{"search_session":{},"preferences":{"l":"ar","queryLanguage":"ar"},"patentId":"US_7354709_B2","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"149-232-661-031-83X"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11695,"type":"PATENT","title":"National Taiwan University - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":6430,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8350,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
determining a level of a mRNA encoding a polypeptide comprising the amino acid sequence of SEQ ID NO: 2 in a first sample cell from said subject; wherein said first sample cell is obtained from a biopsied tissue containing lung tumor cells of said subject; and wherein said lung tumor cells are lung adenocarcinoma cells;\n
determining a level of mRNA expressed by said mRNA in a second sample cell from said subject; wherein said second sample cell is obtained from normal cells of said subject;\n
comparing said level of mRNA in said first sample cell with said level of mRNA in said second sample cell;\n
and categorizing said lung tumor as having invasive or metastatic potential in said subject when the level of mRNA in the first sample cell is lower than the level of mRNA in the second sample cell."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 wherein the subject is a human."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein said mRNA comprises a nucleic acid sequence that corresponds to the DNA nucleic acid sequence of SEQ ID NO:1."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein said lung tumor having invasive or metastatic potential is associated with advanced tumor, lymph node metastasis, early post-operative relapse, and short survival."],"number":4,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}