Screening Assay For Agents That Alter Target Of Rapamycin Activity

Abstract

The present invention provides an assay for the identification of agents which can modulate TOR-mediated phosphorylation of substrate proteins. The assays of the invention utilize substrate proteins whose amino acid sequence contains the Ser/Thr motif recognized by TOR. Naturally occurring TOR which may be used in the methods of the invention include TOR isolated from a variety of species, particularly mammalian tissues.


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Document History
  • Publication: Nov 14, 2006
  • Application: Mar 26, 2003
    US US 40105803 A
  • Priority: Mar 26, 2003
    US US 40105803 A

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