Transgenic Mouse Model For Cardiac Hypertrophy And Methods Of Use Thereof


Transgene constructs for generating transgenic animals, wherein the transgene encodes a gene product which modulates transcription of a hypertrophy-sensitive gene, are provided. Further provided are recombinant vectors comprising the transgenes of the invention. Further provided are transgenic animals generated using the transgene constructs. Further provided are enzyme-based, cell-based, and whole-animal-based assays for detecting substances having therapeutic activity toward cardiac hypertrophy. Further provided are compositions comprising substances which modulate levels of active product of a hypertrophy-sensitive gene. Further provided are methods of treating cardiac hypertrophy.

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Document History
  • Publication: Dec 2, 2003
  • Application: Oct 15, 1998
    US US 17379998 A
  • Priority: Oct 15, 1998
    US US 17379998 A
  • Priority: Apr 16, 1998
    US US 6141798 A
  • Priority: Apr 15, 1998
    US US 8185398 P
  • Priority: Nov 10, 1997
    US US 6517897 P
  • Priority: Oct 16, 1997
    US US 6286497 P

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