Methods For Identifying Cellular Responses Attributable To Signaling Molecule Inhibition And Inhibitors Thereof


The present invention provides a method for the identification of a pattern of changes in cellular responses induced by the selective inhibition of a signaling molecule, by determining the specific effects of a selective inhibitor on a mutant form of a signaling molecule on cellular responses. The pattern of alterations in cellular responses resulting from the inhibition by a selective mutant inhibitor of the mutant signaling molecule are characteristic of the cellular response alterations that a specific inhibitor of the wild-type signaling molecule will produce. After determining the pattern of cellular responses of the mutant cells with the mutant molecule, compounds may be identified capable of inhibiting the wild-type molecule by producing a pattern of cellular responses in wild-type cells matching or having similarity to that of the inhibition of the mutant molecule.

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Document History
  • Publication: Aug 26, 2003
  • Application: Jul 20, 2000
    US US 62129300 A
  • Priority: Jul 20, 2000
    US US 62129300 A
  • Priority: Jul 23, 1999
    US US 14542299 P

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