{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"US_6875566_B2","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"143-168-418-196-077"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":8838,"type":"PATENT","title":"Univ of Illinois Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":10245,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8209,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately = \"Univ Illinois\", \"Illinois Univ\", \"University of Illinois\", \"Illinois University\", \"University Illinois NOT Northern NOT southern NOT State\".
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Search applicants and owners= \"Univ Pennsylvania\", \"Pennsylvania Univ\", \"Univ Penns*\", \"Penn* Univ\", \"University of Pennsylvania\", \"Pennsylvania University\".
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Search Applicants and Owners separately: uni* illinois chicago
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Search Applicants and Owners separately = \"Univ Illinois\", \"Illinois Univ\", \"University of Illinois\", \"Illinois University\", \"University Illinois NOT Northern NOT southern NOT State\".
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Search applicants and owners= \"Univ Pennsylvania\", \"Pennsylvania Univ\", \"Univ Penns*\", \"Penn* Univ\", \"University of Pennsylvania\", \"Pennsylvania University\".
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(a) collecting cells from peripheral tissues from the depressed individual, wherein said cells are blood cells; and\n
(b) determining whether there has been a redistribution of Gsα from a strongly hydrophobic region of the plasma membrane to a less hydrophobic membrane domain or cytoskeleton of the cells collected in step (a)\n
wherein said redistribution is indicative of the effectiveness of the anti-depressant therapy."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 7 wherein the redistribution produces an enhanced coupling between Gsα and adenylyl cyclase."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 7 wherein the redistribution is a redistribution of Gsα from a strongly hydrophobic region of the plasma membrane to a less hydrophobic membrane domain."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 7 where the modification is a redistribution of Gsα from cell processes and process tips to the cell body."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 7 wherein the blood cells are erythrocytes."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 7 wherein the blood cells are leukocytes."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 7 wherein the blood cells are platelets."],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["A method for assaying for an agent or agents having antidepressant activity comprising the step of:\n
(a) contacting said agent or agents with cultured cells expressing Type VI adenylyl cyclase;\n
(b) determining whether there has been a modification of the association of Gsα with components of the plasma membrane or cytoskeleton of the cells in step (a) via comparison to a control cell culture lacking said agent or agents;\n
(c) identifying agents having antidepressant activity from a difference in the modification of the association of Gsα with components of the plasma membrane or cytoskeleton of the cells in step (a), wherein an agent or agents having antidepressant activity increases the modification of the association of Gsα with components of the plasma membrane or cytoskeleton of the cells in step (a)."],"number":14,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 14 wherein the modification is enhanced coupling between Gsα and adenylyl cyclase."],"number":15,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 14 wherein the modification is a redistribution of Gsα from a strongly hydrophobic region of the plasma membrane to a less hydrophobic membrane domain."],"number":16,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 14 the modification is a redistribution of Gsα from cell processes and process tips to the cell body."],"number":17,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 14 wherein the cultured cells are blood cells."],"number":18,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 18 wherein the blood cells are erythrocytes."],"number":19,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 18 wherein the blood cells are leukocytes."],"number":20,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 18 wherein the blood cells are platelets."],"number":21,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 14 wherein the cultured cells are skin fibroblasts."],"number":22,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 14 wherein the cultured cells are of neuronal or glial origin."],"number":23,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 14 wherein the cultured cells are cultured epithelial cells expressing Type VI adenylyl cyclase."],"number":24,"annotation":false,"title":false,"claim":true},{"lines":["A method for assaying for an agent or agents having an activity that modifies the association of Gsα with components of the plasma membrane or cytoskeleton of cells comprising the step of:\n
(a) contacting said agent or agents with cultured cells expressing Type VI adenylyl cyclase;\n
(b) determining whether there has been a modification of the association of Gsα with components of the plasma membrane or cytoskeleton of the cells in step (a) via comparison to a control cell culture lacking said agent or agents;\n
(c) identifying agents having antidepressant activity from a difference in the modification of the association of Gsα with components of the plasma membrane or cytoskeleton of the cells in step (a), wherein an agent or agents having antidepressant activity increases the modification of the association of Gsα with components of the plasma membrane or cytoskeleton of the cells in step (a)."],"number":25,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 25 wherein the modification is enhanced coupling between Gsα and adenylyl cyclase."],"number":26,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 25 wherein the modification is a redistribution of Gsα from a strongly hydrophobic region of the plasma membrane to a less hydrophobic membrane domain."],"number":27,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 25 where the modification is a redistribution of Gsα from cell processes and process tips to the cell body."],"number":28,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 25 wherein the cultured cells are blood cells."],"number":29,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 29 wherein the blood cells are erythrocytes."],"number":30,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 29 wherein the blood cells are leukocytes."],"number":31,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 29 wherein the blood cells are platelets."],"number":32,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 25 wherein the cultured cells are skin fibroblasts."],"number":33,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 25 wherein the cultured cells are of neuronal or glial origin."],"number":34,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 25 wherein the cultured cells are cultured epithelial cells expressing Type VI adenylyl cyclase."],"number":35,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}