{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"US_7378403_B2","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"014-805-288-654-552"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11916,"type":"PATENT","title":"Georgetown University Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":3191,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8504,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately:Georgetown Univ*. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 3015
Search Applicants and Owners separately:Georgetown Univ*. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 3015
wherein X and Y are independently selected from the group consisting of O, CF2, CH2, and CHF;\n
wherein A is P(O)OH;\n
R2 is selected from the group consisting of H, OH, C1-C25 alkyloxy, C6-C10 aryloxy, C3-C8 cycloalkyloxy, C3-C8 cycloalkyl C1C6 alkoxy, C2-C22 alkenyloxy, C3C8 cycloalkenyloxy, C7-C32 aralkyloxy, C7C32 alkylaryloxy, C9-C32 aralkenyloxy, and C9-C32 alkenylaryloxy;\n
R3-R6 are independently selected from the group consisting of H and OH; and\n
R1 and R7 are independently selected from the group consisting of C1C25 alkyl, C6-C10 aryl, C3-C8 cycloalkyl, C2-C22 alkenyl, C3-C8 cycloalkenyl, C7-C32 aralkyl, C7-C32 alkylaryl, C9-C32 aralkenyl, and C9-C32 alkenylaryl;\n
with the provisos that (i) when X is O, Y is O or CH2, and R3 is H, at least one of R2 and R4-R6 is not OH; (ii) all of R2-R6 are not simultaneously H; (iii) R5 and R4 are not simultaneously H; (iv) R2, R3, R5, and R6 are not simultaneously OH or H and (v) when X and Y are O, R1 is C18H37, and only one of R2 and R6 is OCH3, then R3 and R5 are not simultaneously OH."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1, which has the formula Ia:\nor a pharmaceutically acceptable salt thereof."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1, which has the formula Ib:\nor a pharmaceutically acceptable salt thereof."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The compound or a pharmaceutically acceptable salt of claim 1, wherein X and Y are O."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The compound or a pharmaceutically acceptable salt of claim 1, wherein R1 is a C1-C25 alkyl."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The compound or a pharmaceutically acceptable salt of claim 1, wherein R1 is a C10-C25 alkyl."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["The compound or a pharmaceutically acceptable salt of claim 1, wherein R1 is a C15-C20 alkyl."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["The compound or a pharmaceutically acceptable salt of claim 1, wherein R1 is a C18 alkyl."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["The compound or a pharmaceutically acceptable salt of claim 1, wherein R7 is a C1-C25 alkyl."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["The compound or a pharmaceutically acceptable salt of claim 1, wherein R7 is a C1-C15 alkyl."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["The compound or a pharmaceutically acceptable salt of claim 1, wherein R7 is a C1-C5 alkyl."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["The compound or a pharmaceutically acceptable salt of claim 1, wherein R7 is methyl."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["The compound or a pharmaceutically acceptable salt of claim 1, wherein R2 is C1-C25 alkyloxy."],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["The compound or a pharmaceutically acceptable salt of claim 1, wherein R2 is C1-C15 alkyloxy."],"number":14,"annotation":false,"title":false,"claim":true},{"lines":["The compound or a pharmaceutically acceptable salt of claim 1, wherein R2 is C1-C5 alkyloxy."],"number":15,"annotation":false,"title":false,"claim":true},{"lines":["The compound or a pharmaceutically acceptable salt of claim 1, wherein R2 is methoxy."],"number":16,"annotation":false,"title":false,"claim":true},{"lines":["The compound or a pharmaceutically acceptable salt of claim 1, wherein R2 is C7-C32 aralkyloxy."],"number":17,"annotation":false,"title":false,"claim":true},{"lines":["The compound or a pharmaceutically acceptable salt of claim 1, wherein R2 is cyclohexylmethoxy."],"number":18,"annotation":false,"title":false,"claim":true},{"lines":["The compound or a pharmaceutically acceptable salt of claim 1, wherein R2 is H."],"number":19,"annotation":false,"title":false,"claim":true},{"lines":["The compound or a pharmaceutically acceptable salt of claim 1, wherein R3 is H."],"number":20,"annotation":false,"title":false,"claim":true},{"lines":["The compound or a pharmaceutically acceptable salt of claim 1, wherein R4 is H."],"number":21,"annotation":false,"title":false,"claim":true},{"lines":["The compound or a pharmaceutically acceptable salt of claim 1, wherein R5 is H."],"number":22,"annotation":false,"title":false,"claim":true},{"lines":["The compound or a pharmaceutically acceptable salt of claim 1, wherein R6 is H."],"number":23,"annotation":false,"title":false,"claim":true},{"lines":["The compound or a pharmaceutically acceptable salt of claim 1, wherein R2 and R3 are H."],"number":24,"annotation":false,"title":false,"claim":true},{"lines":["The compound or a pharmaceutically acceptable salt of claim 1, wherein R3 and R4 are H."],"number":25,"annotation":false,"title":false,"claim":true},{"lines":["The compound or a pharmaceutically acceptable salt of claim 1, wherein R5 and R6 are H."],"number":26,"annotation":false,"title":false,"claim":true},{"lines":["The compound or a pharmaceutically acceptable salt of claim 2, wherein X and Y are O, R1 is C18H37, and R7 methyl."],"number":27,"annotation":false,"title":false,"claim":true},{"lines":["The compound or a pharmaceutically acceptable salt of claim 27, wherein R2 is methoxy, R3 is H, and R4-R6 are OH."],"number":28,"annotation":false,"title":false,"claim":true},{"lines":["The compound or a pharmaceutically acceptable salt of claim 27, wherein R2-R3 are H and R4-R6 are OH."],"number":29,"annotation":false,"title":false,"claim":true},{"lines":["A compound of the formula:\nwherein X and Y are O, R1 is C18H37, and R7 is methyl; and R2-R3 and R5-R6 are OH and R4 is H or a pharmaceutically acceptable salt thereof."],"number":30,"annotation":false,"title":false,"claim":true},{"lines":["The compound or a pharmaceutically acceptable salt of claim 28, wherein R2 is i-butyloxy, R3 is H, and R4-R6 are OH."],"number":31,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 28, wherein R2 is cyclohexylmethoxy, R3 is H, and R4-R6are OH."],"number":32,"annotation":false,"title":false,"claim":true},{"lines":["A compound of the formula:\nwherein X and Y are O, R1 is C18 H37 R7, is methyl, R2-R3 and R6 are OH, and R4-R5 are H or a pharmaceutically acceptable salt."],"number":33,"annotation":false,"title":false,"claim":true},{"lines":["The compound or a pharmaceutically acceptable salt of claim 27, wherein R2-R4 and R6 are OH and R5 is H."],"number":34,"annotation":false,"title":false,"claim":true},{"lines":["The compound or a pharmaceutically acceptable salt of claim 27, wherein R2, R4, and R6 are OH and R3 and R5 are H."],"number":35,"annotation":false,"title":false,"claim":true},{"lines":["A pharmaceutical composition comprising a compound or a pharmaceutically acceptable salt of claim 1 and a pharmaceutically acceptable carrier."],"number":36,"annotation":false,"title":false,"claim":true},{"lines":["A method of inhibiting activation of the serine/threonine kinase Akt or decreasing phosphorylation in a tumor cell of an animal comprising administering to the animal an effective amount of a compound or a pharmaceutically acceptable salt of claim 1."],"number":37,"annotation":false,"title":false,"claim":true},{"lines":["A method of increasing apoptosis of a cell comprising contacting the cell with a compound or a pharmaceutically acceptable salt of claim 1."],"number":38,"annotation":false,"title":false,"claim":true},{"lines":["A method for inhibiting PH domain binding comprising exposing a material containing an PH domain to a compound or a pharmaceutically acceptable salt of claim 1."],"number":39,"annotation":false,"title":false,"claim":true},{"lines":["A method for determining the presence of a PH domain in a material comprising:\n
(a) exposing a sample of said material to a PH domain binding compound and obtaining a first binding result;\n
(b) exposing another sample of said material to a compound or a pharmaceutically acceptable salt of claim 1 and obtaining a second binding result; and\n
(c) comparing the first and second binding results to determine whether a PH domain is present in the material."],"number":40,"annotation":false,"title":false,"claim":true},{"lines":["A method of treating cancer in a mammal comprising administering to the mammal an effective amount of a compound or a pharmaceutically acceptable salt of claim 1, wherein the cancer is selected from the group consisting of lung cancer, breast cancer, ovarian cancer, colorectal cancer, and brain cancer."],"number":41,"annotation":false,"title":false,"claim":true},{"lines":["A compound of the formula I:\nor a pharmaceutically acceptable salt thereof\n
wherein X and Y are independently selected from the group consisting of O, CF2, CH2, and CHF;\n
wherein A is P(O)OH;\n
R2 is selected from the group consisting of C1-C25 alkyloxy, cyclohexylmethoxy, and C7-C32 aralkyloxy;\n
R3-R6 are independently selected from the group consisting of H, R1 and R7 are independently selected from the group consisting of C1-C25 alkyl, C6-C10 aryl, C3-C8 cycloalkyl, C2-C22 alkenyl, C3-C8 cycloalkenyl, C7-C32 aralkyl, C7-C32 alkylaryl, C9-C32 aralkenyl, and C9-C32 alkenylaryl;\n
with the provisos that (i) when X is O, Y is O or CH2, and R3 is H, at least one of R2 and R4-R6 is not OH; (ii) all of R2-R6 are not simultaneously H; and when X and Y are O, R1 is C18H37, and only one of R2 and R6 is OCH3, then R3 and R5 are not simultaneously OH."],"number":42,"annotation":false,"title":false,"claim":true},{"lines":["The compound or a pharmaceutically acceptable salt of claim 42, wherein R2 is C1-C25 alkyloxy."],"number":43,"annotation":false,"title":false,"claim":true},{"lines":["The compound or a pharmaceutically acceptable salt of claim 42, wherein R2, is C7-C32 aralkyloxy."],"number":44,"annotation":false,"title":false,"claim":true},{"lines":["The compound or a pharmaceutically acceptable salt of claim 42, wherein R2 is cyclohexylmethoxy."],"number":45,"annotation":false,"title":false,"claim":true},{"lines":["The compound or a pharmaceutically acceptable salt of claim 42, wherein R3 and R4 are H."],"number":46,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 42, which has the formula Ia:\nwherein X and Y are O, R1 is C18H37, R7 is methyl, R2 is methoxy, R3 is H, and R4-R6 are OH or a pharmaceutically acceptable salt thereof."],"number":47,"annotation":false,"title":false,"claim":true},{"lines":["A method of increasing apoptosis of a cell comprising contacting the cell with a compound or a pharmaceutically acceptable salt of claim 42."],"number":48,"annotation":false,"title":false,"claim":true},{"lines":["A method for inhibiting PH domain binding comprising exposing a material containing an PH domain to a compound or a pharmaceutically acceptable salt of claim 42."],"number":49,"annotation":false,"title":false,"claim":true},{"lines":["A pharmaceutical composition comprising a compound or a pharmaceutically acceptable salt of claim 42 and a pharmaceutically acceptable carrier."],"number":50,"annotation":false,"title":false,"claim":true},{"lines":["A method of treating cancer in a mammal comprising administering to the mammal an effective amount of a compound or a pharmaceutically acceptable salt of claim 42, wherein the cancer is selected from the group consisting of lung cancer, breast cancer, ovarian cancer, colorectal cancer, and brain cancer."],"number":51,"annotation":false,"title":false,"claim":true},{"lines":["A method of inhibiting activation of the serine/threonine kinase Akt or decreasing phosphorylation in a tumor cell of an animal comprising administering to the animal an effective amount of a compound or a pharmaceutically acceptable salt of claim 42."],"number":52,"annotation":false,"title":false,"claim":true},{"lines":["A pharmaceutical composition comprising a compound or a pharmaceutically acceptable salt of claim 30 and a pharmaceutically acceptable carrier."],"number":53,"annotation":false,"title":false,"claim":true},{"lines":["A pharmaceutical composition comprising a compound or a pharmaceutically acceptable salt of claim 33 and a pharmaceutically acceptable carrier."],"number":54,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}