{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"US_6656684_B1","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"057-681-782-148-784"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11720,"type":"PATENT","title":"University of Iowa - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":3930,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8373,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
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Add to collection. Total patents: 3686
Search Applicants and Owners separately: uni* iowa
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Select all patents in the collection and expand by simple families.
Add to collection. Total patents: 3686
(a) contacting RNA from a human physiological sample suspected of being tumorigenic or cancerous with a Survivin-specific oligonucleotide comprising a first label, and a pro-apoptosis factor (PAF)-specific oligonucleotide comprising a second label under conditions effective to hybridize the RNA to the oligonucleotides so as to yield a first population of RNA labeled with the Survivin-specific oligonucleotide and a second population of RNA labeled with the PAF-specific oligonucleotide;
(b) quantifying the first and second populations of labeled RNA to determine an amount of Survivin RNA and an amount of PAF RNA present in the sample; and
(c) calculating the ratio of the amount of Survivin RNA and the amount of PAF RNA;
wherein a Survivin:PAF ratio of more than about 1.5 is predictive that the tumor will recur."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 , wherein the Survivin:PAF ratio of more than about 1.6 is predictive that the tumor will recur."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 , wherein the Survivin:PAF ratio of more than about 2.0 is predictive that the tumor will recur."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 , wherein the PAF is Fas, BID, p53, DR4, DR5, or TNF-R."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 , wherein the PAF is Fas."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 wherein the physiological sample is a tissue sample."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 6 , wherein the tissue sample is a tissue-lysate protein sample."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 6 , wherein the tissue is from a solid tumor."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 8 , wherein the solid tumor is a childhood tumor."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 9 , wherein the childhood tumor is a Neuroblastoma, Pediatric renal tumor, Hepatoblastoma, Rhabdomysosarcoma, an undifferentiated sarcoma, a germ cell tumor, or an endocrine tumor."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 8 , wherein the solid tumor is an adult tumor."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 11 , wherein the adult tumor is a tumors of the nervous system, of the gastrointestinal or urogenital tract, or a sarcoma."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 wherein the physiological sample is a fluid."],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 13 , wherein the fluid is whole blood or blood serum."],"number":14,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}