US 7282593 B2 - Withanamide And Withanolide Compositions And Method Of Use Thereof - The Lens - Free & Open Patent and Scholarly Search

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US 7282593 B2

Withanamide And Withanolide Compositions And Method Of Use Thereof

Published: Oct 16, 2007
Family: 17
Cited Works: 22
Cited by: 2
Cites: 1
Additional Info: Cited Works Full text Published

Abstract

Novel isolated and purified withanamides and withanolides are described. In particular, compounds from Withania somnifera fruit are the preferred source of the withanamides and withanolides, although they can be from other plant sources. In addition to their use as powerful antioxidants, the withanamides and withanolides can be useful for the treatment of depression, Alzheimer's Disease, obesity and migraine headaches.

Claims

An isolated and purified withanamide of the formula: wherein R is selected from the group consisting of:
The compound of claim 1 wherein R is
The compound of claim 1 wherein R is
The compound of claim 1 wherein R is
The compound of claim 1 wherein R is
The compound of claim 1 wherein R is
The compound of claim 1 wherein R is
The compound of claim 1 wherein R is
The compound of claim 1 wherein R is
An isolated and purified compound of the formula

Owners (US)

Board Of Trustees Of Michigan State University (Aug 13 2004)
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Applicants

Univ Michigan State
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Inventors

Nair Muraleedharan G
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Jayaprakasam Bolleddula
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CPC Classifications

C07H17/02
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IPC Classifications

A61K31/405
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A61K31/70
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C07D405/00
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C07H17/00
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C07H17/02
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US Classifications

548/454
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Document History

Publication: Oct 16, 2007
US 7282593 B2
Application: Aug 13, 2004
US 91828404 A
Priority: Aug 13, 2004
US 91828404 A
Priority: Sep 11, 2003
US 50198503 P