{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"US_2016_0220650_A1","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"166-266-103-525-597"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11697,"type":"PATENT","title":"Oregon Health and Science University - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":2948,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8352,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
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administering to the subject, by intraperitoneal or intravenous administration, a recombinant, replication-deficient cytomegalovirus comprising a nucleic acid encoding the cancer antigen, thereby generating the long term, repeatedly stimulated immune response against the cancer antigen."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the recombinant, replication-deficient cytomegalovirus comprises an inactivated gene, wherein the inactivated gene is the gene encoding glycoprotein B (gB), glycoprotein D (gD), glycoprotein H (gH) or glycoprotein L (gL)."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 2, wherein the inactivated gene is the gene encoding gL."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 3, wherein the gene encoding gL is inactivated by a knock out mutation."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the nucleic acid encoding the cancer antigen is operably linked to a constitutive promoter."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the nucleic acid encoding the cancer antigen is operably linked to an inducible promoter."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the recombinant, replication-deficient cytomegalovirus is a murine cytomegalovirus."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the recombinant, replication-deficient cytomegalovirus is a human cytomegalovirus."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 8, wherein the human cytomegalovirus is selected from the group consisting of AD169, Davis, Toledo, and Towne."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the recombinant, replication-deficient cytomegalovirus is administered by intraperitoneal administration."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the recombinant, replication-deficient cytomegalovirus is administered by intravenous administration."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the recombinant, replication-deficient cytomegalovirus is administered in a single dose."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the subject has been diagnosed with a cancer."],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 13, wherein the cancer is melanoma, breast cancer, prostate cancer, ovarian cancer, pancreatic cancer, lung cancer or squamous cell carcinoma."],"number":14,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 13, further comprising administering a chemotherapeutic agent to the subject."],"number":15,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 13, further comprising administering an immunologic anti-cancer agent to the subject."],"number":16,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 13, further comprising administering radiation therapy to the subject."],"number":17,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}