Transgenic Mouse Expressing Human Tau Gene

Abstract

A bigenic mouse is provided whose germ cells and somatic cells contain (i) inactive mouse TAU genes, and/or (ii) a transgene encoding the human TAU gene, with the transgene including all regulatory elements of the human TAU gene necessary for neuronal expression of the transgene in the bigenic mouse, and/or for human patterns of expression of the transgene in the bigenic mouse. The mice of the invention may contain one or two alleles for the human TAU gene (i.e., one or two TAU alleles). Mice of the invention are useful as a source of human Tau protein, and are useful as a model of Alzheimer's, Frontal Temporal Dementia and Parkinson's-like diseases.


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Document History
  • Publication: Jul 15, 2003
  • Application: Mar 2, 2000
    US US 51743100 A
  • Priority: Mar 2, 2000
    US US 51743100 A
  • Priority: Mar 3, 1999
    US US 12269199 P

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