{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"US_6660270_B2","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"047-648-466-569-715"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":12008,"type":"PATENT","title":"University of Saskatchewan Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":1932,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8572,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately:Univ* Saskatchewan. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1939
Search Applicants and Owners separately:Univ* Saskatchewan. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1939
(I) is a linear amino acid sequence;
B comprises an amino acid sequence that corresponds to an antigenic determinant of a GapC protein;
A and C each comprise an amino acid sequence that is
(i) different from B,
(ii) different from the other, and
(iii) an amino acid sequence that corresponds to an antigenic determinant of a GapC protein wherein said antigenic determinant is not adjacent to B in nature;
A, B and C each comprise epitopes from one or more bacterial species selected from the group consisting of Streptococcus dysgalactiae, Streptococcus agalactiae, Streptococcus uberis, Streptococcus parauberis, and Streptococcus iniae;
y is an integer of 1 or more; and
x and z are each independently integers wherein x+z is 1 or more, and further wherein A, B, and C each comprise amino acid sequences selected from the group consisting of
(a) the amino acid sequences corresponding to amino acid positions 62 to 81, inclusive, of a Streptococcal GapC protein;
(b) the amino acid sequences corresponding to amino acid positions 102 to 112, inclusive, of a Streptococcal GapC protein;
(c)the amino acid sequences corresponding to amino acid positions 165 to 172, inclusive, of a Streptococcal GapC protein;
(d) the amino acid sequences corresponding to amino acid positions 248 to 271, inclusive, of a Streptococcal GapC protein; and
(e) the amino acid sequences corresponding to amino acid positions 286 to 305, inclusive, of a Streptococcal GapC protein."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The isolated multiple epitope fusion polypeptide of claim 1 , wherein A, B, and C each comprise amino acid sequences selected from the group consisting of
(a) an amino acid corresponding to residues 62 to 81, inclusive, of SEQ ID NOS: 12, 14, 16, 18, and 20;
(b) an amino acid corresponding to residues 102-112, inclusive, of SEQ ID NOS: 12, 14, 16, 18, and 20;
(c) an amino acid corresponding to residues 165 to 172, inclusive, of SEQ ID NOS: 12, 14, 16, 18, and 20;
(d) an amino acid corresponding to residues 248 to 271, inclusive, of SEQ ID NOS: 12, 14, 16, 18, and 20; and
(e) an amino acid corresponding to residues 286 to 305, inclusive, of SEQ ID NOS: 12, 14, 16, 18, and 20."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["An immunodiagnostic test kit for detecting Streptococcus infection, said test kit comprising the multiple epitope fusion polypeptide of claim 1 and instructions for conducting the immunodiagnostic test."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The multiple epitope fusion polypeptide of claim 1 , further comprising a signal sequence."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The multiple epitope fusion polypeptide of claim 1 , further comprising a transmembrane sequence."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The multiple epitope fusion polypeptide of claim 1 , wherein A, B, and/or C are linked by one or more spacer sequences, wherein said spacers
(i) are amino acid sequences of from 1 to 1,000 amino acids, inclusive;
(ii) can be the same or different as A, B, or C; and
(iii) can be the same or different as each other."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["A vaccine composition comprising a pharmaceutically acceptable vehicle and the multiple epitope fusion polypeptide of claim 4 ."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["A vaccine composition comprising a pharmaceutically acceptable vehicle and the multiple epitope fusion polypeptide of claim 5 ."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["A vaccine composition comprising a pharmaceutically acceptable vehicle and the multiple epitope fusion polypeptide of claim 6 ."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["A vaccine composition comprising a pharmaceutically acceptable vehicle and the multiple epitope fusion polypeptide of claim 1 ."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["The vaccine composition of claim 10 , further comprising an adjuvant."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["The multiple epitope fusion polypeptide of claim 1 , comprising the amino acid sequence depicted in SEQ ID NO:22."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["A vaccine composition comprising a pharmaceutically acceptable vehicle and the multiple epitope fusion polypeptide of claim 12 ."],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["The vaccine composition of claim 13 , further comprising an adjuvant."],"number":14,"annotation":false,"title":false,"claim":true},{"lines":["The multiple epitope fusion polypeptide of claim 1 , comprising an immunogenic amino acid sequence with at least 90% sequence identity to the amino acid sequence depicted in SEQ ID NO:22."],"number":15,"annotation":false,"title":false,"claim":true},{"lines":["A vaccine composition comprising a pharmaceutically acceptable vehicle and the multiple epitope fusion polypeptide of claim 15 ."],"number":16,"annotation":false,"title":false,"claim":true},{"lines":["The vaccine composition of claim 16 , further comprising an adjuvant."],"number":17,"annotation":false,"title":false,"claim":true},{"lines":["A method of producing a vaccine composition comprising the steps of
(1) providing the multiple epitope fusion polypeptide of claim 15 ; and
(2) combining said polypeptide with a pharmaceutically acceptable vehicle."],"number":18,"annotation":false,"title":false,"claim":true},{"lines":["A method of producing a vaccine composition comprising the steps of
(1) providing the multiple epitope fusion polypeptide of claim 1 ; and
(2) combining said polypeptide with a pharmaceutically acceptable vehicle."],"number":19,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}