 60/441,065 filed Jan. 17, 2003 and U.S. Ser. No. 60/383,050 filed May 23, 2002, which are hereby incorporated by reference. BACKGROUND OF THE INVENTION Extracellular calcium ion concentration is involved in a variety of biological processes, such as blood clotting, nerve and muscle excitability and bone formation (Cell Calcium 11:319, 1990). Calcium ion receptors, which are present on the membranes of various cells in the body, such as parathyroid and kidney cells (Nature 366:574, 1993; J. Bone Miner. Res. 9, Supple. 1, s282, 1994; J. Bone Miner. Res. 9, Supple. 1, s409, 1994; Endocrinology 136:5202, 1995), are important to the regulation of the extracellular calcium ion concentration. For example, concentration of extracellular calcium ion regulates the bone resorption by osteoclasts (Bioscience Reports 10:493, 1990), secretion of parathyroid hormone (PTH) from parathyroid cells and secretion of calcitonin from C-cells (Cell Calcium 11:323, 1990). Parathyroid hormone (PTH) is an important factor in regulating extracellular calcium ion concentration. Secretion of PTH increases extracellular calcium ion concentration by acting on various cells, such as bone and kidney cells, and the extracellular calcium ion concentration reciprocally inhibits the secretion of PTH by acting on parathyroid cells. Several classes of calcimimetic compounds have been disclosed for regulating extracellular calcium ion concentration, particularly for reducing or inhibiting secretion of PTH. For example, U.S. Pat. Nos. 6,011,068 and 5,981,599 disclose arylalkylamines that are calcium receptor active molecules. EP 933354; WO 0021910, WO 96/12697; WO 95/11221; WO 94/18959; WO 93/04373; Endocrinology 128:3047, 1991; Biochem. Biophys. Res. Commun. 167:807, 1990; J. Bone Miner. Res. 5:581, 1990; and Nemeth et al., “Calcium-binding Proteins in Health and Disease,” Academix Press, Inc., pp. 33-35 (1987) disclose various agents that interact with calcium receptors. Dauban et al., Bioorg. Med. Chem. Let. 10:2001-4, 2000, disclose various N1-arylsulfonyl-N2-(1-aryl)ethyl-3-phenylpropane-1,2-diamine compounds as calcimimetics acting on the calcium sensing receptor. Oikawa et al., in U.S. Pat. No. 6,403,832, and publication No. US2002/143212, describes aryl amine compounds useful as chiral intermediates in the synthesis of optically active propionic acid derivatives. Chassot et al., U.S. Pat. No. 6,436,152, describes arylalkylamine compounds useful as hair dye precursor compounds. Bös et al., U.S. Pat. No. 6,407,111, describes phenyl substituted pyridine and benzene derivates that are antagonistic to the NK-1 receptor. SUMMARY OF THE INVENTION The present invention relates to selected calcimimetic compounds and pharmaceutically acceptable salts thereof. The invention compounds advantageously reduce or inhibit PTH secretion. Therefore, this invention also encompasses pharmaceutical compositions, methods for reducing or inhibiting PTH secretion and methods for treatment or prophylaxis of diseases associated with bone disorders, such as osteoporosis, or associated with excessive secretion of PTH, such as hyperparathyroidism. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes. The compounds of the invention are represented by the following general structure: or a pharmaceutically acceptable salt thereof, wherein the variables are defined below. The foregoing merely summarizes certain aspects of the invention and is not intended, nor should it be construed, as limiting the invention in any way. All patents, patent applications and other publications recited herein are hereby incorporated by reference in their entirety. DETAILED DESCRIPTION The invention provides compounds of Formula (I): or a pharmaceutically acceptable salt thereof, wherein: R 1 is aryl, substituted aryl, heterocyclyl, substituted heterocyclyl, cycloalkyl, or substituted cycloalkyl;R 2 is alkyl or haloalkyl;R 3 is H, alkyl, or haloalkyl;R 4 is H, alkyl, or haloalkyl;each R 5 present is independently selected from the group consisting of alkyl, substituted alkyl, alkoxy, substituted alkoxy, halogen, —C(═O)OH, —CN, —NR d S(═O) m R d , —NR d C(═O)NR d R d , —NR d S(═O) m NR d R d , or —NR d C(═O)R d ;R 6 is aryl, substituted aryl, heterocyclyl, substituted heterocyclyl, cycloalkyl, or substituted cycloalkyl; each R a is, independently, H, alkyl or haloalkyl;each R b is, independently, aryl, aralkyl, heterocyclyl, or heterocyclylalkyl, each of which may be unsubstituted or substituted by up to 3 substituents selected from the group consisting of alkyl, halogen, haloalkyl, alkoxy, cyano, and nitro;each R c is, independently, alkyl, haloalkyl, phenyl or benzyl, each of which may be substituted or unsubstituted;each R d is, independently, H, alkyl, aryl, aralkyl, heterocyclyl, or heterocyclylalkyl wherein the alkyl, aryl, aralkyl, heterocyclyl, and heterocyclylalkyl are substituted by 0, 1, 2, 3 or 4 substituents selected from alkyl, halogen, haloalkyl, alkoxy, cyano, nitro, R b , —C(═O)R c , —OR b , —NR a R a , —NR a R b , —C(═O)OR c , C(═O)NR a R a , —OC(═O)R c , —NR a C(═O)R c , —NR a S(═O) n R c and —S(═O) n NR a R a ;m is 1 or 2;n is 0, 1 or 2; andp is 0, 2, 3, or 4; provided that if R 2 is methyl, p is 0, and R 6 is unsubstituted phenyl, then R 1 is not 2,4-dihalophenyl, 2,4-dimethylphenyl, 2,4-diethylphenyl, 2,4,6-trihalophenyl, or 2,3,4-trihalophenyl. Another aspect of the invention relates to compounds having the general structure II: or a pharmaceutically acceptable salt thereof, wherein: R 1 is phenyl, benzyl, naphthyl or a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 atoms selected from N, O and S, with no more than 2 of the atoms selected from O and S, wherein the phenyl, benzyl or heterocycle are substituted by 0, 1, 2 or 3 substituents selected from C 1-6 alkyl, halogen, C 1-4 haloalkyl, —OC 1-6 alkyl, cyano and nitro; R 2 is C 1-8 alkyl or C 1-4 haloalkyl; R 3 is H, C 1-4 haloalkyl or C 1-8 alkyl; R 4 is H, C 1-4 haloalkyl or C 1-8 alkyl; R 5 is, independently, in each instance, H, C 1-8 alkyl, C 1-4 haloalkyl, halogen, cyano, —NR a R d , —NS(═O) 2 R c , —NR a C(═O)NR a R d , —NR d C(═O)R d or —OC 1-6 alkyl substituted by 0, 1, 2 or 3 substituents selected from halogen, —OC 1-6 alkyl, —NR a R d , —NS(═O) 2 R c , —NR a C(═O)NR a R d , —NR d C(═O)R d or cyano; R 6 is phenyl, benzyl, naphthyl, a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 atoms selected from N, O and S, with no more than 2 of the atoms selected from O and S, or a saturated or unsaturated 8-, 9-, 10- or 11-membered heterobicycle containing 1, 2, 3, 4 or 5 atoms selected from N, O and S, with no more than 2 of the atoms selected from O and S, wherein the phenyl, benzyl, naphthyl, heterocycle and heterobicycle are substituted by 0, 1, 2 or 3 substituents selected from C 1-6 alkyl, halogen, C 1-4 haloalkyl, —OC 1-6 alkyl, —OC 1-4 haloalkyl, —NR a R a , —NR a C(═O)C 1-6 alkyl, —S(═O) n C 1-6 alkyl, cyano and nitro; R a is, independently, at each instance, H, C 1-4 haloalkyl or C 1-6 alkyl; R b is, independently, aryl, aralkyl, heterocyclyl, or heterocyclylalkyl, each of which may be unsubstituted or substituted by up to 3 substituents selected from the group consisting of alkyl, halogen, haloalkyl, alkoxy, cyano, and nitro; R c is, independently, at each instance, C 1-6 alkyl, C 1-4 haloalkyl, phenyl or benzyl; R d is, independently, at each instance, H, C 1-6 alkyl, phenyl, benzyl or a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 atoms selected from N, O and S, with no more than 2 of the atoms selected from O and S, wherein the C 1-6 alkyl, phenyl, benzyl, naphthyl and heterocycle are substituted by 0, 1, 2, 3 or 4 substituents selected from C 1-6 alkyl, halogen, C 1-4 haloalkyl, —OC 1-6 alkyl, cyano and nitro, R b , —C(═O)R c , —OR b , —NR a R a , NR a R b , —C(═O)OR c , —C(═O)NR a R a , —OC(═O)R c , —NR a C(═O)R c , —NR a S(═O) m R c and —S(═O) m NR a R a ; m is 1 or 2; n is 0, 1 or 2; and p is 0, 1, 2, 3 or 4. In one embodiment, in conjunction with any one of the above and below embodiments, R 1 is phenyl substituted by 0, 1, 2 or 3 substituents selected from C 1-6 alkyl, halogen, C 1-4 haloalkyl, —OC 1-6 alkyl, cyano and nitro. In another embodiment, in conjunction with any one of the above and below embodiments, R 1 is benzyl substituted by 0, 1, 2 or 3 substituents selected from C 1-6 alkyl, halogen, C 1-4 haloalkyl, —OC 1-6 alkyl, cyano and nitro. In another embodiment, in conjunction with any one of the above and below embodiments, R 1 is naphthyl substituted by 0, 1, 2 or 3 substituents selected from C 1-6 alkyl, halogen, C 1-4 haloalkyl, —OC 1-6 alkyl, cyano and nitro. In another embodiment, in conjunction with any one of the above and below embodiments, R 1 a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 atoms selected from N, O and S, with no more than 2 of the atoms selected from O and S, wherein the heterocycle is substituted by 0, 1, 2 or 3 substituents selected from C 1-6 alkyl, halogen, C 1-4 haloalkyl, —OC 1-6 alkyl, cyano and nitro. In another embodiment, in conjunction with any one of the above and below embodiments, R 6 is phenyl, wherein the phenyl is substituted by 0, 1, 2 or 3 substituents selected from C 1-6 alkyl, halogen, C 1-4 haloalkyl, —OC 1-6 alkyl, —OC 1-4 haloalkyl, —NR a R a , —NR a C(═O)C 1-6 alkyl, —S(═O) n C 1-6 alkyl, cyano and nitro. In another embodiment, in conjunction with any one of the above and below embodiments, R 6 is benzyl, wherein the benzyl is substituted by 0, 1, 2 or 3 substituents selected from C 1-6 alkyl, halogen, C 1-4 haloalkyl, —OC 1-6 alkyl, —OC 1-4 haloalkyl, —NR a R a , —NR a C(═O)C 1-6 alkyl, —S(═O) n C 1-6 alkyl, cyano and nitro. In another embodiment, in conjunction with any one of the above and below embodiments, R 6 is naphthyl, wherein the naphthyl is substituted by 0, 1, 2 or 3 substituents selected from C 1-6 alkyl, halogen, C 1-4 haloalkyl, —OC 1-6 alkyl, —OC 1-4 haloalkyl, —NR a R a , —NR a C(═O)C 1-6 alkyl, —S(═O) n C 1-6 alkyl, cyano and nitro. In another embodiment, in conjunction with any one of the above and below embodiments, R 6 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 atoms selected from N, O and S, with no more than 2 of the atoms selected from O and S, wherein the heterocycle is substituted by 0, 1, 2 or 3 substituents selected from C 1-6 alkyl, halogen, C 1-4 haloalkyl, —OC 1-6 alkyl, —OC 1-4 haloalkyl, —NR a R a , —NR a C(═O)C 1-6 alkyl, —S(═O) n C 1-6 alkyl, cyano and nitro. In another embodiment, in conjunction with any one of the above and below embodiments, R 6 is a saturated or unsaturated 8-, 9-, 10- or 11-membered heterobicycle containing 1, 2, 3, 4 or 5 atoms selected from N, O and S, with no more than 2 of the atoms selected from O and S, wherein the heterobicycle is substituted by 0, 1, 2 or 3 substituents selected from C 1-6 alkyl, halogen, C 1-4 haloalkyl, —OC 1-6 alkyl, —OC 1-4 haloalkyl, —NR a R a , —NR a C(═O)C 1-6 alkyl, —S(═O) n C 1-6 alkyl, cyano and nitro. In another embodiment, in conjunction with any one of the above and below embodiments, R 1 is phenyl, naphthyl or (OC 1-4 alkyl)phenyl. In another embodiment, in conjunction with any one of the above and below embodiments, R 1 is phenyl substituted by 2 or 3 substituents selected from C 1-6 alkyl, halogen, C 1-4 haloalkyl, —OC 1-6 alkyl, cyano and nitro. In another embodiment, in conjunction with any one of the above and below embodiments, R 1 is benzyl substituted by 1, 2 or 3 substituents selected from C 1-6 alkyl, halogen, C 1-4 haloalkyl, —OC 1-6 alkyl, cyano and nitro. In another embodiment, in conjunction with any one of the above and below embodiments, R 1 is naphthyl substituted by 1, 2 or 3 substituents selected from C 1-6 alkyl, halogen, C 1-4 haloalkyl, —OC 1-6 alkyl, cyano and nitro. In another embodiment, in conjunction with any one of the above and below embodiments, R 1 a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 atoms selected from N, O and S, with no more than 2 of the atoms selected from O and S, wherein the heterocycle is substituted by 1, 2 or 3 substituents selected from C 1-6 alkyl, halogen, C 1-4 haloalkyl, —OC 1-6 alkyl, cyano and nitro. In another embodiment, in conjunction with any one of the above and below embodiments, one of R 3 or R 4 is C 1-4 haloalkyl or C 1-8 alkyl. In another embodiment, in conjunction with any one of the above and below embodiments, R 5 is C 1-8 alkyl, C 1-4 haloalkyl, halogen or —OC 1-6 alkyl. In another embodiment, in conjunction with any one of the above and below embodiments, R 6 is phenyl, wherein the phenyl is substituted by 1, 2 or 3 substituents selected from C 1-6 alkyl, halogen, C 1-4 haloalkyl, —OC 1-6 alkyl, —OC 1-4 haloalkyl, —NR a R a , —NR a C(═O)C 1-6 alkyl, —S(═O) n C 1-6 alkyl, cyano and nitro. In another embodiment, in conjunction with any one of the above and below embodiments, R 6 is benzyl, wherein the benzyl is substituted by 1, 2 or 3 substituents selected from C 1-6 alkyl, halogen, C 1-4 haloalkyl, —OC 1-6 alkyl, —OC 1-4 haloalkyl, —NR a R a , —NR a C(═O)C 1-6 alkyl, —S(═O) n C 1-6 alkyl, cyano and nitro. In another embodiment, in conjunction with any one of the above and below embodiments, R 6 is naphthyl, wherein the naphthyl is substituted by 0, 1, 2 or 3 substituents selected from C 1-6 alkyl, halogen, C 1-4 haloalkyl, —OC 1-6 alkyl, —OC 1-4 haloalkyl, —NR a R a , —NR a C(═O)C 1-6 alkyl, —S(═O) n C 1-6 alkyl, cyano and nitro. In another embodiment, in conjunction with any one of the above and below embodiments, R 6 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 atoms selected from N, O and S, with no more than 2 of the atoms selected from O and S, wherein the heterocycle is substituted by 1, 2 or 3 substituents selected from C 1-6 alkyl, halogen, C 1-4 haloalkyl, —OC 1-6 alkyl, —OC 1-4 haloalkyl, —NR a R a , —NR a C(═O)C 1-6 alkyl, —S(═O) n C 1-6 alkyl, cyano and nitro. In another embodiment, in conjunction with any one of the above and below embodiments, R 6 is a saturated or unsaturated 8-, 9-, 10- or 11-membered heterobicycle containing 1, 2, 3, 4 or 5 atoms selected from N, O and S, with no more than 2 of the atoms selected from O and S, wherein the heterobicycle is substituted by 1, 2 or 3 substituents selected from C 1-6 alkyl, halogen, C 1-4 haloalkyl, —OC 1-6 alkyl, —OC 1-4 haloalkyl, —NR a R a , —NR a C(═O)C 1-6 alkyl, —S(═O) n C 1-6 alkyl, cyano and nitro. Another aspect of the invention involves a pharmaceutical composition comprising a pharmaceutically acceptable amount of a compound according to any one of the above embodiments and a pharmaceutically acceptable diluent or carrier. Another aspect of the inventions involve the use of a compound according to any one of the above embodiments as a medicament. Another aspect of the invention involves the use of a compound according to any one of the above embodiments in the manufacture of a medicament for the treatment of diseases associated with bone disorders or associated with excessive secretion of PTH. Another aspect of the invention involves the use of a compound according to any one of the above embodiments in the manufacture of a medicament for the treatment of osteoporosis or hyperparathyroidism. Another aspect of the invention involves a method of using a compound according to any one of the above embodiments for the treatment of diseases associated with bone disorders or associated with excessive secretion of PTH. Another aspect of the invention involves a method of using a compound according to any one of the above embodiments for the treatment of osteoporosis or hyperparathyroidism. Another aspect of the invention involves a process for making a compound according to claim 1 wherein R 3 and R 4 are both hydrogen comprising the steps of: placing a compound having the structure in the presence of acid followed by treatment with a hydride and methanol to form reacting the resulting alcohol with R 6 —B(OH) 2 to form oxidizing the alcohol to form and reacting the aldehyde with an amine having the structure Unless otherwise specified, the following definitions apply to terms found in the specification and claims: “Alkyl” and the prefix “alk-” refer to alkyl groups or substituents wherein the carbon atoms are in a branched, cyclical or linear relationship or any combination of the three. The alkyl groups described in this section contain from 1 to 10 carbon atoms unless otherwise specified and may also contain a double or triple bond. “C V-W alkyl” means an alkyl group comprising from V to W carbon atoms. Examples of C 1-6 alkyl include, but are not limited to the following: “Aryl” means a carbocyclic aromatic ring or ring system. Examples of aryl groups include phenyl, naphthyl, indenyl, fluorenyl, biphenyl, anthracenyl, 9-(9-phenylfluorenyl), phenanthrenyl, and the like. “Halogen” means a halogen atom selected from F, Cl, Br and I. “Haloalkyl”, “haloalk-” and “C V-W haloalkyl” mean an alkyl group, as described above, wherein any number—at least one—of the hydrogen atoms attached to the alkyl group or chain are replaced by F, Cl, Br or I. “Heterocycle” means a ring or ring system comprising at least one carbon atom and at least one other atom selected from N, O and S. Heterocyclic groups can be saturated, unsaturated or aromatic. Aromatic heterocyclic groups are also referred to as “heteroaryl” rings or ring systems. Examples of heterocycles that may be found in the claims include, but are not limited to, the following: Unless otherwise specified, the term “substituted” means that a group is substituted by one or more substituents independently selected from the group consisting of hydroxy, alkyl, alkoxy, alkylthio, halogen, haloalkyl, haloalkoxy, alkylcarbonyl, haloalkylcarbonyl, arylcarbonyl, heterocyclylcarbonyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, —CN, —C(═O)OH, alkoxycarbonyl, alkanoyloxy, alkanoylthio, nitro, —N(R a ) 2 , —N(R a )(R b ), NR d S(═N) 2 R d , —NR d C(═O)NR d R d , —NR d S(═O) 2 NR d R d , or —NR d C(═O)R d and, in the case of heterocyclyl cycloalkyl groups, oxo. Preferred compounds include: (1R)-N-((6-fluoro-4′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(4-(methyloxy)phenyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(6-(methyloxy)-3-pyridinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((3′,6-bis(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;(1R)-N-((3′,6-bis(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(6-(trifluoromethyl)-3-pyridinyl)phenyl)methyl)-1-phenylethanamine;(1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(6-(trifluoromethyl)-3-pyridinyl)phenyl)methyl)ethanamine;(1R)-N-((3-(1-methyl-1H-indol-6-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((3-(1-methyl-1H-indol-6-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine;(1R)-N-((4-(methyloxy)-3-(6-((2,2,2-trifluoroethyl)oxy)-3-pyridinyl)phenyl)methyl)-1-phenylethanamine;(1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(6-((2,2,2-trifluoroethyl)oxy)-3-pyridinyl)phenyl)methyl)ethanamine;(1R)-N-((3-(1-methyl-1H-benzimidazol-2-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((3-(6-(ethyloxy)-3-pyridinyl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine;(1R)-N-((3-(6-(ethyloxy)-3-pyridinyl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(1H-pyrrol-1-yl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(1-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;(1R)-N-((3-(1-methyl-1H-indazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((3-(1-methyl-1H-indazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine;(1R)-1-(3-(methyloxy)phenyl)-N-((6-(methyloxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(1H-pyrrol-1-yl)phenyl)methyl)-1-phenylethanamine;(1R)-N-((4-(methyloxy)-3-(4-(methyloxy)-2-pyridinyl)phenyl)methyl)-1-phenylethanamine;ethyl 4-(2-(methyloxy)-5-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-3,6-dihydro-1(2H)-pyridinecarboxylate;(1R)-N-((6-(methyloxy)-3′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine;(1R)-N-((3-(3-furanyl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((3-(2,2-difluoro-1,3-benzodioxol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((3-(2,2-difluoro-1,3-benzodioxol-5-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine;(1R)-N-((3-(2,2-difluoro-1,3-benzodioxol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;(1R)-N-((3-(3-furanyl)-4-(methyloxy)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;(1R)-N-((6-chloro-4′-((trifluoromethyl)oxy)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine;(1R)-N-((6-chloro-4′-((trifluoromethyl)oxy)-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(6-quinolinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(6-quinolinyl)phenyl)methyl)-1-phenylethanamine;(1R)-N-((3-(2,1,3-benzoxadiazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(1-(2,2,2-trifluoroethyl)-1H-indol-5-yl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((4-chloro-3-(6-((2,2,2-trifluoroethyl)oxy)-3-pyridinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((3-(2,1,3-benzoxadiazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;(1R)-N-((3-(2,1,3-benzoxadiazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine;(1R)-N-((3-(2,3-dihydro-1-benzofuran-5-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine;(1R)-N-((3-(2,3-dihydro-1-benzofuran-5-yl)-4-(methyloxy)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;(1R)-N-((3-(2,3-dihydro-1-benzofuran-5-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((4′-fluoro-6-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(3-fluorophenyl)ethanamine;(1R)-N-((4′,6-bis(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;(1R)-N-((3-(2,1,3-benzothiadiazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine;(1R)-N-((3-(2,1,3-benzothiadiazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;(1R)-N-((3-(1-benzothien-3-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine;1-(3-fluorophenyl)-N-((6-(methyloxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)ethanamine;1-(3-bromophenyl)-N-((6-(methyloxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)ethanamine;1-(3,5-difluorophenyl)-N-((6-(methyloxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)ethanamine;(1R)-N-((3-(1,3-benzothiazol-2-yl)-4-(methyloxy)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;(1R)-N-((6-chloro-4′-((trifluoromethyl)oxy)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((4′-chloro-6-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine;(1R)-N-((4-(methyloxy)-3-(6-quinoxalinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((6-(methyloxy)-3′-((trifluoromethyl)oxy)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine;(1R)-N-((6-iodo-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((6-iodo-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;(1R)-N-((4′-chloro-6-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((3-(2-methyl-1,3-oxazol-4-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine;(1R)-N-((3-(2-methyl-1,3-oxazol-4-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;ethyl 2′-(methyloxy)-5′-((((1R)-1-phenylethyl)amino)methyl)-1,1′-biphenyl-4-carboxylate;ethyl 2′-(methyloxy)-5′-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)-1,1′-biphenyl-4-carboxylate;4-(2-(methyloxy)-5-((((1R)-1-phenylethyl)amino)methyl)phenyl)-1,3-thiazol-2-amine;(1R)-N-((3-(1-(cyclopropylmethyl)-1H-indol-5-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine;(1R)-N-((6-(methyloxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine;(1R)-N-((3-(1-(cyclopropylmethyl)-1H-indol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(2-((tetrahydro-2-furanylmethyl)oxy)-3-pyridinyl)phenyl)methyl)-1-phenylethanamine;(1R)-N-((3-(2-fluoro-3-pyridinyl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine;N,N-dimethyl-5-(2-(methyloxy)-5-((((1R)-1-phenylethyl)amino)methyl)phenyl)-2-pyridinamine;(1R)-N-((4-(methyloxy)-3-(1-methyl-2-(trifluoromethyl)-1H-benzimidazol-5-yl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(1-methyl-2-(trifluoromethyl)-1H-benzimidazol-5-yl)phenyl)methyl)-1-phenylethanamine;(1R)-N-((4-(methyloxy)-3-(2-thienyl)phenyl)methyl)-1-phenylethanamine;(1R)-N-((4-(methyloxy)-3-(2-thienyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(2-thienyl)phenyl)methyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(6-methyl-3-pyridinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(2-pyridinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((3-(1,3-benzoxazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((3-(2-methyl-1,3-benzoxazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine;2′-(methyloxy)-5′-((((1R)-1-phenylethyl)amino)methyl)-1,1′-biphenyl-3-carbonitrile;(1R)-N-((6-(methyloxy)-4′-((trifluoromethyl)oxy)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-1-(3-fluorophenyl)-N-((6-(methyloxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)ethanamine;(1R)-N-((6-(ethyloxy)-4′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine;(1R)-N-((4-(methyloxy)-3-(3-pyridinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(6-(trifluoromethyl)-3-pyridinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(6-((2,2,2-trifluoroethyl)oxy)-3-pyridinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-1-(3-chlorophenyl)-N-((6-(methyloxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)ethanamine(1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(3-pyridinyl)phenyl)methyl)ethanamine;2′-(methyloxy)-5′-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)-1,1′-biphenyl-3-carbonitrile;(1R)-N-((2′-fluoro-1,1′-biphenyl-3-yl)methyl)-1-(4-methylphenyl)ethanamine;(1R)-N-((6-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(4-methylphenyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(6-(methyloxy)-3-pyridazinyl)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(2-pyrazinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(6-((tetrahydro-2-furanylmethyl)oxy)-3-pyridinyl)phenyl)methyl)-1-phenylethanamine;(1R)-N-((4-(methyloxy)-3-(2-(4-morpholinyl)-3-pyridinyl)phenyl)methyl)-1-phenylethanamine;(1R)-N-((3-(1-methyl-1H-imidazol-4-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(1-pyrrolidinyl)phenyl)methyl)-1-phenylethanamine;ethyl 2′-(methyloxy)-5′-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)-1,1′-biphenyl-4-carboxylate;N-((6-(methyloxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-(3-methylphenyl)ethanamine;(1R)-N-((6-fluoro-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine;N,N-dimethyl-2′-(methyloxy)-5′-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)-1,1′-biphenyl-4-carboxamide;N,N-dimethyl-2′-(methyloxy)-5′-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)-1,1′-biphenyl-4-carboxamide;N,N-dimethyl-2′-(methyloxy)-5′-((((1R)-1-phenylethyl)amino)methyl)-1,1′-biphenyl-4-carboxamide;(1R)-N-((6-iodo-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine;(1R)-N-((6-(methyloxy)-3′-((trifluoromethyl)oxy)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-1-(3-(methyloxy)phenyl)-N-((6-(methyloxy)-3′-((trifluoromethyl)oxy)-1,1′-biphenyl-3-yl)methyl)ethanamine;(1R)-N-((4′-chloro-6-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;(1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(2-((2,2,2-trifluoroethyl)oxy)-5-pyrimidinyl)phenyl)methyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(6-quinoxalinyl)phenyl)methyl)-1-phenylethanamine;(1R)-N-((3-(1,3-benzothiazol-2-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine;(1R)-N-((6-((2-(methyloxy)ethyl)oxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(2-naphthalenyl)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(2-naphthalenyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(2-naphthalenyl)phenyl)methyl)-1-phenylethanamine;(1R)-N-((6-chloro-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine;(1R)-N-((4-(methyloxy)-3-(1-(2,2,2-trifluoroethyl)-1H-indol-5-yl)phenyl)methyl)-1-phenylethanamine;(1R)-N-((6-((2-(methyloxy)ethyl)oxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((6-((2-(methyloxy)ethyl)oxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine;(1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(6-quinolinyl)phenyl)methyl)ethanamine;2′-(methyloxy)-5′-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)-1,1′-biphenyl-3-carboxamide;(1R)-1-(1-naphthalenyl)-N-((3-(6-(trifluoromethyl)-3-pyridinyl)phenyl)methyl)ethanamine;(1R)-N-((3-(3-furanyl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine;(1R)-N-((6-(methyloxy)-3′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(2-methyl-1,3-thiazol-4-yl)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;(1R)-N-((4-((difluoromethyl)oxy)-3-(3-pyridinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((3-(2-methyl-2H-indazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((4-chloro-3-(3-pyridinyl)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;(1R)-N-((3-(2-ethyl-2H-1,2,3-benzotriazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine; and(1R)-N-((4′,6-difluoro-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine Compounds of the present invention can possess one or more asymmetric carbon atoms and are thus capable of existing in the form of optical isomers as well as in the form of racemic or non-racemic mixtures thereof. The optical isomers can be obtained by resolution of the racemic mixtures according to conventional processes, e.g., by formation of diastereoisomeric salts, by treatment with an optically active acid or base. Examples of appropriate acids are tartaric, diacetyltartaric, dibenzoyltartaric, ditoluoyltartaric, and camphorsulfonic acid and then separation of the mixture of diastereoisomers by crystallization followed by liberation of the optically active bases from these salts. A different process for separation of optical isomers involves the use of a chiral chromatography column optimally chosen to maximize the separation of the enantiomers. Still another available method involves synthesis of covalent diastereoisomeric molecules by reacting compounds of the invention with an optically pure acid in an activated form or an optically pure isocyanate. The synthesized diastereoisomers can be separated by conventional means such as chromatography, distillation, crystallization or sublimation, and then hydrolyzed to deliver the enantiomerically pure compound. The optically active compounds of the invention can likewise be obtained by using active starting materials. These isomers may be in the form of a free acid, a free base, an ester or a salt. The (R) isomer is generally preferred. Likewise, the compounds of this invention may exist as isomers, that is compounds of the same molecular formula but in which the atoms, relative to one another, are arranged differently. In particular, the alkylene substituents of the compounds of this invention, are normally and preferably arranged and inserted into the molecules as indicated in the definitions for each of these groups, being read from left to right. However, in certain cases, one skilled in the art will appreciate that it is possible to prepare compounds of this invention in which these substituents are reversed in orientation relative to the other atoms in the molecule. That is, the substituent to be inserted may be the same as that noted above except that it is inserted into the molecule in the reverse orientation. One skilled in the art will appreciate that these isomeric forms of the compounds of this invention are to be construed as encompassed within the scope of the present invention. The compounds of the present invention can be used in the form of pharmaceutically acceptable salts derived from inorganic or organic acids. The salts include, but are not limited to, the following: acetate, adipate, alginate, citrate, aspartate, benzoate, benzenesulfonate, bisulfate, butyrate, camphorate, camphorsulfonate, digluconate, cyclopentanepropionate, dodecylsulfate, ethanesulfonate, glucoheptanoate, glycerophosphate, hemisulfate, heptanoate, hexanoate, fumarate, hydrochloride, hydrobromide, hydroiodide, 2-hyroxy-ethanesulfonate, lactate, maleate, mandelate, methansulfonate, nicotinate, 2-naphthalenesulfonate, oxalate, palmoate, pectinate, persulfate, 2-phenylpropionate, picrate, pivalate, propionate, salicylate, succinate, sulfate, tartrate, thiocyanate, tosylate, mesyl ate, and undecanoate. Other examples include salts with alkali metals or alkaline earth metals, such as sodium, potassium, calcium or magnesium or with organic bases. When compounds of the invention include an acidic function such as a carboxy group, then suitable pharmaceutically acceptable cation pairs for the carboxy group are well known to those skilled in the art and include alkaline, alkaline earth, ammonium, quaternary ammonium cations and the like. For additional examples of “pharmacologically acceptable salts,” see infra and Berge et al., J. Pharm. Sci. 66:1 (1977). Also, the basic nitrogen-containing groups can be quaternized with such agents as lower alkyl halides, such as methyl, ethyl, propyl, and butyl chloride, bromides and iodides; dialkyl sulfates like dimethyl, diethyl, dibutyl, and diamyl sulfates, long chain halides such as decyl, lauryl, myristyl and stearyl chlorides, bromides and iodides, aralkyl halides like benzyl and phenethyl bromides, and others. Water or oil-soluble or dispersible products are thereby obtained. Also encompassed in the scope of the present invention are pharmaceutically acceptable esters of a carboxylic acid or hydroxyl containing group, including a metabolically labile ester or a prodrug form of a compound of this invention. A metabolically labile ester is one which may produce, for example, an increase in blood levels and prolong the efficacy of the corresponding non-esterified form of the compound. A prodrug form is one which is not in an active form of the molecule as administered but which becomes therapeutically active after some in vivo activity or biotransformation, such as metabolism, for example, enzymatic or hydrolytic cleavage. For a general discussion of prodrugs involving esters see Svensson and Tunek Drug Metabolism Reviews 165 (1988) and Bundgaard Design of Prodrugs, Elsevier (1985). Examples of a masked carboxylate anion include a variety of esters, such as alkyl (for example, methyl, ethyl), cycloalkyl (for example, cyclohexyl), aralkyl (for example, benzyl, p-methoxybenzyl), and alkylcarbonyloxyalkyl (for example, pivaloyloxymethyl). Amines have been masked as arylcarbonyloxymethyl substituted derivatives which are cleaved by esterases in vivo releasing the free drug and formaldehyde (Bungaard J. Med. Chem. 2503 (1989)). Also, drugs containing an acidic NH group, such as imidazole, imide, indole and the like, have been masked with N-acyloxymethyl groups (Bundgaard Design of Prodrugs, Elsevier (1985)). Hydroxy groups have been masked as esters and ethers. EP 039,051 (Sloan and Little, Apr. 11, 1981) discloses Mannich-base hydroxamic acid prodrugs, their preparation and use. Esters of a compound of this invention, may include, for example, the methyl, ethyl, propyl, and butyl esters, as well as other suitable esters formed between an acidic moiety and a hydroxyl containing moiety. Metabolically labile esters, may include, for example, methoxymethyl, ethoxymethyl, iso-propoxymethyl, α-methoxyethyl, groups such as α-((C 1 -C 4 )alkyloxy)ethyl; for example, methoxyethyl, ethoxyethyl, propoxyethyl, iso-propoxyethyl, etc.; 2-oxo-1,3-dioxolen-4-ylmethyl groups, such as 5-methyl-2-oxo-1,3,dioxolen-4-ylmethyl, etc.; C 1 -C 3 alkylthiomethyl groups, for example, methylthiomethyl, ethylthiomethyl, isopropylthiomethyl, etc.; acyloxymethyl groups, for example, pivaloyloxymethyl, α-acetoxymethyl, etc.; ethoxycarbonyl-1-methyl; or α-acyloxy-α-substituted methyl groups, for example α-acetoxyethyl. Further, the compounds of the invention may exist as crystalline solids which can be crystallized from common solvents such as ethanol, N,N-dimethyl-formamide, water, or the like. Thus, crystalline forms of the compounds of the invention may exist as solvates and/or hydrates of the parent compounds or their pharmaceutically acceptable salts. All of such forms likewise are to be construed as falling within the scope of the invention. “Leaving group” generally refers to groups readily displaceable by a nucleophile, such as an amine, a thiol or an alcohol nucleophile. Such leaving groups are well known in the art. Examples of such leaving groups include, but are not limited to, N-hydroxysuccinimide, N-hydroxybenzotriazole, halides, triflates, tosylates and the like. Preferred leaving groups are indicated herein where appropriate. “Protecting group” generally refers to groups well known in the art which are used to prevent selected reactive groups, such as carboxy, amino, hydroxy, mercapto and the like, from. undergoing undesired reactions, such as nucleophilic, electrophilic, oxidation, reduction and the like. Preferred protecting groups are indicated herein where appropriate. Examples of amino protecting groups include, but are not limited to, aralkyl, substituted aralkyl, cycloalkenylalkyl and substituted cycloalkenyl alkyl, allyl, substituted allyl, acyl, alkoxycarbonyl, aralkoxycarbonyl, silyl and the like. Examples of aralkyl include, but are not limited to, benzyl, ortho-methylbenzyl, trityl and benzhydryl, which can be optionally substituted with halogen, alkyl, alkoxy, hydroxy, nitro, acylamino, acyl and the like, and salts, such as phosphonium and ammonium salts. Examples of aryl groups include phenyl, naphthyl, indanyl, anthracenyl, 9-(9-phenylfluorenyl), phenanthrenyl, durenyl and the like. Examples of cycloalkenylalkyl or substituted cycloalkylenylalkyl radicals, preferably have 6-10 carbon atoms, include, but are not limited to, cyclohexenyl methyl and the like. Suitable acyl, alkoxycarbonyl and aralkoxycarbonyl groups include benzyloxycarbonyl, t-butoxycarbonyl, iso-butoxycarbonyl, benzoyl, substituted benzoyl, butyryl, acetyl, tri-fluoroacetyl, tri-chloro acetyl, phthaloyl and the like. A mixture of protecting groups can be used to protect the same amino group, such as a primary amino group can be protected by both an aralkyl group and an aralkoxycarbonyl group. Amino protecting groups can also form a heterocyclic ring with the nitrogen to which they are attached, for example, 1,2-bis(methylene)benzene, phthalimidyl, succinimidyl, maleimidyl and the like and where these heterocyclic groups can further include adjoining aryl and cycloalkyl rings. In addition, the heterocyclic groups can be mono-, di- or tri-substituted, such as nitrophthalimidyl. Amino groups may also be protected against undesired reactions, such as oxidation, through the formation of an addition salt, such as hydrochloride, toluenesulfonic acid, trifluoroacetic acid and the like. Many of the amino protecting groups are also suitable for protecting carboxy, hydroxy and mercapto groups. For example, aralkyl groups. Alkyl groups are also suitable groups for protecting hydroxy and mercapto groups, such as tert-butyl. Silyl protecting groups are silicon atoms optionally substituted by one or more alkyl, aryl and aralkyl groups. Suitable silyl protecting groups include, but are not limited to, trimethylsilyl, triethylsilyl, tri-isopropylsilyl, tert-butyldimethylsilyl, dimethylphenylsilyl, 1,2-bis(dimethylsilyl)benzene, 1,2-bis(dimethylsilyl)ethane and diphenylmethylsilyl. Silylation of an amino groups provide mono- or di-silylamino groups. Silylation of aminoalcohol compounds can lead to a N,N,O-tri-silyl derivative. Removal of the silyl function from a silyl ether function is readily accomplished by treatment with, for example, a metal hydroxide or ammonium fluoride reagent, either as a discrete reaction step or in situ during a reaction with the alcohol group. Suitable silylating agents are, for example, trimethylsilyl chloride, tert-butyl-dimethylsilyl chloride, phenyldimethylsilyl chloride, diphenylmethyl silyl chloride or their combination products with imidazole or DMF. Methods for silylation of amines and removal of silyl protecting groups are well known to those skilled in the art. Methods of preparation of these amine derivatives from corresponding amino acids, amino acid amides or amino acid esters are also well known to those skilled in the art of organic chemistry including amino acid/amino acid ester or aminoalcohol chemistry. Protecting groups are removed under conditions which will not affect the remaining portion of the molecule. These methods are well known in the art and include acid hydrolysis, hydrogenolysis and the like. A preferred method involves removal of a protecting group, such as removal of a benzyloxycarbonyl group by hydrogenolysis utilizing palladium on carbon in a suitable solvent system such as an alcohol, acetic acid, and the like or mixtures thereof. A t-butoxycarbonyl protecting group can be removed utilizing an inorganic or organic acid, such as HCl or trifluoroacetic acid, in a suitable solvent system, such as dioxane or methylene chloride. The resulting amino salt can readily be neutralized to yield the free amine. Carboxy protecting group, such as methyl, ethyl, benzyl, tert-butyl, 4-methoxyphenylmethyl and the like, can be removed under hydrolysis and hydrogenolysis conditions well known to those skilled in the art. It should be noted that compounds of the invention may contain groups that may exist in tautomeric forms, such as cyclic and acyclic amidine and guanidine groups, heteroatom substituted heteroaryl groups (Y′═O, S, NR), and the like, which are illustrated in the following examples: and though one form is named, described, displayed and/or claimed herein, all the tautomeric forms are intended to be inherently included in such name, description, display and/or claim. A “derivative” of a compound of the invention includes salts, isomers, enantiomers, prodrugs, and metabolites of the compound. Prodrugs of the compounds of this invention are also contemplated by this invention. A prodrug is an active or inactive compound that is modified chemically through in vivo physiological action, such as hydrolysis, metabolism and the like, into a compound of this invention following administration of the prodrug to a patient. The suitability and techniques involved in making and using prodrugs are well known by those skilled in the art. For a general discussion of prodrugs involving esters see Svensson and Tunek, Drug Metabolism Reviews 165 (1988) and Bundgaard, Design of Prodrugs , Elsevier (1985). One method of preparing a prodrug of a compound is by masking one or more potentially reactive groups on the compound, such as carboxylates, hydroxy groups, and amines. Examples of a masked carboxylate anion include a variety of esters, such as alkyl (for example, methyl, ethyl), cycloalkyl (for example cyclohexyl), aralkyl (for example, benzyl, p-methoxybenzyl), and alkylcarbonyloxyalkyl (for example, pivaloyloxymethyl). Amines have been masked as arylcarbonyloxymethyl substituted derivatives which are cleaved by esterases in vivo releasing the free drug and formaldehyde (Bungaard, J. Med. Chem. 2503 (1989)). Also, drugs containing an acidic NH group, such as imidazole, imide, indole and the like, have been masked with N-acyloxymethyl groups (Bundgaard, Design of Prodrugs , Elsevier (1985)). Hydroxy groups have been masked as esters and ethers. EP 039,051 (Sloan and Little, Apr. 11, 1981) discloses Mannich-base hydroxamic acid prodrugs, their preparation and use. EXPERIMENTAL General Method A: the aldehyde (1.6 mmol) is dissolved in methanol (5 mL) and the amine (1.9 mmol) is added. The reaction is shaken for 24 hours or until imine formation is complete (as monitored by LCMS), then solid supported borohydride is added (prepared according to Kabalka, G. W.; Wadgaonkar, P. P.; Chatla, N.; Synth. Commun. ; (1990), 20 (2), 293-299) (ca 2.5 mmol/g; 3.1 mmol) and the mixture is shaken for 24 hours or until reduction is complete (as monitored by LCMS). Dichloromethane (ca 3 mL) is then added followed by Wang-aldehyde resin (4-benzyloxybenzaldehyde, polymer-bound; ca 1.25 mmol/g; 0.6 mmol) and the mixture is shaken for further 24 hours. The resins are filtered off and the solvents are evaporated under reduced pressure, to afford an oil which is purified by column chromatography (usually Hexane/AcOEt 7/3 or DCM/MeOH 95/5). The free-base oil is then treated with 1.5-2.5 1N HCl in diethyl ether and the solvents are evaporated under reduced pressure to afford the mono or bis-HCl salt. Method B: the aldehyde (1.6 mmol) is dissolved in methanol (5 mL) and the amine (1.9 mmol) is added. The reaction is heated to reflux for 10 minutes then left to cool overnight until imine formation is complete (as monitored by LCMS). Solid supported cyanoborohydride is added (prepared according to Sande, A. R.; Jagadale, M. H.; Mane, R. B.; Salunkhe, M. M.; Tetrahedron Lett . (1984), 25(32), 3501-4) (ca 2.5 mmol/g; 3.1 mmol) and the mixture is heated at 50 C for 15 hours or until reduction is complete (as monitored by LCMS). Dichloromethane (ca 3 mL) is then added followed by Wang-aldehyde resin (4-benzyloxybenzaldehyde, polymer-bound; ca 1.25 mmol/g; 0.6 mmol) and the mixture is shaken for further 24 hours. The resins are filtered off and the solvents are evaporated under reduced pressure, to afford an oil which is purified by column chromatography (usually Hexane/AcOEt 7/3 or DCM/MeOH 95/5). The free-base oil is then treated with 1.5-2.5 1N HCl in diethyl ether and the solvents are evaporated under reduced pressure to afford the mono or bis-HCl salt. Method C: The aldehyde is (1.6 mmol) is dissolved in 1,2-dichloroethane (12 mL) and the amine (1.9 mmol) is added, followed by acetic acid (0.09 mL, 1.6 mmol) and finally sodium triacetoxyborohydride (500 mg, 2.4 mmol). The mixture is stirred overnight or until complete by TLC; upon reaction completion, the mixture is diluted with ethyl acetate, washed with saturated NaHCO 3 then with saturated brine, and finally dried over sodium sulphate. The solvents are evaporated under reduced pressure, to afford an oil which is purified by column chromatography on silica gel (usually Hexane/AcOEt 7/3 or DCM/MeOH 95/5). The free-base oil is then treated with 1.5-2.5 equivalents 1N HCl in diethyl ether and the solvents are evaporated under reduced pressure to afford the mono or bis-HCl salt. Method D: Compounds wherein both R 3 and R 4 are other than hydrogen can be prepared by combining an appropriately substituted phenylacetic acid with a strong base such as lithium diisopropylamide or the like at a temperature between −78 and 20° C. to yield a red dianion. The dianion is then reacted with an alkylating agent of formula R 3 -Z, wherein Z is a halide, a sulfonate, or other suitable leaving group to provide an R 3 substituted compound. Treatment of the compound thus obtained with a strong base such as lithium diisopropylamide or the like at a temperature between −78 and 20° C. yields a second red dianion, which is reacted with an alkylating agent of formula R 4 -Z, Wherein Z is a halide, a sulfonate, or other suitable leaving group to yield the R 3 , R 4 disubstituted compound. Treatment of the resultant carboxylic acid with diphenylphosphoryl azide in a refluxing solvent (for example toluene, benzene, chlorobenzene, 1,4-dioxane or the like), followed by aqueous workup yields the R 3 substituted R 4 amine. Reductive coupling of the amine with an aldehyde or ketone according to Method C affords the final product. Method E: Compounds wherein only one of R 3 and R 4 is hydrogen can be prepared by reacting the α-monosubstituted carboxylic acid obtained by reacting an appropriately substituted phenylacetic acid with a strong base such as lithium diisopropylamide and then with an alkylating agent of formula R 3 -Z as described above with diphenylphosphoryl azide in a refluxing solvent such as, for example, toluene, benzene, chlorobenzene, 1,4-dioxane, etc. followed by an aqueous workup to yield a mono-α-substituted amine. This amine can then be reacted with an aldehyde or ketone according to Method C to obtain the final product. The following examples are representative of the invention, but are not to be construed as limiting the claimed invention in any way. The structure of the prepared compounds is verified by mass spectral data; C 13 NMR data is also provided for some compounds. For some compounds, ions having mass greater than M+H are reported. These ions generally represent dimers or trimers of the synthesized compound, and in some instances represent trifluoroacetate adducts generated from the mobile phase of the LC/MS. The trifluoroacetate adducts will have a weight of M+115. Example 1 (R)-N-(1-phenylethyl)-N-((4-acetamido-3-(4-methoxyphenyl)phenylmethyl)amine Step 1) 2-bromo-4-hydroxymethylaniline To a solution of 4-amino-3-bromobenzaldehyde (2.6 g, 13 mmol) (prepared as in J. Chem. Soc., Perkin Trans. 1 (1992), 2235) in methanol (130 mL) solid supported borohydride 6.2 g, 15.5 mmol) was added. The reaction was stirred for 1.5 hours at room temperature, then the resin filtered off and rinsed with little methanol. The filtrate was concentrated in vacuo to give 2.58 g of a brown oil. C 7 H 8 BrNO Mass (calculated) [202.05]; (found) [M + ]=202 (bromine); Lc Rt=0.63, 89%. Step 2) 4-Hydroxymethyl-2-(4′-methoxyphenyl)aniline To a degassed solution of crude 2-bromo-4-hydroxymethylaniline (3.2 g, 15.8 mmol), 4-methoxybenzeneboronic acid (2.89 g, 19 mmol) and potassium carbonate (4.77 g, 34.8 mmol) in toluene/ethanol 2/1 (45 mL) a catalytic amount of Pd(PPh 3 ) 4 (0.2 g, 1 mmol %) was added and the mixture was heated at 90 C for 5 hours. The residue was extracted into ethyl acetate and washed with water and then saturated brine and dried over sodium sulphate. The solvent was removed under reduced pressure to afford 5 g of crude product. C 14 H 15 BNO 2 Mass (calculated) [229.28]; (found) [M+H + ]=230 Lc Rt=0.88, 89%. NMR (400 MHz, CDCl3): 3.75 (3H, s, MeO); 4.5 (2H, s, CH 2 O); 6.65 (1H, d, J=8.5 Hz, aryl-H); 6.9 (2H, d, J=8.5 Hz, aryl-H); 7-7.1 (2H, m, aryl-H); 7.25 (2H, d, J=8.5 Hz, aryl-H). Step 3) 4-Tri-isopropoxymethyl-2-(4′-methoxyphenyl)aniline To a solution of the crude alcohol from Step2 and 4-dimethylaminopyridine (2.12 g, 17.4 mmol) in dichloromethane (45 mL) tri-isopropylsilyl chloride (3.05 g, 15.8 mmol) was added. The reaction was stirred at room temperature for 16 hours and then diluted with dichloromethane and washed with water. The organic phase was dried over sodium sulphate and the solvent removed in vacuo. The crude was purified by column (silica, 5%-10 AcOEt in hexane to 10% methanol in AcOEt) to give 4.70 g of title compound. C 23 H 35 NO 2 Si Mass (calculated) [385.63]; (found) [M+H + ]=386 Lc Rt=1.77. Step 4) 4-Tri-isopropoxymethyl-2-(4′-methoxyphenyl)acetanilide To a solution of 4-tri-isopropoxymethyl-2-(4′-methoxyphenyl)aniline (1.57 g, 4.07 mmol) and 4-pyridine (0.35 mg, 4.48 mmol) in dichloromethane (9 mL), acetic anhydride (0.4 mL, 4.27 mmol) was added and the reaction stirred at room temperature for 72 hours. The reaction mixture was then diluted with dichloromethane and washed with saturated ammonium chloride and water, then dried over sodium sulphate to afford 1.87 g of a solid. C 25 H 37 NO 3 Si Mass (calculated) [427.66]; (found) [M+H + ]=428; Lc Rt=2.10. Step 5) 4-Hydroxymethyl-2-(4′-methoxyphenyl)acetanilide Tetra-butylammonium fluoride (4.48 mL of a 1M solution in THF) was added to a solution of 4-tri-isopropoxymethyl-2-(4′-methoxyphenyl)acetanilide (1.87 g, 4.07 mmol) in THF (12 mL) and stirred for 2 hours. The reaction was diluted with ethyl acetate and washed with saturated ammonium chloride then water and finally dried over sodium sulphate. The solvent was evaporated to afford 1.66 g of a yellow oil. C 16 H 17 NO 3 Mass (calculated) [271.32]; (found) [M+H + ]=272; Lc Rt=0.95. Step 6) 4-Acetamido-3-(4′-methoxyphenyl)benzaldehyde Manganese dioxide (1.77 g, 20.3 mmol) was added portionwise to a stirred solution of the crude alcohol (1.66 g) from step 5 in acetone (12 mL). The reaction was stirred at room temperature for 20 hours, then refluxed for a further 8 hours. The reaction mixture was then filtered on paper and the solvent removed under reduced pressure. The crude was purified on silica (hexane/AcOEt 3/1) to give 0.6 g of title product. C 16 H 15 NO 3 Mass (calculated) [269.30]; (found) [M+H + ]=270; Lc Rt=1.21. NMR (400 MHz, CDCl3): 2.6 (3H, s, CH 3 CO); 3.86 (3H, s, MeO); 6.96 (2H, d, J=8.5 Hz, aryl-H); 7.3 (2H, d, J=8.5 Hz, aryl-H); 7.44 (1H, bs, NH); 7.72 ((1H, d, J=2 Hz, aryl-H); 7.84 (1H, dd, J=2 and 8.5 Hz, aryl-H); 8.6 (1H, bd, J=8.5 Hz, aryl-H); 9.5 (1H, s, CHO). Step 7) (R)-N-(1-Phenylethyl)-N-((4-acetamido-3-(4-methoxyphenyl)phenylmethyl)amine The title compound was prepared from N-[4-formyl-2-(4-methoxyphenyl)phenyl]acetamide and (R)-α-methylbenzylamine according to general procedure C. C 24 H 26 N 2 O 2 Mass (calculated): [374]; (found): [M+H + ]=375. NMR (400 MHz, CDCl 3 ): 1.3 (3H, d, J=6 Hz, NCHCH 3 ); 1.95 (3H, s, CH 3 CO); 3.5 and 3.55 (2H, dd, J=12 Hz, CH 2 N); 3.7 (1H, q, J=6 Hz, NC H Me); 3.75 (3H, s, MeO); 6.9 (2H, d, J=8 Hz, aryl-H); 7-7.1 (2H, m, aryl-H); 7.1-7.35 (7H, m, aryl-H); 8.1 (1H, d, J=8 Hz, aryl-H). Example 2 (R)-N-(1-(3-Methoxyphenyl)ethyl)-N-((4-acetamido-3-(4-methoxyphenyl)phenylmethyl)amine The title compound was prepared from N-[4-formyl-2-(4-methoxyphenyl)phenyl]acetamide and (R)-3-methoxy-α-methylbenzylamine according to general procedure C. C 25 H 28 N 2 O 3 Mass (calculated): [404]; (found): [M+H + ]=254, 405. NMR (400 MHz, CDCl 3 ): 1.3 (3H, d, J=6 Hz, NCHCH 3 ); 1.95 (3H, s, CH 3 CO); 3.5 and 3.55 (2H, dd, J=12 Hz, CH 2 N); 3.7-3.75 (4H, m, MeO and NCHMe); 3.75 (3H, s, MeO); 6.7 (1H, dd, J=1 and 8 Hz, aryl-H); 6.75-6.8 (2H, m, aryl-H); 6.9 (2H, d, J=8 Hz, aryl-H); 7-7.1 (2H, m, aryl-H); 7.1-7.35 (3H, m, aryl-H); 8.1 (H, d, J=8 Hz, aryl-H). Example 3 (R)-N-(1-(1-Naphthyl)ethyl)-N-((4-acetamido-3-(4-methoxyphenyl)-phenylmethyl)amine The title compound was prepared from N-[4-formyl-2-(4-methoxyphenyl)-phenyl]acetamide and (R)-1-(1-naphthyl)ethylamine according to general procedure C. C 28 H 28 N 2 O 2 Mass (calculated): [424]; (found): [M+H + ]=425, 254. NMR (400 MHz, CDCl 3 ): 1.45 (3H, d, J=6 Hz, NCHCH 3 ); 1.95 (3H, s, CH 3 CO); 3.6 and 3.65 (2H, dd, J=12 Hz, CH 2 N); 3.8 (3H, s, MeO); 4.65 (1H, q, J=6 Hz, NCHMe); 6.9 (2H, d, J=8 Hz, aryl-H); 7.0-7.05 (2H, m, aryl-H); 7.1-7.15 (2H, m, aryl-H); 7.35-7.5 (3H, m, aryl-H); 7.7 (2H, d, J=8 Hz, aryl-H); 7.75-7.85 (1H, m, aryl-H); 8-8.05 (1H, m, aryl-H); 8.1 (1H, d, J=8 Hz, aryl-H). Example 4 (R)-N-(1-Phenylethyl)-N-((4-methoxy-3-(1-methylbenzimidazol-5-yl)phenylmethyl)amine Step 1) N-Methyl-4-bromo-2-nitroaniline/(4-Bromo-2-nitrophenyl)methylamine 2,5-Dibromobenzene (5 g, 17.8 mmol) was added to a solution of methylamine (13.8 mL of a 40% aq. solution) and the mixture was stirred for 16 hours, then 8 mL of THF were added and the reaction was stirred for 2 hours at room temperature and then for further 2 hours at 50° C. The reaction mixture was then cooled and extracted twice into ethyl acetate. The solvent was removed under reduced pressure and the crude was chromatographed (silica, AcOEt 2-10% in hexane) to afford 2 g of orange crystals. NMR (400 MHz, CDCl 3 ): 2.95 (3H, d, J=5 Hz, NCH 3 ); 3.92 (3H, s, MeN); 6.7 (d, J=8.5 Hz, aryl-H); 7.45 (1H, dd, J=2 and 8.5 Hz, aryl-H); 7.9 (1H, bs, NH); 8.2 (1H, d, J=2 Hz, aryl-H). Step 2) 2-N-Methylamino-5-bromoaniline/(2-Amino-4-bromophenyl)methylamine A solution of the nitroaniline from Step 1 (1.56 g, 6.75 mmol) and tin(II) chloride (7.62 g, 33.7 mmol) in ethyl acetate (40 mL) was refluxed under nitrogen for 3 hours. The mixture was then poured onto ice, neutralized with saturated NaHCO 3 and extracted into ethyl acetate. The organic layer was washed with brine and dried over sodium sulphate to afford 1.5 g of crude red oil which was used without further purification. C 7 H 9 Br 2 Mass (calculated): [201.07]; (found): [M+]=201 (bromine). NMR (400 MHz, MeOH-d 4 ): 3.88 (3H, s, MeO); 2.8 (3H, s, MeN); 6.7 (1H, d, J=8.5 Hz, aryl-H); 6.85 (1H, dd, J=2 and 8.5 Hz, aryl-H); 6.9 (1H, d, J=2 Hz, aryl-H). Step 3) 5-Bromo-1-methylbenzimidazole A solution of 2-N-methylamino-5-bromoaniline (1 g, 4.97 mmol) in triethyl orthoformate (30 mL) was refluxed for 5 hours. The solvent was removed under reduced pressure to afford 1 g of the title bromobenzimidazole. C 8 H 7 BrN 2 Mass (calculated): [211.06]; (found): [M+]=211 (bromine). NMR (400 MHz, MeOH-d 4 ): 3.88 (3H, s, MeO); 2.8 (3H, s, MeN); 6.7 (1H, d, J=8.5Hz, aryl-H); 6.85 (1H, dd, J=2 and 8.5 Hz, aryl-H); 6.9 (1H, d, J=2 Hz, aryl-H). Step 4) 4-Methoxy-3-(1′-methylbenzimidazol-5′-yl)benzenecarboxaldehyde/4-Methoxy-3-(1-methylbenzimidazol-5-yl)benzaldehyde To a degassed solution of 5-bromo-1-methylbenzimidazole (0.56 g, 2.63 mmol), 5-formyl-2-methoxybenzeneboronic acid (0.57 g, 3.2 mmol) and potassium carbonate (0.91 g, 6.6 mmol) in toluene/ethanol 2/1 (30 mL) a catalytic amount of Pd(PPh 3 ) 4 (0.03 g, 1 mmol %) was added and the solution was degassed for further 5 minutes. The mixture was refluxed for 5 hours. The residue was extracted into ethyl acetate and washed with water and then saturated brine and dried over sodium sulphate. The solvent was removed under reduced pressure and the crude was purified by column (silica, EtOAc to 5% MeOH in AcOEt) to afford 0.6 g of product. C 8 H 7 BrN 2 Mass (calculated): [266.30]; (found): [M + ]=267. NMR (400 MHz, CDCl 3 ): 3.88 (3H, s, MeO); 3.92 (3H, s, MeN); 7.12 (1H, d, J=8.5 Hz, aryl-H); 7.4-7.5 (2H, m, aryl-H); 7.8-7.95 (3H, m, aryl-H); 7.98 (1H, s, imidazole N═CHN); 9.95 (1H, s, CHO). Step 5) (R)-N-(1-Phenylethyl)-N-((4-methoxy-3-(1-methylbenzimidazol-5-yl)phenylmethyl)amine The title compound was prepared from 4-methoxy-3-(1-methylbenzimidazol-5-yl)benzaldehyde and (R)-α-methylbenzylamine according to general procedure C. C 24 H 25 N 3 O Mass (calculated): [371]; (found): [M+H + ]=251, 372, 268. NMR (400 MHz, CDCl 3 ): 1.3 (3H, d, J=6 Hz, NCHCH 3 ); 3.55 and 3.6 (2H, dd, J=12 Hz, CH 2 N); 3.7 (3H, s, NMe); 3.75-3.85 (4H, m and s, NCHMe and MeO); 6.9 (2H, d, J=8 Hz, aryl-H); 7.25-7.3 (3H, m, aryl-H); 7.3-7.4 (5H, m, aryl-H); 7.45 (1H, dd, J=1 and 8 Hz, aryl-H); 7.8 (1H, aryl-H); 7.9 (1H, m, aryl-H). Example 5 (R)-N-(1-(3-Methoxyphenyl)ethyl)-N-((4-methoxy-3-(1-methylbenzimidazol-5-yl)phenylmethyl)amine The title compound was prepared from 4-methoxy-3-(1-methylbenzimidazol-5-yl)benzaldehyde and (R)-3-methoxy-α-methylbenzylamine according to general procedure C. C 25 H 27 N 3 O 2 Mass (calculated): [401]; (found): [M+H + ]=402, 251, 268. NMR (400 MHz, CDCl 3 ): 1.3 (3H, d, J=6 Hz, NCHCH 3 ); 3.55 and 3.6 (2H, dd, J=12 Hz, CH 2 N); 3.7-3.9 (10H, m and 2s, NCHMe, NMe and MeO); 6.7 (1H, dd, J=1 and 8 Hz, aryl-H); 6.85-6.95 (3H, m, aryl-H); 7.15-7.3 (3H, m, aryl-H); 7.35 (1H, m, aryl-H); 7.45 (1H, m, aryl-H); 7.8-7.95 (2H, m, aryl-H). Example 6 (R)-N-(1-(1-Naphthyl)ethyl)-N-((4-methoxy-3-(1-methylbenzimidazol-5-yl)phenylmethyl)amine The title compound was prepared from 4-methoxy-3-(1-methylbenzimidazol-5-yl)benzaldehyde and (R)-1-(1-naphthyl)ethylamine according to general procedure C. C 28 H 27 N 3 O Mass (calculated): [371]; (found): [M+H + ]=155, 422, 268, 251. NMR (400 MHz, CDCl 3 ): 1.6 (3H, d, J=6 Hz, NCHCH 3 ); 3.6-3.7 (4H, m, CH 2 N and Nme); 3.7-3.8 (4H, m, CH 2 N and MeO); 4.8 (1H, q, J=6 Hz, NCHCH 3 ); 6.8 (1H, d, J=8 Hz, aryl-H); 7.15 (1H, d, J=1 Hz, aryl-H); 7.2-7.3 (1H, m, aryl-H); 7.3-7.35 (2H, m, aryl-H); 7.35-7.5 (2H, m, aryl-H); 7.5 (1H, t, J=7 Hz, aryl-H); 7.7 (1H, d, J=8 Hz, aryl-H); 7.8-7.95 (5H, m, aryl-H). Example 7 (R)-N-(1-(4-Methylphenyl)ethyl)-N-((4-methoxy-3-(4′-methoxyphenyl)-phenylmethyl)amine Step 1) 4-Methoxy-3-(4-methoxyphenyl)benzaldehyde 3-Bromo-4-methoxybenzaldehyde (1.92 g, 9 mmol, Aldrich) and 4-methoxyphenylboronic acid (1.52 g, 10 mmol, Aldrich) were dissolved in ethylene glycol dimethyl ether (15 mL, Aldrich). To the solution was added lithium chloride (0.72 g, 30 mmol, Aldrich) and aqueous 2 M sodium carbonate solution (15 mL, 30 mmol). After the mixture was bubbled with nitrogen for 10 min at room temperature, tetrakis(triphenylphosphine)palladium(0) (1.15 g, 1.0 mmol, Aldrich) was added to the mixture. The mixture was stirred under nitrogen at 80 C for overnight then the reaction was cooled at room temperature and diluted in ethyl acetate (50 mL). The solid portion was filtered out through Celite pad. The organic phase was separated and washed by water (30 mL) and brine (30 mL). The resulting organic layer was dried over anhydrous magnesium sulfate and concentrated via vacuo. The title compound was purified by column chromatography (silica gel, hexane/ethyl acetate 5/1) to give the title compound as white solid in 88% yield (2.12 g, 8.8 mmol). C 15 H 14 O 3 MS (ESI, pos. ion) m/z: 243.1 (M+1); MS (ESI, neg. ion) m/z: 241.0 (M−1). Step 2) (R)-N-(1-(4-Methylphenyl)ethyl)-N-((4-methoxy-3-(4′-methoxyphenyl)-phenylmethyl)amine The title compound was prepared from 4-methoxy-3-(4-methoxyphenyl)-benzaldehyde and (R)-4-methyl-α-methylbenzylamine according to general procedure A. C 24 H 27 NO 2 Mass (calculated): [361]; (found): [M+H + ]=262; NMR (400 MHz, MeOH-d 4 ): 1.55 (3H, d, J=7 Hz, NCHCH 3 ); 2.5 (3H, s, aryl-CH 3 ) 3.65 and 3.75 (2H, dd, J=12 Hz, CH 2 N); 3.9 (3H, s, MeO); 3.9 (1H, m, NCHMe); 3.95 (3H, s, MeO); 7.05-7.15 (3H, m, aryl-H); 7.3-7.45 (6H, m, aryl-H); 7.62 (2H, d, J=7 Hz, aryl-H). Example 8 (R)-N-(1-Phenylethyl)-N-((4-methoxy-3-(4′-methoxyphenyl)phenylmethyl)amine The title compound was prepared from 4-methoxy-3-(4-methoxyphenyl)-benzaldehyde and (R)-α-methylbenzylamine according to general procedure A. C 23 H 25 NO 2 Mass (calculated): [347]; (found): [M+H + ]=348. NMR (400 MHz, MeOH-d 4 ): 1.55 (3H, d, J=7 Hz, NCHCH 3 ); 2.5 (3H, s, aryl-CH 3 ) 3.65 and 3.75 (2H, dd, J=12 Hz, CH 2 N); 3.9 (3H, s, MeO); 3.9 (1H, m, NCHMe); 3.95 (3H, s, MeO); 7.05-7.15 (3H, m, aryl-H); 7.3-7.45 (6H, m, aryl-H); 7.62 (2H, d, J=7 Hz, aryl-H). Example 9 (R)-N-(1-(1-Naphthyl)ethyl)-N-((4-methoxy-3-(4′-methoxyphenyl)-phenylmethyl)amine The title compound was prepared from 4-methoxy-3-(4-methoxyphenyl)-benzaldehyde and (R)-1-(1-naphthyl)ethylamine according to general procedure A. C 27 H 27 NO 2 Mass (calculated): [397]; (found): [M+H + ]=398. NMR (400 MHz, MeOH-d 4 ): 1.65 (3H, d, J=7 Hz, NCHCH 3 ); 3.8 and 3.85 (2H, dd, J=15 Hz, CH 2 N); 3.9 (3H, s, MeO); 4 (3H, s, MeO); 3.9 (1H, m, NCHMe); 4.85 (1H, q, J=7 Hz, NCHMe);7.05 (2H, d, J=7 Hz, aryl-H); 7.15 (1H, d, J=7 Hzaryl-H); 7.25 (1H, d, J=1 Hz, aryl-H); 7.35 (1H, dd, J=1 and 7 Hz, aryl-H); 7.5 (2H, d, J=7 Hz, aryl-H); 7.55-7.7 (2H, m, naphthyl-H); 7.7 (1H, t, J=7 Hz, naphthyl-H); 7.9 (1H, d, J=7 Hz, naphthyl-H); 7.95 (1H, d, J=7 Hz, naphthyl-H); 8.05 (1H, d, J=7 Hz, naphthyl-H); 8.15 (1H, d, J=7 Hz, naphthyl-H). Example 10 (R)-N-(1-Phenylethyl)-N-((4-methoxy-3-(pyrid-3-yl)phenylmethyl)amine The title compound was prepared from 4-methoxy-3-(3-pyridyl)benzaldehyde and (R)-α-methylbenzylamine according to general procedure A. C 21 H 22 N 2 O Mass (calculated): [318]; (found): [M+H + ]=319, 198. NMR (400 MHz, MeOH-d 4 ): 1.75 (3H, d, J=7 Hz, NCHCH 3 ); 3.92 (3H, s, MeO); 3.55 and 4.2 (2H, dd, J=10 Hz, CH 2 N); 4.5 (1H, q, J=4.5 Hz; NCHMe); 3.95 (3H, s, MeO); 7.3 (1H, d, J=7 Hz, aryl-H); 7.45-7.65 (7H, m, aryl-H); 8.05 (1H, bt, pyridyl-H); 7.75 (1H, d, J=7 Hz, pyridyl-H); 8.8 (1H, bs, pyridyl-H); 9.05 (1H, bs, pyridyl-H). Example 11 (R)-N-(1-((3-Methoxyphenyl)ethyl)-N-((4-methoxy-3-(4′-fluorophenyl)-phenylmethyl)amine The title compound was prepared from 3-(4-fluorophenyl)-4-methoxybenz-aldehyde and (R)-3-methoxy-α-methylbenzylamine according to general procedure C. C 23 H 24 FNO 2 Mass (calculated): [365]; (found): [M+H + ]=366, 215 base peak NMR (400 MHz, CDCl 3 ): 1.4 (3H, d, J=7 Hz, NCHCH 3 ); 3.65 and 3.75 (2H, dd, J=12 Hz, CH 2 N); 3.82 (3H, s, MeO); 3.85 (3H, s, MeO); 3.8-3.9 (1H, m, NCHMe); 6.85 (1H, dd, J=7 and 2 Hz, aryl-H); 6.9-7.0 (3H, m, aryl-H); 7.1-7.2 (2H, m, aryl-H); 7.2-7.35 (3H, m, aryl-H); 7.5-7.55 (2H, m, aryl-H). Example 12 (R)-N-(1-Phenylethyl)-N-((4-methoxy-3-(4′-fluorophenyl)phenylmethyl)amine The title compound was prepared from 3-(4-fluorophenyl)-4-methoxybenz-aldehyde and (R)-α-methylbenzylamine according to general procedure C. C 22 H 22 FNO Mass (calculated): [335]; (found): [M+H + ]=336, 215 base peak NMR (400 MHz, CDCl 3 ): 1.35 (3H, d, J=7 Hz, NCHCH 3 ); 3.5 and 3.6 (2H, dd, J=11 Hz, J=7 Hz; CH 2 N);3.7 (3H, s, MeO); 4.82 (1H, q, J=7 Hz; NCHMe); 6.85 (1H, d, J=7, aryl-H); 7.0 (2H, t, J=7 Hz; aryl-H); 7.15 (1H, d, J=2 Hz, aryl-H); 7.15-7.25 (2H, m, aryl-H); 7.25-7.35 (4H, m, aryl-H); 7.5 (2H, dd, J=7 and 6 Hz, aryl-H). Example 13 R)-N-(1-Phenylethyl)-N-((4-methoxy-3-(2′-methylpyrid-5′-yl)phenylmethyl)-amine Step 1) 4-Methoxy-3-(1-methylpyrid-5-yl)benzenecarboxaldehyde To a degassed solution of 5-bromo-2-methylpyridine (2.75 g, 15 mmol) and potassium carbonate (4.5 g, 33 mmol) in toluene (70 mL) a catalytic amount of Pd(PPh 3 ) 4 (0.17 g, 0.15 mmol) was added and the solution was degassed for further 5 minutes. A degassed solution of 5-formyl-2-methoxybenzeneboronic acid (prepared according to Keseru, G. M. et al. Tetrahedron (48), 2, 913-922 (1992))(2.7 g, 15 mmol) in ethanol (30 mL) was then added and the mixture was refluxed for 15 hours. The residue was extracted into ethyl acetate and washed with saturated sodium bicarbonate solution and dried over sodium sulphate. The solvent was removed under reduced pressure and the crude was purified by column chromatography (silica, THF/DCM 2/1) to afford 2 g of pale yellow solid. C 14 H 13 NO 2 Mass (calculated) [227]; (found) [M+H + ]=228; Lc Rt=1.0, 92%. NMR (400 MHz, MeOH-d 4 ): 2.65 (3H, s, Me-pyridine); 4.05 (3H, s, MeO); 7.35 (1H, d, J=10 Hz, pyridyl-H); 7.45 (1H, 2, J=7 Hz, aryl-H); 7.95 (1H, m, pyridyl-H); 8 (1H, d, J=2 Hz ; aryl-H); 8.1 (1H, dd, J=2 and 7 Hz, aryl-H); 8.65 (1H, d, J=2 Hz, —H); 10 (1H, s, CHO). Step 2) (R)-N-(1-Phenylethyl)-N-((4-methoxy-3-(2′-methylpyrid-5′-yl)-phenylmethyl)amine The title compound was prepared from 4-methoxy-3-(1-methylpyrid-5-yl)-benzenecarboxaldehyde and (R)-α-methylbenzylamine according to general procedure C. C 22 H 24 N 2 O Mass (calculated): [332]; (found): [M+H + ]=333 NMR (400 MHz, CDCl 3 ): 1.4 (3H, d, J=6.5 Hz, NCHCH 3 ); 2.65 (3H, s, pyridyl-CH 3 ); 3.61 and 3.67 (2H, dd, J=13 Hz, CH 2 N); 3.82 (3H, s, MeO); 3.86 (1H, q, J=6.5 Hz, CH 3 CH); 6.45 (1H, d, J=8.5 Hz); 7.2-7.35 (4H, m, aryl-H); 7.35-7.4 (4H, m, aryl-H); 7.77 (dd, 1H, J=2.2 and 8.1 Hz, aryl-H); 8.66 (1H, d, J=1.8 Hz, aryl-H). Example 14 (R)-N-(1-Phenylethyl)-N-((4-methoxy-3-(2′-methoxypyrid-5′-yl)phenylmethyl)amine The title compound was prepared from 4-methoxy-3-(6-methoxy(3-pyridyl))-benzaldehyde and (R)-α-methylbenzylamine according to general procedure C. C 22 H 24 N 2 O 2 Mass (calculated): [348]; (found): [M+H + ]=349, 228; NMR (400 MHz, CDCl 3 ): 1.32 (3H, d, J=6.8 Hz, NCHCH 3 ); 3.5 and 3.57 (2H, dd, J=13 Hz, CH 2 N); 3.72 (3H, s, OCH 3 ); 3.78 (1H, q, J=6.8 Hz, CHCH 3 ); 6.7 (1H, dd, J=0.6 and 8.6 Hz, aryl-H); 6.8 (1H, d, J=8.4 Hz, aryl-H); 7.10-6.35 (7H, m, aryl-H); 7.7 (1H, dd, J=2.5 and 8.6 Hz, aryl-H); 8.2 (1H, dd, J=1.8 and 8.2 Hz, aryl-H). Example 15 (R)-N-(1-(1-Naphthyl)ethyl)-N-((4-methoxy-3-(6′-methoxypyridazin-3′-yl))phenylmethyl)amine The title compound was prepared from 4-methoxy-3-(6-methoxypyridazin-3-yl)benzaldehyde and (R)-1-(1-naphthyl)ethylamine according to general procedure A. C 25 H 25 N 3 O 2 Mass (calculated): [399]; (found): [M+H + ]=400, [2M+H + ]=799. Example 16 (R)-N-(1-(Phenylethyl)-N-((4-methoxy-3-(3,4-methylendioxyphenyl)-phenylmethyl)amine The title compound was prepared from 3-(2H-benzo[d]1,3-dioxolan-5-yl)-4-methoxybenzaldehyde and (R)-α-methylbenzylamine according to general procedure B. C 23 H 23 NO 3 Mass (calculated): [361]; (found): [M+H + ]=362, 241 NMR (400 MHz, CDCl 3 ): 1.29 (3H, d, J=6.8 Hz, CHCH 3 ); 3.50 and 3.54 (2H, dd, J=13 Hz, CH 2 N); 3.72 (3H, s, CH 3 O); 3.75 (1H, q, J=6.8 Hz, CHCH 3 ); 5.90 (2H, s, OCH 2 O); 6.78 (1H, d, J=7.7 Hz, aryl-H); 6.83 (1H, d, J=7.7 Hz, aryl-H); 6.9 (1H, dd, J=1.7 and 7.7 Hz, aryl-H); 6.97 (1H, d, J=1.7 Hz, aryl-H); 7.10-7.15 (2H, m, aryl-H); 7.15-7.22 (1H, m, aryl-H); 7.24-7.31 (4H, m, aryl-H). Example 17 (R)-N-(1-(3-Methoxyphenyl)ethyl)-N-((4-methoxy-3-(4′-methoxyphenyl)phenylmethyl)amine The title compound was prepared from 4-methoxy-3-(4-methoxyphenyl)-benzaldehyde and (R)-3-methoxy-α-methylbenzylamine according to general procedure A. C 24 H 27 NO 3 Mass (calculated): [377]; (found): [M+H + ]=378, [M+MeCN+H + ]=419. Example 18 (R)-N-(1-(3-Methoxyphenyl)ethyl)-N-((4-methoxy-3-(4,5-methylendioxyphenyl)phenylmethyl)amine The title compound was prepared from 3-(2H-benzo[d]1,3-dioxolan-5-yl)-4-methoxybenzaldehyde and (R)-3-methoxy-α-methylbenzylamine according to general procedure B. C 24 H 25 NO 4 Mass (calculated): [391]; (found): [M+H + ]=392. NMR (400 MHz, CDCl 3 ): 1.35 (3H, d, J=6.8 Hz, NCHCH 3 ); 3.4-3.8 (9H, m, OCH 3 , OCH 3 , CHCH 3 , CH 2 N); 5.9 (2H, s, OCH 2 O); 6.7-7 (8H, m, aryl-H); 7.1-7.2 (2H, m, aryl-H). Example 19 R)-N-(1-Phenylethyl)-N-(4-methoxy-3-phenyl)phenylmethyl)amine The title compound was prepared from 4-methoxy-3-phenylbenzaldehyde and (R)-α-methylbenzylamine according to general procedure A. C 22 H 23 NO Mass (calculated): [317]; (found): [M+H + ]=318, 197 (base peak). Example 20 (R)-N-(1-Phenylethyl)-N-((4-trifluoromethoxy-3-(pyrid-3-yl)phenylmethyl)amine Step 1) 4-Trifluoromethoxy-3-(pyrid-3-yl)benzaldehyde A solution of 3-chloro-4-trifluoromethoxybenzaldehyde (3 g, 13.3 mmol) and 3-pyridylboronic acid (1.97 g, 16.0 mmol) in dioxane (70 mL) and 2M K 2 CO 3 (20 mL) is degassed with nitrogen prior to addition of Pd(PPh 3 ) 4 (1.5 g, 1.33 mmol). The mixture was stirred at 100° C. under nitrogen for 40 hours, then cooled and filtered on celite/silica and the filtrate concentrated under reduced pressure. The crude was purified by column chromatography (2/1 heptane/ethyl acetate) to give 1.51 g of title compound. C 13 H 8 F 3 NO 2 Mass (calculated): [267]; (found) [M+H + ]=268 NMR (400 MHz, CDCl 3 : 7.3-7.35 (1H, m, aryl-H); 7.4-7.45 (1H, m, aryl-H); 7.7-7.75 (1H, m, aryl-H); 7.9-8 (2H, n, aryl-H); 8.65 (1H, bs, aryl-H); 8.7 (1H, bs, aryl-H). Step 2) (R)-N-(1-Phenylethyl)-N-((4-trifluoromethoxy-3-(pyrid-3-yl)phenylmethyl)amine The title compound was prepared from 4-trifluoromethoxy-3-(pyrid-3-yl)benzenecarboxaldehyde and (R)-α-methylbenzylamine according to general procedure C. C 21 H 19 F 3 N 2 O Mass (calculated): [372]; (found): [M+H +] =373 NMR (400 MHz, CDCl3): 1.3 (3H, d, J=6 Hz, NCHCH 3 ); 3.6 (2H, s, CH 2 N); 3.8 (1H, q, J=6 Hz; NCHMe); 7.20-7.40 (9H, m, aryl-H); 7.7 (1H, dt, J=1 and 8 Hz, aryl-H); 8.55 (1H, d, J=3 Hz, aryl-H); 8.65 (1H, bs, aryl-H). Example 21 (R)-N-(1-(3-Methoxyphenyl)ethyl)-N-((4-trifluoromethoxy-3-(pyrid-3-yl)phenylmethyl)amine The title compound was prepared from 4-trifluoromethoxy-3-(pyrid-3-yl)benzenecarboxaldehyde and (R)-3-methoxy-α-methylbenzylamine according to general procedure C. C 22 H 21 F 3 N 2 O 2 Mass (calculated): [402]; (found): [M+H + ]=403 NMR (400 MHz, CDCl3): 1.3 (3H, d, J=6 Hz, NCHCH 3 ); 3.6 (2H, m, CH 2 N); 3.7-3.8 (4H, m, NCHMe and CH 3 O); 6.7 (1H, dd, J=1 and 8 Hz, aryl-H); 6.8-6.9 (2H, m, aryl-H); 7.20-7.40 (5H, m, aryl-H); 7.7 (1H, dt, J=1 and 8 Hz, aryl-H); 8.55 (1H, d, J=3 Hz, aryl-H); 8.65 (1H, bs, aryl-H). Example 22 (R)-N-(1-(1-Naphthyl)ethyl)-N-((4-trifluoromethoxy-3-(pyrid-3-yl)phenylmethyl)amine The title compound was prepared from 4-trifluoromethoxy-3-(pyrid-3-yl)benzene-carboxaldehyde and (R)-1-(1-naphthyl)ethylamine according to general procedure C. C 25 H 21 F 3 N 2 O Mass (calculated): [422]; (found): [M+H + ]=423 NMR (400 MHz, CDCl3): 1.45 (3H, d, J=6 Hz, NCHCH 3 ); 3.65 and 3.75 (2H, dd, J=12 HzCH 2 N); 4.65 (1H, q, J=6 Hz; NCHMe); 7.30-7.40 (4H, m, aryl-H); 7.40-7.5 (3H, m, aryl-H); 7.6-7.7 (3H, m, aryl-H); 7.8-7.85 (1H, m, aryl-H); 8.05-8.1 (1H, m, aryl-H); 8.55 (1H, d, J=3 Hz, aryl-H); 8.65 (1H, bs, aryl-H). Example 23 (R)-N-(1-Phenylethyl)-N-((4-methoxy-3-(benzimidazol-2-yl)lmethyl)amine Step 1) 4-Methoxy-3-(benzimidazol-2-yl)benzenecarboxaldehyde Pd(Ph 3 ) 4 (72 mg, 0.062 mmol) was added to a degassed solution of 2-chlorobenzimidazole (0.95 g, 6.25 mmol) in 1,2-dimethoxyethane (25 mL), followed by 2M Na 2 CO 3 (15 mL) and 5-formyl-2-methoxybenzeneboronic acid (1.35 g, 7.5 mmol). The mixture was stirred at 115 C for 16 hours then more catalyst was added (2% mol) and reaction stirred for further 4 hours. The mixture was cooled and extracted with ethyl acetate. The organic layer was concentrated under reduced pressure and the residue purified by column chromatography (1/1 hexane/ethyl acetate) to afford 0.285 g of title compound. C 15 H 12 N 2 O 2 Mass (calculated): [252]; (found) [M+H + ]=253 NMR (400 MHz, CDCl 3 : 4.1 (3H, s, CH 3 O); 7.2 (1H, d, J=8 Hz, aryl-H); 7.3-7.35 (2H, m, aryl-H); 7.5 (1H, m, aryl-H); 7.8 (1H, m, aryl-H); 8 (1H, dd, J=2 and 8 Hz, aryl-H); 9 (1H, d, J=1 Hz, aryl-H); 10 (1H, s, CHO); 10.4 (1H, bd, NH). Step 2) (R)-N-(1-Phenylethyl)-N-((4-methoxy-3-(benzimidazol-2-yl)lmethyl)amine The title compound was prepared from 4-methoxy-3-(benzimidazol-2-yl)benzenecarboxaldehyde and (R)-α-methylbenzylamine according to general procedure C. C 23 H 23 N 3 O Mass (calculated): [357]; (found): [M+H + ]=358, 715 NMR (400 MHz, CDCl3): 1.3 (3H, d, J=6 Hz, NCHCH 3 ); 3.55 and 3.65 (2H, dd, J=12 Hz, CH 2 N); 3.75 (1H, q, J=6 Hz; NCHMe); 4.0 (3H, s, CH 3 O); 6.95 (1H, d, J=8 Hz, aryl-H); 7.15-7.25 (3H, m, aryl-H); 7.25-7.35 (5H, m, aryl-H); 7.45 (1H, bd, aryl-H); 7.75 (1H, bd, aryl-H); 8.3 (1H, d, J=1 Hz, aryl-H). Example 24 (R)-N-(1-(1-Naphthyl)ethyl)-N-((4-methoxy-3-(benzimidazol-2-yl)lmethyl)amine The title compound was prepared from 4-methoxy-3-(benzimidazol-2-yl)benzenecarboxaldehyde and (R)-1-(1-naphthyl)ethylamine according to general procedure C. C 27 H 25 N 3 O Mass (calculated): [407]; (found): [M+H + ]=408 NMR (400 MHz, CDCl3): 1.5 (3H, d, J=6 Hz, NCHCH 3 ); 3.75 and 3.8 (2H, dd, J=12 Hz, CH 2 N); 4.1 (3H, s, CH 3 O); 4.75 (1H, q, J=6 Hz; NCHMe); 7.0 (1H, d, J=8 Hz, aryl-H); 7.25-7.3 (2H, m, aryl-H); 7.45-7.55 (4H, m, aryl-H); 7.75-7.9 (4H, m, aryl-H); 8.2 (1H, d, J=8 Hz, aryl-H); 8.55 (1H, d, J=1 Hz, aryl-H). Example 25 (R)-N-(1-Phenylethyl)-N-((4-methoxy-3-(1,4-benzodioxan-5-yl)lmethyl)amine Step 1) 4-methoxy-3-(1,4-benzodioxan-5-yl)benzenecarboxaldehyde A solution of 5-formyl-2-methoxybenzeneboronic acid (1 g, 5.6 mmol), 3,4-ethylenedioxybromobenzole (1 g, 4.65 mmol) and K 2 CO 3 (1.6 g, 11.6 mmol) in ethanol (20 mL) and toluene (40 mL) was degassed prior to addition of Pd(Ph 3 ) 4 (54 mg, 0.046 mmol). The mixture was refluxed for 24 hours then cooled and filtered through diatomaceous earth. The filtrate was concentrated in vacuo, extracted with ethyl acetate, washed with water and the organic layer dried over sodium sulphate. The crude was purified by column chromatography (heptane/ethyl acetate 7/3) to give 1 g of title compound. C 16 H 14 O 4 Mass (calculated): [270]; (found): [M+H + ]=271, 312 NMR (400 MHz, CDCl3): 3.95 (3H, s, CH 3 O); 4.3 (4H, s, OCH 2 CH 2 O); 6.9-7.15 (4H, m, aryl-H); 7.9-7.95 (2H, m, aryl-H); 10 (1H, s, CHO). Step 2) (R)-N-(1-Phenylethyl)-N-((4-methoxy-3-(1,4-benzodioxan-5-yl)lmethyl)amine The title compound was prepared from 4-methoxy-3-(1,4-benzodioxan-5-yl)benzenecarboxaldehyde and (R)-α-methylbenzylamine according to general procedure C. C 24 H 25 NO 3 Mass (calculated): [375]; (found): [M+H + ]=376, 255 NMR (400 MHz, CDCl3): 1.3 (3H, d, J=6 Hz, NCHCH 3 ); 3.55 and 3.65 (2H, dd, J=12 Hz, CH 2 N); 3.7 (3H, s, CH 3 O); 3.75 (1H, q, J=6 Hz; NCHMe); 4.2 (4H, s, OCH 2 CH 2 O); 6.8 (2H, m, aryl-H); 6.95 (1H, dd, J=1 and 8 Hz, aryl-H); 7.05 (1H, d, J=1 Hz, aryl-H); 7.15-7.3 (3H, m, aryl-H); 7.35-7.45 (4H, m, aryl-H). Example 26 (R)-N-(1-(3-Methoxyphenyl)ethyl)-N-((4-methoxy-3-(1,4-benzodioxan-5-yl)lmethyl)amine The title compound was prepared from 4-methoxy-3-(1,4-benzodioxan-5-yl)benzenecarboxaldehyde and (R)-3-methoxy-α-methylbenzylamine according to general procedure C. C 25 H 27 NO 4 Mass (calculated): [405]; (found): [M+H + ]=406, 255 NMR (400 MHz, CDCl3): 1.3 (3H, d, J=6 Hz, NCHCH 3 ); 3.55 and 3.65 (2H, dd, J=12 Hz, CH 2 N); 3.75 (3H, s, CH 3 O); 3.77 (3H, s, CH 3 O); 3.75 (1H, m; NCHMe); 4.2 (4H, s, OCH 2 CH 2 O); 6.7 (1H, dd, J=1 and 8 Hz, aryl-H); 6.8-6.9 (4H, m, aryl-H); 7.0 (1H, dd, dd, J=1 and 8 Hz, aryl-H); 7.1 (1H, d, J=1 Hz, aryl-H); 7.25-7.3 (3H, m, aryl-H). Example 27 (R)-N-(1-(1-Naphthyl)ethyl)-N-((4-methoxy-3-(1,4-benzodioxan-5-yl)-methyl)amine The title compound was prepared from 4-methoxy-3-(1,4-benzodioxan-5-yl)benzenecarboxaldehyde and (R)-1-(1-naphthyl)ethylamine according to general procedure C. C 28 H 28 NO 3 Mass (calculated): [425]; (found): [M+H + ]=426, 255. NMR (400 MHz, CDCl3): 1.45 (3H, d, J=6 Hz, NCHCH 3 ); 3.55 and 3.65 (2H, dd, J=12 Hz, CH 2 N); 3.7 (3H, s, CH 3 O); 4.2 (4H, s, OCH 2 CH 2 O); 4.65 (1H, q, J=6 Hz; NCHMe); 6.8 (2H, m, aryl-H); 6.9 (1H, dd, J=1 and 8 Hz, aryl-H); 7.0 (1H, d, J=1 Hz, aryl-H); 7.1-7.15 (2H, m, aryl-H); 7.35-7.45 (3H, m, aryl-H); 7.7 (2H, d, J=8 Hz, aryl-H); 7.8 (1H, m, aryl-H); 8.0 (1H, m, aryl-H). Example 28 (R)-N-(1-Phenylethyl)-N-((4-methoxy-3-(2-methylbenzoxazol-5-yl)methyl)amine Step 1) 2-Amino-4-bromophenol A solution of 4-bromo-2-nitrophenol (2 g, 9.17 mmol) and tin(II) chloride (10.35 g, 45.9 mmol) in ethanol (20 mL) was heated at 70° C. for 2 hours, then cooled, poured onto ice, neutralized with NaHCO 3 . The aqueous phase was then extracted with ethyl acetate, dried over sodium sulphate and the solvent removed in vacuo to afford 1.61 g of the title compound. C 6 H 6 BrNO Mass (calculated): [188]; (found): [M+H + ]=188, 190 (Br) NMR (400 MHz, dmso-d 6 ): 4.8 (2H, bs, NH 2 ); 6.5 (1H, dd, J=2 and 8 Hz, aryl-H); 6.6 (1H, d, J=8 Hz, aryl-H); 6.75 (1H, d, J=2 Hz, aryl-H); 9.3 (1H, bs, OH). Step 2) 2-methyl-5-bromobenzoxazole A solution of 2-amino-4-bromophenol (1 g, 5.32 mmol) in trimethyl orthoacetate (20 mL) was refluxed for 1.5 hours. The reaction was then cooled and the solvent removed under reduced pressure to give 1.1 g of title compound. C 8 H 6 BrNO Mass (calculated): [212]; (found): [M+H + ]=212, 214 (Br). NMR (400 MHz, dmso-d 6 ): 2.55 (3H, s, CH 3 ); 7.3 (1H, d, J=8 Hz, aryl-H); 7.35 (1H, dd, J=1 and 8 Hz, aryl-H); 7.75 (1H, d, J=2 Hz, aryl-H). Step 3) 4-methoxy-3-(2-methylbenzoxazol-5-yl)benzenecarboxaldehyde A solution of 5-formyl-2-methoxybenzeneboronic acid (1 g, 5.6 mmol), 2-methyl-5-bromobenzoxazole (1 g, 4.72 mmol) and K 2 CO 3 (1.63 g, 11.8 mmol) in ethanol (20 mL) and toluene (40 mL) was degassed prior to addition of Pd(Ph 3 ) 4 (55 mg, 0.047 mmol). The mixture was refluxed for 20 hours then cooled and filtered through diatomaceous earth. The filtrate was concentrated in vacuo, extracted with ethyl acetate, washed with water and the organic layer dried over sodium sulphate. The crude was purified by column chromatography (heptane/ethyl acetate 7/3 to 6/4) to give 1.13 g of title compound. C 16 H 13 NO 4 Mass (calculated): [267]; (found): [M+H + ]: 268. NMR (400 MHz, CDCl3): 2.6 (3H, s, CH 3 ); 3.85 (3H, s, CH 3 O); 7.05 (1H, d, J=8 Hz, aryl-H); 7.35 (1H, d, J=8 Hz, aryl-H); 7.45 (1H, d, J=8 Hz, aryl-H); 7.75 (1H, s, aryl-H); 7.8-7.85 (2H, m, aryl-H); 9.9 (1H, s, CHO). Step 4) (R)-N-(1-Phenylethyl)-N-((4-methoxy-3-(2-methylbenzoxazol-5-yl)methyl)amine The title compound was prepared from 4-methoxy-3-(benzimidazol-2-yl)benzenecarboxaldehyde and (R)-α-methylbenzylamine according to general procedure C. C 24 H 24 N 2 O 2 Mass (calculated): [372]; (found): [M+H + ]=373. NMR (400 MHz, CDCl3): 1.3 (3H, d, J=6 Hz, NCHCH 3 ); 2.6 (3H, s, CH 3 ); 3.55 and 3.6 (2H, dd, J=12 Hz, CH 2 N); 3.7 (3H, s, CH 3 O); 3.75 (1H, q, J=6 Hz; NCHMe); 6.8 (1H, d, J=8 Hz, aryl-H); 7.2-7.3 (3H, m, aryl-H); 7.3-7.35 (4H, m, aryl-H); 7.4 (1H, dd, J=1 and 8 Hz, aryl-H); 7.45 (1H, d, J=8 Hz, aryl-H); 7.7 (1H, d, J=1 Hz, aryl-H). Example 29 (R)-N-(1-(3-Methoxyphenyl)ethyl)-N-((4-methoxy-3-(2-methylbenzoxazol-5-yl)methyl)amine The title compound was prepared from 4-methoxy-3-(2-methylbenzoxazol-5-yl)benzenecarboxyaldehyde and (R)-3-methoxy-α-methylbenzylamine according to general procedure C. C 25 H 26 N 2 O 3 Mass (calculated): [402]; (found): [M+H + ]=403. NMR (400 MHz, CDCl3): 1.3 (3H, bd, J=6 Hz, NCHCH 3 ); 2.6 (3H, s, CH 3 ); 3.55 and 3.6 (2H, dd, J=12 Hz, CH 2 N); 3.7 (3H, s, CH 3 O); 3.72 (3H, s, CH 3 O); 3.75 (1H, q, J=6 Hz; NCHMe); 6.75 (1H, dd, J=1 and 8 Hz, aryl-H); 6.8-6.9 (3H, m, aryl-H); 7.2-7.3 (3H, m, aryl-H); 7.4 (1H, dd, J=1 and 8 Hz, aryl-H); 7.45 (1H, d, J=8 Hz, aryl-H); 7.7 (1H, d, J=1 Hz, aryl-H). Example 30 (R)-N-(1-(1-Naphthylethyl)-N-((4-methoxy-3-(2-methylbenzoxazol-5-yl)methyl)amine The title compound was prepared from 4-methoxy-3-(2-methylbenzoxazol-5-yl)benzenecarboxyaldehyde and (R)-1-(1-naphthyl)ethylamine according to general procedure C. C 28 H 26 N 2 O 2 Mass (calculated): [422]; (found): [M+H + ]=423. NMR (400 MHz, CDCl3): 1.45 (3H, d, J=6 Hz, NCHCH 3 ); 2.6 (3H, s, CH 3 ); 3.6 and 3.65 (2H, dd, J=12 Hz, CH 2 N); 3.7 (3H, s, CH 3 O); 4.6 (1H, q, J=6 Hz; NCHMe); 6.8 (1H, d, J=8 Hz, aryl-H); 7.2-7.3 (3H, m, aryl-H); 7.35 (1H, dd, J=1 and 8 Hz, aryl-H); 7.4-7.5 (3H, m, aryl-H); 7.7-7.75 (3H, m, aryl-H); 7.8-7.85 (1H, m, aryl-H); 8.05-8.1 (1H, m, aryl-H). Example 31 (R)-N-(1-Phenylethyl)-N-((4-methoxy-3-(benzoxazol-5-yl)methyl)amine Step 1) 5-Bromobenzoxazole A solution of 2-amino-4-bromophenol (2 g, 10.6 mmol) in triethylorthoformate (40 mL) was refluxed for 1.5 hours. The reaction was then cooled and the solvent removed under reduced pressure to give a crude which was purified by washing through a plug of silica eluting with hexane/ethyl acetate 3/2 to afford 1.1 g of title compound. C 7 H 4 BrNO Mass (calculated): [198]; (found): [M+H + ]=198, 200 (Br) NMR (400 MHz, CDCl 3 ): 7.25-7.3 (2H, m, aryl-H); 7.8 (1H, d, J=1, aryl-H); 8.0 (1H, s, aryl-H). Step 2) 4-Methoxy-3-(benzoxazol-5-yl)benzenecarboxyaldehyde A solution of 5-formyl-2-methoxybenzeneboronic acid (1 g, 5.6 mmol), 2-methyl-5-bromobenzoxazole (1 g, 4.72 mmol) and K 2 CO 3 (1.63 g, 11.8 mmol) in ethanol (20 mL) and toluene (40 mL) was degassed prior to addition of Pd(Ph 3 ) 4 (55 mg, 0.047 mmol). The mixture was refluxed for 20 hours then cooled and filtered through diatomaceous earth. The filtrate was concentrated in vacuo, extracted with ethyl acetate, washed with water and the organic layer dried over sodium sulphate. The crude was purified by column chromatography (heptane/ethyl acetate 7/3 to 6/4) to give 1.13 g of title compound. C 15 H 11 NO 3 Mass (calculated): [253]; (found): [M+H + ]: 254, 295. NMR (400 MHz, CDCl3): 2.6 (3H, s, CH 3 ); 3.95 (3H, s, CH 3 O); 7.15 (1H, d, J=8 Hz, aryl-H); 7.55 (1H, d, J=8 Hz, aryl-H); 7.65 (1H, d, J=8 Hz, aryl-H); 7.85-7.95 (2H, aryl-H); 8 (1H, s, aryl-H); 8.15 (1H, s, aryl-H); 10.0 (1H, s, CHO). Step 3) (R)-N-(1-Phenylethyl)-N-((4-methoxy-3-(benzoxazol-5-yl)methyl)amine The title compound was prepared from 4-methoxy-3-(benzoxazol-5-yl)benzenecarboxyaldehyde and (R)-α-methylbenzylamine according to general procedure C. C 23 H 22 N 2 O 2 Mass (calculated): [358]; (found): [M+H + ]=359, 831. NMR (400 MHz, CDCl3): 1.3 (3H, d, J=6 Hz, NCHCH 3 ); 2.6 (3H, s, CH 3 ); 3.5 and 3.55 (2H, dd, J=12 Hz, CH 2 N); 3.7 (3H, s, CH 3 O); 3.75 (1H, q, J=6 Hz; NCHMe); 6.85 (1H, d, J=8 Hz, aryl-H); 7.1-7.2 (3H, m, aryl-H); 7.2-7.3 (4H, m, aryl-H); 7.45 (1H, dd, J=1 and 8 Hz, aryl-H); 7.5 (1H, d, J=8 Hz, aryl-H); 7.8 (1H, d, J=1 Hz, aryl-H); 8 (1H, s, aryl-H). Example 32 (R)-N-(1-(1-(3-Methoxyphenyl)ethyl)-N-((4-methoxy-3-(benzoxazol-5-yl)methyl)amine The title compound was prepared from 4-methoxy-3-(benzoxazol-5-yl)benzene-carboxyaldehyde and (R)-3-methoxy-α-methylbenzylamine according to general procedure C. C 24 H 24 N 2 O 3 Mass (calculated): [388]; (found): [M+H + ]=389, 891. NMR (400 MHz, CDCl3): 1.3 (3H, d, J=6 Hz, NCHCH 3 ); 2.6 (3H, s, CH 3 ); 3.5 and 3.55 (2H, dd, J=12 Hz, CH 2 N); 3.7-3.8 (4H, m, CH 3 O and NCHMe); 6.7 (1H, dd, J=2 and 8 Hz, aryl-H); 6.8-6.9 (3H, m, aryl-H); 7.15-7.25 (3H, m, aryl-H); 7.45 (1H, dd, J=1 and 8 Hz, aryl-H); 7.5 (1H, d, J=8 Hz, aryl-H); 7.85 (1H, d, J=1 Hz, aryl-H); 8 (1H, s, aryl-H). Example 33 (R)-N-(1-(1-Naphthyl)ethyl)-N-((4-methoxy-3-(benzoxazol-5-yl)methyl)amine The title compound was prepared from 4-methoxy-3-(benzoxazol-5-yl)benzene-carboxyaldehyde and (R)-1-(1-naphthyl)ethylamine according to general procedure C. C 27 H 24 N 2 O 2 Mass (calculated): [408]; (found): [M+H + ]=409, 931. NMR (400 MHz, CDCl3): 1.45 (3H, d, J=6 Hz, NCHCH 3 ); 3.6 and 3.65 (2H, dd, J=12 Hz, CH 2 N); 3.7 (3H, s, CH 3 O); 4.65 (1H, q, J=6 Hz; NCHMe); 6.85 (1H, d, J=8 Hz, aryl-H); 7.2-7.3 (2H, m, aryl-H); 7.4-7.5 (4H, m, aryl-H); 7.5 (1H, d, J=6 Hz, aryl-H); 7.7-7.75 (2H, m, aryl-H); 7.75-7.8 (1H, m, aryl-H); 7.85 (1H, d, J=1 Hz, aryl-H); 8 (1H, s, aryl-H); 8.05-8.1 (1H, m, aryl-H). Example 34 (R)-N-(1-Phenylethyl)-N-((4-chloro-3-(4′-methoxyphenyl)phenylmethyl)amine Step 1) 3-Bromo-4-chlorobenzyl alcohol A solution of 3-bromo-4-chlorobenzoic acid (3.53 g, 15 mmol) was dissolved in anhydrous THF (20 mL) and cooled to 0 C prior to addition of borane (1M soln in THF, 20 mL, 20 mmol). The solution was then heated at 65 C for 12 hours then cooled to 0 C and methanol was added dropwise to quench excess borane. The solvent was evaporated under reduced pressure, the residue was redissolved in ethyl acetate and washed with saturated NH 4 Cl then brine, dried over sodium sulphate. The solvent was removed in vacuo to afford 3.23 g of title compound. C 7 H 6 BrClO Mass (calculated): [221], MH + not found. NMR (400 MHz, CDCl 3 ): 4.6 (2H, s, CH 2 OH); 7.15 (1H, dd, J=1 and 8 Hz, aryl-H); 7.35 (1H, d, J=8 Hz, aryl-H); 7.55 (1H, d, J=1 Hz, aryl-H). Step 2) 3-Bromo-4-chlorobenzaldehyde A solution of 3-bromo-4-chlorobenzyl alcohol (3.24 g, 14.6 mmol) in acetone (100 mL) was treated with MnO 2 (16.2 g, 73 mmol) and the mixture stirred for 3 days then filtered over diatomaceous earth. The filtrate was concentrated under reduced pressure to afford 2.0 g of title compound. C 7 H 4 BrClO Mass (calculated): [219]; MH + not found. NMR (400 MHz, CDCl 3 ): 7.55 (1H, d, J=8 Hz, aryl-H); 7.7 (1H, dd, J=1 and 8 Hz, aryl-H); 8.05 (1H, d, J=1 Hz, aryl-H); 9.85 (1H, s, CHO). Step 3) 4-chloro-3-(4-methoxyphenyl)benzenecarboxaldehyde To a degassed solution of 4-methoxybenzeneboronic acid (1.51 g, 10 mmol), 3-bromo-4-chlorobenzaldehyde (2 g, 9.13 mmol), and potassium carbonate (3.13 g, 22.8 mmol) in toluene/ethanol 2/1, (60 mL), Pd(PPh 3 ) 4 (130 mg, 1 mol %) is added and the mixture is degassed for further 5 minutes. The mixture is then refluxed for 2 days. The mixture was partitioned between ethyl acetate and water and extracted. The organic solvent was dried over sodium sulphate, removed under reduced pressure, and the residue purified by column chromatography (heptane/ethyl acetate 19/1 to afford 1.41 g of product. C 14 H 11 ClO 2 Mass (calculated): [246]; MH + not found. NMR (400 MHz, CDCl 3 ): 3.8 (3H, s, MeO); 6.9 (2H, d, J=8 Hz, aryl-H); 7.35 (2H, d, J=8 Hz, aryl-H); 7.55 (1H, d, J=8 Hz, aryl-H); 7.7 (1H, dd, J=2 and 8 Hz, aryl-H); 7.75 (1H, d, J=2 Hz, aryl-H); 9.9 (1H, s, CHO). Step 4) (R)-N-(1-Phenylethyl)-N-((4-chloro-3-(4′-methoxyphenyl)phenylmethyl)amine The title compound was prepared from 4-chloro-3-(4-methoxyphenyl)-benzenecarboxaldehyde and (R)-α-methylbenzylamine according to general procedure C. C 22 H 22 ClNO Mass (calculated): [351]; (found): [M+H + ]=352, 354 (Cl). NMR (400 MHz, CDCl 3 ): 1.15 (3H, d, J=6 Hz, NCHCH 3 ); 3.4 and 3.45 (2H, dd, J=12 Hz, CH 2 N); 3.55 (1H, m, NCHMe); 3.6 (3H, s, MeO); 6.8 (2H, d, J=8 Hz, aryl-H); 7 (1H, dd, J=1 and 8 Hz, aryl-H); 7.05-7.1 (2H, m, aryl-H); 7.15-7.25 (7H, m, aryl-H). Example 35 (R)-N-(1-(3-Methoxyphenyl)ethyl)-N-((4-chloro-3-(4′-methoxyphenyl)-phenylmethyl)amine The title compound was prepared from 4-chloro-3-(4-methoxyphenyl)benzene-carboxaldehyde and (R)-3-methoxy-α-methylbenzylamine according to general procedure C. C 23 H 23 ClNO 2 Mass (calculated): [381]; (found): [M+H + ]=382, 384 (Cl). NMR (400 MHz, CDCl 3 ): 1.3 (3H, d, J=6 Hz, NCHCH 3 ); 3.55 and 3.6 (2H, dd, J=12 Hz, CH 2 N); 3.7-3.75 (4H, m, NCHMe and MeO); 3.8 (3H, s, MeO); 6.75 (1H, dd, J=2 and 8 Hz, aryl-H); 7.85 (1H, d, J=1 Hz, aryl-H); 7.9 (2H, d, J=8 Hz, aryl-H); 7.15 (1H, dd, J=1 and 8 Hz, aryl-H); 7.15-7.25 (2H, m, aryl-H); 7.3-7.4 (3H, m, aryl-H). Example 36 (R)-N-(1-(1-Naphthyl)ethyl)-N-((4-chloro-3-(4′-methoxyphenyl)phenylmethyl)amine The title compound was prepared from 4-chloro-3-(4-methoxyphenyl)benzene-carboxaldehyde and (R)-1-(1-naphthyl)ethylamine according to general procedure C. C 26 H 24 ClNO Mass (calculated): [401]; (found): [M+H + ]=402, 404 (Cl). NMR (400 MHz, CDCl 3 ): 1.45 (3H, d, J=6 Hz, NCHCH 3 ); 3.6 and 3.65 (2H, dd, J=12 Hz, CH 2 N); 3.75 (3H, s, MeO); 4.6 (1H, m, NCHMe); 6.85 (2H, d, J=8 Hz, aryl-H); 7.1 (1H, dd, J=1 and 8 Hz, aryl-H); 7.2 (1H, d, J=1 Hz, aryl-H); 7.3-7.35 (3H, m, aryl-H); 7.4-7.45 (3H, m, aryl-H); 7.65-7.7 (2H, m, aryl-H); 7.8-7.85 (1H, m, aryl-H); 8.05-8.1 (1H, m, aryl-H). Example 37 (R)-N-(1-Phenylethyl)-N-((4-propargyloxy-3-(4′-methoxyphenyl)phenylmethyl)amine Step 1) Benzyl 4-benzyloxy-3-bromobenzoate A 500 mL round bottom flask was charged with DMF (250 mL), 3-bromo-4-hydroxybenzoic acid (8.68 g, 40 mmol), potassium carbonate (22.06 g, 160 mmol) potassium iodide (50 mg) and benzyl bromide (9.26 mL, 78 mmol). The mixture was heated at 75 C for 3 days, then cooled, the solvent removed under reduced pressure and the residue redissolved in ethyl acetated and washed with aqueous potassium carbonate, then brine. The organic layer was dried over sodium sulphate then removed under reduced pressure to give an off-white solid which was purified by column chromatography (eluting with DCM/hexane 1/1) to give 12.1 g of title compound). C 21 H 17 BrO 3 Mass (calculated): [397]; found 397, 399 (Br). NMR (400 MHz, CDCl 3 ): 5.15 (2H, s, OCH 2 Ph); 5.25 (2H, s, OCH 2 Ph); 6.85 (1H, d, J=8 Hz, aryl-H); 7.3-7.5 (10H, m, aryl-H); 7.9 (1H, dd, J=1 and 8 Hz, aryl-H); 8.2 (1H, d, J=1 Hz, aryl-H). Step 2) Benzyl 4-benzyloxy-3-(4-methoxyphenyl)benzoate To a degassed solution of 4-methoxybenzeneboronic acid (5.0 g, 32.9 mmol), benzyl 4-benzyloxy-3-bromobenzoate (12.1 g, 30.5 mmol), and potassium carbonate (10.4 g, 76.2 mmol) in toluene/ethanol 2/1, (140 mL), Pd(PPh 3 ) 4 (400 mg, 1 mol %) was added and the mixture is degassed for further 5 minutes. The mixture is then refluxed for 12 hours. The mixture was partitioned between ethyl acetate and water and extracted. The organic solvent was dried over sodium sulphate, removed under reduced pressure, and the residue purified by column chromatography (9/1 DCM/hexane) to afford 0.73 g of pure title compound, 9.74 g of a 4:6 mixture of title compound and the corresponding ethyl ester, and 0.71 g of the ethyl ester derivative. C 28 H 24 O 4 NMR (400 MHz, CDCl 3 ): C 28 H 24 O 4 Ethyl ester: NMR (400 MHz, CDCl 3 ): 1.3 (3H, t, J=6 Hz, OCH 2 CH 3 ); 3.75 (3H, s, CH 3 O); 4.3 (2H, q, J=6 Hz, OCH 2 CH 3 ); 5.1 (2H, s, OCH 2 Ph); 6.95 (2H, m, aryl-H); 7.2-7.3 (2H, m, aryl-H); 7.45 (2H, m, aryl-H); 7.85 (1H, dd, J=1 and 8 Hz, aryl-H). Benzyl ester: NMR (400 MHz, CDCl 3 ): 3.75 (3H, s, CH 3 O); 4.65 (2H, s, OCH 2 Ph); 5.1 (2H, s, OCH 2 Ph); 7 (2H, m, aryl-H); 7.2-7.3 (2H, m, aryl-H); 7.45 (2H, m, aryl-H); 8.05 (1H, dd, J=1 and 8 Hz, aryl-H). Step 3) Ethyl 4-hydroxy-3-(4-methoxyphenyl)benzoate and 4-hydroxy-3-(4-methoxyphenyl)benzoic acid A mixture of benzyl and ethyl 4-benzyloxy-3-(4-methoxyphenyl)benzoates (9.74 g, ca, 22.9 mmol) was hydrogenated in THF/ethanol (100 mL) under atmospheric pressure for 60 hours, then the catalyst removed by filtration and the solvent evaporated in vacuo to afford 6.62 g of a mixture of the title compounds. C 12 H 14 O 4 Mass (calculated): [244]. Found: 245. NMR (400 MHz, CDCl 3 ): 3.8 (3H, s, CH 3 O); 5.8 (1H, bs, OH); 6.95 (3H, m, aryl-H); 7.35 (2H, d, J=8 Hz, aryl-H); 7.9-8 (2H, m, aryl-H). C 16 H 16 O 4 Mass (calculated): [272]. Found: 273. NMR (400 MHz, CDCl 3 ): 1.3 (3H, t, J=6 Hz, CH 3 CH 2 O); 3.8 (3H, s, CH 3 O); 4.3 (2H, q, J=6 Hz, CH 3 CH 2 O); 5.75 (1H, s, OH); 6.9-7 (3H, m, aryl-H); 7.35 (2H, d, J=8 Hz, aryl-H); 7.9-7.95 (2H, m, aryl-H). Step 4) 4-hydroxy-3-(4-methoxyphenyl)benzyl alcohol A solution of Ethyl 4-hydroxy-3-(4-methoxyphenyl)benzoate and 4-hydroxy-3-(4-methoxyphenyl)benzoic acid (5.3 g, 19.47 mmol) in anhydrous THF (100 mL) was cooled to 0° C. and treated with LiAlH 4 (2.95 g, 77.8 mmol); the mixture was then heated at 65 C for one hour then cooled and aqueous NaOH (5%, 19.4 mL) was added drop wise. The resulting precipitate was filtered off and the filtrate concentrated under reduced pressure to afford 5.54 g of crude product. C 14 H 14 O 3 Mass (calculated): [230]. Found: 213 [MH + -OH]. NMR (400 MHz, CDCl 3 ): 3.8 (3H, s, CH 3 O); 4.55 (2H, s, CH 2 ); 6.9 (1H, d, J=8 Hz, aryl-H); 6.9-7 (2H, m, aryl-H); 7.25-7.35 (2H, m, aryl-H); 7.4-7.45 (2H, m, aryl-H). Step 5) 4-Hydroxy-3-(4-methoxyphenyl)benzaldehyde A solution of 4-hydroxy-3-(4-methoxyphenyl)benzyl alcohol (5.54 g, 24 mmol) in acetone (250 mL) was treated with MnO 2 and the mixture stirred for 3 days. The solid was filtered on diatomaceous earth and the filtrate was concentrated under reduced pressure to afford 5.96 g of title compound as a pale green oil, impure with manganese salts. C 14 H 12 O 3 Mass (calculated): [228]. Found: 229. Step 6) 4-Propargyloxy-3-(4-methoxyphenyl)benzaldehyde A solution of 4-hydroxy-3-(4-methoxyphenyl)benzaldehyde (1.14 g, 5 mmol) in DMF (10 mL) was treated with potassium carbonate (2.48 g, 18 mmol), potassium iodide (10 mg) and propargyl bromide (0.67 mL, 6 mmol). The mixture was heated at 80 C for 3 days, then cooled and the solvent removed under reduced pressure. The residue was redissolved in ethyl acetate and washed water then brine. The organic layer was dried over sodium sulphate then the solvent removed under reduced pressure and the residue purified by column chromatography (3/1 hexane/ethyl acetate) to afford 0.078 g of title compound. C 17 H 14 O 3 Mass (calculated): [266]. Found: 267. NMR (400 MHz, CDCl 3 ): 2.45 (1H, t, J=1 Hz, C#CH); 3.75 (3H, s, CH 3 O); 4.7 (2H, d, J=1 Hz, C#CCH 2 O); 6.85 (2H, d, J=8 Hz, aryl-H); 7.15 (1H, d, J=8 Hz, aryl-H); 7.4 (2H, d, J=8 Hz, aryl-H); 7.75-7.85 (2H, m, aryl-H). Step 7) (R)-N-(1-Phenylethyl)-N-((4-propargyloxy-3-(4′-methoxyphenyl)phenylmethyl)amine The title compound was prepared from 4-propargyloxy-3-(4-methoxyphenyl)-benzaldehyde and (R)-α-methylbenzylamine according to general procedure C. C 25 H 25 NO 2 Mass (calculated): [371]; (found): [M+H + ]=372. NMR (400 MHz, CDCl 3 ): 1.3 (3H, d, J=6 Hz, NCHCH 3 ); 2.3 (1H, t, J=1 Hz, C#CH); 3.5 and 3.55 (2H, dd, J=12 Hz, CH 2 N); 3.75-3.8 (4H, m, NCHMe and MeO); 4.55 (2H, d, J=1 Hz, C#CCH 2 O); 6.85 (2H, d, J=8 Hz, aryl-H); 7 (1H, d, J=8 Hz, aryl-H); 7.1-7.2 (3H, m, aryl-H); 7.25-7.35 (4H, m, aryl-H); 7.4 (2H, d, J=8 Hz, aryl-H). Example 38 (R)-N-(1-Phenylethyl)-N-((4-ethoxy-3-(4′-methoxyphenyl)phenylmethyl)amine Step 1) 4-Ethoxy-3-(4-methoxyphenyl)benzaldehyde A solution of 4-hydroxy-3-(4-methoxyphenyl)benzaldehyde (0.5 g, 2.19 mmol) in DMF (5 mL) was treated with potassium carbonate (0.9 g, 6.57 mmol), potassium iodide (10 mg) and ethyl iodide (0.21 mL,02.63 mmol). The mixture was heated at 80° C. for 3 days, then cooled and the solvent removed under reduced pressure. The residue was redissolved in ethyl acetate and washed water then brine. The organic layer was dried over sodium sulphate then the solvent removed under reduced pressure and the residue purified by column chromatography (3/1 hexane/ethyl acetate) to afford 0.043 g of title compound. C 16 H 16 O 3 Mass (calculated): [256]. Found: 257. NMR (400 MHz, CDCl 3 ): 1.3 (3H, t, J=6 Hz, CH 3 CH 2 O); 3.75 (3H, s, CH 3 O); 4.1 (2H, q, J=6 Hz, CH 3 CH 2 O); 6.85 (2H, d, J=8 Hz, aryl-H); 6.95 (1H, d, J=8 Hz, aryl-H); 7.4 (2H, d, J=8 Hz, aryl-H); 7.7 (1H, dd, J=1 and 8 Hz, aryl-H); 7.75 (1H, d, J=1 Hz, aryl-H). Step 2) (R)-N-(1-Phenylethyl)-N-((4-ethoxy-3-(4′-methoxyphenyl)phenylmethyl)amine The title compound was prepared from 4-ethoxy-3-(4-methoxyphenyl)benzaldehyde and (R)-α-methylbenzylamine according to general procedure C. C 24 H 27 NO 2 Mass (calculated): [361]; (found): [M+H + ]=362. NMR (400 MHz, CDCl 3 ): 1.25 (3H, t, J=6 Hz, OCH 2 CH 3 ) 1.3 (3H, d, J=6 Hz, NCHCH 3 ); 3.5 and 3.55 (2H, dd, J=12 Hz, CH 2 N); 3.75-3.8 (4H, m, NCHMe and MeO); 3.95 (2H, q, J=6 Hz, OCH 2 CH 3 ); 6.8 (1H, d, J=8 Hz, aryl-H); 6.85 (2H, d, J=8 Hz, aryl-H); 7.15-7.35 (2H, m, aryl-H); 7.35-7.4 (4H, m, aryl-H); 7.45 (2H, d, J=8 Hz, aryl-H). Example 39 (R)-N-(1-Phenylethyl)-N-((4-methoxy-3-(3,4-dimethoxyphenyl)phenylmethyl)amine Step 1) 4-Methoxy-3-(3,4-dimethoxyphenyl)benzenecarboxaldehyde To a degassed solution of 3,4-dimethoxybenzeneboronic acid (2.18 g, 12 mmol), 3-bromo-4-methoxybenzaldehyde (3.23 g, 15 mmol) and potassium carbonate (5.18 g, 37.5 mmol) in toluene/ethanol 2/1 (72 mL), Pd(PPh 3 ) 4 (173 mg, 1.2 mol %) was added and the mixture was degassed for further 5 minutes. The mixture was then refluxed for 15 hours. The solid was filtered off and the filtrate concentrated under reduced pressure. The residue was dissolved in AcOEt, partitioned between ethyl acetate and water and extracted then washed with brine. The organic solvent was dried over sodium sulphate, removed under reduced pressure, and the residue purified by column chromatography (heptane/ethyl acetate 1/1) to afford 2.95 of title compound. C 16 H 16 O 4 Mass (calculated): [272]. Found: 273. NMR (400 MHz, CDCl 3 ): 3.85-3.87 (9H, 3s, 3 CH 3 O); 6.9 (1H, d, J=8 Hz, aryl-H); 6.9-7.05 (3H, m, aryl-H); 7.85-7.9 (2H, m, aryl-H); 9.85 (1H, s, CHO). Step 2) (R)-N-(1-Phenylethyl)-N-((4-methoxy-3-(3,4-dimethoxyphenyl)-phenylmethyl)amine The title compound was prepared from 4-methoxy-3-(3,4-dimethoxyphenyl)benzenecarboxaldehyde and (R)-α-methylbenzylamine according to general procedure C. C 24 H 27 NO 3 Mass (calculated): [377]; (found): [M+H + ]=378. NMR (400 MHz, CDCl 3 ): 1.3 (3H, t, J=6 Hz, NCHCH 3 ); 3.55 and 3.6 (2H, dd, J=12 Hz, CH 2 N); 3.7 (3H, s, CH 3 O); 3.8-4 (7H, m, NCHMe and 2 MeO); 6.8-6.85 (2H, m, aryl-H); 6.95-7.05 (2H, m, aryl-H); 7.1-7.15 (2H, m, aryl-H); 7.25-7.4 (4H, m, aryl-H). Example 40 (R)-N-(1-(3-Methoxyphenyl)ethyl)-N-((4-methoxy-3-(3,4-dimethoxyphenyl)phenylmethyl)amine The title compound was prepared from 4-methoxy-3-(3,4-dimethoxyphenyl)-benzenecarboxaldehyde and (R)-3-methoxy-α-methylbenzylamine according to general procedure C. C 25 H 29 NO 4 Mass (calculated): [407]; (found): [M+H + ]=408. NMR (400 MHz, CDCl 3 ): 1.3 (3H, t, J=6 Hz, NCHCH 3 ); 3.55 and 3.6 (2H, dd, J=12 Hz, CH 2 N); 3.7 and 3.72 (6H, 2 s, 2 CH 3 O); 3.8-3.9 (4H, m, NCHMe and CH 3 O); 6.8 (1H, dd, J=2 and 8 Hz, aryl-H); 6.8-6.9 (2H, m, aryl-H); 6.9-7 (2H, m, aryl-H); 7-7.05 (2H, m, aryl-H); 7.15-7.3 (3H, m, aryl-H). Example 41 (R)-N-(1-(1-Naphthyl)ethyl)-N-((4-methoxy-3-(3,4-dimethoxyphenyl)-phenylmethyl)amine The title compound was prepared from 4-methoxy-3-(3,4-dimethoxyphenyl)benzenecarboxaldehyde and (R)-1-(1-naphthyl)ethylamine according to general procedure C. C 28 H 29 NO 3 Mass (calculated): [427]; (found):. [M+H + ]=428, 257, 155. NMR (400 MHz, CDCl 3 ): 1.4 (3H, t, J=6 Hz, NCHCH 3 ); 3.55 and 3.6 (2H, dd, J=12 Hz, CH 2 N); 3.7 (3H, s, CH 3 O); 3.8 and 3.82 (6H, 2 s, 2 CH+O); 6.8-6.85 (2H, m, aryl-H); 6.95-7.0 (2H, m, aryl-H); 7.1-7.2 (2H, m, aryl-H); 7.3-7.5 (3H, m, aryl-H); 7.65-7.7 (2H, m, aryl-H); 7.75-7.8 (1H, m, aryl-H); 8.05-8.1 (1H, m, aryl-H). Example 42 (R)-N-(1-Phenylethyl)-N-((4-methoxy-3-(pyrid-2-yl)phenylmethyl)amine Step 1) 4-Methoxy-3-(pyrid-2-yl)benzenecarboxaldehyde A degassed solution of 2-bromopyridine (1.0 g, 6.33 mmol), 3-borono-4-methoxybenzaldehyde (1.37 g, 7.6 mmol) and [(PPh 3 ) 2 PdCl 2 (64 mg, 0.09 mmol) in dimethoxyethane (30 mL), methanol (5 mL) and Na 2 CO 3 (2M, 20 mL) was heated at 75° C. for 16 hours. The mixture was then cooled, diluted with water and extracted with DCM. The organic layer was dried over sodium sulphate and the solvent removed under reduced pressure. The crude was purified by column chromatography (heptane/AcOEt 7/3 to 6/4) to afford 1.31 g of title compound. C 13 H 11 NO 2 Mass (calculated): [213]; (found) [M+H + ]=214. NMR (400 MHz, CDCl 3 ): 3.85 (3H, s, MeO); 7.05 (1H, d, J=8 Hz, aryl/pyridyl-H); 7.2 (1H, m, aryl/pyridyl-H); 7.65 (1H, m, aryl/pyridyl-H); 7.75 (1H, m, aryl/pyridyl-H); 7.85 (1H, m, aryl/pyridyl-H); 8.2 (1H, s, aryl/pyridyl-H); 8.65 (1H, s, aryl/pyridyl-H); 9.9 (1H, s, CHO). Step 2) (R)-N-(1-Phenylethyl)-N-((4-methoxy-3-(pyrid-2-yl)phenylmethyl)amine The title compound was prepared from 4-methoxy-3-(pyrid-2-yl)-benzenecarboxaldehyde and (R)-α-methylbenzylamine according to general procedure C. C 21 H 22 N 2 O Mass (calculated): [318]; (found): [M+H + ]=319, 198. NMR (400 MHz, CDCl 3 ): 1.3 (3H, d, J=6 Hz, NCHCH 3 ); 3.5 and 3.55 (2H, dd, J=12 Hz, CH 2 N); 3.7 (3H, s, MeO); 3.75 (1H, q, J=7 Hz; NCHMe); 6.8 (1H, d, J=8 Hz, aryl-H); 7.05-7.1 (1H, m, aryl-H); 7.15-7.35 (6H, m, aryl-H); 7.55-7.6 (2H, m, aryl-H); 7.7 (1H, d, J=8 Hz, aryl-H); 8.55-8.6 (1H, m, pyridyl-H). Example 43 (R)-N-(1-(3-Methoxyphenyl)ethyl)-N-((4-methoxy-3-(pyrid-2-yl)phenylmethyl)amine The title compound was prepared from 4-methoxy-3-(pyrid-2-yl)benzenecarboxaldehyde and (R)-3-methoxy-α-methylbenzylamine according to general procedure C. C 22 H 24 N 2 O 2 Mass (calculated): [348]; (found): [M+H + ]=349, 198. NMR (400 MHz, CDCl 3 ): 1.3 (3H, d, J=6 Hz, NCHCH 3 ); 3.55 and 3.6 (2H, dd, J=12 Hz, CH 2 N); 3.7-3.8 (7H, m, 2 MeO and NCHMe); 6.7 (1H, dd, J=1 and 8 Hz, aryl-H); 6.8-6.9 (3H, m, aryl-H); 7.05-7.3 (3H, m, aryl-H); 7.55-7.65 (2H, m, aryl-H); 7.75 (1H, d, J=8 Hz, aryl-H); 7.7 (1H, d, J=8 Hz, aryl-H); 8.6 (1H, m, pyridyl-H). Example 44 (R)-N-(1-(1-Naphthyl)ethyl)-N-((4-methoxy-3-(pyrid-2-yl)phenylmethyl)amine The title compound was prepared from 4-methoxy-3-(pyrid-2-yl)benzenecarboxaldehyde and (R)-1-(1-naphthyl)ethylamine according to general procedure C. C 25 H 24 N 2 O Mass (calculated): [368]; (found): [M+H + ]=369, 198. NMR (400 MHz, CDCl 3 ): 1.45 (3H, d, J=6 Hz, NCHCH 3 ); 3.6 and 3.65 (2H, dd, J=12 Hz, CH 2 N); 3.75 (3H, s, MeO); 4.65 (1H, q, J=7 Hz; NCHMe); 6.8 (1H, d, J=8 Hz, aryl-H); 7.05-7.1 (1H, m, aryl-H); 7.15-7.25 (1H, m, aryl-H); 7.3-7.45 (3H, m, aryl-H); 7.5-7.6 (2H, m, aryl-H); 7.6-7.75 (3H, m, aryl-H); 7.75-7.8 (1H, m, aryl-H): 8-8.05 (1H, m, aryl-H); 8.55-8.6 (1H, m, pyridyl-H). Example 45 (R)-N-(1-Phenylethyl)-N-((4-methoxy-3-(pyrid-4-yl)phenylmethyl)amine Step 1) 4-Methoxy-3-(pyrid-4-yl)benzenecarboxaldehyde A degassed solution of 4-bromopyridine hydrochloride (1.36 g, 7 mmol), 3-borono-4-methoxybenzaldehyde (1.37 g, 7.6 mmol) and [(PPh 3 ) 2 PdCl 2 (246 mg, 0.35 mmol) in dimethoxyethane (30 mL), methanol (5 mL) and Na 2 CO 3 (2M, 20 mL) was heated at 75° C. for 16 hours. The mixture was then cooled, diluted with water and extracted with DCM. The organic layer was dried over sodium sulphate and the solvent removed under reduced pressure. The crude was purified by column chromatography (heptane/AcOEt 3/1) to afford 1.18 g of title compound C 13 H 11 NO 2 Mass (calculated): [213]; (found) [M+H + ]=214. NMR (400 MHz, CDCl 3 ): 3.85 (3H, s, MeO); 7.05 (1H, d, J=8 Hz, aryl-H); 7.4 (2H, d, J=7 Hz, pyridyl-H); 7.8 (1H, d, J=1 Hz, aryl-H); 7.85 (1H, dd, J=1 and 8 Hz); 8.6 (2H, d, J=7 Hz, pyridyl-H). Step 2) (R)-N-(1-Phenylethyl)-N-((4-methoxy-3-(pyrid-4-yl)phenylmethyl)amine The title compound was prepared from 4-methoxy-3-pyrid-4-yl)benzenecarboxaldehyde and (R)-α-methylbenzylamine according to general procedure C. C 21 H 22 N 2 O Mass (calculated): [318]; (found): [M+H + ]=319, 215. NMR (400 MHz, CDCl 3 ): 1.3 (3H, d, J=6 Hz, NCHCH 3 ); 3.55 (2H, bq, CH 2 N); 3.75 (3H, s, MeO); 3.8 (1H, bq, NCHMe); 6.85 (1H, d, J=8 Hz, aryl-H); 7.15-7.25 (3H, m, aryl-H); 7.25-7.3 (4H, m, aryl-H); 7.45 (2H, bs, pyridyl-H); 8.4-8.6 (2H, bs, pyridyl-H). Example 46 (R)-N-(1-(3-Methoxyphenyl)ethyl)-N-((4-methoxy-3-(pyrid-4-yl)phenylmethyl)amine The title compound was prepared from 4-methoxy-3-(pyrid-4-yl)benzene-carboxaldehyde and (R)-3-methoxy-α-methylbenzylamine according to general procedure C. C 22 H 24 N 2 O 2 Mass (calculated): [348]; (found): [M+H + ]=349, 215. NMR (400 MHz, CDCl 3 ): 1.3 (3H, d, J=7 Hz, NCHCH 3 ); 3.55 and 3.6 (2H, dd, J=12 Hz, CH 2 N); 3.75 (3H, s, MeO); 3.8 (1H, q, J=7 Hz, NCHMe); 6.75 (1H, d, J=8 Hz, aryl-H); 6.85-6.9 (3H, m, aryl-H); 7.15-7.25 (3H, m, aryl-H); 7.4 (2H, bd, pyridyl-H); 8.5 (2H, bs, pyridyl-H). Example 47 (R)-N-(1-(1-Naphthyl)ethyl)-N-((4-methoxy-3-(pyrid-4-yl)phenylmethyl)amine The title compound was prepared from 4-methoxy-3-(pyrid-4-yl)benzenecarboxaldehyde and (R)-1-(1-naphthyl)ethylamine according to general procedure C. C 25 H 24 N 2 O Mass (calculated): [368]; (found): [M+H + ]=369, 215. NMR (400 MHz, CDCl 3 ): 1.5 (3H, d, J=6 Hz, NCHCH 3 ); 3.55 and 3.6 (2H, dd, J=12 Hz, CH 2 N); 3.75 (3H, s, MeO); 4.7 (1H, bq, NCHMe); 6.85 (1H, d, J=8 Hz, aryl-H); 7.15 (1H, d, J=1 Hz, aryl-H); 7.3 (1H, dd, J=1 and 8 Hz, aryl-H); 7.35 (2H, d, J=5 Hz, pyridyl-H); 7.35-7.5 (3H, m, aryl-H); 7.65-7.7 (2H, m, aryl-H); 7.85 (1H, dd, J=1 and 8 Hz, aryl-H); 8 (1H, d, J=8 Hz, aryl-H); 8.5 (2H, bd, pyridyl-H). Example 48 ((1R)-1-Phenylethyl){[4-methoxy-3-(1-methylindol-5-yl)phenyl]methyl}amine Step 1) 3-(Indol-5-yl)-4-methoxybenzaldehyde A solution of 5-formyl-2-methoxybenzeneboronic acid (5 g, 28.5 mmol5-bromoindole (5 g, 25.5 mmol) and K 2 CO 3 (7.7 g, 56 mmol) in ethanol (25 mL) and toluene (50 mL) was degassed prior to addition of Pd(Ph 3 ) 4 (300 mg, 0.25 mmol). The mixture was refluxed for 16 hours then cooled and concentrated in vacuo, extracted with dichloromethane, washed with water and the organic layer dried over sodium sulphate. The crude was purified by column chromatography (hexane/ethyl acetate 6/4) to give 4.5 g of title compound. C 16 H 13 NO 2 Mass (calculated): [251]; (found): [M+H + ]=252. NMR (400 MHz, CDCl3): 3.75 (3H, s, CH 3 O); 6.45 (1H, m, indole-H); 6.95 (1H, d, J=8 Hz, aryl-H); 7.05-7.15 (1H, m, aryl-H); 7.3 (1H, dd, J=1 and 8 Hz, aryl-H); 7.4 (1H, d, J=8 Hz, aryl-H); 7.65 (1H, s, aryl-H); 7.7 (1H, dd, J=1 and 8 Hz, aryl-H); 7.75 (1H, d, J=1 Hz, aryl-H); 8.1 (1H, bs, NH); 9.8 (1H, s, CHO). Step 2) 3-(1-Methylindol-5-yl)-4-methoxybenzaldehyde A solution of 3-(indol-5-yl)-4-methoxybenzaldehyde (0.50 g, 2.0 mmol) in DMF (10 mL) was cooled to 0° C. and NaH (60% dispersion in mineral oil, 0.14 g, 3.0 mmol) was added. The mixture was stirred at 0° C. for 45 minutes, then methyl iodide (0.34 g, 4.4 mmol) was added and the reaction was stirred for 16 hours at room temperature. The mixture was then poured into water and extracted with ethyl acetate, washed with water and dried over sodium sulphate. The solvent was removed in vacuo and the crude was purified by column chromatography (hexane/ethyl acetate 7/3) to give 0.48 g of title compound. C 17 H 15 NO 2 Mass (calculated): [265]; (found): [M+H + ]=266. NMR (400 MHz, CDCl3): 3.85 (3H, s, CH 3 O); 3.95 (3H, s, CH 3 N); 6.65 (1H, m, indole-H); 7.10-7.25 (2H, m, aryl-H); 7.4-7.5 (2H, m, aryl-H); 7.8 (1H, s, aryl-H): 7.9 (1H, dd, J=1 and 8 Hz, aryl-H); 8 (1H, d, J=1 Hz, aryl-H); 10 (1H, s, CHO). Step 3) ((1R)-1-Phenylethyl){[4-methoxy-3-(1-methylindol-5-yl)phenyl]methyl}amine The title compound was prepared from 3-(1-methylindol-5-yl)-4-methoxybenzaldehyde and (R)-α-methylbenzylamine according to general procedure C. C 25 H 26 N 2 O Mass (calculated): [370]; (found): [M+H + ]=371, 250. Example 49 [(1R)-1-(3-Methoxyphenyl)ethyl]{[4-methoxy-3-(1-methylindol-5-yl)phenyl]methyl}amine The title compound was prepared from 3-(1-methylindol-5-yl)-4-methoxybenzaldehyde and (R)-3-methoxy-α-methylbenzylamine according to general procedure C. C 26 H 28 N 2 O 2 Mass (calculated): [400]; (found): [M+H + ]=401. NMR (400 MHz, CDCl3): 1.3 (3H, d, J=6 Hz, NCHCH 3 ); 3.55 and 3.6 (2H, dd, J=12 Hz, CH 2 N); 3.65-3.8 (10H, m, 3 MeO and NCHMe); 6.4 (1H, d, J=5 Hz, indole-H); 6.7 (1H, dd, J=1 and 8 Hz, aryl-H); 6.8-6.9 (3H, m, aryl-H); 6.95 (1H, d, J=2 Hz, aryl-H); 7.1-7.3 (4H, m, aryl-H); 7.35 (1H, dd, J=1 and 8 Hz, aryl-H); 7.65 (1H, d, J=1 Hz, aryl-H). Example 50 ((1R)-1-Naphthylethyl){[4-methoxy-3-(1-methylindol-5-yl)phenyl]methyl}amine The title compound was prepared from 3-(1-methylindol-5-yl)-4-methoxybenzaldehyde and (R)-1-(1-naphthyl)ethylamine according to general procedure C. C 29 H 28 N 2 O Mass (calculated): [420]; (found): [M+H + ]=421. NMR (400 MHz, CDCl3): 1.6 (3H, d, J=6 Hz, NCHCH 3 ); 3.8 and 3.85 (2H, dd, J=12 Hz, CH 2 N); 3.85 and 3.87 (6H, m, 2 MeO); 4.8 (1H, q, J=6 Hz, NCHMe); 6.6 (1H, d, J=5 Hz, indole-H); 7 (1H, d, J=8 Hz, aryl-H); 7.1 (1H, d, J=1 Hz, aryl-H); 7.3 (1H, dd, J=1 and 8 Hz, aryl-H); 7.35-7.4 (2H, m, aryl-H); 7.5 (1H, dd, J=1 and 8 Hz, aryl-H); 7.5-7.6 (3H, m, aryl-H); 7.8-7.9 (3H, m, aryl-H); 7.95-7.8 (1H, m, aryl-H); 8.2-8.3 (1H, m, aryl-H). Example 51 (R)-N-(1-Phenylethyl)-N-((4-methoxy-3-(3-methoxyphenyl)phenylmethyl)amine Step 1) 4-Methoxy-3-(3-methoxyphenyl)benzenecarboxaldehyde A degassed solution of 3-bromoanisole (1.31 g, 7 mmol), 3-borono4-methoxybenzaldehyde (1.38 g, 7.4 mmol) and [(PPh 3 ) 2 PdCl 2 (246 mg, 0.35 mmol) in dimethoxyethane (35 mL), methanol and Na 2 CO 3 2M (20 mL) was heated at 75° C. for 24 hours. The mixture was then cooled, diluted with water and extracted with ethyl acetate. The organic layer was dried over sodium sulphate and the solvent removed under reduced pressure. The crude was purified by column chromatography (heptane/AcOEt 4/1) to afford 1.14 g of title compound. C 15 H 14 O 3 Mass (calculated): [242]; (found): [M+H + ]=243; [M+H + +MeCN]=284. NMR (400 MHz, CDCl 3 ): 3.85 (3H, s, MeO); 3.95 (3H, s, MeO); 6.9 (1H, dd, J=1 and 8 Hz, aryl-H); 7.05-7.15 (1H, m, aryl-H); 7.35 (1H, t, J=8 Hz, aryl-H); 7.85-7.95 (2H, m, aryl-H); 9.85 (1H, s, CHO). Step 2) (R)-N-(1-Phenylethyl)-N-((4-methoxy-3-(3-methoxyphenyl)phenylmethyl)amine The title compound was prepared from 4-methoxy-3-(3-methoxyphenyl)benzenecarboxaldehyde and (R)-α-methylbenzylamine according to general procedure C. C 23 H 25 NO 2 Mass (calculated): [347]; (found): [M+H + ]=348. NMR (400 MHz, CDCl 3 ): 1.3 (3H, d, J=6 Hz, NCHCH 3 ); 3.5 and 3.55 (2H, dd, J=12 Hz, CH 2 N); 3.7 (3H, s, MeO); 3.75-3.85 (4H, m, NCHMe and MeO); 6.75-6.9 (2H, m, aryl-H); 7-7.1 (2H, m, aryl-H); 7.1-7.2 (3H, m, aryl-H); 7.2-7.3 (5H, m, aryl-H). Example 52 (R)-N-(1-(3-Methoxyphenyl)ethyl)-N-((4-methoxy-3-(3-methoxyphenyl)phenylmethyl)amine The title compound was prepared from 4-methoxy-3-(3-methoxyphenyl)benzenecarboxaldehyde and (R)-3-methoxy-α-methylbenzylamine according to general procedure C. C 24 H 27 NO 3 Mass (calculated): [377]; (found): [M+H + ]=378. NMR (400 MHz, CDCl 3 ): 1.4 (3H, d, J=6 Hz, NCHCH 3 ); 3.6 and 3.65 (2H, dd, J=12 Hz, CH 2 N); 3.8-3.9 (10H, 3 s and m, NCHMe and 3 MeO); 6.8 (1H, dd, J=1 and 8 Hz, aryl-H); 6.9 (1H, dd, J=1 and 8 Hz, aryl-H); 6.95-7 (3H, m, aryl-H); 7.1-7.2 (2H, m, aryl-H); 7.2-7.4 (4H, m, aryl-H). Example 53 (R)-N-(1-(1-Napthyl)ethyl)-N-((4-methoxy-3-(3-methoxyphenyl)phenylmethyl)amine The title compound was prepared from 4-methoxy-3-(3-methoxyphenyl)benzenecarboxaldehyde and (R)-1-(1-naphthyl)ethylamine according to general procedure C. C 27 H 27 NO 2 Mass (calculated): [397]; (found): [M+H + ]=398. NMR (400 MHz, CDCl 3 ): 1.45 (3H, d, J=6 Hz, NCHCH 3 ); 3.6 and 3.65 (2H, dd, J=12 Hz, CH 2 N); 3.7 and 3.75 (6H, 2 s, 2 MeO); 4.65 (1H, q, J=6 Hz, NCHMe); 6.75-6.9 (2H, m, aryl-H); 7-7.1 (2H, m, aryl-H); 7.1-7.25 (3H, m, aryl-H); 7.4-7.45 (3H, m, aryl-H); 7.7 (2H, d, J=8 Hz, aryl-H); 7.75-7.8 (1H, m, aryl-H); 8.05-8.1 (1H, m, aryl-H). Example 54 N-(1-(Quinol-5-yl)ethyl)-N-((4-methoxy-3-(4′-methoxyphenyl)phenylmethyl)amine Step 1) 5-Trifluoromethanesulphonyloxyquinoline A solution of 5-hydroxyquinoline (0.5 g, 3.4 mmol) in DCM (5 mL) was treated with pyridine (1.08 g, 13.7 mmol) and then trifluoromethanesulphone anhydride (1.1 g, 4.12 mmol). The mixture was stirred overnight then diluted with dichloromethane and washed with water. The organic layer was concentrated under reduced pressure and the excess pyridine azeotropically removed with toluene, to afford 0.47 g of title compound. Step 2) 5-Acetylquinoline A degassed solution of 5-trifluoromethanesulphonyloxyquinoline (0.41 g, 1.47 mmol), butyl vinyl ether (0.38 mL, 2.94 mmol), palladium acetate (10 mg, 0.043 mmol), potassium carbonate (0.24 g, 1.76 mmol), 1,3-bis(diphenylphosphino)propane (40 mg, 0.097 mmol) in DMF (3.67 mL) and water (0.88 mL) was heated in a sealed tube at 100° C. for 16 hours. The reaction mixture was then cooled and treated with 1M HCl and the mixture stirred for 30 minutes, then basified and extracted with dichloromethane. The organic layer was then evaporated under reduced pressure to afford the title compound. Step 3) 4-Methoxy-3-(4-methoxyphenyl)benzyl alcohol A solution of 4-methoxy-3-(4-methoxyphenyl)benzenecarboxaldehyde (1 g, 4.13 mmol) in methanol (12 mL) was treated with polymer-supported borohydride (10.3 mmol) and the mixture shaken for 16 hours. The resin was then filtered and the filtrate concentrated under reduced pressure to afford 0.88 g of title compound. Step 4) 4-Methoxy-3-(4-methoxyphenyl)benzylazide A solution of 4-methoxy-3-(4-methoxyphenyl)benzyl alcohol (0.88 g, 3.59 mmol) and diphenylphosphoryl azide (1.18 g, 4.32 mmol) in anhydrous THF (15 mL) was cooled in an ice-bath prior to addition of 1,8-diazabicyclo[5.4.0]undec-7-ene (0.87 g, 5.76 mmol). The resulting mixture was then stirred at room temperature for 48 hours. More diphenylphosphoryl azide was added (1.4 mol, 0.39 g) and the mixture stirred for further 16 hours. The solvent was then evaporated, the residue taken into dichloromethane and washed with acid. The organic layer was separated and the solvent removed under reduced pressure to afford 0.82 g of title compound. Step 5) 4-Methoxy-3-(4-methoxyphenyl)benzylamine A solution of 4-methoxy-3-(4-methoxyphenyl)benzylazide (0.82 g, 3.07 mmol) in ethanol (50 mL) was hydrogenated under atmospheric pressure for 16 hours. The catalyst was filtered off, the solvent removed under reduced pressure and the crude purified by column chromatography (hexane/ethyl acetate 6/1) to afford 400 mg of title compound. C 15 H 17 NO 2 Mass (calculated): [243]. Found: 227 (MH + -NH 2 ). NMR (400 MHz, CDCl 3 ): 3.65 (3H, s, CH 3 O); 3.7-3.8 (5H, m, CH 3 O and aryl-CH 2 O); 5.45 (2H, bs, NH 2 ); 6.75-6.95 (3H, m, aryl-H); 7.1-7.25 (2H, m, aryl-H); 7.4 (2H, d, J=8 Hz, aryl-H). Step 6) N-(1-(Quinol-5-yl)ethyl)-N-((4-methoxy-3-(4′-methoxyphenyl)phenylmethyl)amine A solution of 4-methoxy-3-(4-methoxyphenyl)benzylamine (243 mg, 1, mmol) and 5-acetylquinoline (152 mg, 0.89 mmol) in methanol (3 mL) was treated with acetic acid (0.05 mL) and polymer-supported cyanoborohydride (0.9 g, 2.25 mmol). The mixture was stirred at 50 C for 20 hours, then cooled. The solid was filtered off and the filtrate concentrated in vacuo. The crude was purified by column chromatography (AcOEt/cyHex 7/3 to 100% AcOEt) to afford 91 mg of title compound. C 26 H 26 N 2 O 2 Mass (calculated): [398]. Found: 399, 797. NMR (400 MHz, CDCl 3 ): 1.45 (3H, d, J=6 Hz, NCHCH 3 ); 3.6 and 3.65 (2H, dd, J=12 Hz, CH 2 N); 3.7 and 3.75 (6H, 2 s, 2 MeO); 4.55 (1H, q, J=6 Hz, NCHCH 3 ); 6.8-6.9 (3H, m, aryl-H); 7.1-7.2 (2H, m, aryl-H); 7.3 (1H, dd, J=4 and 8 Hz, aryl-H); 7.35 (2H, J=8 Hz, aryl-H); 7.75 (1H, t, J=6 Hz, aryl-H); 7.75 (1H, d, J=8 Hz, aryl-H); 7.95 (1H, d, J=8 Hz, aryl-H); 8.55 (1H, d, J=8 Hz, aryl-H); 8.8-8.9 (1H, m, aryl-H). Example 55 (R)-N-(1-(1-Naphthyl)ethyl)-N-((4-(3-N,N-dimethylamino)propoxy-3-(4-methoxyphenyl)phenylmethyl)amine Step 1) 3-Bromo-4-(3-chloropropoxy)benzaldehyde A solution of 3-bromo-4-hydroxybenzaldehyde (1.88 g, 9.36 mmol) 1-bromo-3-chloropropane (9.25 mL, 93.6 mmol) and potassium carbonate (3.22 g, 23.4 mmol) in acetonitrile (15 mL) was heated at 80 C for 2 days. The solid was filtered through a plug of silica eluting with MeCN. The filtrate was evaporated to yield 2.46 g of title compound. C 10 H 10 BrClO 2 Step 2) 3-Bromo-4-(3-N,N-dimethylamino)propoxybenzaldehyde A suspension of 3-bromo4-(3-chloropropoxy)benzaldehyde (2.47 g, 8.08 mmol) dimethylamine hydrochloride (6.58 g, 80.8 mmol) and potassium carbonate (11.1 g, 80.8 mmol) in acetonitrile (120 mL) was stirred for 2 days a room temperature, then more Me 2 NH HCl 6.58 g, 80.8 mmol) was added together with KI (50 mg). After 4 days the mixture was filtered and the filtrate concentrated under reduced pressure. The residue was dissolved in ethyl acetate and washed with water then brine. The organic layer was dried over MgSO 4 then evaporated to give a crude which was purified by column chromatography (DCM/MeOH 9/1) to give 1.24 g of title compound. C 12 H 16 BrNO 2 Step 3) 4-(3-N,N-Dimethylamino)propoxy-3-(4-methoxyphenyl)benzaldehyde A solution of 4-methoxybenzeneboronic acid (0.79 g, 5.19 mmol), 3-bromo-4-(3-N,N-dimethylamino)propoxybenzaldehyde (1.28 g, 4.33 mmol) and K 2 CO 3 (1.78 g, 12.9 mmol) in ethanol (12 mL) and toluene (24 mL) was degassed prior to addition of Pd(Ph 3 ) 4 (100 mg, 1 mmol %). The mixture was refluxed for 18 hours then cooled and filtered through diatomaceous earth. The filtrate was concentrated in vacuo, extracted with ethyl acetate, washed with water and the organic layer dried over sodium sulphate. The crude was purified by column chromatography (DCM/MeOH 85/15) to give 0.4 g of title compound. C 19 H 23 NO 3 Step 4) (R)-N-(1-(1-Naphthyl)ethyl)-N-((4-(3-N,N-dimethylamino)propoxy-3-(4-methoxyphenyl)phenylmethyl)amine The title compound was prepared from 4-(3-N,N-dimethylamino)propoxy-3-(4- ethoxyphenyl)benzaldehyde and (R)-1-(1-naphthyl)ethylamine according to general procedure B. C 31 H 36 N 2 O 2 Mass (calculated): [468]; (found): [M+H + ]=469. NMR (400 MHz, CDCl3): 1.45 (3H, d, J=6 Hz, NCHCH 3 ); 1.85-1.95 (2H, m, OCH 2 CH 2 CH 2 N); 2.25 (6H, s, Me 2 N); 2.4-2.5 (2H, m, OCH 2 CH 2 CH 2 N); 3.6 and 3.65 (2H, dd, J=12 Hz, CH 2 N); 3.7 (3H, s, CH 3 O); 3.9 (2H, t, J=6 Hz, OCH 2 CH 2 CH 2 N); 4.65 (1H, q, J=6 Hz, NCHCH 3 ); 6.8-6.9 (3H, m, aryl-H); 7.1-7.2 (2H, m, aryl-H); 7.3-7.5 (5H, m, aryl-H); 7.7 (2H, d, J=8 Hz, aryl-H); 7.8-7.85 (1H, m, aryl-H); 8.05-8.1 (1H, m, aryl-H). Example 56 (R)-N-(1-Phenylethyl)-N-((4-(cyclopropylmethoxy-3-(4-methoxyphenyl)-phenylmethyl)amine Step 1) 3-bromo-4-cyclopropylmethoxybenzaldehyde A suspension of 3-bromo-4-hydroxybenzaldehyde (5.03 g, 25 mmol), bromomethylcyclopropane (28 mmol, 2.72 mL) and potassium carbonate (37.5 mmol, 5.14 g) in DMF (30 mL) was heated at 110 C for three days. The solid was filtered off and the solvent was removed under reduced pressure, to give an orange residue which was taken into ethyl acetate and washed with water and then saturated brine. The organic phase was dried over Mg 2 SO 4 and solvent removed to afford 5.56 g of the title material. C 11 H 11 BrO 2 Mass (calculated): [255]; (found): 255, 257 and 296, 298 (M+MeCN). NMR (400 MHz, CDCl 3 ): 0.15-0.2 (2H, m, cyclopropyl-CH 2 ); 0.4-0.5 (2H, m, cyclopropyl-CH 2 ); 1-1.15 (1H, m, cyclopropyl-CH); 3.8 (2H, d, J=7 Hz, OCH 2 ); 7.75 (1H, d, J=8 Hz, aryl-H); 7.55 (1H, dd, J=2 and 8 Hz, aryl-H); 7.9 (1H, d, J=2 Hz, aryl-H); 9.6 (1H, s, CHO). Step 2) 4-Cyclopropylmethoxy-3-(4′-methoxyphenyl)benzenecarboxaldehyde To a degassed solution of 3-bromo-4-cyclopropylmethoxybenzaldehyde (1.53 g, 6 mmol), 4-methoxybenzeneboronic acid (1.22 g, 8 mmol) and potassium carbonate (2.74 g, 20 mmol) in toluene/ethanol 2/1 (40 mL), Pd(PPh 3 ) 4 (100 mg) was added and the mixture was degassed for further 5 minutes. The mixture was then refluxed for 12 hours. The solid is filtered off, and the solvent partitioned between ethyl acetate and water and extracted. The organic solvent was removed under reduced pressure, dried over sodium sulphate and purified by column chromatography on silica (hexane/ethyl acetate 8/2) to afford 1.52 g of product. C 18 H 18 O 3 Mass (calculated): [282]; (found): [M+H + ]=283; LC Rt=1.65, 97%. NMR (400 MHz, CDCl 3 0.15-0.25 (2H, m, cyclopropyl-CH 2 ); 0.45-0.55 (2H, m, cyclopropyl-CH 2 ); 1.05-1.15 (1H, m, cyclopropyl-CH); 3.75 (3H, s, MeO); 3.8 (2H, d, J=7 Hz, arylOCH 2 ); 6.9 (2H, 2, J=7Hz, 8.5 Hz, aryl-H); 7.9 (1H, d, J=8.5 Hz, aryl-H); 7.4 (2H, d, J=8.5 Hz, aryl-H); 7.65 (1H, dd, J=2 and 8.5 Hz, aryl-H); 7.75 (1H, d, J=2 Hz, aryl-H); 9.8 (1H, s, CHO). Step 3) (R)-N-(1l-Phenylethyl)-N-((4-(cyclopropylmethoxy-3-(4-methoxyphenyl)-phenylmethyl)amine The title compound was prepared from 4-cyclopropylmethoxy-3-(4′-methoxyphenyl)benzenecarboxaldehyde and (R)-α-methylbenzylamine according to general procedure A. C 26 H 29 NO 2 Mass (calculated): [387]; (found): [M+H + ]=267, 388. NMR (400 MHz, CDCl 3 ): 0.2 (2H, m, cyclopropyl-H); 0.45 (2H, m, cyclopropyl-H); 1.15 (1H, m, cyclopropyl-H); 1.3 (3H, d, J=6 Hz, NCHCH 3 ); 3.5 and 3.55 (2H, dd, J=12 Hz, CH 2 N); 3.7 (2H, d, J=6 Hz, cyclopropylCH 2 O); 3.7-3.8 (4H, m, MeO and NCHMe); 6.8 (1H, d, J=8 Hz, aryl-H); 6.85 (2H, d, J=8 Hz, aryl-H); 7.1 (1H, dd, J=1 and 8 Hz, aryl-H); 7.15-7.25 (2H, m, aryl-H); 7.25-7.35 (4H, m, aryl-H); 7.45 (2H, d, J=8 Hz, aryl-H). Example 57 (R)-N-(1-(3-Methoxyphenyl)ethyl)-N-((4-cyclopropylmethoxy-3-(4′-methoxyphenyl)phenylmethyl)amine The title compound was prepared from 4-cyclopropylmethoxy-3-(4′-methoxy-phenyl)benzenecarboxaldehyde and (R)-3-methoxy-α-methylbenzylamine according to general procedure A. C 27 H 31 NO 3 Mass (calculated): [417]; (found): [M+H + ]=267, 418. NMR (400 MHz, CDCl 3 ): 0.2 (2H, m, cyclopropyl-H); 0.45 (2H, m, cyclopropyl-H); 1.1 (1H, m, cyclopropyl-H); 1.3 (3H, d, J=6 Hz, NCHCH 3 ); 3.5 and 3.55 (2H, dd, J=12 Hz, CH 2 N); 3.65 (2H, d, J=6 Hz, cyclopropylCH 2 O); 3.7 (3H, s, CH 3 O); 3.75-3.85 (4H, m, MeO and NCHMe); 6.75 (1H, dd, J=1 and 8 Hz, aryl-H); 6.8 (1H, d, J=8 Hz, aryl-H); 6.85-6.95 (4H, m, aryl-H); 7.1 (1H, dd, J=1 and 8 Hz, aryl-H); 7.15 (1H, d, J=1 Hz, aryl-H); 7.15-7.25 (1H, m, aryl-H); 7.45 (2H, d, J=8 Hz, aryl-H). Example 58 (R)-N-(1-(1-Naphthyl)ethyl)-N-((4-(cyclopropylmethoxy-3-(4-methoxyphenyl)phenylmethyl)amine The title compound was prepared from 4-cyclopropylmethoxy-3-(4′-methoxyphenyl)benzenecarboxaldehyde and (R)-1-(1-naphthyl)ethylamine according to general procedure A. C 30 H 31 NO 2 Mass (calculated): [437]; (found): [M+H + ]=438, 267, 875. NMR (400 MHz, CDCl 3 ): 0.2 (2H, m, cyclopropyl-H); 0.45 (2H, m, cyclopropyl-H); 1.15 (1H, m, cyclopropyl-H); 1.45 (3H, d, J=6 Hz, NCHCH 3 ); 3.6 (1H, d, J=12 Hz, CH 2 N); 3.65-3.75 (3H, m, CH 2 N and cyclopropylCH 2 O); 3.75 (3H, s, MeO); 4.65 (1H, q, J=6 Hz, NCHMe); 6.75-6.9 (3H, m, aryl-H); 7.1-7.2 (2H, m, aryl-H); 7.35-7.5 (5H, m, aryl-H); 7.65-7.5 (2H, m, aryl-H); 7.8-7.9 (1H, m, aryl-H); 8.0-8.1 (1H, m, aryl-H). Example 59 (6,4′-Dimethoxy-biphenyl-3-ylmethyl)-(1-pyridin-3-yl-ethyl)-amine Step 1) 1-Pyridin-3-yl-ethylamine 3-Acetylpyridine (2.4 g, 20 mmol, Aldrich) was dissolved in 2M ammonia solution in methyl alcohol (50 mL, 100 mmol, Aldrich) and acetic acid (15 mL, J. T. Baker) was slowly added at 0 C. After stirring for 3 h at room temperature, the sodium cyanoborohydride (5.0 g, 80 mmol, Aldrich) was added to the solution at 0 C. The mixture was stirred under nitrogen at room temperature for overnight then the reaction was cooled at ice bath and quenched with aqueous 5 N sodium hydroxide (30 mL, 150 mmol, J. T. Baker). The methyl alcohol was removed from the mixture via vacuo. The residue was extracted by diethyl ether (30 mL×4). The combined organic phases were dried over anhydrous magnesium sulfate and concentrated via vacuo to give crude 1-pyridin-3-yl-ethylamine as light yellow oil in 44% yield (1.07 g, 8.8 mmol). C 7 H 10 N 2 MS (ESI, pos. ion) m/z: 123.0 (M+1); MS (ESI, neg. ion) m/z: 121.0 (M−1). Step 2) (6,4′-Dimethoxy-biphenyl-3-ylmethyl)-(1-pyridin-3-yl-ethyl)-amine 1-Pyridin-3-yl-ethylamine (245 mg, 2 mmol) and 6,4′-Dimethoxy-biphenyl-3-carbaldehyde (121 mg, 0.5 mmol) were dissolved in dichloroethane (10 mL). After stirring for 6 h at room temperature, the sodium triacetoxyborohydride (212 mg, 1.0 mmol, Aldrich) was added to the solution at 0 C. The mixture was stirred under nitrogen at room temperature for overnight then the reaction was cooled at ice bath and quenched with saturated aqueous sodium bicarbonate (10 mL). The organic phase was separated and the aqueous phase was extracted with dichloroethane (10 mL×3). The combined organic layers were dried over anhydrous magnesium sulfate and concentrated via vacuo. The crude was purified by column chromatography (silica gel, ethyl acetate) to give the title compound as white solid in 50% yield (87 mg, 0.25 mmol). C 22 H 24 N 2 O 2 MS (ESI, pos. ion) m/z: 349.2 (M+1); MS (ESI, neg. ion) m/z: 347.2 (M−1). Example 60 (6,4′-Dimethoxy-biphenyl-3-ylmethyl)-(1-pyridin-4-yl-ethyl)-amine Step 1) 1-Pyridin-4-yl-ethylamine The title compound was prepared by the same procedure for preparing 1-pyridin-3-yl-ethylamine from 4-acetylpyridine (2.4 g, 20 mmol, Aldrich), 2 M ammonia solution in methyl alcohol (50 mL, 100 mmol, Aldrich), acetic acid (15 mL, J. T. Baker) and sodium cyanoborohydride (5.0 g, 80 mmol, Aldrich). The title compound was obtained in form as light yellow oil in 51% yield (1.25 g, 10.2 mmol). C 7 H 10 N 2 MS (ESI, pos.-ion) m/z: 123.0 (M+1); MS (ESI, neg. ion) m/z: 121.0 (M−1). Step 2) (6,4′-Dimethoxy-biphenyl-3-ylmethyl)-(1-pyridin-4-yl-ethyl)-amine The title compound was prepared by the same procedure for preparing (6,4′-dimethoxy-biphenyl-3-ylmethyl)-(1-pyridin-3-yl-ethyl)-amine from 1-Pyridin-4-yl-ethylamine (245 mg, 2 mmol), 6,4′-Dimethoxy-biphenyl-3-carbaldehyde (121 mg, 0.5 mmol) and sodium triacetoxyborohydride (212 mg, 1.0 mmol, Aldrich). The title compound was purified by column chromatography (silica gel, ethyl acetate) in form as white solid in 51% yield (89 mg, 0.26 mmol). C 22 H 24 N 2 O 2 MS (ESI, pos. ion) m/z: 349.2 (M+1); MS (ESI, neg. ion) m/z: 347.2 (M−1). Example 61 (6,4′-Dimethoxy-biphenyl-3-ylmethyl)-(1-quinolin-4-yl-ethyl)-amine Step 1) 1-Quinolin-4-yl-ethanol 4-Quinolinecarboxaldehyde (1.57 g, 10 mmol, Aldrich) was dissolved in anhydrous THF (30 mL) and cooled to −78° C. The 3 M methyl magnesium iodide solution in diethyl ether (5 mL, 15 mmol, Aldrich) was slowly added to the reaction solution in dry ice bath. The reaction mixture was allowed to stir under nitrogen at room temperature for overnight then the reaction was cooled at ice bath and quenched with saturated aqueous ammonium chloride (30 mL). The organic phase was separated and the aqueous phase was extracted with ethyl acetate (30 mL×2). The combined organic layers were dried over anhydrous magnesium sulfate and concentrated via vacuo to give crude title compound as light yellow syrup in 100% yield (1.73 g, 10 mmol). C 11 H 11 NO MS (ESI, pos. ion) m/z: 174.4 (M+1); MS (ESI, neg. ion) m/z: 172.2 (M−1). Step 2) 1-Quinolin-4-yl-ethanone To the mixture of manganese oxide (8.69 g, 100 mmol, Aldrich) in dichloromethane (80 mL) was added 1-quinolin4-yl-ethanol (1.73 g, 10 mmol). The reaction mixture was refluxed for overnight and then cooled to room temperature. The solid was filtered out through Celite pad. The organic solution dried over anhydrous magnesium sulfate and concentrated via vacuo to give crude title compound as light yellow solid in 100% yield (1.71 g, 10.0 mmol). C 11 H 9 NO MS (ESI, pos. ion) m/z: 172.10 (M+1); MS (ESI, neg. ion) m/z: 170.0 (M−1). Step 3) 1-Quinolin-4-yl-ethylamine The title compound was prepared by the same procedure for preparing 1-pyridin-3-yl-ethylamine from 1-quinolin-4-yl-ethanone, (1.71 g, 10 mmol, Aldrich), 2 M ammonia solution in methyl alcohol, (40 mL, 80 mmol, Aldrich), acetic acid (10 mL, J. T. Baker) and sodium cyanoborohydride (5.0 g, 80 mmol, Aldrich). The title compound obtained in form as light yellow solid in 100% yield (1.72 g, 10 mmol). C 11 H 12 N 2 MS (ESI, pos ion) m/z: 173.0 (M+1); MS (ESI, neg. ion) m/z: 171.0 (M−1). Step 4) (6,4′-Dimethoxy-biphenyl-3-ylmethyl)-(1-quinolin-4-yl-ethyl)-amine The 1-quinolin-4-yl-ethylamine (510 mg, 3 mmol) and 6,4′-dimethoxy-biphenyl-3-carbaldehyde (242 mg, 1.0 mmol) were stirred with acetic acid (300 mg, J. T. Baker) in methyl alcohol (15 mL0 at room temperature for 4 h. To the reaction solution was added sodium cyanoborohydride (1.0 g, 16 mmol, Aldrich) at 0° C. The mixture was stirred under nitrogen at room temperature for overnight then the reaction was cooled at ice bath and quenched with saturated aqueous sodium bicarbonate (30 mL). The methyl alcohol was removed from the mixture via vacuo. The residue was extracted by ethyl acetate (30 mL×4). The combined organic phases were dried over anhydrous magnesium sulfate and concentrated via vacuo. The title compound was purified by column chromatography (silica gel, ethyl acetate) in form as white solid in 72% yield (287 mg, 0.72 mmol). C 26 H 26 N 2 O 2 MS (ESI, pos. ion) m/z: 399.2 (M+1); MS (ESI, neg. ion) m/z: 397.2 (M−1). Example 62 (6,4′-Dimethoxy-biphenyl-3-ylmethyl)-(1-quinolin-8-yl-ethyl)-amine Step 1) Quinoline-8-carboxylic acid methoxy-methyl-amide To the solution of 1-isoquinolonecarboxylic acid (1.73 g, 10 mmol, Aldrich) in anhydrous N,N-dimethylformamide (30 mL) were added N,N-diisopropylethylaime (5.29 g, 40 mmol, Aldrich), O-(7-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (7.6 g, 20 mmol, PerSeptive Biosystems GmbH), N,O-dimethylhydroxylamine hydrochloride (1.8 g, 20 mmol, Aldrich) subsequently at room temperature. The reaction solution was allowed to stir for overnight at room temperature. The N,N-Dimethylformamide was removed via vacuo and the resulting residue was diluted in ethyl acetate (50 mL). After being was washed by saturate aqueous sodium bicarbonate (50 mL) and brine (50 mL), the organic portion was dried over anhydrous magnesium sulfate and concentrated. The title compound was purified by column chromatography (silica gel, ethyl acetate) in form as yellow syrup in 94% yield (2.04 g, 9.4 mmol). C 12 H 12 N 2 O 2 MS (ESI, pos. ion) m/z: 217.1 (M+1); MS (ESI, neg. ion) m/z: 215.0 (M−1). Step 2) 1-Quinolin-8-yl-ethanone Quinoline-8-carboxylic acid methoxy-methyl-amide (2.16 g, 10 mmol) was dissolved in anhydrous THF (40 mL) and cooled to −78° C. The 3 M methyl magnesium iodide solution in diethyl ether (4.0 mL, 12 mmol, Aldrich) was slowly added to the reaction solution in dry ice bath. The reaction mixture was allowed to stir under nitrogen at room temperature for overnight then the reaction was cooled at ice bath and quenched with saturated aqueous ammonium chloride (40 mL). The organic phase was separated and the aqueous phase was extracted with ethyl acetate (30 mL×2). The combined organic layers were dried over anhydrous magnesium sulfate and concentrated via vacuo to give crude title compound as light yellow solid in 83% yield (1.42 g, 8.3 mmol). C 11 H 9 NO MS (ESI, pos. ion) m/z: 172.0 (M+1); MS (ESI, neg. ion) m/z: 170.1 (M−1). Step 3) 1-Quinolin-8-yl-ethylamine The title compound was prepared by the same procedure for preparing 1-pyridin-3-yl-ethylamine from 1-quinolin-8-yl-ethanone (1.71 g, 10 mmol), 2 M ammonia solution in methyl alcohol, acetic acid (25 mL, 50 mmol, Aldrich) and sodium cyanoborohydride (2.5 g, 40 mmol, Aldrich). The title compound was purified by column chromatography (silica gel, ethyl acetate) in form as light yellow solid in 98% yield (1.68 g, 9.8 mmol). MS (ESI, pos. ion) m/z: 173.2 (M+1); MS (ESI, neg. ion) m/z: 171.0 (M−1). Step 4) (6,4′-Dimethoxy-biphenyl-3-ylmethyl)-(1-quinolin-8-yl-ethyl)-amine The title compound was prepared by the same procedure for (6,4′-dimethoxy-biphenyl-3-ylmethyl)-(1-quinolin-4-yl-ethyl)-amine from 1-quinolin-8-yl-ethylamine (510 mg, 3.0 mmol), 6,4′-Dimethoxy-biphenyl-3-carbaldehyde (242 mg, 1.0 mmol) and sodium cyanoborohydride (1.0 g, 16 mmol, Aldrich). The title compound was purified by column chromatography (silica gel, ethyl acetate) in form as white solid in 72% yield (287 mg, 0.72 mmol). C 26 H 26 N 2 O 2 MS (ESI, pos. ion) m/z: 399.2 (M+1); MS (ESI, neg. ion) m/z: 397.2 (M−1). Example 63 (6,4′-Dimethoxy-biphenyl-3-ylmethyl)-[1-(1-methyl-1H-indol-4-yl)-ethyl]-amine Step 1) 1-Methyl-1H-indole-4-carbonitrile 4-Cyanoindole (2.8 g, 20 mmol, Biosynth International) was dissolved in N,N-Dimethylformamide (25 mL). To the solution were added potassium carbonate powder (5.5 g, 40 mmol, 325 mesh, Aldrich) and iodomethane (3.4 g, 24 mmol, Aldrich). The mixture was stirred at room temperature for 48 h then the N,N-Dimethylformamide was removed via vacuo and the residue was diluted in ethyl acetate (100 mL). The organic solution was washed by water (50 mL), brine (50 mL). The resulting organic solution was dried over anhydrous magnesium sulfate and concentrated via vacuo. The title compound was purified by column chromatography (silica gel, hexane/ethyl acetate 3/2) in form as white solid in 97% yield (3.02 g, 19.4 mmol). C 10 H 8 N 2 MS (ESI, pos. ion) m/z: 157.0 (M+1); MS (ESI, neg. ion) m/z: 155.0 (M−1). Step 2) 1-Methyl-1H-indole-4-carbaldehyde 1-Methyl-1H-indole-4-carbonitrile (3.02 g, 19 mmol) was dissolved in anhydrous dichloromethane (30 mL) and the solution was cooled to −78° C. To the reaction solution was slowly added 1.5 M diisobutylaluminum hydride in toluene (12.6 mL, 19 mmol, Aldrich). The reaction mixture was allowed to stir under nitrogen at room temperature for 6 h then it was cooled again in ice bath and quenched with methyl alcohol (4 mL). The resulting solution was poured to 15% aqueous sulfuric acid solution (40 mL) at 0° C. After stirring vigorously for 1 h, the mixture was added aqueous 5 N sodium hydroxide to adjust PH>12. The organic phase was separated and the aqueous phase was extracted with ethyl acetate (40 mL×3). The combined organic layers were dried over anhydrous magnesium sulfate and concentrated via vacuo. The title compound was purified by column chromatography (silica gel, hexane/ethyl acetate 2/3) in form as light yellow oil in 92% yield (2.8 g, 17.6 mmol). C 10 H 9 NO MS (ESI, pos. ion) m/z: 160.1 (M+1); MS (ESI, neg. ion) m/z: 158.0 (M−1). Step 3) 1-(1-Methyl-1H-indol-4-yl)-ethanol The title compound was prepared by the same procedure for 1-quinolin-4-yl-ethanol from 1-methyl-1H-indole-4-carbaldehyde (2.8 g, 17.6 mmol), 3 M methyl magnesium iodide solution in diethyl ether (10 mL, 30 mmol, Aldrich) and anhydrous tetrahydrofuran (20 mL). The crude title compound obtained in form as yellow oil in 97% yield (3.0 g, 17.1 mmol). C 11 H 13 NO MS (ESI, pos. ion) m/z: 176.0 (M+1); MS (ESI, neg. ion) m/z: 174.0 (M−1). Step 4) 1-(1-Methyl-1H-indol-4-yl)-ethanone The title compound was prepared by the same procedure for 1-quinolin-4-yl-ethanone from 1-(1-Methyl-1H-indol-4-yl)-ethanol (3.0 g, 17 mmol), manganese oxide (8.69 g, 100 mmol, Aldrich) and dichloromethane (50 mL). The crude title compound was obtained in form as yellow oil in 98% yield (2.9 g, 16.7 mmol). C 11 H 11 NO MS (ESI, pos. ion) m/z: 174.0 (M+1); MS (ESI, neg. ion) m/z: 172.0 (M−1). Step 5) 1-(1-Methyl-1H-indol-4-yl)-ethylamine The title compound was prepared by the same procedure for preparing 1-pyridin-3-yl-ethylamine from 1-(1-methyl-1H-indol-4-yl)-ethanone (1.75 g, 10 mmol), 2 M ammonia solution in methyl alcohol (25 mL, 50 mmol, Aldrich), acetic acid (15 mL, J. T. Baker) and sodium cyanoborohydride (2.5 g, 40 mmol, Aldrich). The title compound was purified by column chromatography (silica gel, 2 M ammonia solution in methyl alcohol/ethyl acetate 1/10) in form as light yellow oil in 48% yield (0.83 g, 4.8 mmol). C 11 H 14 N 2 MS (ESI, pos. ion) m/z: 175.0 (M+1); MS (ESI, neg. ion) m/z: 173.0 (M−1). Step 6) (6,4′-Dimethoxy-biphenyl-3-ylmethyl)-[1-(1-methyl-1H-indol-4-yl)-ethyl]-amine The title compound was prepared by the same procedure for (6,4′-dimethoxy-biphenyl-3-ylmethyl)-(1-quinolin-4-yl-ethyl)-amine from 1-(1-Methyl-1H-indol-4-yl)-ethylamine (522 mg, 3.0 mmol), 6,4′-Dimethoxy-biphenyl-3-carbaldehyde (242 mg, 1.0 mmol) and sodium cyanoborohydride (1.0 g, 16 mmol, Aldrich). The title compound was purified by column chromatography (silica gel, hexane/ethyl acetate 3/2) in form as white solid in 74% yield (296 mg, 0.74 mmol). C 26 H 28 N 2 O 2 MS (ESI, pos. ion) m/z: 401.6 (M+1); MS (ESI, neg. ion) m/z: 399.2 (M−1). Example 64 (6,4′-Dimethoxy-biphenyl-3-ylmethyl)-[1-(1-methyl-2,3-dihydro-1H-indol-4-yl)-ethyl]-amine Step 1) 1-(1-Methyl-2,3-dihydro-1H-indol-4-yl)-ethylamine To the solution of 1-(1-Methyl-1H-indol-4-yl)-ethylamine (1.74 g, 10 mmol) with acetic acid (10 mL, J. T. Baker) was added sodium cyanoborohydride (1.0 g, 16 mmol, Aldrich) at 0 C. The reaction mixture was stirred at room temperature for 4 h then quenched with saturate aqueous sodium bicarbonate (40 mL). The aqueous phase was extracted with ethyl acetate (30 mL×4). The combined organic layers were dried over anhydrous magnesium sulfate and concentrated via vacuo. The title crude compound was obtained in form as light yellow oil in 78% yield (1.37, 7.8 mmol). C 11 H 16 N 2 MS (ESI, pos. ion) m/z: 177.2 (M+1); MS (ESI, neg. ion) m/z: 175.0 (M−1). Step 2) (6,4′-Dimethoxy-biphenyl-3-ylmethyl)-[1-(1-methyl-2,3-dihydro-1H-indol-4-yl)-ethyl]-amine The title compound was prepared by the same procedure for (6,4′-dimethoxy-biphenyl-3-ylmethyl)-(1-quinolin-4-yl-ethyl)-amine from 1-(1-Methyl-2,3-dihydro-1H-indol-4-yl)-ethylamine (528 mg, 3.0 mmol), 6,4′-Dimethoxy-biphenyl-3-carbaldehyde (242 mg, 1.0 mmol) and sodium cyanoborohydride (1.0 g, 16 mmol, Aldrich). The title compound was purified by column chromatography (silica gel, ethyl acetate) in form as white solid in 55% yield (221 mg, 5.5 mmol). C 26 H 30 N 2 O 2 MS (ESI, pos. ion) m/z: 403.3 (M+1); MS (ESI, neg. ion) m/z: 401.4 (M−1). Example 65 ((1R)-1-Phenylethyl){[4,5-dimethoxy-3-(4-methoxyphenyl)phenyl]methyl}amine Step 1) ((1R)-1-Phenylethyl)[(3-bromo-4,5-dimethoxyphenyl)methyl]amine To a solution if 3-bromo-4,5-dimethoxybenzaldehyde (5 g, 0.020 mol, Aldrich), (R)-α-methylbenzylamine (2.6 mL, 0.020 mol) and AcOH (5 mL) in 70 mL of MeOH was stirred at RT for 2 hours. The reaction solution was then cooled to 0 C and NaBH 3 CN (2.51 g, 0.040 mol) was added. The reaction was warmed up to RT in 2 hours and continued to stir for 16 hours. The reaction solution was concentrated in vacuo and the residue was re-dissolved in 150 mL of EtOAc. The organic solution was washed with 50 mL of saturated NaHCO 3 aqueous solution, followed by 50 mL of brine. The organic phase was dried over Na 2 SO 4 and concentrated in vacuo. The crude product was purified by a silica gel column chromatography (50% EtOAc in hexane) to provide white waxy solid (5.1 g). C 17 H 20 BrNO 2 MS (ESI, pos. ion) m/z: 350.2 (M+1). Step 2) ((1R)-1-Phenylethyl){[4,5-dimethoxy-3-(4-methoxyphenyl)phenyl]methyl}amine To a mixture of ((1R)-1-phenylethyl)[(3-bromo-4,5-dimethoxyphenyl)-methyl]amine (1.1 g, 3.15 mmol), 4-methoxyphenylboronic acid (0.479 g, 3.15 mmol), 2M Na 2 CO 3 (5 mL). 4 mL of EtOH in 10 mL of toluene was added 83 mg of PPh 3 (0.315 mmol) and 0.364 g of Pd (PPh 3 ) 4 (0.315 mmol). The mixture was then heated to 80 C under N 2 for 16 hours. The mixture was cooled to RT and was diluted with 50 mL of EtOAc and 20 mL of sat. NaHCO 3 aq. solution. The organic phase was washed with 30 mL of brine, dried over Na 2 SO 4 and concentrated in vacuo. The light yellow oil was chromatographed (silica gel, 10% to 50% EtOAc in hexane) to provide light yellow oil (0.5 g). The product was treated with 1N HCl in Et 2 O to afford the HCl salt, which was re-crystallized in EtOAc to afford light yellow solid (0.5 g). C 24 H 27 BNO 3 MS (ESI, pos. ion) m/z: 378.4 (M+1). Example 66 ((1R)-1-Phenylethyl)[(4-ethyl-3-(3-pyridyl)phenyl)methyl]amine Step 1) 3-Bromo-4-ethylbenzaldehyde To a solution of 4-ethylbenzaldehyde (10 g, 0.0745 mol, Aldrich) in TFA/98% H 2 SO 4 (4/1, 125 mL) mixture was added NBS (13.26 g, 0.0745 mol, Aldrich) at RT and continued to stir for 16 hours. The solvent was then removed in vacuo and the residue was dissolved in 200 mL of EtOAc. 1N NaOH solution (about 150 mL) was added to the solution and the organic phase was separated, washed with 100 mL of brine, dried over Na 2 SO 4 and concentrated in vacuo. The oily residue was chromatographed (silica gel, 50% EtOAc in hexane) to afford orange oil as desired product (11.55 g). C 9 H 9 BrO MS (ESI, pos. ion) m/z: 227.0 (M+15). Step 2) 4-Ethyl-3-(3-pyridyl)benzaldehyde To a mixture of 3-bromo-4-ethylbenzaldehyde (2.45 g, 0.0115 mol), pyridine 3-boronic acid (1.42 g, 0.0115 mol, Matrix Scientific), 2M Na 2 CO 3 (15 mL) in 30 mL of toluene was added 1.33 g of Pd (PPh 3 ) 4 (1.15 mmol, Aldrich). The mixture was then heated to 80 C under N 2 for 16 hours. The mixture was cooled to RT and was diluted with 100 mL of EtOAc and 40 mL of sat. NaHCO 3 aq. solution. The organic phase was washed with 40 mL of brine, dried over Na 2 SO 4 and concentrated in vacuo. The crude product was chromatographed (silica gel, 20% EtOAc in hexane) to provide yellow oil (1.2 g). C 14 H 13 NO MS (ESI, pos. ion) m/z: 212.4 (M+1). Step 3) ((1R)-1-Phenylethyl)[(4-ethyl-3-(3-pyridyl)phenyl)methyl]amine A solution of 4-ethyl-3-(3-pyridyl)benzaldehyde (0.2 g, 0.95 mmol), (R)-α-methylbenzylamine (0.121 mL, 0.95 mmol) and AcOH (1 mL) in 10 mL of MeOH was stirred at RT for 3 hours. The reaction solution was then cooled to 0 C and NaBH 3 CN (0.18 g, 2.85 mmol) was added. The reaction was warmed up to RT continued to stir 3 hours. The reaction solution was concentrated in vacuo and the residue was re-dissolved in 50 mL of EtOAc. The organic solution was washed with 20 mL of saturated NaHCO 3 aqueous solution, followed by 20 mL of brine. The organic phase was dried over Na 2 SO 4 and concentrated in vacuo. The crude product was purified by a silica gel column chromatography (20% of EtOAc in hexane) to provide colorless oil (0.2 g). The product was treated with 1N HCl in Et 2 O and the HCl salt was re-crystallized in MeOH/Et 2 O (1:10) mixture to provide white solid (0.2 g). C 22 H 24 N 2 MS (ESI, pos. ion) m/z: 317.3 (M+1). Example 67 ((1R)-1-Naphthylethyl)[(4-ethyl-3-(3-pyridyl)phenyl)methyl]amine The title compound (0.22 g, white solid as HCl salt) was prepared from 4-ethyl-3-(3-pyridyl)benzaldehyde (0.22 g) and (R)-1-(1-naphthyl)ethylamine (0.17 mL) analogously to Example 66, step 3. C 26 H 26 N 2 MS (ESI, pos. ion) m/z: 367.3 (M+1). Example 68 ((1R)-1-phenylethyl){[4-ethyl-3-(4-methoxyphenyl)phenyl]methyl}amine Step 1) 4-Ethyl-3-(4-methoxyphenyl)benzaldehyde To a mixture of 3-bromo-4-ethylbenzaldehyde (1.5 g, 7.07 mmol), 4-methoxyphenylboronic acid (1.075 g, 7.07 mmol), 2M Na 2 CO 3 (10 mL) in 20 mL of toluene was added 0.817 g of Pd (PPh 3 ) 4 (0.707 mmol). The mixture was then heated to 80 C under N 2 for 16 hours. The mixture was cooled to RT and was diluted with 100 mL of EtOAc and 50 mL of sat. NaHCO 3 aq. solution. The organic phase was washed with 40 mL of brine, dried over Na 2 SO 4 and concentrated in vacuo. The crude product was chromatographed (silica gel, 10% EtOAc in hexane) to provide light yellow solid (2.1 g). C 16 H 16 O 2 MS (ESI, pos. ion) m/z: 241.1 (M+1). Step 2) ((1R)-1-phenylethyl){[4-ethyl-3-(4-methoxyphenyl)phenyl]methyl}amine The title compound (0.2 g, white solid as HCl salt) was prepared from 4-ethyl-3-(4-methoxyphenyl)benzaldehyde (0.5 g) and (R)-α-methylbenzylamine (0.265 mL) analogously to Example 66, step 3. Example 69 Methyl 5-(5-{[((1R)-1-phenylethyl)amino]methyl}-2-methoxyphenyl)pyridine-3-carboxylate Step 1) Methyl 5-(3-formyl-6-methoxyphenyl)-3-pyridine-3-carboxylate To a mixture of 5-bromonicotinate (2.16 g, 0.01 mol, Avocado Research) and (5-formyl-2-methoxyphenyl)boronic acid (1.79 g, 0.01 mol, Matrix Scientific), 2M Na 2 CO 3 (10 mL) in 20 mL of toluene was added 1.15 g of Pd (PPh 3 ) 4 (1.0 mmol). The mixture was then heated to 80 C under N 2 for 16 hours. The mixture was cooled to RT and was diluted with 100 mL of EtOAc and 50 mL of sat. NaHCO 3 aq. solution. The organic phase was washed with 40 mL of brine, dried over Na 2 SO 4 and concentrated in vacuo. The crude product was chromatographed (silica gel, 50% EtOAc in hexane) to provide white solid (1.2 g). C 15 H 13 NO 4 MS (ESI, pos. ion) m/z: 272.3 (M+1). Step 2) Methyl 5-(5-{[((1R)-1-phenylethyl)amino]methyl}-2-methoxyphenyl)pyridine-3-carboxylate The title compound (0.4 g, white solid as HCl salt) was prepared from 4-ethyl-3-(4-methoxyphenyl)benzaldehyde (0.5 g) and (R)-α-methylbenzylamine (0.265 mL) analogously to Example 66, step 3. C 23 H 24 N 2 O 3 MS (ESI, pos. ion) m/z: 377.5 (M+1). Example 70 ((1R)-1-Phenylethyl){[4-methoxy-3-(5-methoxy(3-pyridyl))phenyl]methyl}amine Step 1) 3-Bromo-5-methoxypyridine 1.45 g of Na (0.063 mol) were added to 100 mL of MeOH and the resulted solution was stirred at RT for 30 minutes. The solution was then concentrated at 65 C in vacuo for 40 minutes. The white solid obtained was dissolved in 100 mL of DMF. 15 g of 3,5-dibromopyridine (0.063 mol) were added and the reaction was heated to 65 C for 16 hours. The reaction was cooled to RT and diluted with 200 mL of EtOAc and 100 mL of sat. aq. NaHCO 3 solution. The organic phase was separated and was washed with 100 mL of brine, dried over Na 2 SO 4 and concentrated in vacuo. The crude product was chromatographed (silica gel, 10% EtOAc in hexane) to provide colorless crystals (10 g). C 6 H 6 BrNO MS (ESI, pos. ion) m/z: 188.1 (M+1). Step 2) 4-Methoxy-3-(5-methoxy(3-pyridyl))benzaldehyde The title compound (2.5 g, white solid) was prepared from 3-Bromo-5-methoxypyridine (2.17 g, 0.0116 mol) and (5-formyl-2-methoxyphenyl)boronic acid (2.5 g, 0.014 mol, Matrix Scientific) analogously to Example 69, step 1. C 14 H 13 NO 3 MS (ESI, pos. ion) m/z: 244.4 (M+1). Step 3) ((1R)-1-Phenylethyl){[4-methoxy-3-(5-methoxy(3-pyridyl))phenyl]methyl}amine The title compound (0.8 g, white solid as HCl salt) was prepared from 4-methoxy-3-(5-methoxy(3-pyridyl))benzaldehyde (0.71 g) and (R)-α-methylbenzylamine (0.371 mL) analogously to Example 66, step 3. C 22 H 24 N 2 O 2 MS (ESI, pos. ion) m/z: 349.4 (M+1). Example 71 ((1R)-1-Phenylethyl){[3-(4-methoxyphenyl)-4-methylphenyl]methyl}amine and 4-(5-{[((1R)-1-Phenylethyl)amino]methyl}-2-methylphenyl)phenol Step 1) N-((1R)-1-Phenylethyl)(3-bromo-4-methylphenyl)carboxamide To a solution of 3-bromo-4-methylbenzoic acid (5.0 g, 0.023 mol) in CH 2 CH 2 (100 mL) was added oxalyl chloride (8.67 g, 0.069 mol). After 10 minutes, 1.0 mL of DMF was added slowly and the mixture was continued to stir at RT for 2 hours. The volatile was removed in vacuo. The residue was re-dissolved in CH 2 CH 2 (100 mL) and transferred to a 125 mL additional funnel. To a 500 mL Erlenmeyer flask equipped with a stir bar was added 100 mL of sat. aq. NaHCO 3 solution followed by 2.79 g of (R)-α-methylbenzylamine (0.023 mol) in 100 mL of CH 2 CH 2 . 3-Bromo-4-methylbenzoyl chloride in CH 2 Cl 2 (from above) was added dropwise to the Erlenmeyer flask and the reaction mixture was continued to stir at RT for 16 hours. The organic phase was diluted with 50 mL of CH 2 CH 2 , separated from aqueous phase, dried over Na 2 SO 4 and concentrated in vacuo. The residue was washed with 50 mL of Et 2 O and dried in an oven at 40 C overnight to afford light yellow solid (7.0 g, 0.022 mol, 96%). C 16 H 16 BrNO MS (ESI, pos. ion) m/z: 316.1 (M+1). Step 2) N-((1R)-1-Phenylethyl)[3-(4-methoxyphenyl)-4-methylphenyl]carboxamide To a mixture of N-((1R)-1-phenylethyl)(3-bromo-4-methylphenyl)carboxamide (1.38 g, 4.32 mmol) and 4-methoxyphenylboronic acid (0.53 g, 4.32 mmol) in 10 mL of 2M Na 2 CO 3 aq. soln and 20 mL of toluene was bubbled through N 2 for 5 min. Catalyst Pd(PPh 3 ) 4 (0.36 g, 0.314 mmol) was then added and the mixture was heated to 80 C for 19 hours under N 2 . The reaction mixture was cooled to RT and was diluted with 100 mL of EtOAc and 50 mL of water. The organic layer was separated and washed with 50 mL of brine, and dried over Na 2 SO 4 and concentrated in vacuo. The residue was purified by silica gel column chromatography (CHCl 3 to EtOAc) to provide yellow solid (1.0 g, 2.9 mmol, 92%). C 23 H 23 NO 2 MS (ESI, pos. ion) m/z: 346.3 (M+1). Step 3) ((1R)-1-Phenylethyl){[3-(4-methoxyphenyl)-4-methylphenyl]methyl}amine and 4-(5-{[((1R)-1-Phenylethyl)amino]methyl}-2-methylphenyl)phenol To a solution of N-((1R)-1-phenylethyl)[3-(4-methoxyphenyl)-4-methylphenyl]carboxamide (0.12 g, 0.34 mmol) in 10 mL of toluene was added DIBAL-H (1 mL, 1.5 mmol). The reaction was then heated to 100 C for 16 hours and cooled to RT. The reaction was quenched with 5 mL of 2N NaOH aq. soln. 100 mL of CH 2 Cl 2 was used to extract the product. The organic phase was washed with 30 mL of brine, dried over Na 2 SO 3 and concentrated in vacuo. The desired products were separated by silica gel column chromatography (30% to 60% EtOAc in hexane) provide ((1R)-1-phenylethyl){[3-(4-methoxyphenyl)-4-methylphenyl]methyl}amine and 4-(5-{[((1R)-1-phenylethyl)amino]methyl}-2-methylphenyl)phenol, which were treated with 1N HCl in Et 2 O separately to provide the HCl salts as white solids. ((1R)-1-Phenylethyl){[3-(4-methoxyphenyl)-4-methylphenyl]methyl}amine C 23 H 25 NO MS (ESI, pos. ion) m/z: 332.3 (M+1). 4-(5-{[((1R)-1-Phenylethyl)amino]methyl}-2-methylphenyl)phenol C 22 H 23 NO MS (ESI, pos. ion) m/z: 318.2 (M+1); MS (ESI, neg. ion) m/z: 316.2 (M−1). Example 72 ((1R)-1-Phenylpropyl){[4-methoxy-3-(4-methoxyphenyl)phenyl]methyl}amine The title compound was prepared by the same procedure for (6,4′-dimethoxybiphenyl-3-ylmethyl)-(1-quinolin-4-yl-ethyl)-amine from (R)-(+)-1-phenylpropylamine (405 mg, 3.0 mmol, Lancaster Synthesis Ltd.), 6,4′-Dimethoxybiphenyl-3-carbaldehyde (242 mg, 1.0 mmol) and sodium cyanoborohydride (1.0 g, 16 mmol, Aldrich). The title compound was purified by column chromatography (silica gel, hexane/ethyl acetate 2/3) in form as white solid in 52% yield (187 mg, 0.52 mmol). C 24 H 27 NO 2 MS (ESI, pos. ion) m/z: 362.4 (M+1); MS (ESI, neg. ion) m/z: 360.3 (M−1). The final products disclosed in Examples 73 to 109 were prepared according to Method C described earlier. Example 73 (1R)-1-(3-fluorophenyl)-N-((6-(methyloxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)ethanamine MS (EI) calcd for C 23 H 22 F 4 NO (MH + ) 404.1. Found 404.1; 265.1. Example 74 (1R)-1-(3-((2-(methyloxy)ethyl)oxy)phenyl)-N-((6-(methyloxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)ethanamine MS (EI) calcd for C 26 H 29 F 3 NO 3 (MH + ) 460.2. Found 460.2; 265.1. Example 75 (1R)-1-(3-fluorophenyl)-N-((6-(methyloxy)-4′-(methylsulfonyl)-1,1′-biphenyl-3-yl)methyl)ethanamine MS (EI) calcd for C 23 H 25 FNO 3 S (MH + ) 414.1. Found 414.2; 275.2. Example 76 (1R)-1-(3-fluorophenyl)-N-((6-(methyloxy)-1,1′-biphenyl-3-yl)methyl)ethanamine MS (EI) calcd for C 22 H 23 FNO (MH + ) 336.2. Found 336.2; 197.1. Example 77 (1R)-N-((4-chloro-3-iodophenyl)methyl)-1-(3-fluorophenyl)ethanamine MS (EI) calcd for C 15 H 15 ClFIN (MH + ) 390.0. Found 390.0; 251.0, 123.1. Example 78 (1R)-N-((4′-fluoro-6-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(3-fluorophenyl)ethanamine MS (EI) calcd for C 22 H 22 F 2 NO (MH + ) 354.1. Found 354.1; 215.1. Example 79 2,2,2-trifluoro-N-((6-(methyloxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine MS (EI) calcd for C 23 H 20 F 6 NO (MH + ) 440.0. Found 439.9; 264.7. Example 80 (1R)-1-(3-chlorophenyl)-N-((6-(methyloxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)ethanamine MS (EI) calcd for C 23 H 21 Cl F 3 NO 420.87 (MH+). Found: 420.1; 422.1, 265.1 Example 81 N-((6-(methyloxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-(3-methylphenyl)ethanamine MS (EI) calcd for C 24 H 24 F 3 NO 400.45 (MH+). Found: 400.1; 265.1 Example 82 3-(1-(((6-(methyloxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)amino)ethyl)benzonitrile MS (EI) calcd for C 24 H 21 F 3 N 2 O 411.44 (MH+) Found: 411.3; 265.1 Example 83 (1R)-N-((6-fluoro-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine MS (EI) calcd for C 22 H 19 F 4 N 374.30 (MH+) Found: 374.2; Example 84 1-(3,5-difluorophenyl)-N-((6-(methyloxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)ethanamine MS (EI) calcd for C 23 H 20 F 5 NO 422.41 (MH+) Found: 422.2; 265.2 Example 85 1-(3-bromophenyl)-N-((6-(methyloxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)ethanamine MS (EI) calcd for C 23 H 21 BrF 3 NO 465.32 (MH+) Found: 466.0; 265.1 Example 86 1-(3-fluorophenyl)-N-((6-(methyloxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)ethanamine MS (EI) calcd for C 23 H 21 F 4 NO 404.42 (MH+) Found: 404.2; 265.1 Example 87 (1R)-1-(3-chlorophenyl)-N-((6-(methyloxy)-1,1′-biphenyl-3-yl)methyl)ethanamine MS (EI) calcd for C 22 H 22 ClNO 352.88 (MH+) Found: 353.1; 197.1 Example 88 N-1-(3-(dimethylamino)phenyl)ethyl)-N-((6-(methyloxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)amine MS (EI) calcd for C 25 H 27 F 3 N 2 O 429.50 (MH+) Found: 429.2; 265.1 Example 89 N-((6-(methyloxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-(3-((trifluoromethyl)oxy)phenyl)ethanamine MS (EI) calcd for C 24 H 21 F 6 NO 2 470.42 (MH+) Found: 470.1; 265.1 Example 90 1-(4-fluorophenyl)-N-((6-(methyloxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)ethanamine MS (EI) calcd for C 23 H 21 F 4 NO 404.42 (MH+) Found: 404.2; 265.1 Example 91 1-(2,3-dichlorophenyl)-N-((6-(methyloxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)ethanamine MS (EI) calcd for C 23 H 20 Cl 2 F 3 NO 455.32 (MH+) Found: 454.0; 456.0 Example 92 N-((6-(methyloxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-(2-(trifluoromethyl)phenyl)ethanamine MS (EI) calcd for C 24 H 21 F 6 NO 454.42 (MH+) Found: 454.2; 265.1 Example 93 (1R)-N-((4-(methyloxy)-3-(6-((tetrahydro-2-furanylmethyl)oxy)-3-pyridinyl)phenyl)methyl)-1-phenylethanamine MS (ESI, pos. ion) m/z: Calc'd for C 26 H 30 N 2 O 3 : 418.5 g/mol. Found: (M+1) 418.7, 334.9, 297.7 Example 94 5-(2-(methyloxy)-5-((((1R)-1-phenylethyl)amino)methyl)phenyl)-2-pyridinamine MS (ESI, pos. ion) m/z: Calc'd for C 21 H 23 N 3 O: 333.43 g/mol. Found: (M+1) 334.1, 213.2 Example 95 N,N-dimethyl-5-(2-(methyloxy)-5-((((1R)-1-phenylethyl)amino)methyl)phenyl)-2-pyridinamine MS (ESI, pos. ion) m/z: Calc'd for C 23 H 27 N 3 O: 361.48 g/mol. Found: (M+1) 362.0, 241.2 Example 96 1-(3-((5-(2-(methyloxy)-5-((((1R)-1-phenylethyl)amino)methyl)phenyl)-2-pyridinyl)amino)propyl)-2-pyrrolidinone MS (ESI, pos. ion) m/z: Calc'd for C 28 H 34 N 4 O 2 : 458.60 g/mol. Found: (M+1) 458.8, 355.0, 337.7, 306.0, 239.1 Example 97 (1S)-N-((6-(methyloxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine MS (ESI, pos. ion) m/z: Calc'd for C 23 H 22 F 3 NO: 385.43 g/mol. Found: (M+1) 385.9, 264.6, 245.2 Example 98 5-(2-(methyloxy)-5-((((1R)-1-phenylethyl)amino)methyl)phenyl)-2(1H)-pyridinone MS (ESI, pos. ion) m/z: Calc'd for C 21 H 22 N 2 O 2 : 334.42 g/mol. Found: (M+1) 334.9, 214.2 Example 99 (1R)-N-((4-(methyloxy)-3-(6-((2-(methyloxy)ethyl)oxy)-3-pyridinyl)phenyl)methyl)-1-phenylethanamine MS (ESI, pos. ion) m/z: Calc'd for C 24 H 28 N 2 O 3 : 392.50 g/mol. Found: (M+1) 392.9, 334.9, 271.9, 226.2 Example 100 N-methyl-N-(5-(2-(methyloxy)-5-((((1R)-1-phenylethyl)amino)methyl)phenyl)-2-pyridinyl)glycine MS (ESI, pos. ion) m/z: Calc'd for C 24 H 27 N 3 O 3 : 405.50 g/mol. Found: (M+1) 406.3, 284.9 Example 101 N-1-,N-2-dimethyl-N-1-(5-(2-(methyloxy)-5-((((1R)-1-phenylethyl)amino)methyl)phenyl)-2-pyridinyl)-1,2-ethanediamine MS (ESI, pos. ion) m/z: Calc'd for C 25 H 32 N 4 O: 404.56 g/mol. Found: (M+1) 404.8, 373.7, 301.0, 284.0, 270.0 Example 102 (1R)-N-((3-(6-((2-aminoethyl)oxy)-3-pyridinyl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine MS (ESI, pos. ion) m/z: Calc'd for C 23 H 27 N 3 O 2 : 377.49 g/mol. Found: (M+1) 377.8, 274.1, 256.9 Example 103 3-(2-(methyloxy)-5-((((1R)-1-phenylethyl)amino)methyl)phenyl)-N-(3-(4-morpholinyl)propyl)-2-pyridinamine MS (ESI, pos. ion) m/z: Calc'd for C 28 H 36 N 4 O 2 : 460.62 g/mol. Found: (M+1) 461.1, 356.8 Example 104 3-(2-(methyloxy)-5-((((1R)-1-phenylethyl)amino)methyl)phenyl)-N-(tetrahydro-2-furanylmethyl)-2-pyridinamine MS (ESI, pos. ion) m/z: Calc'd for C 26 H 31 N 3 O 2 : 417.55 g/mol. Found: (M+1) 418.1, 297.1, 265.1 Example 105 (1R)-N-((4-(methyloxy)-3-(2-(4-morpholinyl)-3-pyridinyl)phenyl)methyl)-1-phenylethanamine MS (ESI, pos. ion) m/z: Calc'd for C 25 H 29 N 3 O 2 : 403.52 g/mol. Found: (M+1) 404.2, 283.0 Example 106 (1R)-N-((3-(2-fluoro-3-pyridinyl)methyl)-1-phenylethanamine MS (ESI, pos. ion) m/z: Calc'd for C 21 H 21 FN 2 O: 336.41 g/mol. Found: (M+1) 336.9, 233.1, 217.1 Example 107 (1R)-N-((4-(methyloxy)-3-(2-((2,2,2-trifluoroethyl)oxy)-3-pyridinyl)phenyl)methyl)-1-phenylethanamine MS (ESI, pos. ion) m/z: Calc'd for C 23 H 23 F 3 N 2 O 2 : 416.44 g/mol. Found: (M+1) 416.7, 295.8 Example 108 (1R)-N-((4-(methyloxy)-3-(2-((tetrahydro-2-furanylmethyl)oxy)-3-pyridinyl)phenyl)methyl)-1-phenylethanamine MS (ESI, pos. ion) m/z: Calc'd for C 26 H 30 N 2 O 3 : 418.54 g/mol. Found: (M+1) 419.2, 298.1, 216.1 Example 109 (1R)-N-(3-(2-chloropyrid-4-yl)-4-methoxyphenyl)methyl-N-1-phenylethylamine MS (ESI, pos. ion) m/z: Calc'd for C 21 H 21 ClN 2 O: 352.86 g/mol. Found: (M+1) 353.0 (d), 231.9 (d) Example 110 (1R)-N-((6-(methyloxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine Prepared using Method C. MW 385.427 Mass found: 265, 386 Example 111 (1R)-N-((4-(methyloxy)-3-(6-((2,2,2-trifluoroethyl)oxy)-3-pyridinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine Prepared using Method C. MW 466.5 Mass found: 467, 155 Example 112 (1R)-N-((6-(methyloxy)-4′-((trifluoromethyl)oxy)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine Prepared using Method C. MW 401.426 Mass found: 402, 803, 917 Example 113 (1R)-N-((4-(methyloxy)-3-(6-(trifluoromethyl)-3-pyridinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine Prepared using Method C. MW 436.475 Mass found: 437, 478 Example 114 (1R)-N-((4-(methyloxy)-3-(3-pyridinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine Prepared using Method A. MW 368.478 Mass found: 369, 155 Example 115 (1R)-N-((6-(ethyloxy)-4′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine Prepared using Method C. MW 361.482 Mass found: 362 Example 116 (1R)-N-((6-(methyloxy)-4′-((trifluoromethyl)oxy)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine Prepared using Method C. MW 451.486 Mass found: 452, 155 Examples 117-252 were prepared using Method A: Example 117 (1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(3-pyridinyl)phenyl)methyl)ethanamine MW 348.444 Mass found: 198, 349 Example 118 (1R)-1-(3-(methyloxy)phenyl)-N-((3-(1,3-thiazol-2-yl)phenyl)methyl)ethanamine MW 324.446 Mass found: 325, 649 Example 119 (1R)-N-((4-(methyloxy)-3-(3-pyridinyl)phenyl)methyl)-1-(4-methylphenyl)ethanamine MW 332.445 Mass found: 333, 779 Example 120 (1R)-1-(4-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(3-pyridinyl)phenyl)methyl)ethanamine MW 348.444 Mass found: 349 Example 121 (1R)-N-((3-(1,3-benzodioxol-5-yl)phenyl)methyl)-1-phenylethanamine MW 331.413 Mass found: 332, 777 Example 122 (1R)-N-((3-(1,3-benzodioxol-5-yl)phenyl)methyl)-1-(4-methylphenyl)ethanamine MW 345.44 Mass found: 346 Example 123 (1R)-N-((3-(1,3-benzodioxol-5-yl)phenyl)methyl)-1-(4-(methyloxy)phenyl)ethanamine MW 361.439 Mass found: 362 Example 124 (1R)-N-((3-(1,3-benzodioxol-5-yl)phenyl)methyl)-1-(4-(methyloxy)phenyl)ethanamine MW 361.439 Mass found: 362 Example 125 2′-(methyloxy)-5′-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)-1,1′-biphenyl-3-carbonitrile MW 392.5 Mass found: 393 Example 126 2′-(methyloxy)-5′-((((1R)-1-phenylethyl)amino)methyl)-1,1′-biphenyl-3-carbonitrile MW 342.44 Mass found: 343, 384 Example 127 2′-(methyloxy)-5′-((((1R)-1-(4-methylphenyl)ethyl)amino)methyl)-1,1′-biphenyl-3-carbonitrile MW 356.467 Mass found: 357, 398 Example 128 2′-(methyloxy)-5′-((((1R)-1-(4-(methyloxy)phenyl)ethyl)amino)methyl)-1,1′-biphenyl-3-carbonitrile MW 372.466 Mass found: 373, 414 Example 129 2′-(methyloxy)-5′-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)-1,1′-biphenyl-3-carbonitrile MW 372.466 Mass found: 373, 414 Example 130 (1R)-N-((4-(methyloxy)-3-(2-pyrimidinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine MW 369.466 Mass found: 370, 739 Example 131 (1R)-N-((4-(methyloxy)-3-(2-pyrimidinyl)phenyl)methyl)-1-phenylethanamine MW 319.406 Mass found: 320 Example 132 (1R)-N-((4-(methyloxy)-3-(2-pyrimidinyl)phenyl)methyl)-1-(4-methylphenyl)ethanamine MW 333.433 Mass found: 334, 667 Example 133 (1R)-1-(4-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(2-pyrimidinyl)phenyl)methyl)ethanamine MW 349.432 Mass found: 350, 699 Example 134 (1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(2-pyrimidinyl)phenyl)methyl)ethanamine MW 349.432 Mass found: 350, 699 Example 135 (1R)-N-((3′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine MW 317.43 Mass found: 318, 197, 214 Example 136 (1R)-N-((3′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(4-methylphenyl)ethanamine MW 331.457 Mass found: 332, 214 Example 137 (1R)-N-((3′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(4-(methyloxy)phenyl)ethanamine MW 347.456 Mass found: 348, 214 Example 138 (1R)-N-((3′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine MW 347.456 Mass found: 348, 214, 255 Example 139 (1R)-N-((2′-methyl-1,1′-biphenyl-3-yl)methyl)-1-(4-methylphenyl)ethanamine MW 315.457 Mass found: 181, 316, 198 Example 140 (1R)-N-((2′-methyl-1,1′-biphenyl-3-yl)methyl)-1-(4-(methyloxy)phenyl)ethanamine MW 331.457 Mass found: 332, 181, 198 Example 141 (1R)-N-((2′-methyl-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine MW 331.457 Mass found: 332, 198, 181 Example 142 (1R)-N-((2′-fluoro-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine MW 305.394 Mass found: 202, 306, 243 Example 143 (1R)-N-((2′-fluoro-1,1′-biphenyl-3-yl)methyl)-1-(4-methylphenyl)ethanamine MW 319.421 Mass found: 202, 320, 243 Example 144 (1R)-N-((2′-fluoro-1,1′-biphenyl-3-yl)methyl)-1-(4-(methyloxy)phenyl)ethanamine MW 335.42 Mass found: 336, 202, 243 Example 145 (1R)-N-((2′-fluoro-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine MW 335.42 Mass found: 202, 336, 243 Example 146 5-(2-(methyloxy)-5-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)phenyl)-2-furancarboxylic acid MW 381.426 Mass found: 382, 423 Example 147 5-(2-(methyloxy)-5-((((1R)-1-(4-methylphenyl)ethyl)amino)methyl)phenyl)-2-furancarboxylic acid MW 365.427 Mass found: 366, 731 Example 148 5-(2-(methyloxy)-5-((((1R)-1-(4-(methyloxy)phenyl)ethyl)amino)methyl)phenyl)-2-furancarboxylic acid MW 381.426 Mass found: 352, 393 Example 149 4-oxo-4-((5-(3-((((1R)-1-phenylethyl)amino)methyl)phenyl)-2-pyridinyl)amino)butanoic acid MW 403.479 Mass found: 404, 300 Example 150 4-((5-(3-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-2-pyridinyl)amino)-4-oxobutanoic acid MW 453.539 Mass found: 454, 300 Example 151 4-((5-(3-((((1R)-1-(4-methylphenyl)ethyl)amino)methyl)phenyl)-2-pyridinyl)amino)-4-oxobutanoic acid MW 417.506 Mass found: 418, 300 Example 152 4-((5-(3-((((1R)-1-(4-(methyloxy)phenyl)ethyl)amino)methyl)phenyl)-2-pyridinyl)amino)-4-oxobutanoic acid MW 433.505 Mass found: 434, 300 Example 153 (1R)-N-((3-(6-(methyloxy)-3-pyridazinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine MW 369.466 Mass found: 370, 739 Example 154 (1R)-N-((3-(1H-indol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(4-(methyloxy)phenyl)ethanamine MW 386.492 Mass found: 387, 773 Example 155 (1R)-N-((3-(1H-indol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine MW 386.492 Mass found: 387, 773 Example 156 (1R)-N-((3-(1H-indol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(2-naphthalenyl)ethanamine MW 406.526 Mass found: 371, 407, 326 Example 157 (1R)-N-((3-(6-(methyloxy)-3-pyridazinyl)phenyl)methyl)-1-phenylethanamine MW 319.406 Mass found: 320, 639 Example 158 (1R)-1-(4-(methyloxy)phenyl)-N-((3-(6-(methyloxy)-3-pyridazinyl)phenyl)methyl)ethanamine MW 349.432 Mass found: 350, 699 Example 159 (1R)-1-(3-(methyloxy)phenyl)-N-((3-(6-(methyloxy)-3-pyridazinyl)phenyl)methyl)ethanamine MW 349.432 Mass found: 350, 699 Example 160 (1R)-N-((4′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(2-naphthalenyl)ethanamine MW 367.49 Mass found: 368 Example 161 (1R)-N-((4′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine MW 367.49 Mass found: 368, 735 Example 162 (1R)-N-((4′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(4-(methyloxy)phenyl)ethanamine MW 347.456 Mass found: 348, 695 Example 163 (1R)-N-((4′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine MW 347.456 Mass found: 348, 695 Example 164 (1R)-1-phenyl-N-((3-(2-pyrazinyl)phenyl)methyl)ethanamine MW 289.38 Mass found: 290, 579, 693 Example 165 (1R)-1-(4-methylphenyl)-N-((3-(2-pyrazinyl)phenyl)methyl)ethanamine MW 303.407 Mass found: 304, 607, 721 Example 166 (1R)-1-(4-(methyloxy)phenyl)-N-((3-(2-pyrazinyl)phenyl)methyl)ethanamine MW 319.406 Mass found: 320, 639, 753 Example 167 (1R)-1-(3-(methyloxy)phenyl)-N-((3-(2-pyrazinyl)phenyl)methyl)ethanamine MW 319.406 Mass found: 320, 639, 753 Example 168 (1R)-1-(2-naphthalenyl)-N-((3-(2-pyridinyl)phenyl)methyl)ethanamine MW 338.452 Mass found: 339, 677 Example 169 (1R)-1-phenyl-N-((3-(2-pyridinyl)phenyl)methyl)ethanamine MW 288.392 Mass found: 289, 577 Example 170 (1R)-1-(1-naphthalenyl)-N-((3-(2-pyridinyl)phenyl)methyl)ethanamine MW 338.452 Mass found: 339, 677 Example 171 (1R)-1-(4-methylphenyl)-N-((3-(2-pyridinyl)phenyl)methyl)ethanamine MW 302.419 Mass found: 303, 605 Example 172 (1R)-1-(4-(methyloxy)phenyl)-N-((3-(2-pyridinyl)phenyl)methyl)ethanamine MW 318.418 Mass found: 319, 637 Example 173 (1R)-1-(3-(methyloxy)phenyl)-N-((3-(2-pyridinyl)phenyl)methyl)ethanamine MW 318.418 Mass found: 319, 637 Example 174 (1R)-N-((3-(6-methyl-3-pyridinyl)phenyl)methyl)-1-(2-naphthalenyl)ethanamine MW 352.479 Mass found: 353, 705 Example 175 (1R)-N-((3-(6-methyl-3-pyridinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine MW 352.479 Mass found: 353, 705 Example 176 (1R)-N-((3-(6-methyl-3-pyridinyl)phenyl)methyl)-1-phenylethanamine MW 302.419 Mass found: 303, 719 Example 177 (1R)-1-(4-methylphenyl)-N-((3-(6-methyl-3-pyridinyl)phenyl)methyl)ethanamine MW 316.446 Mass found: 317, 747 Example 178 (1R)-1-(4-(methyloxy)phenyl)-N-((3-(6-methyl-3-yridinyl)phenyl)methyl)ethanamine MW 332.445 Mass found: 333, 779, 665 Example 179 (1R)-1-(3-(methyloxy)phenyl)-N-((3-(6-methyl-3-yridinyl)phenyl)methyl)ethanamine MW 332.445 Mass found: 333, 779, 665 Example 180 (1R)-N-((4-(methyloxy)-3-(3-thienyl)phenyl)methyl)-1-(2-naphthalenyl)ethanamine MW 373.518 Mass found: 374, 747 Example 181 (1R)-N-((4-(methyloxy)-3-(3-thienyl)phenyl)methyl)-1-phenylethanamine MW 323.458 Mass found: 324, 647, 761 Example 182 (1R)-N-((4-(methyloxy)-3-(3-thienyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine MW 373.518 Mass found: 374, 747 Example 183 (1R)-N-((4-(methyloxy)-3-(3-thienyl)phenyl)methyl)-1-(4-methylphenyl)ethanamine MW 337.485 Mass found: 338, 675 Example 184 (1R)-1-(4-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(3-thienyl)phenyl)methyl)ethanamine MW 353.484 Mass found: 354, 707 Example 185 (1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(3-thienyl)phenyl)methyl)ethanamine MW 353.484 Mass found: 354, 707 Example 186 (1R)-N-((4-(methyloxy)-3-(5-pyrimidinyl)phenyl)methyl)-1-phenylethanamine MW 319.406 Mass found: 320, 361, 753 Example 187 (1R)-N-((4-(methyloxy)-3-(5-pyrimidinyl)phenyl)methyl)-1-(4-methylphenyl)ethanamine MW 333.433 Mass found: 334, 781 Example 188 (1R)-1-(4-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(5-pyrimidinyl)phenyl)methyl)ethanamine MW 349.432 Mass found: 350, 699 Example 189 (1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(5-pyrimidinyl)phenyl)methyl)ethanamine MW 349.432 Mass found: 350, 699 Example 190 N-(3′-((((1R)-1-(2-naphthalenyl)ethyl)amino)methyl)-1,1′-biphenyl-3-yl)acetamide MW 394.515 Mass found: 395, 789 Example 191 (1R)-N-((4′-fluoro-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine MW 305.394 Mass found: 306, 202, 243 Example 192 N-(3′-((((1R)-1-phenylethyl)amino)methyl)-1,1′-biphenyl-3-yl)acetamide MW 344.456 Mass found: 345, 689 Example 193 N-(3′-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)-1,1′-biphenyl-3-yl)acetamide MW 394.515 Mass found: 395, 789 Example 194 N-(3′-((((1R)-1-(4-methylphenyl)ethyl)amino)methyl)-1,1′-biphenyl-3-yl)acetamide MW 358.482 Mass found: 359, 717 Example 195 N-(3′-((((1R)-1-(4-(methyloxy)phenyl)ethyl)amino)methyl)-1,1′-biphenyl-3-yl)acetamide MW 374.481 Mass found: 375, 749 Example 196 N-(3′-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)-1,1′-biphenyl-3-yl)acetamide MW 374.481 Mass found: 375, 749, 416 Example 197 (1R)-N-((4′-fluoro-1,1′-biphenyl-3-yl)methyl)-1-(4-methylphenyl)ethanamine MW 319.421 Mass found: 320, 202, 243 Example 198 (1R)-1-phenyl-N-((3-(5-pyrimidinyl)phenyl)methyl)ethanamine MW 289.38 Mass found: 290, 693, 331 Example 199 (1R)-N-((4′-fluoro-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine MW 335.42 Mass found: 336, 202, 243 Example 200 (1R)-1-(4-methylphenyl)-N-((3-(5-pyrimidinyl)phenyl)methyl)ethanamine MW 303.407 Mass found: 304, 721, 345 Example 201 (1R)-1-(4-(methyloxy)phenyl)-N-((3-(5-pyrimidinyl)phenyl)methyl)ethanamine MW 319.406 Mass found: 320, 753 Example 202 (1R)-1-(3-(methyloxy)phenyl)-N-((3-(5-pyrimidinyl)phenyl)methyl)ethanamine MW 319.406 Mass found: 320, 753, 361 Example 203 (1R)-N-((4-(methyloxy)-3-(1,3-thiazol-2-yl)phenyl)methyl)-1-(2-naphthalenyl)ethanamine MW 374.506 Mass found: 375, 749 Example 204 (1R)-N-((4-(methyloxy)-3-(1,3-thiazol-2-yl)phenyl)methyl)-1-phenylethanamine MW 324.446 Mass found: 325, 649 Example 205 (1R)-N-((4-(methyloxy)-3-(1,3-thiazol-2-yl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine MW 374.506 Mass found: 375, 749 Example 206 (1R)-N-((4-(methyloxy)-3-(1,3-thiazol-2-yl)phenyl)methyl)-1-(4-methylphenyl)ethanamine MW 338.473 Mass found: 339, 677 Example 207 (1R)-1-(4-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(1,3-thiazol-2-yl)phenyl)methyl)ethanamine MW 354.472 Mass found: 355, 709 Example 208 (1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(1,3-thiazol-2-yl)phenyl)methyl)ethanamine MW 354.472 Mass found: 355, 709 Example 209 (1R)-N-((3′,4′-dimethyl-1,1′-biphenyl-3-yl)methyl)-1-(4-methylphenyl)ethanamine MW 329.484 Mass found: 330, 195, 212 Example 210 (1R)-N-((6-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(4-methylphenyl)ethanamine MW 331.457 Mass found: 197, 332 Example 211 (1R)-N-((6-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(4-(methyloxy)phenyl)ethanamine MW 347.456 Mass found: 197, 348 Example 212 (1R)-N-((6-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine MW 347.456 Mass found: 197, 348 Example 213 (1R)-1-phenyl-N-((4-(1-pyrrolidinyl)phenyl)methyl)ethanamine MW 280.413 Mass found: 160, 561, 281 Example 214 (1R)-N-((4-(3,5-dimethyl-4-isoxazolyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine MW 356.467 Mass found: 155, 357, 203 Example 215 (1R)-N-((4′-fluoro-6-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(4-methylphenyl)ethanamine MW 349.447 Mass found: 350 Example 216 (1R)-N-((4′-fluoro-6-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(4-(methyloxy)phenyl)ethanamine MW 365.446 Mass found: 366 Example 217 (1R)-1-(1-naphthalenyl)-N-((3-(1,3-thiazol-2-yl)phenyl)methyl)ethanamine MW 344.48 Mass found: 345, 689 Example 218 (1R)-1-phenyl-N-((3-(1,3-thiazol-2-yl)phenyl)methyl)ethanamine MW 294.42 Mass found: 295, 589 Example 219 (1R)-1-(4-methylphenyl)-N-((3-(1,3-thiazol-2-yl)phenyl)methyl)ethanamine MW 303.407 Mass found: 304, 607 Example 220 (1R)-1-(4-(methyloxy)phenyl)-N-((3-(1,3-thiazol-2-yl)phenyl)methyl)ethanamine MW 324.446 Mass found: 325, 649 Example 221 5-(2-(methyloxy)-5-((((1R)-1-(4-methylphenyl)ethyl)amino)methyl)phenyl)-3-pyridinecarboxamide MW 375.47 Mass found: 376, 417, 751, 865 Example 222 (1R)-N-((3-(3-furanyl)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine MW 307.391 Mass found: 308, 615 Example 223 (1R)-N-((3-(3-furanyl)phenyl)methyl)-1-(4-(methyloxy)phenyl)ethanamine MW 307.391 Mass found: 308, 615 Example 224 (1R)-N-((3-(3-furanyl)phenyl)methyl)-1-(4-methylphenyl)ethanamine MW 291.392 Mass found: 292, 583 Example 225 (1R)-N-((3-(3-furanyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine MW 327.425 Mass found: 328, 655 Example 226 (1R)-N-((3-(3-furanyl)phenyl)methyl)-1-phenylethanamine MW 277.365 Mass found: 278, 555 Example 227 5-(2-(methyloxy)-5-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-3-pyridinecarboxamide MW 411.503 Mass found: 412, 823 Example 228 (1R)-N-((4-(methyloxy)-3-(6-(methyloxy)-3-pyridazinyl)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine MW 379.457 Mass found: 380, 759 Example 229 (1R)-N-((4-(methyloxy)-3-(6-(methyloxy)-3-pyridazinyl)phenyl)methyl)-1-(4-(methyloxy)phenyl)ethanamine MW 379.457 Mass found: 380, 759 Example 230 (1R)-N-((4-(methyloxy)-3-(6-(methyloxy)-3-pyridazinyl)phenyl)methyl)-1-(4-methylphenyl)ethanamine MW 363.458 Mass found: 364, 727 Example 231 (1R)-N-((4-(methyloxy)-3-(6-(methyloxy)-3-pyridazinyl)phenyl)methyl)-1-phenylethanamine MW 349.432 Mass found: 350, 699 Example 232 (1R)-N-((4-(methyloxy)-3-(6-(methyloxy)-3-pyridazinyl)phenyl)methyl)-1-(2-naphthalenyl)ethanamine MW 399.491 Mass found: 400, 799 Example 233 5-(2-(methyloxy)-5-((((1R)-1-phenylethyl)amino)methyl)phenyl)-3-pyridinecarboxamide MW 361.443 Mass found: 362, 403, 723, 837 Example 234 (1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(2-pyrazinyl)phenyl)methyl)ethanamine MW 349.432 Mass found: 350, 699 Example 235 (1R)-1-(4-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(2-pyrazinyl)phenyl)methyl)ethanamine MW 349.432 Mass found: 350, 699 Example 236 (1R)-N-((4-(methyloxy)-3-(2-pyrazinyl)phenyl)methyl)-1-(4-methylphenyl)ethanamine MW 333.433 Mass found: 334, 667 Example 237 (1R)-N-((4-(methyloxy)-3-(2-pyrazinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine MW 369.466 Mass found: 370, 739 Example 238 (1R)-N-((4-(methyloxy)-3-(2-pyrazinyl)phenyl)methyl)-1-phenylethanamine MW 319.406 Mass found: 320, 639 Example 239 5-(2-(methyloxy)-5-((((1R)-1-(2-naphthalenyl)ethyl)amino)methyl)phenyl)-3-pyridinecarboxamide MW 411.503 Mass found: 412, 453, 823, 937 Example 240 (1R)-N-((4-(methyloxy)-3-(2-pyrazinyl)phenyl)methyl)-1-(2-naphthalenyl)ethanamine MW 369.466 Mass found: 370, 739 Example 241 (1R)-1-(4-methylphenyl)-N-((3-(9-methyl-9H-purin-6-yl)phenyl)methyl)ethanamine MW 357.459 Mass found: 358, 715 Example 242 (1R)-N-((6-(methyloxy)-4′-(methylsulfonyl)-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine MW 425.546 Mass found: 426, 851 Example 243 (1R)-N-((6-(methyloxy)-4′-(methylsulfonyl)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine MW 395.521 Mass found: 396, 437 Example 244 (1R)-N-((4-(methyloxy)-3-(6-methyl-3-pyridinyl)phenyl)methyl)-1-(4-methylphenyl)ethanamine MW 346.471 Mass found: 347, 807, 693 Example 245 (1R)-N-((4-(methyloxy)-3-(6-methyl-3-pyridinyl)phenyl)methyl)-1-(2-naphthalenyl)ethanamine MW 382.504 Mass found: 383, 879, 765 Example 246 N-(5-(3-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)phenyl)-2-pyridinyl)acetamide MW 375.47 Mass found: 242, 376 Example 247 N-(5-(3-((((1R)-1-(4-(methyloxy)phenyl)ethyl)amino)methyl)phenyl)-2-pyridinyl)acetamide MW 375.47 Mass found: 375, 242, 751 Example 248 N-(5-(3-((((1R)-1-(4-methylphenyl)ethyl)amino)methyl)phenyl)-2-pyridinyl)acetamide MW 359.47 Mass found: 242, 360 Example 249 N-(5-(3-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-2-pyridinyl)acetamide MW 395.504 Mass found: 155, 242, 396 Example 250 N-(5-(3-((((1R)-1-phenylethyl)amino)methyl)phenyl)-2-pyridinyl)acetamide MW 345.444 Mass found: 242, 346 Example 251 (1R)-N-((4′,6-difluoro-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine MW 323.384 Mass found: 324, 647, 761 Example 252 (1R)-N-((4′,6-difluoro-1,1′-biphenyl-3-yl)methyl)-1-(4-(methyloxy)phenyl)ethanamine MW 353.41 Mass found: 354, 707, 821 Examples 253-451 were prepared using Method C: Example 253 (1R)-N-((2′,6-bis(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine MW 347.456 Mass found: 227, 348 Example 254 (1R)-N-((3-(2-methyl-1,3-benzoxazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine MW 402.491 Mass found: 403 Example 255 (1R)-N-((3-(2-methyl-1,3-benzoxazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine MW 422.525 Mass found: 423 Example 256 (1R)-N-((3-(2-methyl-1,3-benzoxazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine MW 372.466 Mass found: 373 Example 257 N-(4′-(methyloxy)-5-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)-1,1′-biphenyl-2-yl)methanesulfonamide MW 460.595 Mass found: 155, 290, 461 Example 258 N-ethyl-N′-(4′-(methyloxy)-5-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)-1,1′-biphenyl-2-yl)urea MW 453.583 Mass found: 283, 454 Example 259 N-(4′-(methyloxy)-5-((((1R)-1-phenylethyl)amino)methyl)-1,1′-biphenyl-2-yl)methanesulfonamide MW 410.535 Mass found: 411 Example 260 (1R)-N-((3-(1,3-benzoxazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine MW 408.499 Mass found: 409 Example 261 N-ethyl-N′-(4′-(methyloxy)-5-((((1R)-1-phenylethyl)amino)methyl)-1,1′-biphenyl-2-yl)urea MW 403.523 Mass found: 404, 283 Example 262 (1R)-N-((4-(methyloxy)-3-(2-pyridinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine MW 368.478 Mass found: 369, 737 Example 263 N-ethyl-N′-(4′-(methyloxy)-5-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)-1,1′-biphenyl-2-yl)urea MW 433.549 Mass found: 434 Example 264 (1R)-N-((3-(1,3-benzoxazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine MW 358.439 Mass found: 359 Example 265 N-(4′-(methyloxy)-5-(((( 1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)-1,1′-biphenyl-2-yl)methanesulfonamide MW 440.561 Mass found: 290, 441 Example 266 (1R)-N-((3-(1,3-benzoxazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine MW 388.465 Mass found: 389, 891 Example 267 (1R)-N-((4-(methyloxy)-3-(6-methyl-3-pyridinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine MW 382.504 Mass found: 383, 229, 155 Example 268 (1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(2-thienyl)phenyl)methyl)ethanamine MW 353.484 Mass found: 354 Example 269 (1R)-N-((4-(methyloxy)-3-(2-thienyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine MW 373.518 Mass found: 374 Example 270 (1R)-N-((4-(methyloxy)-3-(2-thienyl)phenyl)methyl)-1-phenylethanamine MW 323.458 Mass found: 324, 203, 647 Example 271 (1R)-N-((4-(methyloxy)-3-(1-methyl-2-(trifluoromethyl)-1H-benzimidazol-5-yl)phenyl)methyl)-1-phenylethanamine MW 439.479 Mass found: 440, 481 Example 272 (1R)-N-((4-(methyloxy)-3-(1-methyl-2-(trifluoromethyl)-1H-benzimidazol-5-yl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine MW 489 Mass found: 490, 155 Example 273 (1R)-1-(3-(methyloxy)phenyl)-N-((6-(methyloxy)-4′-((trifluoromethyl)oxy)-1,1′-biphenyl-3-yl)methyl)ethanamine MW 431.452 Mass found: 432 Example 274 (1R)-N-((4-(methyloxy)-3-(4-piperidinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine MW 374.525 Mass found: 375, 489, 155 Example 275 (1R)-N-((4-(methyloxy)-3-(4-piperidinyl)phenyl)methyl)-1-phenylethanamine MW 324.465 Mass found: 325, 439 Example 276 2-(5-(2-(methyloxy)-5-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-1H-indol-1-yl)acetamide MW 463.578 Mass found: 464 Example 277 2-(5-(2-(methyloxy)-5-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)phenyl)-1H-indol-1-yl)acetamide MW 443.544 Mass found: 444 Example 278 2-(5-(2-(methyloxy)-5-((((1R)-1-phenylethyl)amino)methyl)phenyl)-1H-indol-1-yl)acetamide MW 413.518 Mass found: 414 Example 279 (1R)-N-((3-(1-(cyclopropylmethyl)-1H-indol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine MW 460.618 Mass found: 491 Example 280 (1R)-N-((3-(1-(cyclopropylmethyl)-1H-indol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine MW 440.584 Mass found: 441 Example 281 (1R)-N-((3-(1-(cyclopropylmethyl)-1H-indol-5-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine MW 410.558 Mass found: 411 Example 282 4-(2-(methyloxy)-5-((((1R)-1-phenylethyl)amino)methyl)phenyl)-1,3-thiazol-2-amine MW 339.461 Mass found: 340, 679 Example 283 (1R)-N-((3-(1-methyl-1H-imidazol-4-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine MW 371.482 Mass found: 372, 155, 743 Example 284 (1R)-N-((3-(1-methyl-1H-imidazol-4-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine MW 321.422 Mass found: 322, 643 Example 285 N-((3-(6-((3-(diethylamino)propyl)oxy)-3-pyridinyl)-4-(methyloxy)phenyl)methyl)-N-((1R)-1-(3-(methyloxy)phenyl)ethyl)amine MW 477.645 Mass found: 478, 344 Example 286 N-((3-(6-((3-(diethylamino)propyl)oxy)-3-pyridinyl)-4-(methyloxy)phenyl)methyl)-N-((1R)-1-(1-naphthalenyl)ethyl)amine MW 497.679 Mass found: 498, 155, 344 Example 287 N-((3-(6-((3-(diethylamino)propyl)oxy)-3-pyridinyl)-4-(methyloxy)phenyl)methyl)-N-((1R)-1-phenylethyl)amine MW 447.619 Mass found: 448, 344 Example 288 (1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(6-((2-(1-pyrrolidinyl)ethyl)oxy)-3-pyridinyl)phenyl)methyl)ethanamine MW 461.603 Mass found: 462, 328 Example 289 (1R)-N-((4-(methyloxy)-3-(6-((2-(1-pyrrolidinyl)ethyl)oxy)-3-pyridinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine MW 481.637 Mass found: 155, 482, 328 Example 290 (1R)-N-((4-(methyloxy)-3-(1-pyrrolidinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine MW 360.498 Mass found: 361, 721 Example 291 (1R)-N-((4-(methyloxy)-3-(1-pyrrolidinyl)phenyl)methyl)-1-phenylethanamine MW 310.438 Mass found: 311, 621 Example 292 (1R)-N-((4-(methyloxy)-3-(6-((2-(1-pyrrolidinyl)ethyl)oxy)-3-pyridinyl)phenyl)methyl)-1-phenylethanamine MW 431.577 Mass found: 432, 328 Example 293 (1R)-N-((3-(2-methyl-2H-indazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine MW 371.482 Mass found: 372, 744, 858 Example 294 2′-(methyloxy)-5′-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)-1,1′-biphenyl-4-carboxamide MW 390.48 Mass found: 240, 391, 781 Example 295 (1R)-N-((4-(methyloxy)-3-(1-methyl-4-piperidinyl)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine MW 368.518 Mass found: 369, 483 Example 296 (1R)-N-((4-(methyloxy)-3-(1-methyl-4-piperidinyl)phenyl)methyl)-1-phenylethanamine MW 338.492 Mass found: 339, 453 Example 297 2′-(methyloxy)-5′-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)-1,1′-biphenyl-4-carboxamide MW 410.514 Mass found: 155, 411, 240, 257 Example 298 (1R)-N-((4-(methyloxy)-3-(1-methyl-4-piperidinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine MW 388.552 Mass found: 389, 503 Example 299 ethyl 2′-(methyloxy)-5′-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)-1,1′-biphenyl-4-carboxylate MW 419.518 Mass found: 953, 420 Example 300 ethyl 2′-(methyloxy)-5′-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)-1,1′-biphenyl-4-carboxylate MW 439.552 Mass found: 440, 993 Example 301 ethyl 2′-(methyloxy)-5′-((((1R)-1-phenylethyl)amino)methyl)-1,1′-biphenyl-4-carboxylate MW 389.492 Mass found: 390, 893 Example 302 ethyl 4-(2-(methyloxy)-5-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-1-piperidinecarboxylate MW 446.588 Mass found: 447 Example 303 ethyl 4-(2-(methyloxy)-5-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)phenyl)-1-piperidinecarboxylate MW 426.554 Mass found: 427, 967 Example 304 ethyl 4-(2-(methyloxy)-5-((((1R)-1-phenylethyl)amino)methyl)phenyl)-1-piperidinecarboxylate MW 396.528 Mass found: 397, 907 Example 305 (1R)-N-((3-(2-methyl-1,3-oxazol-4-yl)-4-(methyloxy)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine MW 352.432 Mass found: 353, 705 Example 306 (1R)-N-((3-(2-methyl-1,3-oxazol-4-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine MW 372.466 Mass found: 373, 745 Example 307 (1R)-N-((3-(2-methyl-1,3-oxazol-4-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine MW 322.406 Mass found: 323, 645 Example 308 2-(methyloxy)-5′-((((1R)-1-phenylethyl)amino)methyl)-1,1′-biphenyl-4-carboxamide MW 360.455 Mass found: 835, 361 Example 309 5-(2-(methyloxy)-5-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-1-(2,2,2-trifluoroethyl)-2(1H)-pyridinone MW 466.5 Mass found: 155, 296, 467 Example 310 1-(2-(methyloxy)ethyl)-5-(2-(methyloxy)-5-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)phenyl)-2(1H)-pyridinone MW 422.522 Mass found: 272, 423, 290 Example 311 1-(2-(methyloxy)ethyl)-5-(2-(methyloxy)-5-((((1R)-1-phenylethyl)amino)methyl)phenyl)-2(1H)-pyridinone MW 392.496 Mass found: 272, 393 Example 312 1-(2-(methyloxy)ethyl)-5-(2-(methyloxy)-5-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-2(1H)-pyridinone MW 442.556 Mass found: 289, 272, 443 Example 313 (1R)-N-((6-(methyloxy)-4′-(methylsulfonyl)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine MW 445.58 Mass found: 155, 446, 275 Example 314 (1R)-N-((4′,6-bis(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine MW 423.398 Mass found: 424, 361 Example 315 (1R)-N-((4′-chloro-6-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine MW 401.935 Mass found: 155, 231, 402 Example 316 N,N-dimethyl-2′-(methyloxy)-5′-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)-1,1′-biphenyl-4-carboxamide MW 418.534 Mass found: 286, 268, 441, 419 Example 317 N,N-dimethyl-2′-(methyloxy)-5′-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)-1,1′-biphenyl-4-carboxamide MW 438.568 Mass found: 268, 155, 461, 439 Example 318 N,N-dimethyl-2′-(methyloxy)-5′-((((1R)-1-phenylethyl)amino)methyl)-1,1′-biphenyl-4-carboxamide MW 388.508 Mass found: 286, 268, 389, 411 Example 319 (1R)-N-((6-iodo-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine MW 511.319 Mass found: 512, 402, 361 Example 320 (1R)-N-((6-iodo-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine MW 481.293 Mass found: 482, 523 Example 321 (1R)-N-((6-iodo-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine MW 531.353 Mass found: 155, 532 Example 322 (1R)-N-((6-(methyloxy)-3′-((trifluoromethyl)oxy)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine MW 451.486 Mass found: 155, 452, 281 Example 323 (1R)-1-(3-(methyloxy)phenyl)-N-((6-(methyloxy)-3′-((trifluoromethyl)oxy)-1,1′-biphenyl-3-yl)methyl)ethanamine MW 431.452 Mass found: 432, 281 Example 324 (1R)-N-((6-(methyloxy)-3′-((trifluoromethyl)oxy)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine MW 401.426 Mass found: 281, 402 Example 325 (1R)-N-((4′-chloro-6-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine MW 381.901 Mass found: 231, 382 Example 326 (1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(2-((2,2,2-trifluoroethyl)oxy)-5-pyrimidinyl)phenyl)methyl)ethanamine MW 447.455 Mass found: 448 Example 327 (1R)-N-((4-(methyloxy)-3-(2-((2,2,2-trifluoroethyl)oxy)-5-pyrimidinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine MW 467.489 Mass found: 155, 468 Example 328 (1R)-N-((4-(methyloxy)-3-(2-((2,2,2-trifluoroethyl)oxy)-5-pyrimidinyl)phenyl)methyl)-1-phenylethanamine MW 417.429 Mass found: 418, 297 Example 329 (1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(6-quinoxalinyl)phenyl)methyl)ethanamine MW 399.491 Mass found: 249, 400 Example 330 (1R)-N-((4-(methyloxy)-3-(6-quinoxalinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine MW 419.526 Mass found: 420, 249, 155 Example 331 (1R)-N-((4-(methyloxy)-3-(6-quinoxalinyl)phenyl)methyl)-1-phenylethanamine MW 369.466 Mass found: 370, 249 Example 332 (1R)-N-((4′-chloro-6-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine MW 351.875 Mass found: 231, 352 Example 333 (1R)-N-((3-(1,3-benzothiazol-2-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine MW 374.506 Mass found: 375, 749 Example 334 (1R)-N-((4-(methyloxy)-3-(2-(1-piperidinyl)-1,3-thiazol-4-yl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine MW 457.639 Mass found: 458, 155 Example 335 (1R)-N-((4-(methyloxy)-3-(2-(1-piperidinyl)-1,3-thiazol-4-yl)phenyl)methyl)-1-phenylethanamine MW 407.579 Mass found: 408, 304 Example 336 (1R)-1-phenyl-N-((6-((2,2,2-trifluoroethyl)oxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)ethanamine MW 453.424 Mass found: 454, 333 Example 337 (1R)-N-((6-((2-(methyloxy)ethyl)oxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine MW 459.505 Mass found: 460, 309 Example 338 N,N-dimethyl-2-((5-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)-4′-(trifluoromethyl)-1,1′-biphenyl-2-yl)oxy)acetamide MW 486.531 Mass found: 487, 336, 509 Example 339 N,N-dimethyl-2-((5-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)-4′-(trifluoromethyl)-1,1′-biphenyl-2-yl)oxy)acetamide MW 506.565 Mass found: 507, 336, 529 Example 340 (1R)-N-((3-(4-morpholinylsulfonyl)phenyl)methyl)-1-phenylethanamine MW 360.476 Mass found: 298, 361, 402 Example 341 (1R)-N-((6-chloro-4′-((trifluoromethyl)oxy)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine MW 455.905 Mass found: 456, 911 Example 342 (1R)-N-((3-(1,3-benzothiazol-2-yl)-4-(methyloxy)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine MW 404.532 Mass found: 405, 809 Example 343 (1R)-N-((3-(1,3-benzothiazol-2-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine MW 424.566 Mass found: 425, 849 Example 344 N,N-dimethyl-2-((5-((((1R)-1-phenylethyl)amino)methyl)-4′-(trifluoromethyl)-1,1′-biphenyl-2-yl)oxy)acetamide MW 456.505 Mass found: 336, 457, 354 Example 345 (1R)-N-((4-(methyloxy)-3-(2-naphthalenyl)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine MW 433.98 Mass found: 247, 398 Example 346 (1R)-N-((4-(methyloxy)-3-(2-naphthalenyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine MW 454.02 Mass found: 247, 155, 418 Example 347 (1R)-N-((4-(methyloxy)-3-(2-naphthalenyl)phenyl)methyl)-1-phenylethanamine MW 403.96 Mass found: 247, 368 Example 348 (1R)-N-((3-(1-benzothien-3-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine MW 460.04 Mass found: 253, 155, 424 Example 349 (1R)-N-((3-(1-benzothien-3-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine MW 409.98 Mass found: 253, 374 Example 350 (1R)-N-((3-(2,1,3-benzothiadiazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine MW 441.98 Mass found: 273, 255, 406 Example 351 (1R)-N-((3-(2,1,3-benzothiadiazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine MW 411.96 Mass found: 273, 255, 376 Example 352 (1R)-N-((4′,6-bis(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine MW 489.89 Mass found: 454, 361, 344 Example 353 (1R)-N-((4′,6-bis(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine MW 509.93 Mass found: 155 Example 354 (1R)-N-((6-chloro-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine MW 439.91 Mass found: 155 Example 355 (1R)-N-((6-chloro-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine MW 389.95 Mass found: 390, 269, 310 Example 356 1-(2-(methyloxy)-5-((((1R)-1-phenylethyl)amino)methyl)phenyl)-2-pyrrolidinone MW 324.43 Mass found: 204, 347, 325 Example 357 (1R)-N-((3-(2,3-dihydro-1-benzofuran-5-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine MW 409.53 Mass found: 239, 410 Example 358 (1R)-N-((3-(2,3-dihydro-1-benzofuran-5-yl)-4-(methyloxy)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine MW 389.50 Mass found: 239, 390 Example 359 (1R)-N-((3-(2,3-dihydro-1-benzofuran-5-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine MW 359.47 Mass found: 239, 360 Example 360 (1R)-N-((3-(2,1,3-benzoxadiazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine MW 359.43 Mass found: 239, 360, 401 Example 361 (1R)-N-((3-(2,1,3-benzoxadiazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine MW 389.46 Mass found: 390, 431, 779 Example 362 (1R)-N-((4-chloro-3-(6-((2,2,2-trifluoroethyl)oxy)-3-pyridinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine MW 470.93 Mass found: 155, 472 Example 363 (1R)-N-((4-(methyloxy)-3-(1-(2,2,2-trifluoroethyl)-1H-indol-5-yl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine MW 488.55 Mass found: 318, 489 Example 364 (1R)-N-((4-(methyloxy)-3-(1-(2,2,2-trifluoroethyl)-1H-indol-5-yl)phenyl)methyl)-1-phenylethanamine MW 438.491 Mass found: 318, 439 Example 365 1-(2-(methyloxy)-5-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-2-pyrrolidinone MW 374.49 Mass found: 240, 375, 397, 749 Example 366 (1R)-N-((3-(2,1,3-benzoxadiazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine MW 409.49 Mass found: 155, 410, 239 Example 367 5-(2-(methyloxy)-5-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)phenyl)-1-(2,2,2-trifluoroethyl)-2(1H)-pyridinone MW 446.466 Mass found: 296, 447, 314 Example 368 5-(2-(methyloxy)-5-(((( 1R)-1-phenylethyl)amino)methyl)phenyl)-1-(2,2,2-trifluoroethyl)-2(1H)-pyridinone MW 416.441 Mass found: 296, 314, 417 Example 369 1-methyl-5-(2-(methyloxy)-5-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-2(1H)-pyridinone MW 398.503 Mass found: 245, 399, 228, 155 Example 370 1-methyl-5-(2-(methyloxy)-5-((((1R)-1-phenylethyl)amino)methyl)phenyl)-2(1H)-pyridinone MW 348.444 Mass found: 228, 349 Example 371 (1R)-N-((6-((2-(methyloxy)ethyl)oxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine MW 479.539 Mass found: 480, 959 Example 372 (1R)-N-((6-((2-(methyloxy)ethyl)oxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine MW 429.479 Mass found: 309, 430 Example 373 (1R)-N-((3-imidazo[1,2-a]pyridin-6-yl-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine MW 407.514 Mass found: 408, 254, 155 Example 374 (1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(6-quinolinyl)phenyl)methyl)ethanamine MW 398.503 Mass found: 399, 248, 265 Example 375 (1R)-N-((4-(methyloxy)-3-(6-quinolinyl)phenyl)methyl)-1-phenylethanamine MW 368.478 Mass found: 248, 369, 265 Example 376 (1R)-N-((4-(methyloxy)-3-(6-quinolinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine MW 418.537 Mass found: 419, 248, 265 Example 377 2′-(methyloxy)-5′-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)-1,1′-biphenyl-3-carboxamide MW 410.514 Mass found: 411, 821 Example 378 (1R)-1-(1-naphthalenyl)-N-((6-((2,2,2-trifluoroethyl)oxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)ethanamine MW 503.484 Mass found: 155, 504 Example 379 1-methyl-5-(2-(methyloxy)-5-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)phenyl)-2(1H)-pyridinone MW 378.469 Mass found: 228, 379 Example 380 (1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(2-(1-piperidinyl)-1,3-thiazol-4-yl)phenyl)methyl)ethanamine MW 437.605 Mass found: 438, 875 Example 381 (1R)-N-((6-chloro-4′-((trifluoromethyl)oxy)-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine MW 435.871 Mass found: 436, 477 Example 382 (1R)-N-((6-chloro-4′-((trifluoromethyl)oxy)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine MW 405.845 Mass found: 406 Example 383 2′-(methyloxy)-5′-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)-1,1′-biphenyl-3-carboxamide MW 390.48 Mass found: 391, 432, 781, 895 Example 384 2′-(methyloxy)-5′-((((1R)-1-phenylethyl)amino)methyl)-1,1′-biphenyl-3-carboxamide MW 360.455 Mass found: 361, 721, 402 Example 385 (1R)-N-((3-(3-furanyl)-4-(methyloxy)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine MW 337.417 Mass found: 187, 338 Example 386 (1R)-1-(1-naphthalenyl)-N-((3-(6-(trifluoromethyl)-3-pyridinyl)phenyl)methyl)ethanamine MW 406.449 Mass found: 155, 407 Example 387 (1R)-N-((3-(2,2-difluoro-1,3-benzodioxol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine MW 427.445 Mass found: 428, 855, 969 Example 388 (1R)-N-((3-(2,2-difluoro-1,3-benzodioxol-5-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine MW 397.419 Mass found: 398, 277 Example 389 (1R)-N-((3-(2,2-difluoro-1,3-benzodioxol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine MW 447.479 Mass found: 448, 895 Example 390 (1R)-N-((3-(3-furanyl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine MW 357.451 Mass found: 358 Example 391 4′-(methyloxy)-5-((((1R)-1-phenylethyl)amino)methyl)-1,1′-biphenyl-2-ol MW 333.429 Mass found: 334, 213 Example 392 (1R)-N-((3-imidazo[1,2-a]pyridin-6-yl-4-(methyloxy)phenyl)methyl)-1-phenylethanamine MW 357.455 Mass found: 358 Example 393 (1R)-N-((3-(3-furanyl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine MW 307.391 Mass found: 308, 187 Example 394 (1R)-N-((3-(1-acetyl-4-piperidinyl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine MW 416.562 Mass found: 417 Example 395 (1R)-N-((4-(methyloxy)-3-(1-((methyloxy)acetyl)-4-piperidinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine MW 446.588 Mass found: 447 Example 396 (1R)-N-((4-(methyloxy)-3-(1-((methyloxy)acetyl)-4-piperidinyl)phenyl)methyl)-1-phenylethanamine MW 396.528 Mass found: 397 Example 397 (1R)-N-((6-(methyloxy)-3′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine MW 435.487 Mass found: 155, 436 Example 398 (1R)-N-((6-(methyloxy)-3′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine MW 385.427 Mass found: 386, 265 Example 399 (1R)-N-((4-(methyloxy)-3-(2-methyl-1,3-thiazol-4-yl)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine MW 368.499 Mass found: 369, 218 Example 400 (1R)-N-((4-(methyloxy)-3-(2-methyl-1,3-thiazol-4-yl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine MW 388.533 Mass found: 389, 218 Example 401 (1R)-N-((4-(methyloxy)-3-(2-methyl-1,3-thiazol-4-yl)phenyl)methyl)-1-phenylethanamine MW 338.473 Mass found: 218, 339 Example 402 (1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl)phenyl)methyl)ethanamine MW 407.39 Mass found: 408, 274 Example 403 ethyl 4-(2-(methyloxy)-5-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-3,6-dihydro-1(2H)-pyridinecarboxylate MW 444.572 Mass found: 445, 274, 155 Example 404 (1R)-N-((4-(methyloxy)-3-(4-(methyloxy)-2-pyridinyl)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine MW 378.469 Mass found: 379 Example 405 (1R)-N-((4-(methyloxy)-3-(4-(methyloxy)-2-pyridinyl)phenyl)methyl)-1-phenylethanamine MW 348.444 Mass found: 349 Example 406 (1R)-N-((4-((difluoromethyl)oxy)-3-(3-pyridinyl)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine MW 384.424 Mass found: 385, 251 Example 407 (1R)-N-((4-((difluoromethyl)oxy)-3-(3-pyridinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine MW 404.458 Mass found: 405, 155 Example 408 (1R)-N-((4-((difluoromethyl)oxy)-3-(3-pyridinyl)phenyl)methyl)-1-phenylethanamine MW 354.398 Mass found: 355, 251 Example 409 2′-(methyloxy)-5′-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)-1,1′-biphenyl-3-carboxylic acid MW 391.465 Mass found: 241, 392 Example 410 2′-(methyloxy)-5′-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)-1,1′-biphenyl-3-carboxylic acid MW 411.499 Mass found: 155, 412, 241 Example 411 2′-(methyloxy)-5′-((((1R)-1-phenylethyl)amino)methyl)-1,1′-biphenyl-3-carboxylic acid MW 361.439 Mass found: 241, 362 Example 412 (1R)-N-((4-(methyloxy)-3-(5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl)phenyl)methyl)-1-phenylethanamine MW 377.364 Mass found: 274, 378 Example 413 (1R)-N-((4-(methyloxy)-3-(1H-pyrrol-1-yl)phenyl)methyl)-1-phenylethanamine MW 306.407 Mass found: 186, 307 Example 414 (1R)-1-(3-(methyloxy)phenyl)-N-((6-(methyloxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)ethanamine MW 415.453 Mass found: 265, 416 Example 415 (1R)-N-((6-(methyloxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine MW 435.487 Mass found: 155, 436 Example 416 (1R)-N-((3-(1-methyl-1H-indazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine MW 371.482 Mass found: 251, 372 Example 417 (1R)-N-((3-(1-methyl-1H-indazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine MW 421.541 Mass found: 251, 422 Example 418 (1R)-N-((3-(2-methyl-2H-indazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine MW 421.541 Mass found: 422, 251, 155 Example 419 (1R)-1-(3-(methyloxy)phenyl)-N-((6-(methyloxy)-3′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)ethanamine MW 415.453 Mass found: 416, 265 Example 420 (1R)-N-((4-(methyloxy)-3-(5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine MW 427.424 Mass found: 155, 428 Example 421 (1R)-N-((4-(methyloxy)-3-(1-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine MW 401.507 Mass found: 251, 402, 268 Example 422 (1R)-N-((4-(methyloxy)-3-(1-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine MW 421.541 Mass found: 422, 251, 155, 268 Example 423 (1R)-N-((4-(methyloxy)-3-(1H-pyrrol-1-yl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine MW 356.467 Mass found: 155, 357 Example 424 (1R)-N-((4-(methyloxy)-3-(5-(methyloxy)-2-pyridinyl)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine MW 378.469 Mass found: 379, 757 Example 425 (1R)-N-((4-(methyloxy)-3-(5-(methyloxy)-2-pyridinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine MW 398.503 Mass found: 399, 797 Example 426 (1R)-N-((4-(methyloxy)-3-(5-(methyloxy)-2-pyridinyl)phenyl)methyl)-1-phenylethanamine MW 348.444 Mass found: 349, 697 Example 427 (1R)-N-((3-(6-(ethyloxy)-3-pyridinyl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine MW 412.53 Mass found: 413, 155, 242, 259 Example 428 (1R)-N-((3-(6-(ethyloxy)-3-pyridinyl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine MW 362.47 Mass found: 242, 363, 725 Example 429 (1R)-N-((3-(1-methyl-1H-benzimidazol-2-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine MW 421.541 Mass found: 422, 155 Example 430 (1R)-N-((3-(1-methyl-1H-benzimidazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine MW 371.482 Mass found: 251, 268, 372, 743 Example 431 (1R)-N-((4-(methyloxy)-3-(1-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)methyl)-1-phenylethanamine MW 371.482 Mass found: 251, 372, 268 Example 432 (1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(6-((2,2,2-trifluoroethyl)oxy)-3-pyridinyl)phenyl)methyl)ethanamine MW 446.466 Mass found: 447, 296 Example 433 (1R)-N-((4-(methyloxy)-3-(6-((2,2,2-trifluoroethyl)oxy)-3-pyridinyl)phenyl)methyl)-1-phenylethanamine MW 416.441 Mass found: 417, 296 Example 434 (1R)-N-((4-chloro-3-(3-pyridinyl)phenyl)methyl)-1-phenylethanamine MW 322.837 Mass found: 323, 219, 645 Example 435 (1R)-N-((4-chloro-3-(3-pyridinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine MW 372.897 Mass found: 155, 373, 219 Example 436 (1R)-N-((4-chloro-3-(3-pyridinyl)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine MW 352.863 Mass found: 353, 219 Example 437 (1R)-N-((3-(1-methyl-1H-benzimidazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine MW 401.507 Mass found: 402, 251, 268 Example 438 (1R)-N-((3-(1-methyl-1H-benzimidazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine MW 421.541 Mass found: 155, 422, 251, 268 Example 439 (1R)-N-((3-(1-methyl-1H-indol-6-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine MW 370.493 Mass found: 250, 371 Example 440 (1R)-N-((3-(1-methyl-1H-indol-6-yl)-4-(methyloxy)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine MW 400.519 Mass found: 401, 250 Example 441 (1R)-N-((3-(1-methyl-1H-indol-6-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine MW 420.553 Mass found: 421, 250 Example 442 (1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(6-(trifluoromethyl)-3-pyridinyl)phenyl)methyl)ethanamine MW 416.441 Mass found: 417, 947 Example 443 (1R)-N-((4-(methyloxy)-3-(6-(trifluoromethyl)-3-pyridinyl)phenyl)methyl)-1-phenylethanamine MW 386.415 Mass found: 887, 387, 428 Example 444 (1R)-N-((3-(2-ethyl-2H-1,2,3-benzotriazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine MW 386.496 Mass found: 887, 387 Example 445 N-1,N-1-dimethyl-N-2-(4-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)phenyl)-N-2-phenyl-1,2-ethanediamine MW 403.567 Mass found: 253, 404 Example 446 N-1,N-1-dimethyl-N-2-(4-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-N-2-phenyl-1,2-ethanediamine MW 423.601 Mass found: 253, 424 Example 447 (1R)-N-((3′,6-bis(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine MW 397.515 Mass found: 398 Example 448 (1R)-N-((3′,6-bis(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine MW 377.481 Mass found: 378 Example 449 (1R)-N-((3′,6-bis(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine MW 347.456 Mass found: 348 Example 450 (1R)-N-((4′,6-bis(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-phenyl-1-propanamine MW 361.482 Mass found: MS (EI) calcd for C 24 H 27 NO 2 362 (MH+). Found: 362, 227, 212 Example 451 (1R)-N-((4-methyl-3-(3-pyridinyl)phenyl)methyl)-1-phenylethanamine MW 302.419 Mass found: MS (EI) calcd for C 21 H 22 N 2 303 (MH+) Found: 303, 199, 183 Examples 452-465 were prepared using Method A: Example 452 (1R)-N-((3-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine MW 323.394 Mass found: 324, 231, 190 Example 453 (1R)-N-((3-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl)methyl)-1-phenylethanamine MW 293.368 Mass found: 294, 231, 190 Example 454 (1R)-N-((4-(methyloxy)-3-(6-(methyloxy)-3-pyridinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine MW 398.503 Mass found: 399, 155, 245, 228 Example 455 (1R)-N-((4-(methyloxy)-3-(6-(methyloxy)-3-pyridinyl)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine MW 378.469 Mass found: 379 Example 456 (1R)-N-((4′,6-difluoro-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine MW 353.41 Mass found: 354 Example 457 5-(2-(methyloxy)-5-((((1R)-1-(4-methylphenyl)ethyl)amino)methyl)phenyl)-2-pyrimidinamine MW 348.448 Mass found: 214, 349, 231 Example 458 5-(2-(methyloxy)-5-((((1R)-1-(2-naphthalenyl)ethyl)amino)methyl)phenyl)-2-pyrimidinamine MW 384.481 Mass found: 155, 385, 231 Example 459 5-(3-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)phenyl)-3-pyridinecarboxamide MW 361.443 Mass found: 362, 228 Example 460 5-(3-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-3-pyridinecarboxamide MW 381.477 Mass found: 155, 382, 228 Example 461 5-(3-((((1R)-1-(2-naphthalenyl)ethyl)amino)methyl)phenyl)-3-pyridinecarboxamide MW 381.477 Mass found: 155, 382, 228 Example 462 (1R)-N-((6-fluoro-4′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine MW 365.446 Mass found: 366, 215 Example 463 (1R)-N-((6-fluoro-4′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(4-(methyloxy)phenyl)ethanamine MW 365.446 Mass found: 366, 215 Example 464 (1R)-N-((6-fluoro-4′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(4-methylphenyl)ethanamine MW 349.447 Mass found: 350, 215 Example 465 (1R)-N-((6-fluoro-4′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine MW 335.42 Mass found: 336, 215 The following compounds were prepared using Synthetic Method C: ExampleNo:Structure466467468469470471472473474475476477478479480481482 Biological Activity The activities of the compounds of the present invention on calcium receptors were measured. In one embodiment, the measurement was performed in accordance with the method described in Example 4 of Nemeth et al., PCT/US95/13704 (International Publication No. WO96/12697) herein incorporated by reference. A 4.0-kb NotI-HindIII fragment of the human parathyroid cell Ca 2+ receptor (hPCaR) cDNA was subcloned into the mammalian expression vector pCEP4 (Invitrogen) containing the hygromycin-resistant gene as a selectable marker. This plasmid was transfected into HEK 293 cells by calcium phosphate precipitation. Transfected cells were grown in Dulbecco's modified Eagle's medium containing 10% fetal bovine serum and hygromycin (200 μg/mL). Hygromycin-resistant colonies were subcloned and assayed for hPCaR mRNA by solution hybridization using a 32 P-labeled RNA probe complementary to the (4.0 kb) hPCaR sequence (Garrett, et al., J. Biol. Chem. 270, 12919-12925 (1995)). Clone 7 was used to assess the effects of compounds on [Ca 2+ ] i . This stably transfected cell line is termed HEK 293 4.0-7. For measurements of [Ca 2+ ] i , the cells were recovered from tissue culture flasks by brief treatment with 0,02% EDTA and then washed and resuspended in PCB containing 1 mM CaCl 2 and 0.1% Bovine Serum Albumin (“BSA”). The cells were loaded with fluo-3 by incubation for 30 min at 37° C., with parathyroid cell buffer (126 mM NaCl, 4 mM KCl, 1mM MgSO 4 , 0.7 mM K 2 HPO 4 /KH 2 PO 4 , 20 mM HEPES.NaOH (pH 7.45)) containing 0.5% BSA in 1 mM CaCl 2 and 2 μM fluo-3 acetoxymethyl ester. The cells were subsequently washed, each test compound was added to the cells and the fluorescence was recorded by using excitation and emission wavelengths of 485 and 530 nm, respectively. The following compounds of the invention were tested according to the procedure described above and found to have an EC50 of 10 μM or less: (1R)-N-((6-(methyloxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine;(1R)-N-((4-(methyloxy)-3-(6-((2,2,2-trifluoroethyl)oxy)-3-pyridinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((6-(methyloxy)-4′-((trifluoromethyl)oxy)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine;(1R)-N-((4-(methyloxy)-3-(6-(trifluoromethyl)-3-pyridinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(3-pyridinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((6-(ethyloxy)-4′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine;(1R)-1-(3-chlorophenyl)-N-((6-(methyloxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)ethanamine;(1R)-1-(3-fluorophenyl)-N-((6-(methyloxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)ethanamine;(1R)-N-((6-(methyloxy)-4′-((trifluoromethyl)oxy)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(3-pyridinyl)phenyl)methyl)ethanamine;(1R)-1-(3-(methyloxy)phenyl)-N-((3-(1,3-thiazol-2-yl)phenyl)methyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(3-pyridinyl)phenyl)methyl)-1-(4-methylphenyl)ethanamine;(1R)-1-(4-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(3-pyridinyl)phenyl)methyl)ethanamine;(1R)-N-((3-(1,3-benzodioxol-5-yl)phenyl)methyl)-1-phenylethanamine;(1R)-N-((3-(1,3-benzodioxol-5-yl)phenyl)methyl)-1-(4-methylphenyl)ethanamine;(1R)-N-((3-(1,3-benzodioxol-5-yl)phenyl)methyl)-1-(4-(methyloxy)phenyl)ethanamine;(1R)-N-((3-(1,3-benzodioxol-5-yl)phenyl)methyl)-1-(4-(methyloxy)phenyl)ethanamine;2′-(methyloxy)-5′-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)-1,1′-biphenyl-3-carbonitrile;2′-(methyloxy)-5′-((((1R)-1-phenylethyl)amino)methyl)-1,1′-biphenyl-3-carbonitrile;2′-(methyloxy)-5′-((((1R)-1-(4-methylphenyl)ethyl)amino)methyl)-1,1′-biphenyl-3-carbonitrile;2′-(methyloxy)-5′-((((1R)-1-(4-(methyloxy)phenyl)ethyl)amino)methyl)-1,1′-biphenyl-3-carbonitrile;2′-(methyloxy)-5′-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)-1,1′-biphenyl-3-carbonitrile;(1R)-N-((4-(methyloxy)-3-(2-pyrimidinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(2-pyrimidinyl)phenyl)methyl)-1-phenylethanamine;(1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(2-pyrimidinyl)phenyl)methyl)ethanamine;(1R)-N-((3′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine;(1R)-N-((3′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(4-methylphenyl)ethanamine;(1R)-N-((3′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(4-(methyloxy)phenyl)ethanamine;(1R)-N-((3′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;(1R)-N-((2′-methyl-1,1′-biphenyl-3-yl)methyl)-1-(4-methylphenyl)ethanamine;(1R)-N-((2′-methyl-1,1′-biphenyl-3-yl)methyl)-1-(4-(methyloxy)phenyl)ethanamine;(1R)-N-((2′-fluoro-1,1′-biphenyl-3-yl)methyl)-1-(4-methylphenyl)ethanamine;(1R)-N-((2′-fluoro-1,1′-biphenyl-3-yl)methyl)-1-(4-(methyloxy)phenyl)ethanamine;(1R)-N-((2′-fluoro-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;5-(2-(methyloxy)-5-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)phenyl)-2-furancarboxylic acid;4-oxo-4-((5-(3-(((( 1R)-1-phenylethyl)amino)methyl)phenyl)-2-pyridinyl)amino)butanoic acid;4-((5-(3-((((1R)-1-(4-(methyloxy)phenyl)ethyl)amino)methyl)phenyl)-2-pyridinyl)amino)-4-oxobutanoic acid;(1R)-N-((3-(6-(methyloxy)-3-pyridazinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((3-(1H-indol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(4-(methyloxy)phenyl)ethanamine;(1R)-N-((3-(1H-indol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;(1R)-N-((3-(1H-indol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(2-naphthalenyl)ethanamine;(1R)-N-((3-(6-(methyloxy)-3-pyridazinyl)phenyl)methyl)-1-phenylethanamine;(1R)-1-(4-(methyloxy)phenyl)-N-((3-(6-(methyloxy)-3-pyridazinyl)phenyl)methyl)ethanamine;(1R)-1-(3-(methyloxy)phenyl)-N-((3-(6-(methyloxy)-3-pyridazinyl)phenyl)methyl)ethanamine;(1R)-N-((4′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(2-naphthalenyl)ethanamine;(1R)-N-((4′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((4′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(4-(methyloxy)phenyl)ethanamine;(1R)-N-((4′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;(1R)-1-phenyl-N-((3-(2-pyrazinyl)phenyl)methyl)ethanamine;(1R)-1-(4-(methyloxy)phenyl)-N-((3-(2-pyrazinyl)phenyl)methyl)ethanamine;(1R)-1-(3-(methyloxy)phenyl)-N-((3-(2-pyrazinyl)phenyl)methyl)ethanamine;(1R)-1-(2-naphthalenyl)-N-((3-(2-pyridinyl)phenyl)methyl)ethanamine;(1R)-1-phenyl-N-((3-(2-pyridinyl)phenyl)methyl)ethanamine;(1R)-1-(1-naphthalenyl)-N-((3-(2-pyridinyl)phenyl)methyl)ethanamine;(1R)-1-(4-methylphenyl)-N-((3-(2-pyridinyl)phenyl)methyl)ethanamine;(1R)-1-(4-(methyloxy)phenyl)-N-((3-(2-pyridinyl)phenyl)methyl)ethanamine;(1R)-1-(3-(methyloxy)phenyl)-N-((3-(2-pyridinyl)phenyl)methyl)ethanamine;(1R)-N-((3-(6-methyl-3-pyridinyl)phenyl)methyl)-1-(2-naphthalenyl)ethanamine;(1R)-N-((3-(6-methyl-3-pyridinyl)phenyl)methyl)-1-phenylethanamine;(1R)-N-((3-(6-methyl-3-pyridinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-1-(4-methylphenyl)-N-((3-(6-methyl-3-pyridinyl)phenyl)methyl)ethanamine;(1R)-1-(4-(methyloxy)phenyl)-N-((3-(6-methyl-3-pyridinyl)phenyl)methyl)ethanamine;(1R)-1-(3-(methyloxy)phenyl)-N-((3-(6-methyl-3-pyridinyl)phenyl)methyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(3-thienyl)phenyl)methyl)-1-(2-naphthalenyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(3-thienyl)phenyl)methyl)-1-phenylethanamine;(1R)-N-((4-(methyloxy)-3-(3-thienyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(3-thienyl)phenyl)methyl)-1-(4-methylphenyl)ethanamine;(1R)-1-(4-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(3-thienyl)phenyl)methyl)ethanamine;(1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(3-thienyl)phenyl)methyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(5-pyrimidinyl)phenyl)methyl)-1-phenylethanamine;(1R)-N-((4-(methyloxy)-3-(5-pyrimidinyl)phenyl)methyl)-1-(4-methylphenyl)ethanamine;(1R)-1-(4-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(5-pyrimidinyl)phenyl)methyl)ethanamine;(1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(5-pyrimidinyl)phenyl)methyl)ethanamine;(1R)-N-((4′-fluoro-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine;N-(3′-((((1R)-1-phenylethyl)amino)methyl)-1,1′-biphenyl-3-yl)acetamide;N-(3′-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)-1,1′-biphenyl-3-yl)acetamide;N-(3′-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)-1,1′-biphenyl-3-yl)acetamide;(1R)-N-((4′-fluoro-1,1′-biphenyl-3-yl)methyl)-1-(4-methylphenyl)ethanamine;(1R)-N-((4′-fluoro-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;(1R)-1-(3-(methyloxy)phenyl)-N-((3-(5-pyrimidinyl)phenyl)methyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(1,3-thiazol-2-yl)phenyl)methyl)-1-(2-naphthalenyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(1,3-thiazol-2-yl)phenyl)methyl)-1-phenylethanamine;(1R)-N-((4-(methyloxy)-3-(1,3-thiazol-2-yl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(1,3-thiazol-2-yl)phenyl)methyl)-1-(4-methylphenyl)ethanamine;(1R)-1-(4-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(1,3-thiazol-2-yl)phenyl)methyl)ethanamine;(1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(1,3-thiazol-2-yl)phenyl)methyl)ethanamine;(1R)-N-((3′,4′-dimethyl-1,1′-biphenyl-3-yl)methyl)-1-(4-methylphenyl)ethanamine;(1R)-N-((6-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(4-methylphenyl)ethanamine;(1R)-N-((6-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(4-(methyloxy)phenyl)ethanamine;(1R)-N-((6-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;(1R)-N-((4′-fluoro-6-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(4-methylphenyl)ethanamine(1R)-N-((4′-fluoro-6-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(4-(methyloxy)phenyl)ethanamine;(1R)-1-(1-naphthalenyl)-N-((3-(1,3-thiazol-2-yl)phenyl)methyl)ethanamine;(1R)-1-phenyl-N-((3-(1,3-thiazol-2-yl)phenyl)methyl)ethanamine;(1R)-1-phenyl-N-((4-(1-pyrrolidinyl)phenyl)methyl)ethanamine;(1R)-N-((4-(3,5-dimethyl-4-isoxazolyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;5-(2-(methyloxy)-5-((((1R)-1-(4-methylphenyl)ethyl)amino)methyl)phenyl)-3-pyridinecarboxamide;(1R)-N-((3-(3-furanyl)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;(1R)-N-((3-(3-furanyl)phenyl)methyl)-1-(4-(methyloxy)phenyl)ethanamine;(1R)-N-((3-(3-furanyl)phenyl)methyl)-1-(4-methylphenyl)ethanamine;(1R)-N-((3-(3-furanyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((3-(3-furanyl)phenyl)methyl)-1-phenylethanamine;5-(2-(methyloxy)-5-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-3-pyridinecarboxamide;(1R)-N-((4-(methyloxy)-3-(6-(methyloxy)-3-pyridazinyl)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(6-(methyloxy)-3-pyridazinyl)phenyl)methyl)-1-(4-(methyloxy)phenyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(6-(methyloxy)-3-pyridazinyl)phenyl)methyl)-1-phenylethanamine;(1R)-N-((4-(methyloxy)-3-(6-(methyloxy)-3-pyridazinyl)phenyl)methyl)-1-(2-naphthalenyl)ethanamine;5-(2-(methyloxy)-5-((((1R)-1-phenylethyl)amino)methyl)phenyl)-3-pyridinecarboxamide;(1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(2-pyrazinyl)phenyl)methyl)ethanamine;(1R)-1-(4-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(2-pyrazinyl)phenyl)methyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(2-pyrazinyl)phenyl)methyl)-1-(4-methylphenyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(2-pyrazinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(2-pyrazinyl)phenyl)methyl)-1-phenylethanamine;5-(2-(methyloxy)-5-((((1R)-1-(2-naphthalenyl)ethyl)amino)methyl)phenyl)-3-pyridinecarboxamide;(1R)-N-((4-(methyloxy)-3-(2-pyrazinyl)phenyl)methyl)-1-(2-naphthalenyl)ethanamine;(1R)-1-(4-methylphenyl)-N-((3-(9-methyl-9H-purin-6-yl)phenyl)methyl)ethanamine;(1R)-N-((6-(methyloxy)-4′-(methylsulfonyl)-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;(1R)-N-((6-(methyloxy)-4′-(methylsulfonyl)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine;N-(5-(3-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)phenyl)-2-pyridinyl)acetamide;N-(5-(3-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-2-pyridinyl)acetamide;N-(5-(3-((((1R)-1-phenylethyl)amino)methyl)phenyl)-2-pyridinyl)acetamide;(1R)-N-((4′,6-difluoro-1,1′biphenyl-3-yl)methyl)-1-phenylethanamine;(1R)-N-((4′,6-difluoro-1,1′-biphenyl-3-yl)methyl)-1-(4-(methyloxy)phenyl)ethanamine;(1R)-N-((2′,6-bis(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine;(1R)-N-((3-(2-methyl-1,3-benzoxazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;(1R)-N-((3-(2-methyl-1,3-benzoxazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((3-(2-methyl-1,3-benzoxazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine;N-(4′-(methyloxy)-5-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)-1,1′-biphenyl-2-yl)methanesulfonamide;N-ethyl-N′-(4′-(methyloxy)-5-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)-1,1′-biphenyl-2-yl)urea;N-(4′-(methyloxy)-5-((((1R)-1-phenylethyl)amino)methyl)-1,1′-biphenyl-2-yl)methanesulfonamide;(1R)-N-((3-(1,3-benzoxazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;N-ethyl-N′-(4′-(methyloxy)-5-((((1R)-1-phenylethyl)amino)methyl)-1,1′-biphenyl-2-yl)urea;(1R)-N-((4-(methyloxy)-3-(2-pyridinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;N-ethyl-N′-(4′-(methyloxy)-5-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)-1,1′-biphenyl-2-yl)urea;(1R)-N-((3-(1,3-benzoxazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine;N-(4′-(methyloxy)-5-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)-1,1′-biphenyl-2-yl)methanesulfonamide;(1R)-N-((4-(methyloxy)-3-(6-methyl-3-pyridinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(2-thienyl)phenyl)methyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(2-thienyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(2-thienyl)phenyl)methyl)-1-phenylethanamine;(1R)-N-((4-(methyloxy)-3-(1-methyl-2-(trifluoromethyl)-1H-benzimidazol-5-yl)phenyl)methyl)-1-phenylethanamine;(1R)-N-((4-(methyloxy)-3-(1-methyl-2-(trifluoromethyl)-1H-benzimidazol-5-yl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-1-(3-(methyloxy)phenyl)-N-((6-(methyloxy)-4′-((trifluoromethyl)oxy)-1,1′-biphenyl-3-yl)methyl)ethanamine;3-(2-(methyloxy)-5-((((1R)-1-phenylethyl)amino)methyl)phenyl)-N-(3-(4-morpholinyl)propyl)-2-pyridinamine;(1R)-N-((4-(methyloxy)-3-(6-((tetrahydro-2-furanylmethyl)oxy)-3-pyridinyl)phenyl)methyl)-1-phenylethanamine;3-(2-(methyloxy)-5-((((1R)-1-phenylethyl)amino)methyl)phenyl)-N-(tetrahydro-2-furanylmethyl)-2-pyridinamine;5-(2-(methyloxy)-5-((((1R)-1-phenylethyl)amino)methyl)phenyl)-2-pyridinamine;N,N-dimethyl-5-(2-(methyloxy)-5-((((1R)-1-phenylethyl)amino)methyl)phenyl)-2-pyridinamine;(1R)-N-((4-(methyloxy)-3-(4-piperidinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;2-(5-(2-(methyloxy)-5-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-1H-indol-1-yl)acetamide;2-(5-(2-(methyloxy)-5-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)phenyl)-1H-indol-1-yl)acetamide;2-(5-(2-(methyloxy)-5-((((1R)-1-phenylethyl)amino)methyl)phenyl)-1H-indol-1-yl)acetamide;(1R)-N-((4-(methyloxy)-3-(2-(4-morpholinyl)-3-pyridinyl)phenyl)methyl)-1-phenylethanamine;(1R)-N-((3-(2-fluoro-3-pyridinyl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine;(1R)-N-((4-(methyloxy)-3-(2-((2,2,2-trifluoroethyl)oxy)-3-pyridinyl)phenyl)methyl)-1-phenylethanamine;(1R)-N-((4-(methyloxy)-3-(2-((tetrahydro-2-furanylmethyl)oxy)-3-pyridinyl)phenyl)methyl)-1-phenylethanamine;(1R)-N-((3-(1-(cyclopropylmethyl)-1H-indol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((3-(1-(cyclopropylmethyl)-1H-indol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;(1R)-N-((3-(1-(cyclopropylmethyl)-1H-indol-5-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine;4-(2-(methyloxy)-5-((((1R)-1-phenylethyl)amino)methyl)phenyl)-1,3-thiazol-2-amine;(1R)-N-((3-(1-methyl-1H-imidazol-4-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((3-(1-methyl-1H-imidazol-4-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine;N-((3-(6-((3-(diethylamino)propyl)oxy)-3-pyridinyl)-4-(methyloxy)phenyl)methyl)-N-((1R)-1-(3-(methyloxy)phenyl)ethyl)amine;N-((3-(6-((3-(diethylamino)propyl)oxy)-3-pyridinyl)-4-(methyloxy)phenyl)methyl)-N-((1R)-1-(1-naphthalenyl)ethyl)amine;(1R)-N-((4-(methyloxy)-3-(6-((2-(1-pyrrolidinyl)ethyl)oxy)-3-pyridinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-N-((4-(methyloxy)-3-(1-pyrrolidinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine; (1R)-N-((4-(methyloxy)-3-(1-pyrrolidinyl)phenyl)methyl)-1-phenylethanamine;(1R)-N-((4-(methyloxy)-3-(6-((2-(1-pyrrolidinyl)ethyl)oxy)-3-pyridinyl)phenyl)methyl)-1-phenylethanamine;(1R)-N-((3-(2-methyl-2H-indazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine;2′-(methyloxy)-5′-((((l R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)-1,1′-biphenyl-4-carboxamide;(1R)-N-((4-(methyloxy)-3-(1-methyl-4-piperidinyl)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;2′-(methyloxy)-5′-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)-1,1′-biphenyl-4-carboxamide;(1R)-N-((4-(methyloxy)-3-(1-methyl-4-piperidinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;ethyl 2′-(methyloxy)-5′-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)-1,1′-biphenyl-4-carboxylate;ethyl 2′-(methyloxy)-5′-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)-1,1′-biphenyl-4-carboxylate;ethyl 2′-(methyloxy)-5′-((((1R)-1-phenylethyl)amino)methyl)-1,1′-biphenyl-4-carboxylate;ethyl 4-(2-(methyloxy)-5-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-1-piperidinecarboxylate;ethyl 4-(2-(methyloxy)-5-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)phenyl)-1-piperidinecarboxylate;ethyl 4-(2-(methyloxy)-5-((((1R)-1-phenylethyl)amino)methyl)phenyl)-1-piperidinecarboxylate;(1R)-N-((3-(2-methyl-1,3-oxazol-4-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((3-(2-methyl-1,3-oxazol-4-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine;2′-(methyloxy)-5′-((((1R)-1-phenylethyl)amino)methyl)-1,1′-biphenyl-4-carboxamide;1-(2-(methyloxy)ethyl)-5-(2-(methyloxy)-5-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)phenyl)-2(1H)-pyridinone;1-(2-(methyloxy)ethyl)-5-(2-(methyloxy)-5-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-2(1H)-pyridinone;(1R)-N-((6-(methyloxy)-4′-(methylsulfonyl)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((4′,6-bis(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine;N-((6-(methyloxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-(3-methylphenyl)ethanamine;3-(1-(((6-(methyloxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)amino)ethyl)benzonitrile;(1R)-1-(3-((2-(methyloxy)ethyl)oxy)phenyl)-N-((6-(methyloxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)ethanamine;(1R)-N-((6-fluoro-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine;(1R)-N-((4′-chloro-6-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine;N,N-dimethyl-2′-(methyloxy)-5′-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)-1,1′-biphenyl-4-carboxamide;N,N-dimethyl-2′-(methyloxy)-5′-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)-1,1′-biphenyl-4-carboxamide;N,N-dimethyl-2′-(methyloxy)-5′-((((1R)-1-phenylethyl)amino)methyl)-1,1′-biphenyl-4-carboxamide;(1R)-N-((6-iodo-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;(1R)-N-((6-iodo-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine;(1R)-N-((6-iodo-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((6-(methyloxy)-3′-((trifluoromethyl)oxy)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-1-(3-(methyloxy)phenyl)-N-((6-(methyloxy)-3′-((trifluoromethyl)oxy)-1,1′-biphenyl-3-yl)methyl)ethanamine;(1R)-N-((6-(methyloxy)-3′-((trifluoromethyl)oxy)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine;(1R)-N-((4′-chloro-6-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;(1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(2-((2,2,2-trifluoroethyl)oxy)-5-pyrimidinyl)phenyl)methyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(2-((2,2,2-trifluoroethyl)oxy)-5-pyrimidinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(2-((2,2,2-trifluoroethyl)oxy)-5-pyrimidinyl)phenyl)methyl)-1-phenylethanamine;(1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(6-quinoxalinyl)phenyl)methyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(6-quinoxalinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(6-quinoxalinyl)phenyl)methyl)-1-phenylethanamine;(1R)-N-((4′-chloro-6-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine;(1R)-N-((3-(1,3-benzothiazol-2-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine;(1R)-N-((4-(methyloxy)-3-(2-(1-piperidinyl)-1,3-thiazol-4-yl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(2-(1-piperidinyl)-1,3-thiazol-4-yl)phenyl)methyl)-1-phenylethanamine;(1R)-1-phenyl-N-((6-((2,2,2-trifluoroethyl)oxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)ethanamine;(1R)-N-((6-((2-(methyloxy)ethyl)oxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;(1R)-N-((6-chloro-4′-((trifluoromethyl)oxy)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((3-(1,3-benzothiazol-2-yl)-4-(methyloxy)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;(1R)-N-((3-(1,3-benzothiazol-2-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;1-(3,5-difluorophenyl)-N-((6-(methyloxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)ethanamine;1-(3-bromophenyl)-N-((6-(methyloxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)ethanamine;1-(3-fluorophenyl)-N-((6-(methyloxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)ethanamine;(1S)-N-((6-(methyloxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine;(1R)-N-(3-(2-chloropyrid-4-yl)-4-methoxyphenyl)methyl-N-1-phenylethylamine;(1R)-1-(3-fluorophenyl)-N-((6-(methyloxy)-4′-(methylsulfonyl)-1,1′-biphenyl-3-yl)methyl)ethanamine;(1R)-1-(3-fluorophenyl)-N-((6-(methyloxy)-1,1′-biphenyl-3-yl)methyl)ethanamine;(1R)-1-(3-chlorophenyl)-N-((6-(methyloxy)-1,1′-biphenyl-3-yl)methyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(2-naphthalenyl)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(2-naphthalenyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(2-naphthalenyl)phenyl)methyl)-1-phenylethanamine;(1R)-N-((3-(1-benzothien-3-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((3-(1-benzothien-3-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine;(1R)-N-((3-(2,1,3-benzothiadiazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;(1R)-N-((3-(2,1,3-benzothiadiazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine;(1R)-N-((4′,6-bis(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;(1R)-N-((4′,6-bis(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((4′-fluoro-6-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(3-fluorophenyl)ethanamine;(1R)-N-((6-chloro-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((6-chloro-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine;(1R)-N-((3-(2,3-dihydro-1-benzofuran-5-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((3-(2,3-dihydro-1-benzofuran-5-yl)-4-(methyloxy)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;(1R)-N-((3-(2,3-dihydro-1-benzofuran-5-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine;(1R)-N-((3-(2,1,3-benzoxadiazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine;(1R)-N-((3-(2,1,3-benzoxadiazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;(1R)-N-((4-chloro-3-(6-((2,2,2-trifluoroethyl)oxy)-3-pyridinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(1-(2,2,2-trifluoroethyl)-1H-indol-5-yl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(1-(2,2,2-trifluoroethyl)-1H-indol-5-yl)phenyl)methyl)-1-phenylethanamine;(1R)-N-((3-(2,1,3-benzoxadiazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;N-1-(3-(dimethylamino)phenyl)ethyl)-N-((6-(methyloxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)amine;N-((6-(methyloxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-(3-((trifluoromethyl)oxy)phenyl)ethanamine;5-(2-(methyloxy)-5-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)phenyl)-1-(2,2,2-trifluoroethyl)-2(1H)-pyridinone;5-(2-(methyloxy)-5-((((1R)-1-phenylethyl)amino)methyl)phenyl)-1-(2,2,2-trifluoroethyl)-2(1H)-pyridinone;1-(4-fluorophenyl)-N-((6-(methyloxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)ethanamine;1-(2,3-dichlorophenyl)-N-((6-(methyloxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)ethanamine;1-methyl-5-(2-(methyloxy)-5-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-2(1H)-pyridinone;1-methyl-5-(2-(methyloxy)-5-((((1R)-1-phenylethyl)amino)methyl)phenyl)-2(1H)-pyridinone;(1R)-N-((6-((2-(methyloxy)ethyl)oxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((6-((2-(methyloxy)ethyl)oxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine;(1R)-N-((3-imidazo[1,2-a]pyridin-6-yl-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(6-quinolinyl)phenyl)methyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(6-quinolinyl)phenyl)methyl)-1-phenylethanamine;(1R)-N-((4-(methyloxy)-3-(6-quinolinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine; 2′-(methyloxy)-5′-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)-1,1′-biphenyl-3-carboxamide; (1R)-1-(1-naphthalenyl)-N-((6-((2,2,2-trifluoroethyl)oxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)ethanamine;1-methyl-5-(2-(methyloxy)-5-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)phenyl)-2(1H)-pyridinone;(1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(2-(1-piperidinyl)-1,3-thiazol-4-yl)phenyl)methyl)ethanamine;(1R)-N-((6-chloro-4′-((trifluoromethyl)oxy)-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;(1R)-N-((6-chloro-4′-((tri fluoromethyl)oxy)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine;2′-(methyloxy)-5′-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)-1,1′-biphenyl-3-carboxamide;2′-(methyloxy)-5′-((((1R)-1-phenylethyl)amino)methyl)-1,1′-biphenyl-3-carboxamide;(1R)-N-((3-(3-furanyl)-4-(methyloxy)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;(1R)-1-(1-naphthalenyl)-N-((3-(6-(trifluoromethyl)-3-pyridinyl)phenyl)methyl)ethanamine;(1R)-N-((3-(2,2-difluoro-1,3-benzodioxol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;(1R)-N-((3-(2,2-difluoro-1,3-benzodioxol-5-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine;(1R)-N-((3-(2,2-difluoro-1,3-benzodioxol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((3-(3-furanyl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;4′-(methyloxy)-5-((((1R)-1-phenylethyl)amino)methyl)-1,1′-biphenyl-2-ol;(1R)-N-((3-imidazo[1,2-a]pyridin-6-yl-4-(methyloxy)phenyl)methyl)-1-phenylethanamine;(1R)-N-((3-(3-furanyl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine;(1R)-N-((3-(1-acetyl-4-piperidinyl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(1-((methyloxy)acetyl)-4-piperidinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(6-((2-(methyloxy)ethyl)oxy)-3-pyridinyl)phenyl)methyl)-1-phenylethanamine;(1R)-N-((6-(methyloxy)-3′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((6-(methyloxy)-3′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine;(1R)-N-((4-(methyloxy)-3-(2-methyl-1,3-thiazol-4-yl)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(2-methyl-1,3-thiazol-4-yl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(2-methyl-1,3-thiazol-4-yl)phenyl)methyl)-1-phenylethanamine;(1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl)phenyl)methyl)ethanamine;ethyl 4-(2-(methyloxy)-5-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-3,6-dihydro-1 (2H)-pyridinecarboxylate;(1R)-N-((4-(methyloxy)-3-(4-(methyloxy)-2-pyridinyl)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(4-(methyloxy)-2-pyridinyl)phenyl)methyl)-1-phenylethanamine;(1R)-N-((4-((difluoromethyl)oxy)-3-(3-pyridinyl)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;(1R)-N-((4-((difluoromethyl)oxy)-3-(3-pyridinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((4-((difluoromethyl)oxy)-3-(3-pyridinyl)phenyl)methyl)-1-phenylethanamine;2′-(methyloxy)-5′-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)-1,1′-biphenyl-3-carboxylic acid;2′-(methyloxy)-5′-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)-1,1′-biphenyl-3-carboxylic acid;2′-(methyloxy)-5′-((((1R)-1-phenylethyl)amino)methyl)-1,1′-biphenyl-3-carboxylic acid;(1R)-N-((4-(methyloxy)-3-(5-(trifluoromethyl)-1,3 ,4-oxadiazol-2-yl)phenyl)methyl)-1-phenylethanamine;(1R)-N-((4-(methyloxy)-3-(1H-pyrrol-1-yl)phenyl)methyl)-1-phenylethanamine;(1R)-1-(3-(methyloxy)phenyl)-N-((6-(methyloxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)ethanamine;(1R)-N-((6-(methyloxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((3-(1-methyl-1H-indazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine;(1R)-N-((3-(1-methyl-1H-indazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((3-(2-methyl-2H-indazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-1-(3-(methyloxy)phenyl)-N-((6-(methyloxy)-3′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(1-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(1-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(1H-pyrrol-1-yl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(5-(methyloxy)-2-pyridinyl)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(5-(methyloxy)-2-pyridinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(5-(methyloxy)-2-pyridinyl)phenyl)methyl)-1-phenylethanamine;(1R)-N-((3-(6-(ethyloxy)-3-pyridinyl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((3-(6-(ethyloxy)-3-pyridinyl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine;(1R)-N-((3-(1-methyl-1H-benzimidazol-2-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((3-(1-methyl-1H-benzimidazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine;(1R)-N-((4-(methyloxy)-3-(1-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)methyl)-1-phenylethanamine;(1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(6-((2,2,2-trifluoroethyl)oxy)-3-pyridinyl)phenyl)methyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(6-((2,2,2-trifluoroethyl)oxy)-3-pyridinyl)phenyl)methyl)-1-phenylethanamine;(1R)-N-((4-chloro-3-(3-pyridinyl)phenyl)methyl)-1-phenylethanamine;(1R)-N-((4-chloro-3-(3-pyridinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((4-chloro-3-(3-pyridinyl)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;(1R)-N-((3-(1-methyl-1H-benzimidazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;(1R)-N-((3-(1-methyl-1H-benzimidazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((3-(1-methyl-1H-indol-6-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine;(1R)-N-((3-(1-methyl-1H-indol-6-yl)-4-(methyloxy)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;(1R)-N-((3-(1-methyl-1H-indol-6-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(6-(trifluoromethyl)-3-pyridinyl)phenyl)methyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(6-(trifluoromethyl)-3-pyridinyl)phenyl)methyl)-1-phenylethanamine;(1R)-N-((3-(2-ethyl-2H-1,2,3-benzotriazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine;(1R)-N-((3′,6-bis(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((3′,6-bis(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;(1R)-N-((3′,6-bis(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine;(1R)-N-((4′,6-bis(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-phenyl-1-propanamine;(1R)-N-((4-methyl-3-(3-pyridinyl)phenyl)methyl)-1-phenylethanamine;(1R)-N-((3-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;(1R)-N-((3-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl)methyl)-1-phenylethanamine;(1R)-N-((4-(methyloxy)-3-(6-(methyloxy)-3-pyridinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;(1R)-N-((4-(methyloxy)-3-(6-(methyloxy)-3-pyridinyl)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;(1R)-N-((4′,6-difluoro-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;5-(2-(methyloxy)-5-((((1R)-1-(4-methylphenyl)ethyl)amino)methyl)phenyl)-2-pyrimidinamine;5-(2-(methyloxy)-5-((((1R)-1-(2-naphthalenyl)ethyl)amino)methyl)phenyl)-2-pyrimidinamine;5-(3-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)phenyl)-3-pyridinecarboxamide;5-(3-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-3-pyridinecarboxamide;5-(3-((((1R)-1-(2-naphthalenyl)ethyl)amino)methyl)phenyl)-3-pyridinecarboxamide;(1R)-N-((6-fluoro-4′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;(1R)-N-((6-fluoro-4′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(4-(methyloxy)phenyl)ethanamine;(1R)-N-((6-fluoro-4′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(4-methylphenyl)ethanamine; and(1R)-N-((6-fluoro-4′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine; For the treatment of bone disorders, such as osteoporosis, excessive secretion of PTH, such as hyperparathyroidism, and the like, the compounds of the present invention may be administered orally, parentally, by inhalation spray, rectally, or topically in dosage unit formulations containing conventional pharmaceutically acceptable carriers, adjuvants, and vehicles. The term “parenteral” as used herein includes, subcutaneous, intravenous, intramuscular, intrasternal, infusion techniques or intraperitoneally. Treatment of diseases and disorders herein is intended to also include the prophylactic administration of a compound of the invention, a pharmaceutical salt thereof, or a pharmaceutical composition of either to a subject (i.e., an animal, preferably a mammal, most preferably a human) believed to be in need of preventative treatment, such as, for example, pain, inflammation and the like. The dosage regimen for treating the disclosed diseases with the compounds of this invention and/or compositions of this invention is based on a variety of factors, including the type of disease, the age, weight, sex, medical condition of the patient, the severity of the condition, the route of administration, and the particular compound employed. Thus, the dosage regimen may vary widely, but can be determined routinely using standard methods. Dosage levels of the order from about 0.01 mg to 30 mg per kilogram of body weight per day, preferably from about 0.1 mg to 10 mg/kg, more preferably from about 0.25 mg to 1 mg/kg are useful for all methods of use disclosed herein. The pharmaceutically active compounds of this invention can be processed in accordance with conventional methods of pharmacy to produce medicinal agents for administration to patients, including humans and other mammals. For oral administration, the pharmaceutical composition may be in the form of, for example, a capsule, a tablet, a suspension, or liquid. The pharmaceutical composition is preferably made in the form of a dosage unit containing a given amount of the active ingredient. For example, these may contain an amount of active ingredient from about 1 to 2000 mg, preferably from about 1 to 500 mg, more preferably from about 5 to 150 mg. A suitable daily dose for a human or other mammal may vary widely depending on the condition of the patient and other factors, but, once again, can be determined using routine methods. The active ingredient may also be administered by injection as a composition with suitable carriers including saline, dextrose, or water. The daily parenteral dosage regimen will be from about 0.1 to about 30 mg/kg of total body weight, preferably from about 0.1 to about 10 mg/kg, and more preferably from about 0.25 mg to 1 mg/kg. Injectable preparations, such as sterile injectable aqueous or oleaginous suspensions, may be formulated according to the known are using suitable dispersing or wetting agents and suspending agents. The sterile injectable preparation may also be a sterile injectable solution or suspension in a non-toxic parenterally acceptable diluent or solvent, for example as a solution in 1,3-butanediol. Among the acceptable vehicles and solvents that may be employed are water, Ringer's solution, and isotonic sodium chloride solution. In addition, sterile, fixed oils are conventionally employed as a solvent or suspending medium. For this purpose any bland fixed oil may be employed, including synthetic mono- or diglycerides. In addition, fatty acids such as oleic acid find use in the preparation of injectables. Suppositories for rectal administration of the drug can be prepared by mixing the drug with a suitable non-irritating excipient such as cocoa butter and polyethylene glycols that are solid at ordinary temperatures but liquid at the rectal temperature and will therefore melt in the rectum and release the drug. A suitable topical dose of active ingredient of a compound of the invention is 0.1 mg to 150 mg administered one to four, preferably one or two times daily. For topical administration, the active ingredient may comprise from 0.001% to 10% w/w, e.g., from 1% to 2% by weight of the formulation, although it may comprise as much as 10% w/w, but preferably not more than 5% w/w, and more preferably from 0.1% to 1% w/w of the formulation. Formulations suitable for topical administration include liquid or semi-liquid preparations suitable for penetration through the skin (e.g., liniments, lotions, ointments, creams, or pastes) and drops suitable for administration to the eye, ear, or nose. For administration, the compounds of this invention are ordinarily combined with one or more adjuvants appropriate for the indicated route of administration. The compounds may be admixed with lactose, sucrose, starch powder, cellulose esters of alkanoic acids, stearic acid, talc, magnesium stearate, magnesium oxide, sodium and calcium salts of phosphoric and sulphuric acids, acacia, gelatin, sodium alginate, polyvinyl-pyrrolidine, and/or polyvinyl alcohol, and tableted or encapsulated for conventional administration. Alternatively, the compounds of this invention may be dissolved in saline, water, polyethylene glycol, propylene glycol, ethanol, corn oil, peanut oil, cottonseed oil, sesame oil, tragacanth gum, and/or various buffers. Other adjuvants and modes of administration are well known in the pharmaceutical art. The carrier or diluent may include time delay material, such as glyceryl monostearate or glyceryl distearate alone or with a wax, or other materials well known in the art. The pharmaceutical compositions may be made up in a solid form (including granules, powders or suppositories) or in a liquid form (e.g., solutions, suspensions, or emulsions). The pharmaceutical compositions may be subjected to conventional pharmaceutical operations such as sterilization and/or may contain conventional adjuvants, such as preservatives, stabilizers, wetting agents, emulsifiers, buffers etc. Solid dosage forms for oral administration may include capsules, tablets, pills, powders, and granules. In such solid dosage forms, the active compound may be admixed with at least one inert diluent such as sucrose, lactose, or starch. Such dosage forms may also comprise, as in normal practice, additional substances other than inert diluents, e.g., lubricating agents such as magnesium stearate. In the case of capsules, tablets, and pills, the dosage forms may also comprise buffering agents. Tablets and pills can additionally be prepared with enteric coatings. Liquid dosage forms for oral administration may include pharmaceutically acceptable emulsions, solutions, suspensions, syrups, and elixirs containing inert diluents commonly used in the art, such as water. Such compositions may also comprise adjuvants, such as wetting, sweetening, flavoring, and perfuming agents. While the compounds of the invention can be administered as the sole active pharmaceutical agent, they can also be used in combination with one or more compounds of the invention or other agents. When administered as a combination, the therapeutic agents can be formulated as separate compositions that are given at the same time or different times, or the therapeutic agents can be given as a single composition. The foregoing is merely illustrative of the invention and is not intended to limit the invention to the disclosed compounds. Variations and changes which are obvious to one skilled in the art are intended to be within the scope and nature of the invention which are defined in the appended claims.","lang":"en","source":"USPTO_FULLTEXT","data_format":"ORIGINAL"}},"description_lang":["en"],"has_description":true,"has_docdb":true,"has_inpadoc":true,"has_full_text":true,"biblio_lang":"en"},"jurisdiction":"US","collections":[],"usersTags":[],"lensId":"147-700-757-926-365","publicationKey":"US_7524873_B2","displayKey":"US 7524873 B2","docAssets":{"lensId":"147-700-757-926-365","pdfUrl":"https://www.lens.org/images/patent/US/7524873/B2/US_7524873_B2.pdf","images":[{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000001.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000001.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000002.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000002.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000003.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000003.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000004.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000004.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000005.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000005.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000006.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000006.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000007.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000007.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000008.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000008.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000009.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000009.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000010.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000010.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000011.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000011.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000012.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000012.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000013.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000013.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000014.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000014.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000015.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000015.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000016.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000016.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000017.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000017.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000018.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000018.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000019.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000019.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000020.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000020.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000021.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000021.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000022.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000022.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000023.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000023.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000024.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000024.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000025.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000025.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000026.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000026.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000027.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000027.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000028.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000028.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000029.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000029.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000030.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000030.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000031.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000031.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000032.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000032.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000033.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000033.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000034.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000034.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000035.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000035.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000036.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000036.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000037.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000037.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000038.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000038.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000039.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000039.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000040.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000040.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000041.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000041.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000042.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000042.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000043.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000043.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000044.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000044.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000045.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000045.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000046.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000046.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000047.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000047.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000048.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000048.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000049.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000049.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000050.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000050.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000051.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000051.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000052.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000052.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000053.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000053.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000054.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000054.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000055.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000055.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000056.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000056.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000057.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000057.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000058.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000058.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000059.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000059.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000060.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000060.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000061.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000061.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000062.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000062.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000063.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000063.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000064.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000064.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000065.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000065.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000066.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000066.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000067.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000067.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000068.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000068.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000069.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000069.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000070.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000070.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000071.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000071.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000072.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000072.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000073.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000073.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000074.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000074.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000075.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000075.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000076.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000076.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000077.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000077.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000078.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000078.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000079.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000079.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000080.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000080.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000081.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000081.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000082.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000082.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000083.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000083.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000084.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000084.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000085.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000085.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000086.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000086.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000087.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000087.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000088.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000088.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000089.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000089.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000090.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000090.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000091.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000091.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000092.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000092.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000093.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000093.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000094.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000094.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000095.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000095.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000096.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000096.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000097.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000097.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000098.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000098.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000099.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000099.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000100.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000100.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000101.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000101.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000102.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000102.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000103.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000103.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000104.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000104.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000105.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000105.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000106.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000106.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000107.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000107.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000108.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000108.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000109.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000109.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000110.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000110.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000111.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000111.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000112.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000112.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000113.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000113.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000114.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000114.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000115.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000115.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000116.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000116.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000117.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000117.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000118.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000118.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000119.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000119.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000120.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000120.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000121.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000121.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000122.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000122.png"},{"thumb":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/10pc/00000123.png","full":"https://s3-us-west-2.amazonaws.com/lens-resource/patent/US/B2/7524/7524873/image/page/full/00000123.png"}],"fallover":false},"countryName":"USA","inventorModel":{"inventors":[{"name":{"value":"KELLY MICHAEL G","valueNormalised":"Kelly Michael G"},"inventorship":null},{"name":{"value":"XU SHIMIN","valueNormalised":"Xu Shimin"},"inventorship":null},{"name":{"value":"XI NING","valueNormalised":"Xi Ning"},"inventorship":null},{"name":{"value":"MILLER PHILIP","valueNormalised":"Miller Philip"},"inventorship":null},{"name":{"value":"KINCAID JOHN F","valueNormalised":"Kincaid John F"},"inventorship":null},{"name":{"value":"GHIRON CHIARA","valueNormalised":"Ghiron Chiara"},"inventorship":null},{"name":{"value":"COULTER THOMAS S","valueNormalised":"Coulter Thomas S"},"inventorship":null}],"inventorships":[],"unmatchedInventorships":[],"activeUserHasInventorship":false},"simpleFamilyId":187965568,"citesPatentCount":1,"countrySpec":{"countryName":"USA","description":"GRANTED PATENT AS SECOND PUBLICATION [FROM 2001 ONWARDS]","rule":"pubdate:AFTER:01-01-2001","docType":"GRANTED_PATENT"},"pageTitle":"US 7524873 B2 - Calcium receptor modulating agents","documentTitle":"Calcium receptor modulating agents"},"claims":{"source":"xml_claims","claims":[{"lines":["A compound selected from the group consisting of:\n
(1R)-N-((6-(methyloxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine;\n
(1R)-N-((6-(methyloxy)-4′-((trifluoromethyl)oxy)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine;\n
(1R)-1-(3-(methyloxy)phenyl)-N-((6-(methyloxy)-4′-((trifluoromethyl)oxy)-1,1′-biphenyl-3-yl)methyl)ethanamine;\n
(1R)-N-((3-(1,3-benzoxazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine;\n
(1R)-N-((3′,6-bis(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine;\n
(1R)-N-((4-(methyloxy)-3-(1-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;\n
(1R)-N-((3-(1-methyl-1H-indazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;\n
(1R)-N-((3-(2-methyl-1,3-benzoxazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;\n
(1R)-N-((3-(1-methyl-1H-indazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine;\n
N-1,N-1-dimethyl-N-2-(4-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-N-2-phenyl-1,2-ethanediamine;\n
(1R)-N-((6-chloro-3′-fluoro-3-biphenylyl)methyl)-1-(3-chlorophenyl)ethanamine;\n
(1R)-N-((4-(methyloxy)-3-(2-methyl-1,3-thiazol-4-yl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;\n
(1R)-1-(3-(methyloxy)phenyl)-N-((6-(methyloxy)-3′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)ethanamine;\n
(1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(6-((2,2,2-trifluoroethyl)oxy)-3-pyridinyl)phenyl)methyl)ethanamine;\n
(1R)-N-((4-(methyloxy)-3-(3-thienyl)phenyl)methyl)-1-phenylethanamine;\n
(1R)-N-((6-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;\n
(1R)-N-((4-(methyloxy)-3-(1-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)methyl)-1-phenylethanamine;\n
(1R)-N-((6-chloro-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine;\n
(1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(2-pyrazinyl)phenyl)methyl)ethanamine;\n
(1R)-N-((4-chloro-3-(3-pyridinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;\n
(1R)-N-((4-(methyloxy)-3-(2-pyrazinyl)phenyl)methyl)-1-phenylethanamine;\n
(1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(1,3-thiazol-2-yl)phenyl)methyl)ethanamine;\n
(1R)-N-((6-fluoro-4′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;\n
(1R)-N-((3-(1-(cyclopropylmethyl)-1H-indol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;\n
(1R)-N-((3-(1-methyl-1H-benzimidazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;\n
N-1,N-1-dimethyl-N-2-(4-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)phenyl)-N-2-phenyl-1,2-ethanediamine;\n
(1R)-N-((6-fluoro-4′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine;\n
(1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(3-thienyl)phenyl)methyl)ethanamine;\n
(1R)-N-((3-(1,3-benzodioxol-5-yl)phenyl)methyl)-1-phenylethanamine;\n
(1R)-N-((4-(methyloxy)-3-(5-(methyloxy)-2-pyridinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;\n
(1R)-N-((3-(3-furanyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;\n
(1R)-N-((3-(1-methyl-1H-indol-6-yl)-4-(methyloxy)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;\n
(1R)-N-((2′,6-bis(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine;\n
(1R)-N-((4-(methyloxy)-3-(1,3-thiazol-2-yl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;\n
(1R)-N-((4-(methyloxy)-3-(5-(methyloxy)-2-pyridinyl)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;\n
(1R)-N-((3-imidazo[1,2-a]pyridin-6-yl-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;\n
ethyl 4-(2-(methyloxy)-5-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-1-piperidinecarboxylate;\n
(1R)-N-((4-(methyloxy)-3-(6-(methyloxy)-3-pyridinyl)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;\n
(1R)-N-((6-(methyloxy)-4′-(methylsulfonyl)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine;\n
(1R)-N-((4′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine;\n
(1R)-N-((4-(methyloxy)-3-(4-piperidinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;\n
(1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(6-quinoxalinyl)phenyl)methyl)ethanamine;\n
2-(5-(2-(methyloxy)-5-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-1H-indol-1-yl)acetamide;\n
2′-(methyloxy)-5′-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)-1,1′-biphenyl-3-carboxamide;\n
(1R)-N-((4-((difluoromethyl)oxy)-3-(3-pyridinyl)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;\n
2′-(methyloxy)-5′-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)-1,1′-biphenyl-3-carbonitrile;\n
(1R)-N-((3-(6-(methyloxy)-3-pyridazinyl)phenyl)methyl)-1-phenylethanamine;\n
(1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl)phenyl)methyl)ethanamine;\n
(1R)-N-((4-(methyloxy)-3-(3-thienyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;\n
(1R)-N-((4-((difluoromethyl)oxy)-3-(3-pyridinyl)phenyl)methyl)-1-phenylethanamine;\n
(1R)-N-((3-(2-methyl-2H-indazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine;\n
(1R)-N-((3-(1-methyl-1H-benzimidazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;\n
5-(2-(methyloxy)-5-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-3-pyridinecarboxamide;\n
(1R)-N-((4-(methyloxy)-3-(1,3-thiazol-2-yl)phenyl)methyl)-1-phenylethanamine;\n
(1R)-N-((4-(methyloxy)-3-(1-pyrrolidinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;\n
(1R)-N-((4-(methyloxy)-3-(6-methyl-3-pyridinyl)phenyl)methyl)-1-(4-methylphenyl)ethanamine;\n
(1R)-N-((4-(3,5-dimethyl-4-isoxazolyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;\n
(1R)-N-((4-(methyloxy)-3-(2-methyl-1,3-thiazol-4-yl)phenyl)methyl)-1-phenylethanamine;\n
(1R)-N-((4′,6-bis(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine;\n
(1R)-N-((4-(methyloxy)-3-(6-(methyloxy)-3-pyridazinyl)phenyl)methyl)-1-phenylethanamine;\n
2′-(methyloxy)-5′-((((1R)-1-phenylethyl)amino)methyl)-1,1′-biphenyl-4-carboxamide;\n
(1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(5-pyrimidinyl)phenyl)methyl)ethanamine;\n
(1R)-N-((4-(methyloxy)-3-(4-(methyloxy)-2-pyridinyl)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;\n
(1R)-N-((3-(4-morpholinylsulfonyl)phenyl)methyl)-1-phenylethanamine;\n
(1R)-N-((4-chloro-3-(3-pyridinyl)phenyl)methyl)-1-phenylethanamine;\n
5-(3-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-3-pyridinecarboxamide;\n
(1R)-N-((3-(1-methyl-1H-benzimidazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine;\n
2′-(methyloxy)-5′-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)-1,1′-biphenyl-4-carboxamide;\n
1-methyl-5-(2-(methyloxy)-5-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-2(1H)-pyridinone;\n
(1R)-N-((3-(1-benzothien-3-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;\n
(1R)-N-((6-(methyloxy)-4′-(methylsulfonyl)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine;\n
(1R)-N-((3-(1-methyl-1H-imidazol-4-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine;\n
(1R)-N-((3-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;\n
(1R)-N-((3-(1,3-benzodioxol-5-yl)phenyl)methyl)-1-(4-(methyloxy)phenyl)ethanamine;\n
(1R)-N-((3-(1-acetyl-4-piperidinyl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;\n
(1R)-N-((6-(methyloxy)-4′-(methylsulfonyl)-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;\n
2-(5-(2-(methyloxy)-5-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)phenyl)-1H-indol-1-yl)acetamide;\n
N-(5-(3-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-2-pyridinyl)acetamide;\n
5-(2-(methyloxy)-5-((((1R)-1-(4-methylphenyl)ethyl)amino)methyl)phenyl)-3-pyridinecarboxamide;\n
(1R)-N-((4-(methyloxy)-3-(5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl)phenyl)methyl)-1-phenylethanamine;\n
(1R)-N-((3-(6-methyl-3-pyridinyl)phenyl)methyl)-1-phenylethanamine;\n
(1R)-N-((4′,6-bis(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-phenyl-1-propanamine;\n
2′-(methyloxy)-5′-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)-1,1′-biphenyl-3-carboxylic acid;\n
(1R)-N-((4′,6-bis(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine;\n
N-((3-(6-((3-(diethylamino)propyl)oxy)-3-pyridinyl)-4-(methyloxy)phenyl)methyl)-N-((1R)-1-(1-naphthalenyl)ethyl)amine;\n
(1R)-N-((4′,6-difluoro-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine;\n
(1R)-1-(1-naphthalenyl)-N-((3-(2-pyridinyl)phenyl)methyl)ethanamine;\n
(1R)-N-((4′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;\n
(1R)-N-((4-(methyloxy)-3-(1-methyl-4-piperidinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;\n
(1R)-N-((4′-fluoro-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine;\n
2′-(methyloxy)-5′-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)-1,1′-biphenyl-4-carboxamide;\n
1-methyl-5-(2-(methyloxy)-5-((((1R)-1-phenylethyl)amino)methyl)phenyl)-2(1H)-pyridinone;\n
(1R)-N-((4-(methyloxy)-3-(2-((2,2,2-trifluoroethyl)oxy)-5-pyrimidinyl)phenyl)methyl)-1-phenylethanamine;\n
(1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(2-(1-piperidinyl)-1,3-thiazol-4-yl)phenyl)methyl)ethanamine;\n
(1R)-N-((3-imidazo[1,2-a]pyridin-6-yl-4-(methyloxy)phenyl)methyl)-1-phenylethanamine;\n
(1R)-N-((6-fluoro-4′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(4-methylphenyl)ethanamine;\n
(1R)-N-((3-(1H-indol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;\n
(1R)-N-((4-(methyloxy)-3-(6-methyl-3-pyridinyl)phenyl)methyl)-1-(2-naphthalenyl)ethanamine;\n
(1R)-N-((2′-methyl-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;\n
(1R)-1-(1-naphthalenyl)-N-((6-((2,2,2-trifluoroethyl)oxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)ethanamine;\n
(1R)-N-((4-(methyloxy)-3-(2-((2,2,2-trifluoroethyl)oxy)-5-pyrimidinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;\n
(1R)-N-((3-(6-methyl-3-pyridinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;\n
(1R)-1-(3-(methyloxy)phenyl)-N-((3-(6-(methyloxy)-3-pyridazinyl)phenyl)methyl)ethanamine;\n
2′-(methyloxy)-5′-((((1R)-1-phenylethyl)amino)methyl)-1,1′-biphenyl-3-carboxamide;\n
(1R)-N-((4′-fluoro-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;\n
(1R)-N-((4-(methyloxy)-3-(6-((2-(1-pyrrolidinyl)ethyl)oxy)-3-pyridinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;\n
(1R)-N-((3′,4′-dimethyl-1,1′-biphenyl-3-yl)methyl)-1-(4-methylphenyl)ethanamine;\n
(1R)-N-((4-(methyloxy)-3-(5-(methyloxy)-2-pyridinyl)phenyl)methyl)-1-phenylethanamine;\n
ethyl 4-(2-(methyloxy)-5-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)phenyl)-1-piperidinecarboxylate;\n
(1R)-N-((4-(methyloxy)-3-(6-(methyloxy)-3-pyridazinyl)phenyl)methyl)-1-(4-methylphenyl)ethanamine;\n
(1R)-N-((4-(methyloxy)-3-(2-(1-piperidinyl)-1,3-thiazol-4-yl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;\n
(1R)-N-((4-methyl-3-(3-pyridinyl)phenyl)methyl)-1-phenylethanamine;\n
(1R)-N-((4-(methyloxy)-3-(1-((methyloxy)acetyl)-4-piperidinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;\n
(1R)-N-((3′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine;\n
(1R)-N-((3-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl)methyl)-1-phenylethanamine;\n
(1R)-N-((3′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;\n
(1R)-N-((3-(1,3-benzothiazol-2-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;\n
(1R)-N-((2′-fluoro-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine;\n
(1R)-N-((3-(2-methyl-1,3-benzoxazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;\n
N-((3-(6-((3-(diethylamino)propyl)oxy)-3-pyridinyl)-4-(methyloxy)phenyl)methyl)-N-((1R)-1-(3-(methyloxy)phenyl)ethyl)amine;\n
ethyl 4-(2-(methyloxy)-5-((((1R)-1-phenylethyl)amino)methyl)phenyl)-1-piperidinecarboxylate;\n
(1R)-N-((4′-fluoro-6-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(4-methylphenyl)ethanamine;\n
N-(3′-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)-1,1′-biphenyl-3-yl)acetamide;\n
1-methyl-5-(2-(methyloxy)-5-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)phenyl)-2(1H)-pyridinone;\n
2′-(methyloxy)-5′-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)-1,1′-biphenyl-3-carboxylic acid;\n
(1R)-N-((4-(methyloxy)-3-(3-thienyl)phenyl)methyl)-1-(2-naphthalenyl)ethanamine;\n
(1R)-N-((4-(methyloxy)-3-(5-pyrimidinyl)phenyl)methyl)-1-phenylethanamine;\n
(1R)-1-phenyl-N-((6-((2,2,2-trifluoroethyl)oxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)ethanamine;\n
(1R)-N-((4-(methyloxy)-3-(1-methyl-4-piperidinyl)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;\n
N-ethyl-N′-(4′-(methyloxy)-5-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)-1,1′-biphenyl-2-yl)urea;\n
5-(2-(methyloxy)-5-((((1R)-1-phenylethyl)amino)methyl)phenyl)-1-(2,2,2-trifluoroethyl)-2(1H)-pyridinone;\n
(1R)-N-((6-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(4-(methyloxy)phenyl)ethanamine;\n
5-(3-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)phenyl)-3-pyridinecarboxamide;\n
4′-(methyloxy)-5-((((1R)-1-phenylethyl)amino)methyl)-1,1′-biphenyl-2-ol;\n
(1R)-N-((4-(methyloxy)-3-(2-(1-piperidinyl)-1,3-thiazol-4-yl)phenyl)methyl)-1-phenylethanamine;\n
4-oxo-4-((5-(3-((((1R)-1-phenylethyl)amino)methyl)phenyl)-2-pyridinyl)amino)butanoic acid;\n
5-(2-(methyloxy)-5-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)phenyl)-1-(2,2,2-trifluoroethyl)-2(1H)-pyridinone;\n
(1R)-N-((4-(methyloxy)-3-(3-thienyl)phenyl)methyl)-1-(4-methylphenyl)ethanamine;\n
N-ethyl-N′-(4′-(methyloxy)-5-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)-1,1′-biphenyl-2-yl)urea;\n
2′-(methyloxy)-5′-((((1R)-1-(4-methylphenyl)ethyl)amino)methyl)-1,1′-biphenyl-3-carbonitrile;\n
(1R)-N-((4-(methyloxy)-3-(6-((2-(1-pyrrolidinyl)ethyl)oxy)-3-pyridinyl)phenyl)methyl)-1-phenylethanamine;\n
1-(2-(methyloxy)ethyl)-5-(2-(methyloxy)-5-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)phenyl)-2(1H)-pyridinone;\n
5-(2-(methyloxy)-5-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)phenyl)-2-furancarboxylic acid;\n
2-(5-(2-(methyloxy)-5-((((1R)-1-phenylethyl)amino)methyl)phenyl)-1H-indol-1-yl)acetamide;\n
N-(4′-(methyloxy)-5-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)-1,1′-biphenyl-2-yl)methanesulfonamide;\n
1-(2-(methyloxy)ethyl)-5-(2-(methyloxy)-5-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-2(1H)-pyridinone;\n
(1R)-N-((3-(2-methyl-1,3-oxazol-4-yl)-4-(methyloxy)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;\n
(1R)-N-((4-(methyloxy)-3-(1-methyl-4-piperidinyl)phenyl)methyl)-1-phenylethanamine;\n
(1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(6-((2-(1-pyrrolidinyl)ethyl)oxy)-3-pyridinyl)phenyl)methyl)ethanamine;\n
N-((3-(6-((3-(diethylamino)propyl)oxy)-3-pyridinyl)-4-(methyloxy)phenyl)methyl)-N-((1R)-1-phenylethyl)amine;\n
(1R)-N-((4-(methyloxy)-3-(4-piperidinyl)phenyl)methyl)-1-phenylethanamine;\n
(1R)-N-((4-(methyloxy)-3-(1-((methyloxy)acetyl)-4-piperidinyl)phenyl)methyl)-1-phenylethanamine;\n
N,N-dimethyl-2-((5-((((1R)-1-phenylethyl)amino)methyl)-4′-(trifluoromethyl)-1,1′-biphenyl-2-yl)oxy)acetamide;\n
N,N-dimethyl-2-((5-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)-4′-(trifluoromethyl)-1,1′-biphenyl-2-yl)oxy)acetamide;\n
N,N-dimethyl-2-((5-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)-4′-(trifluoromethyl)-1,1′-biphenyl-2-yl)oxy)acetamide;\n
1-(2-(methyloxy)ethyl)-5-(2-(methyloxy)-5-((((1R)-1-phenylethyl)amino)methyl)phenyl)-2(1H)-pyridinone;\n
5-(2-(methyloxy)-5-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-1-(2,2,2-trifluoroethyl)-2(1H)-pyridinone;\n
1-(2-(methyloxy)-5-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-2-pyrrolidinone;\n
1-(2-(methyloxy)-5-((((1R)-1-phenylethyl)amino)methyl)phenyl)-2-pyrrolidinone;\n
(1R)-1-(4-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(1,3-thiazol-2-yl)phenyl)methyl)ethanamine;\n
(1R)-N-((2′-methyl-1,1′-biphenyl-3-yl)methyl)-1-(4-methylphenyl)ethanamine;\n
(1R)-N-((4′-fluoro-1,1′-biphenyl-3-yl)methyl)-1-(4-methylphenyl)ethanamine;\n
(1R)-N-((4-(methyloxy)-3-(2-pyrimidinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;\n
(1R)-N-((3-(6-(methyloxy)-3-pyridazinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;\n
(1R)-N-((2′-fluoro-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;\n
(1R)-1-(1-naphthalenyl)-N-((3-(1,3-thiazol-2-yl)phenyl)methyl)ethanamine;\n
N-(5-(3-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)phenyl)-2-pyridinyl)acetamide;\n
(1R)-1-(4-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(3-thienyl)phenyl)methyl)ethanamine;\n
(1R)-N-((4-(methyloxy)-3-(2-pyrazinyl)phenyl)methyl)-1-(4-methylphenyl)ethanamine;\n
(1R)-N-((4-(methyloxy)-3-(1,3-thiazol-2-yl)phenyl)methyl)-1-(2-naphthalenyl)ethanamine;\n
(1R)-N-((4′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(2-naphthalenyl)ethanamine;\n
(1R)-1-(3-(methyloxy)phenyl)-N-((3-(2-pyrazinyl)phenyl)methyl)ethanamine;\n
(1R)-1-(3-(methyloxy)phenyl)-N-((3-(6-methyl-3-pyridinyl)phenyl)methyl)ethanamine;\n
(1R)-N-((3′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(4-methylphenyl)ethanamine;\n
(1R)-N-((3-(3-furanyl)phenyl)methyl)-1-phenylethanamine;\n
(1R)-N-((4-(methyloxy)-3-(2-pyrazinyl)phenyl)methyl)-1-(2-naphthalenyl)ethanamine;\n
N-(4′-(methyloxy)-5-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)-1,1′-biphenyl-2-yl)methanesulfonamide;\n
(1R)-1-(3-(methyloxy)phenyl)-N-((3-(2-pyridinyl)phenyl)methyl)ethanamine;\n
5-(2-(methyloxy)-5-((((1R)-1-phenylethyl)amino)methyl)phenyl)-3-pyridinecarboxamide;\n
(1R)-N-((3-(3-furanyl)phenyl)methyl)-1-(4-(methyloxy)phenyl)ethanamine;\n
N-(3′-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)-1,1′-biphenyl-3-yl)acetamide;\n
(1R)-N-((4′-fluoro-6-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(4-(methyloxy)phenyl)ethanamine;\n
(1R)-1-(3-(methyloxy)phenyl)-N-((3-(1,3-thiazol-2-yl)phenyl)methyl)ethanamine;\n
5-(2-(methyloxy)-5-((((1R)-1-(4-methylphenyl)ethyl)amino)methyl)phenyl)-2-pyrimidinamine;\n
(1R)-N-((4-(methyloxy)-3-(1,3-thiazol-2-yl)phenyl)methyl)-1-(4-methylphenyl)ethanamine;\n
(1R)-1-(4-methylphenyl)-N-((3-(6-methyl-3-pyridinyl)phenyl)methyl)ethanamine;\n
(1R)-1-(4-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(2-pyrazinyl)phenyl)methyl)ethanamine;\n
(1R)-N-((4-(methyloxy)-3-(6-(methyloxy)-3-pyridazinyl)phenyl)methyl)-1-(4-(methyloxy)phenyl)ethanamine;\n
(1R)-1-phenyl-N-((3-(1,3-thiazol-2-yl)phenyl)methyl)ethanamine;\n
(1R)-N-((3-(1,3-benzodioxol-5-yl)phenyl)methyl)-1-(4-methylphenyl)ethanamine;\n
(1R)-1-phenyl-N-((3-(2-pyridinyl)phenyl)methyl)ethanamine;\n
4-((5-(3-((((1R)-1-(4-(methyloxy)phenyl)ethyl)amino)methyl)phenyl)-2-pyridinyl)amino)-4-oxobutanoic acid;\n
(1R)-N-((3-(1H-indol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(2-naphthalenyl)ethanamine;\n
(1R)-N-((4-(methyloxy)-3-(6-(methyloxy)-3-pyridazinyl)phenyl)methyl)-1-(2-naphthalenyl)ethanamine;\n
(1R)-N-((3-(3-furanyl)phenyl)methyl)-1-(4-methylphenyl)ethanamine;\n
5-(2-(methyloxy)-5-((((1R)-1-(4-methylphenyl)ethyl)amino)methyl)phenyl)-3-pyridinecarboxamide;\n
(1R)-1-(3-(methyloxy)phenyl)-N-((3-(5-pyrimidinyl)phenyl)methyl)ethanamine;\n
(1R)-N-((3′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(4-(methyloxy)phenyl)ethanamine;\n
(1R)-N-((4-(methyloxy)-3-(5-pyrimidinyl)phenyl)methyl)-1-(4-methylphenyl)ethanamine;\n
(1R)-N-((4-(methyloxy)-3-(3-pyridinyl)phenyl)methyl)-1-(4-methylphenyl)ethanamine;\n
(1R)-1-(4-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(3-pyridinyl)phenyl)methyl)ethanamine;\n
5-(2-(methyloxy)-5-((((1R)-1-(2-naphthalenyl)ethyl)amino)methyl)phenyl)-3-pyridinecarboxamide;\n
(1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(2-pyrimidinyl)phenyl)methyl)ethanamine;\n
(1R)-1-phenyl-N-((3-(2-pyrazinyl)phenyl)methyl)ethanamine;\n
(1R)-N-((4′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(4-(methyloxy)phenyl)ethanamine;\n
(1R)-1-(4-methylphenyl)-N-((3-(9-methyl-9H-purin-6-yl)phenyl)methyl)ethanamine;\n
(1R)-1-phenyl-N-((4-(1-pyrrolidinyl)phenyl)methyl)ethanamine;\n
(1R)-N-((3-(6-methyl-3-pyridinyl)phenyl)methyl)-1-(2-naphthalenyl)ethanamine;\n
(1R)-N-((4-(methyloxy)-3-(2-pyrimidinyl)phenyl)methyl)-1-phenylethanamine;\n
(1R)-1-(4-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(5-pyrimidinyl)phenyl)methyl)ethanamine; and\n
(1R)-1-(4-(methyloxy)phenyl)-N-((3-(6-(methyloxy)-3-pyridazinyl)phenyl)methyl)ethanamine;\nor a pharmaceutically acceptable salt thereof."],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["The compound or pharmaceutically acceptable salt there of as set forth in claim 1 wherein the compound is selected from the group consisting of:\n
(1R)-N-((6-(methyloxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine;\n
(1R)-N-((6-(methyloxy)-4′-((trifluoromethyl)oxy)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine;\n
(1R)-1-(3-(methyloxy)phenyl)-N-((6-(methyloxy)-4′-((tri fluoromethyl)oxy)-1,1′-biphenyl-3-yl)methyl)ethanamine;\n
(1R)-N-((3-(1,3-benzoxazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine;\n
(1R)-N-((3′,6-bis(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine;\n
(1R)-N-((4-(methyloxy)-3-(1-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;\n
(1R)-N-((3-(1-methyl-1H-indazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;\n
(1R)-N-((3-(2-methyl-1,3-benzoxazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;\n
(1R)-N-((3-(1-methyl-1H-indazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine;\n
N-1,N-1-dimethyl-N-2-(4-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-N-2-phenyl-1,2-ethanediamine;\n
(1R)-N-((4-(methyloxy)-3-(2-methyl-1,3-thiazol-4-yl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;\n
(1R)-N-((6-chloro-3′-fluoro-3-biphenylyl)methyl)-1-(3-chlorophenyl)ethanamine;\n
(1R)-1-(3-(methyloxy)phenyl)-N-((6-(methyloxy)-3′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)ethanamine;\n
(1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(6-((2,2,2-trifluoroethyl)oxy)-3-pyridinyl)phenyl)methyl)ethanamine;\n
(1R)-N-((4-(methyloxy)-3-(3-thienyl)phenyl)methyl)-1-phenylethanamine;\n
(1R)-N-((6-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;\n
(1R)-N-((4-(methyloxy)-3-(1-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)methyl)-1-phenylethanamine;\n
(1R)-N-((6-chloro-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine;\n
(1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(2-pyrazinyl)phenyl)methyl)ethanamine;\n
(1R)-N-((4-chloro-3-(3-pyridinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;\n
(1R)-N-((4-(methyloxy)-3-(2-pyrazinyl)phenyl)methyl)-1-phenylethanamine;\n
(1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(1,3-thiazol-2-yl)phenyl)methyl)ethanamine;\n
(1R)-N-((6-fluoro-4′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;\n
(1R)-N-((3-(1-(cyclopropylmethyl)-1H-indol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;\n
(1R)-N-((3-(1-methyl-1H-benzimidazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;\n
N-1,N-1-dimethyl-N-2-(4-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)phenyl)-N-2-phenyl-1,2-ethanediamine;\n
(1R)-N-((6-fluoro-4′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine;\n
(1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(3-thienyl)phenyl)methyl)ethanamine;\n
(1R)-N-((3-(1,3-benzodioxol-5-yl)phenyl)methyl)-1-phenylethanamine;\n
(1R)-N-((4-(methyloxy)-3-(5-(methyloxy)-2-pyridinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;\n
(1R)-N-((3-(3-furanyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;\n
(1R)-N-((3-(1-methyl-1H-indol-6-yl)-4-(methyloxy)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;\n
(1R)-N-((2′,6-bis(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine;\n
(1R)-N-((4-(methyloxy)-3-(1,3-thiazol-2-yl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;\n
(1R)-N-((4-(methyloxy)-3-(5-(methyloxy)-2-pyridinyl)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;\n
(1R)-N-((3-imidazo[1,2-a]pyridin-6-yl-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;\n
ethyl 4-(2-(methyloxy)-5-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-1-piperidinecarboxylate;\n
(1R)-N-((4-(methyloxy)-3-(6-(methyloxy)-3-pyridinyl)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;\n
(1R)-N-((6-(methyloxy)-4′-(methylsulfonyl)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine;\n
(1R)-N-((4′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine;\n
(1R)-N-((4-(methyloxy)-3-(4-piperidinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;\n
(1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(6-quinoxalinyl)phenyl)methyl)ethanamine;\n
2-(5-(2-(methyloxy)-5-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-1H-indol-1-yl)acetamide;\n
2′-(methyloxy)-5′-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)-1,1′-biphenyl-3-carboxamide;\n
(1R)-N-((4-((difluoromethyl)oxy)-3-(3-pyridinyl)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;\n
2′-(methyloxy)-5′-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)-1,1′-biphenyl-3-carbonitrile;\n
(1R)-N-((3-(6-(methyloxy)-3-pyridazinyl)phenyl)methyl)-1-phenylethanamine;\n
(1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl)phenyl)methyl)ethanamine;\n
(1R)-N-((4-(methyloxy)-3-(3-thienyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;\n
(1R)-N-((4-((difluoromethyl)oxy)-3-(3-pyridinyl)phenyl)methyl)-1-phenylethanamine;\n
(1R)-N-((3-(2-methyl-2H-indazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine;\n
(1R)-N-((3-(1-methyl-1H-benzimidazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;\n
5-(2-(methyloxy)-5-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-3-pyridinecarboxamide;\n
(1R)-N-((4-(methyloxy)-3-(1,3-thiazol-2-yl)phenyl)methyl)-1-phenylethanamine;\n
(1R)-N-((4-(methyloxy)-3-(1-pyrrolidinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;\n
(1R)-N-((4-(methyloxy)-3-(6-methyl-3-pyridinyl)phenyl)methyl)-1-(4-methylphenyl)ethanamine;\n
(1R)-N-((4-(3,5-dimethyl-4-isoxazolyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;\n
(1R)-N-((4-(methyloxy)-3-(2-methyl-1,3-thiazol-4-yl)phenyl)methyl)-1-phenylethanamine;\n
(1R)-N-((4′,6-bis(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine;\n
(1R)-N-((4-(methyloxy)-3-(6-(methyloxy)-3-pyridazinyl)phenyl)methyl)-1-phenylethanamine;\n
2′-(methyloxy)-5′-((((1R)-1-phenylethyl)amino)methyl)-1,1′-biphenyl-4-carboxamide;\n
(1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(5-pyrimidinyl)phenyl)methyl)ethanamine;\n
(1R)-N-((4-(methyloxy)-3-(4-(methyloxy)-2-pyridinyl)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;\n
(1R)-N-((3-(4-morpholinylsulfonyl)phenyl)methyl)-1-phenylethanamine;\n
(1R)-N-((4-chloro-3-(3-pyridinyl)phenyl)methyl)-1-phenylethanamine;\n
5-(3-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-3-pyridinecarboxamide;\n
(1R)-N-((3-(1-methyl-1H-benzimidazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine;\n
2′-(methyloxy)-5′-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)-1,1′-biphenyl-4-carboxamide;\n
1-methyl-5-(2-(methyloxy)-5-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-2(1H)-pyridinone;\n
(1R)-N-((3-(1-benzothien-3-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;\n
(1R)-N-((6-(methyloxy)-4′-(methylsulfonyl)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine;\n
(1R)-N-((3-(1-methyl)-1H-imidazol-4-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine;\n
(1R)-N-((3-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;\n
(1R)-N-((3-(1,3-benzodioxol-5-yl)phenyl)methyl)-1-(4-(methyloxy)phenyl)ethanamine;\n
(1R)-N-((3-(1-acetyl-4-piperidinyl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;\n
(1R)-N-((6-(methyloxy)-4′-(methylsulfonyl)-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;\n
2-(5-(2-(methyloxy)-5-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)phenyl)-1H-indol-1-yl)acetamide;\n
N-(5-(3-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-2-pyridinyl)acetamide;\n
5-(2-(methyloxy)-5-((((1R)-1-(4-methylphenyl)ethyl)amino)methyl)phenyl)-3-pyridinecarboxamide;\n
(1R)-N-((4-(methyloxy)-3-(5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl)phenyl)methyl)-1-phenylethanamine;\n
(1R)-N-((3-(6-methyl-3-pyridinyl)phenyl)methyl)-1-phenylethanamine;\n
(1R)-N-((4′,6-bis(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-phenyl-1-propanamine;\n
2′-(methyloxy)-5′-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)-1,1′-biphenyl-3-carboxylic acid;\n
(1R)-N-((4′,6-bis(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine;\n
N-((3-(6-((3-(diethylamino)propyl)oxy)-3-pyridinyl)-4-(methyloxy)phenyl)methyl)-N-((1R)-1-(1-naphthalenyl)ethyl)amine;\n
(1R)-N-((4′,6-difluoro-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine;\n
(1R)-1-(1-naphthalenyl)-N-((3-(2-pyridinyl)phenyl)methyl)ethanamine;\n
(1R)-N-((4′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine; and\n
(1R)-N-((4-(methyloxy)-3-(1-methyl-4-piperidinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine."],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["The compound of pharmaceutically acceptable salt thereof as set forth in claim 1, wherein the compound is selected from the group consisting of:\n
(1R)-N-((6-(methyloxy)-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine;\n
(1R)-N-((6-(methyloxy)-4′-((trifluoromethyl)oxy)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine;\n
(1R)-1-(3-(methyloxy)phenyl)-N-((6-(methyloxy)-4′-((trifluoromethyl)oxy)-1,1′-biphenyl-3-yl)methyl)ethanamine;\n
(1R)-N-((3-(1,3-benzoxazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine;\n
(1R)-N-((3′,6-bis(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine;\n
(1R)-N-((4-(methyloxy)-3-(1-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;\n
(1R)-N-((3-(1-methyl-1H-indazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;\n
(1R)-N-((3-(2-methyl-1,3-benzoxazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;\n
(1R)-N-((3-(1-methyl-1H-indazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-phenylethanamine;\n
N-1,N-1-dimethyl-N-2-(4-((((1R)-1-(1-naphthalenyl)ethyl)amino)methyl)phenyl)-N-2-phenyl-1,2-ethanediamine;\n
(1R)-N-((4-(methyloxy)-3-(2-methyl-1,3-thiazol-4-yl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;\n
(1R)-1-(3-(methyloxy)phenyl)-N-((6-(methyloxy)-3′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)ethanamine;\n
(1R)-N-((6-chloro-3′-fluoro-3-biphenylyl)methyl)-1-(3-chlorophenyl)ethanamine;\n
(1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(6-((2,2,2-trifluoroethyl)oxy)-3-pyridinyl)phenyl)methyl)ethanamine;\n
(1R)-N-((4-(methyloxy)-3-(3-thienyl)phenyl)methyl)-1-phenylethanamine;\n
(1R)-N-((6-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;\n
(1R)-N-((4-(methyloxy)-3-(1-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)methyl)-1-phenylethanamine;\n
(1R)-N-((6-chloro-4′-(trifluoromethyl)-1,1′-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine;\n
(1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(2-pyrazinyl)phenyl)methyl)ethanamine;\n
(1R)-N-((4-chloro-3-(3-pyridinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;\n
(1R)-N-((4-(methyloxy)-3-(2-pyrazinyl)phenyl)methyl)-1-phenylethanamine;\n
(1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(1,3-thiazol-2-yl)phenyl)methyl)ethanamine;\n
(1R)-N-((6-fluoro-4′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;\n
(1R)-N-((3-(1-(cyclopropylmethyl)-1H-indol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(3-(methyloxy)phenyl)ethanamine;\n
(1R)-N-((3-(1-methyl-1H-benzimidazol-5-yl)-4-(methyloxy)phenyl)methyl)-1-(1-naphthalenyl)ethanamine;\n
N-1,N-1-dimethyl-N-2-(4-((((1R)-1-(3-(methyloxy)phenyl)ethyl)amino)methyl)phenyl)-N-2-phenyl-1,2-ethanediamine;\n
(1R)-N-((6-fluoro-4′-(methyloxy)-1,1′-biphenyl-3-yl)methyl)-1-phenylethanamine;\n
(1R)-1-(3-(methyloxy)phenyl)-N-((4-(methyloxy)-3-(3-thienyl)phenyl)methyl)ethanamine;\n
(1R)-N-((3-(1,3-benzodioxol-5-yl)phenyl)methyl)-1-phenylethanamine;\n
(1R)-N-((4-(methyloxy)-3-(5-(methyloxy)-2-pyridinyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine; and\n
(1R)-N-((3-(3-furanyl)phenyl)methyl)-1-(1-naphthalenyl)ethanamine."],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["A pharmaceutical composition comprising a compound as set forth in claim 1 or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable diluent or carrier."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["A pharmaceutical composition comprising a compound as set forth in claim 2 or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable diluent or carrier."],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["A pharmaceutical composition comprising a compound as set forth in claim 3 or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable diluent or carrier."],"number":6,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}