Circulating Insulin-like Growth Factor-i, Insulin-like Growth Factor Binding Protein-3 And Prostate Cancer Risk

Abstract

Methods of predicting a propensity to developing prostate cancer are presented. The method consists of measuring the IGF status of individual. Individuals with high IGF status, as compared with normal reference range values, are at increased risk for developing prostate cancer. More particularly, the IGF status may be determined by measuring IGF-I levels and/or IGFBP-3 levels. High IGF and low IGFBP levels are indicative of a high IGF status. A method of determining the prognosis of existing prostate cancers or of monitoring disease progression involves determining the IGF/PSA status of an individual. Individuals with a high IGF/PSA status (both high IGF status and high PSA levels) tend to develop severe prostate cancer and have a poorer overall prognosis.


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Document History
  • Publication: Nov 11, 2003
  • Application: Mar 14, 2001
    US US 80845901 A
  • Priority: Mar 14, 2001
    US US 80845901 A
  • Priority: Jan 21, 1999
    US US 23465199 A
  • Priority: Jan 21, 1998
    US US 7256098 P

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