{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"US_7439415_B2","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"178-187-204-163-193"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":10834,"type":"PATENT","title":"University of Utah - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":9195,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8283,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately: Univ* AND Utah NOT state;
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 7034
Search Applicants and Owners separately: Univ* AND Utah NOT state;
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 7034
A. administering the agent or combination of agents to be screened to a mouse with a HOXB8 gene mutation, wherein the gene mutation is a frameshift mutation resulting in a premature stop codon within the first exon, or is an insertion of a floxed pMC-1neor cassette into a homeodomain, and\n
B. determining whether one or more repetitive behaviors of the mouse is reduced, the reduction in one or more repetitive behaviors indicating an agent or combination of agents that reduces repetitive behaviors."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the gene mutation results in reduced expression of gene transcripts."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the administering step is in vivo."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 3, wherein the administering step is achieved by intravenous injection of the agent or combination of agents."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 3, wherein the administering step is achieved by intraventricular injection of the agent or combination of agents."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 3, wherein the administering step is achieved by intracerebral injection of the agent or combination of agents."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 3, wherein the administering step is achieved by subdural injection of the agent or combination of agents."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 3, wherein the administering step is achieved by intrathecal injection of the agent or combination of agents."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the reduction in one or more repetitive behaviors comprises a reduction in excessive grooming behavior."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 9, wherein the reduction in excessive grooming behavior comprises a reduction in the total amount of time the mouse grooms."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 9, wherein the reduction in excessive grooming behavior comprises a reduction in the total number of times the mouse initiates grooming."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 9, wherein the reduction in excessive grooming behavior comprises a reduction in hair removal caused by grooming."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 9, wherein the reduction in excessive grooming behavior comprises a reduction in lesions caused by grooming."],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 9, wherein the reduction in excessive grooming behavior comprises a reduction in self-grooming."],"number":14,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 9, wherein the reduction in excessive grooming behavior comprises a reduction in grooming of other animals."],"number":15,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 9, wherein the excessive grooming behavior is non-induced or induced."],"number":16,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}