Abstract
Novel human GIL-19/AE289 protein is disclosed which shows a high degree of homology to interleukin-10 (IL-10). Polynucleotides encoding such protein are also enclosed.
Claims
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An isolated protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:2; and
(b) amino acid 34-179 of SEQ ID NO:2; and
(c) the amino acid sequence encoded by the cDNA insert of clone hGIL-19/AE289 deposited under accession number ATCC 207231.
- The protein of claim 1, wherein said protein comprises the amino acid sequence of SEQ ID NO:2.
- A composition comprising the protein of claim 1 and a pharmaceutically acceptable carrier.
- The protein of claim 1, wherein the protein comprises the amino acid sequence encoded by the cDNA insert of clone hGIL-19/AE289 deposited under accession number ATCC 207231.
- The protein of claim 1, wherein the protein comprises amino acids 34-179 of SEQ ID NO:2.
- An isolated protein comprising one or more fragments of SEQ ID NO:2, wherein the one or more fragments comprise amino acids 50-60 of SEQ ID NO:2, amino acids 63-81 of SEQ ID NO:2, and amino acids 168-177 of SEQ ID NO:2.
- The protein of claim 6, wherein the one or more fragments comprises at least one fragment comprising 30 or more contiguous amino acids of SEQ ID NO:2.
- The protein of claim 7, wherein the at least one fragment is at least 50% of the length of SEQ ID NO:2.
- The protein of claim 7, wherein the at least one fragment is at least 75% of the length of SEQ ID NO:2.
- An isolated protein, comprising an amino acid sequence which is at least 95% identical to SEQ ID NO:2 wherein said protein is capable of inducing the phosphorylation of a Stat-3 protein.
- A composition comprising the protein of claim 10 and a pharmaceutically acceptable carrier.
Owners (US)
Information currently unavailable.
Applicants
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Genetics Inst Llc
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Inventors
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Jacobs Kenneth
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Fouser Lynette
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Spaulding Vikki
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Xuan Dejun
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CPC Classifications
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C07K14/5428
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A61K38/00
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A61K2039/505
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IPC Classifications
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C07K1/00
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A61K38/00
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C07K2/00
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C07K4/00
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C07K5/00
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C07K7/00
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C07K14/00
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C07K14/54
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C07K16/00
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C07K17/00
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Document History
- Publication: Dec 2, 2008
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Application:
Dec 17, 2004
US 1374104 A
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Priority:
Dec 17, 2004
US 1374104 A
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Priority:
Apr 28, 2000
US 56181100 A
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Priority:
Apr 28, 1999
US 13147399 P