Target Of Rnaiii Activating Protein(trap)

Abstract

The present invention is directed to a protein isolated from S. aureus that is the target of RAP, called TRAP, which is characterized by a molecular weight of about 21 KDa, is capable of being phosphorylated by RAP, and comprises an amino acid sequence of SEQ ID NO:2. In addition, the present invention is directed towards an antibody immunoreactive with TRAP that is preferably a monoclonal antibody or a humanized antibody but may be a polyclonal antibody. The invention provides a method of treating S. aureus infection by administering such a TRAP-inhibiting agent. The invention also features methods for identifying compounds that inhibit TRAP activity and/or inhibit TRAP-RAP interaction.


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Document History
  • Publication: Jun 8, 2004
  • Application: Sep 10, 1999
    US US 39386299 A
  • Priority: Sep 10, 1999
    US US 39386299 A
  • Priority: Sep 15, 1998
    US US 10041598 P

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