Interaction Between Cyclin D1 And Steroid Receptor Coactivators And Users Thereof In Assays

Abstract

The present invention relates to the finding that cyclin D1 interacts in a ligand-independent fashion with coactivators of the SRC-1 family. The direct interaction of cyclin D1 enhances estrogen receptor (ER) mediated transcription and provides a novel target for the development of assays for substances which modulate the cell cycle. The invention provides assay methods for the prevention of growth of tumours, for assays for compounds useful in the prevention of tumours and compounds obtainable by such assays.


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Document History
  • Publication: Feb 26, 2002
  • Application: Apr 30, 1999
    US US 30230599 A
  • Priority: Feb 12, 1999
    GB GB 9900440 W
  • Priority: Aug 20, 1998
    GB GB 9818243 A
  • Priority: Feb 12, 1998
    GB GB 9803035 A

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