US 7459533 B2 - Human Gil-19/ae289 Proteins And Polynucleotides Encoding The Same - The Lens - Free & Open Patent and Scholarly Search

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US 7459533 B2

Human Gil-19/ae289 Proteins And Polynucleotides Encoding The Same

Published: Dec 2, 2008
Earliest Priority: Apr 28 1999
Family: 7
Cited Works: 37
Cited by: 16
Cites: 25
Sequences: 2
Additional Info: Cited Works Full text Published Sequence

Abstract

Novel human GIL-19/AE289 protein is disclosed which shows a high degree of homology to interleukin-10 (IL-10). Polynucleotides encoding such protein are also enclosed.

Claims

An isolated protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:2; and

(b) amino acid 34-179 of SEQ ID NO:2; and

(c) the amino acid sequence encoded by the cDNA insert of clone hGIL-19/AE289 deposited under accession number ATCC 207231.
The protein of claim 1, wherein said protein comprises the amino acid sequence of SEQ ID NO:2.
A composition comprising the protein of claim 1 and a pharmaceutically acceptable carrier.
The protein of claim 1, wherein the protein comprises the amino acid sequence encoded by the cDNA insert of clone hGIL-19/AE289 deposited under accession number ATCC 207231.
The protein of claim 1, wherein the protein comprises amino acids 34-179 of SEQ ID NO:2.
An isolated protein comprising one or more fragments of SEQ ID NO:2, wherein the one or more fragments comprise amino acids 50-60 of SEQ ID NO:2, amino acids 63-81 of SEQ ID NO:2, and amino acids 168-177 of SEQ ID NO:2.
The protein of claim 6, wherein the one or more fragments comprises at least one fragment comprising 30 or more contiguous amino acids of SEQ ID NO:2.
The protein of claim 7, wherein the at least one fragment is at least 50% of the length of SEQ ID NO:2.
The protein of claim 7, wherein the at least one fragment is at least 75% of the length of SEQ ID NO:2.
An isolated protein, comprising an amino acid sequence which is at least 95% identical to SEQ ID NO:2 wherein said protein is capable of inducing the phosphorylation of a Stat-3 protein.
A composition comprising the protein of claim 10 and a pharmaceutically acceptable carrier.

Owners (US)

Information currently unavailable.

Applicants

Genetics Inst Llc
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Inventors

Jacobs Kenneth
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Fouser Lynette
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Spaulding Vikki
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Xuan Dejun
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CPC Classifications

C07K14/5428
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A61K38/00
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A61K2039/505
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IPC Classifications

C07K1/00
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A61K38/00
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C07K2/00
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C07K4/00
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C07K5/00
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C07K7/00
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C07K14/00
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C07K14/54
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C07K16/00
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C07K17/00
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US Classifications

530/351
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530/350
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530/300
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Document History

Publication: Dec 2, 2008
US 7459533 B2
Application: Dec 17, 2004
US 1374104 A
Priority: Dec 17, 2004
US 1374104 A
Priority: Apr 28, 2000
US 56181100 A
Priority: Apr 28, 1999
US 13147399 P

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