Antibody Methods For Selectively Inhibiting Vegf

Abstract

Disclosed are antibodies that specifically inhibit VEGF binding to only one (VEGFR2) of the two VEGF receptors. The antibodies effectively inhibit angiogenesis and induce tumor regression, and yet have improved safety due to their specificity. The present invention thus provides new antibody-based compositions, methods and combined protocols for treating cancer and other angiogenic diseases. Advantageous immunoconjugate and prodrug compositions and methods using the new VEGF-specific antibodies are also provided.


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Document History
  • Publication: Jun 6, 2006
  • Application: Feb 24, 2003
    US US 37356103 A
  • Priority: Feb 24, 2003
    US US 37356103 A
  • Priority: Apr 28, 2000
    US US 56149900 A
  • Priority: Apr 28, 1999
    US US 13143299 P

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