Abstract
Novel isolated and purified withanamides and withanolides are described. In particular, compounds from Withania somnifera fruit are the preferred source of the withanamides and withanolides, although they can be from other plant sources. In addition to their use as powerful antioxidants, the withanamides and withanolides can be useful for the treatment of depression, Alzheimer's Disease, obesity and migraine headaches.
Claims
- An isolated and purified withanamide of the formula: wherein R is selected from the group consisting of:
- The compound of claim 1 wherein R is
- The compound of claim 1 wherein R is
- The compound of claim 1 wherein R is
- The compound of claim 1 wherein R is
- The compound of claim 1 wherein R is
- The compound of claim 1 wherein R is
- The compound of claim 1 wherein R is
- The compound of claim 1 wherein R is
- An isolated and purified compound of the formula
Owners (US)
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Board Of Trustees Of Michigan State University
(Aug 13 2004)
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Applicants
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Univ Michigan State
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Inventors
CPC Classifications
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C07H17/02
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IPC Classifications
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A61K31/405
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A61K31/70
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C07D405/00
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C07H17/00
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C07H17/02
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US Classifications
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548/454
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Document History
- Publication: Oct 16, 2007
-
Application:
Aug 13, 2004
US 91828404 A
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Priority:
Aug 13, 2004
US 91828404 A
-
Priority:
Sep 11, 2003
US 50198503 P