Trisubstituted Carbocyclic Cyclophilin Binding Compounds And Their Use

Abstract

The present invention relates to novel, non-peptidic small organic compounds having an affinity for cyclophilin (CyP)-type immunophilin proteins, and to pharmaceutical compositions comprising one or more of the said compounds. The invention further relates to the uses of these compounds and compositions for binding CyP-type proteins, inhibiting their peptidyl-prolyl isomerase activity, and for research, development, and therapeutic applications in a variety of medical disorders.


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Document History
  • Publication: Dec 2, 2003
  • Application: Jan 25, 2002
    US US 5720302 A
  • Priority: Jan 25, 2002
    US US 5720302 A
  • Priority: May 21, 2001
    US US 29196501 P
  • Priority: Jan 25, 2001
    US US 26370301 P

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