{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"US_7470777_B2","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"082-716-259-785-723"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11689,"type":"PATENT","title":"Iowa State University - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":3342,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8345,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
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a) a recombinant retroviral integrase having a domain comprising a non-native protein binding site inserted in an exposed unstructured loop of said integrase; and\n
b) a DNA binding protein comprising a DNA binding domain and a peptide binding domain that binds the non-native protein binding site of the recombinant integrase."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The complex of claim 1, wherein the retroviral integrase is a FIV integrase, a MLV integrase, or lentivirus integrase."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The complex of claim 2, wherein the retroviral integrase is a FIV integrase."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The complex of claim 3, wherein the FIV integrase comprises an amino acid modification of H14N, E170A, or both H14N and E170A."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The complex of claim 1, wherein the peptide binding domain is a WW binding domain."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The complex of claim 1, wherein the exposed unstructed loop corresponds to amino acids encoded by a viral central-polypurine tract region (cPPT)."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["The complex of claim 1, wherein the non-native protein binding site comprises a PY motif or a PGR motif."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["The complex of claim 1, wherein the non-native protein binding site is at least 20 amino acid in length."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["The complex of claim 1, wherein the non-native protein binding site is at least 15 amino acids in length."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["The complex of claim 9, wherein the non-native protein binding site is at least 12 amino acids in length."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["The complex of claim 10, wherein the non-native protein binding site is at least 10 amino acids in length."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["The complex of claim 1, wherein the DNA binding domain is a designed zinc finger comprising at least 2 finger modules."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["The complex of claim 12, wherein the zinc-finger domain is Zif268."],"number":13,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}